Cancers, Vol. 15, Pages 5003: Evening Primrose Extract Modulates TYMS Expression via SP1 Transcription Factor in Malignant Pleural Mesothelioma

Conclusion: EPE components reduced TYMS expression by occupation of SP1 motifs on the tyms promoter and reversed the EMT phenotype of invasive MPM cells. Further in-depth analysis of the molecular docking of polyphenol compounds with SP1 regulatory motifs is required.

Source: Cancers - October 16, 2023 Category: Cancer & Oncology Authors: Ma łgorzata Chmielewska-Kassassir Katarzyna Sobierajska Wojciech M. Ciszewski Jakub Kryczka Andrzej Zieleniak Lucyna A. Wozniak Tags: Article Source Type: research