Fractional microablative CO2 laser in breast cancer survivors affected by iatrogenic vulvovaginal atrophy after failure of nonestrogenic local treatments: a retrospective study Erratum
No abstract available (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Erratum Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

Metabolic syndrome and its components in premenopausal and postmenopausal women: a comprehensive systematic review and meta-analysis on observational studies
Conclusions: The prevalence of MetS is relatively high in postmenopausal women and was more prevalent among postmenopausal than premenopausal women. Menopausal hormone therapy should be used with caution in patients with MetS, as its safety has not yet been evaluated among MetS patients and meticulous evaluation of each individual patient before starting MHT is needed. (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Review Article Source Type: research

Drug holidays in women treated for postmenopausal osteoporosis
In this Practice Pearl, the experience with long-term treatment of osteoporosis with bisphosphonates and denosumab will be reviewed as well as the effects of discontinuing therapy, providing the platform for recommendations about “drug holidays” for these medications. (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research

Therapeutic progestin segesterone acetate promotes neurogenesis: implications for sustaining regeneration in female brain
Conclusion: These findings provide preclinical evidence and mechanistic insights for the development of ST-1435 as a neuroregenerative therapy to promote intrinsic regenerative capacity in female brains against aging and neurodegenerative disorders. (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Physical activity modifies genetic susceptibility to obesity in postmenopausal women
Conclusion: Our study suggests that physical activity attenuates the influence of genetic predisposition to obesity, and this effect is more profound in the oldest age group. (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Efficacy of injecting platelet concentrate combined with hyaluronic acid for the treatment of vulvovaginal atrophy in postmenopausal women with history of breast cancer: a phase 2 pilot study
Objective: Approximately 50% to 70% of breast cancer survivors are affected by one or more symptoms of vulvovaginal atrophy (VVA). For those who cannot take hormone therapy, autologous platelet-rich plasma combined with hyaluronic acid (A-PRP-HA) may provide a new alternative therapy for the treatment of VVA in postmenopausal women with history of breast cancer. Methods: We enrolled 20 postmenopausal breast cancers survivors with VVA and a score of (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Sex hormone levels and risk of primary open-angle glaucoma in postmenopausal women
Conclusions: Overall, plasma sex hormone levels in postmenopausal women were not associated with POAG risk; however, a trend of higher testosterone levels being associated with higher POAG risk and higher IOP at diagnosis was observed and needs confirmation. (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Anxiety levels predict fracture risk in postmenopausal women assessed for osteoporosis
This study aimed at investigating the role of severity of anxiety in bone health. Methods: Multiple clinical risk factors for fractures, the Fracture Risk Assessment Tool score, the bone mineral density (BMD) at the lumbar spine and femoral neck, Hamilton Anxiety Rating Scale (HAMA) scores, Beck Depression Inventory scores, and the 36-Item Short Form Health Survey (SF-36) scores for evaluation of the quality of life were determined, and x-ray vertebral morphometry was carried out in postmenopausal women referred for osteoporosis. Results: Of the 192 women recruited (mean age 67.5 ± 9.5 years), participants...
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Vasomotor symptoms in women over 60: results from the Data Registry on Experiences of Aging, Menopause, and Sexuality (DREAMS)
Objective: Frequency of vasomotor symptoms (VMS) in older women and the contributing factors are largely undefined. We measured the frequency of moderate-to-severe vasomotor symptoms (msVMS) in women ≥60 years of age and examined their characteristics to determine factors that may associate with VMS in older women. Methods: A cross-sectional survey was completed using the Menopause Health Questionnaire from the Data Registry on Experiences of Aging, Menopause, and Sexuality. Data were collected from women presenting for menopause consultation to Mayo Clinic, Rochester, MN, from January 1, 2006 to October 7, 2014. W...
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Factors associated with developing vaginal dryness symptoms in women transitioning through menopause: a longitudinal study
Conclusion: In these longitudinal analyses, our data support many clinical observations about the relationship between vaginal dryness, menopause, and pain during intercourse, and suggest that reporting of vaginal dryness is not related to androgen level or sexual intercourse frequency. (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Effects of vaginal estradiol tablets and moisturizer on menopause-specific quality of life and mood in healthy postmenopausal women with vaginal symptoms: a randomized clinical trial
Conclusions: Treatment with low-dose vaginal estradiol, but not vaginal moisturizer, modestly improved menopause-related quality of life and sexual function domain scores in postmenopausal women with moderate–severe vulvovaginal symptoms. (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Guidelines for the evaluation and treatment of perimenopausal depression: summary and recommendations
There is a new appreciation of the perimenopause – defined as the early and late menopause transition stages as well as the early postmenopause - as a window of vulnerability for the development of both depressive symptoms and major depressive episodes. However, clinical recommendations on how to identify, characterize and treat clinical depression are lacking. To address this gap, an expert panel was convened to systematically review the published literature and develop guidelines on the evaluation and management of perimenopausal depression. The areas addressed included: 1) epidemiology; 2) clinical presentation; 3...
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Consensus Recommendations Source Type: research

Time to advocate for better science, and better treatments for women
No abstract available (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Editorials Source Type: research

Do current treatment options fall short for persistent vasomotor symptom bother in women over 60?
No abstract available (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Editorials Source Type: research

Clinician practice: bridging what we clinically know about genitourinary syndrome of menopause and what research data report to us
No abstract available (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Editorials Source Type: research

25 years and sex is still hot
No abstract available (Source: Menopause)
Source: Menopause - September 14, 2018 Category: OBGYN Tags: Editorials Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

Is ovarian reserve associated with body mass index and obesity in reproductive aged women? A meta-analysis
Conclusion: Ovarian reserve markers of AMH and FSH are significantly lower in obese than in nonobese women, and BMI is negatively correlated with AMH in all study populations, and with FSH in fertile non-PCOS subgroups. PCOS and fertility status do not appear to affect the associations. (Source: Menopause)
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Review Article Source Type: research

Tissue selective estrogen complex (TSEC): a review
Conclusions: Choice of SERM, selection of doses, and clinical trial data evaluating safety and efficacy are key to ensuring safety and adequate therapeutic effect of TSECs for addressing menopausal symptoms. (Source: Menopause)
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Clinical Corner: Invited Review Source Type: research

Design and protocol of Estrogenic Regulation of Muscle Apoptosis (ERMA) study with 47 to 55-year-old women's cohort: novel results show menopause-related differences in blood count
Conclusions: The ERMA study was successful in recruiting and characterizing the menopausal status of a cohort sample of middle-aged women. The significant group differences found in the blood count variables and their associations with E2 and FSH verifies menopause-associated changes in WBC composition potentially being an early sign of low-grade inflammation that may develop later in life. (Source: Menopause)
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Vascular dysfunction across the stages of the menopausal transition is associated with menopausal symptoms and quality of life
Objective: The menopausal transition is associated with somatic symptoms and increased rates of depression, which can impair quality of life (QOL) and increase cardiovascular disease (CVD) risk. This period is also associated with accelerated vascular aging (arterial stiffening and endothelial dysfunction), an antecedent to CVD. This secondary analysis sought to explore associations between depression, menopausal symptoms and QOL, and vascular aging across menopause stages. Methods: Arterial stiffness (carotid artery compliance), endothelial function (brachial artery flow-mediated dilation [FMD]), menopausal symptoms ...
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Effect of a 1-year elastic band resistance exercise program on cardiovascular risk profile in postmenopausal women
Conclusion: One year of progressive resistance training with elastic bands has beneficial effects on anti-inflammatory and anthropometric cardiovascular risk factors in menopausal women, including changes in lipid profile. (Source: Menopause)
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Original Articles Source Type: research

The effects of mindfulness and relaxation training for insomnia (MRTI) on postmenopausal women: a pilot study
Conclusions: Eight weeks mindfulness meditation training improved sleep quality, quality of life, attention levels, and reduced vasomotor symptoms in postmenopausal women with insomnia. (Source: Menopause)
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Estrogen-alone therapy and invasive breast cancer incidence by dose, formulation, and route of delivery: findings from the WHI observational study
This study directly compared different estrogen doses, formulations, and route of delivery of estrogen alone among women with a hysterectomy in relation to invasive breast cancer incidence. Methods: The Women's Health Initiative Observational Study is a large multicenter prospective cohort study conducted at 40 US sites. Analyses included 26,525 postmenopausal women with a hysterectomy, aged 50 to 79 years, at study entry, recruited between September, 1993 and December, 1998, with annual follow-up through September 12, 2005. Results: Average follow-up was 8.2 years. For conjugated equine estrogen (CEE) users, no diff...
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Negative beliefs about back pain are associated with persistent, high levels of low back disability in community-based women
This study examined the association between beliefs about back pain and the development and progression of low back pain and disability over a 2-year period in community-dwelling women. Methods: A total of 506 women were recruited at baseline to participate in a 2-year cohort study. Beliefs about back pain were measured at baseline using the Back Beliefs Questionnaire, and low back pain and disability were assessed at baseline and 2 years using the Chronic Pain Grade Questionnaire (CPG). Participants were categorized into the following groups based on their CPG scores: no, developing, resolving, and persistent high-inte...
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Endometrial cancer in the elderly: does age influence surgical treatments, outcomes, and prognosis?
Objective: To compare clinicopathological characteristics, surgical outcomes, and survival rates for nonelderly ( (Source: Menopause)
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Multifactorial: pain in the menopause transition
No abstract available (Source: Menopause)
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Editorials Source Type: research

Endometrial cancer in the elderly: does patient age influence the choice of treatment interventions and do age-related treatment choices impact survival?
No abstract available (Source: Menopause)
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Editorials Source Type: research

Deciphering the complex relationship between menopause and heart disease: 25 years and counting
No abstract available (Source: Menopause)
Source: Menopause - August 21, 2018 Category: OBGYN Tags: Editorials Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - July 26, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - July 26, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - July 26, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - July 26, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - July 26, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - July 26, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

Perspectives on counseling patients about menopausal hormone therapy: strategies in a complex data environment
Conclusions: Necessary components for achieving high-quality, shared decisions about HT involve a combination of medical evidence, communication skills, and recognition of patient goals and concerns. Use of such strategies can enhance women's satisfaction with care. (Source: Menopause)
Source: Menopause - July 26, 2018 Category: OBGYN Tags: Review Article Source Type: research

Hormone therapy in menopausal women with fibroids: is it safe?
Menopause is an important transition in the life of women. It has been estimated that by the year 2030, worldwide 1.2 billion women will be menopausal. The most bothersome symptoms of menopause are believed to be due to declines in estrogen levels in postmenopausal women. Thus, hormone therapy is an effective treatment option for menopausal women, although prolonged use of hormone therapy is associated with a slightly increased risk of breast cancer, thromboembolism, and stroke. A literature search for studies evaluating the effects of hormone therapy in menopausal women with asymptomatic fibroids demonstrated variable eff...
Source: Menopause - July 26, 2018 Category: OBGYN Tags: Personal Perspective Source Type: research

Evaluation and management of migraine in midlife women
Migraine is highly prevalent in women and, in addition to the pain component, can be associated with significant disability and loss of productivity. Migraine is often connected to fluctuations in hormones (primarily estrogen), commonly arising in puberty, worsening in perimenopause, and quiescing in late menopause. This Practice Pearl discusses the various types of migraine with respect to hormone fluctuations and details acute as well as preventive treatment. (Source: Menopause)
Source: Menopause - July 26, 2018 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research

A randomized, double-blind, placebo-controlled trial of Chinese herbal medicine capsules for the treatment of premature ovarian insufficiency
This study was conducted to evaluate the treatment effectiveness of Chinese herbal medicine capsules containing the Yangyin Shugan formula (YYSG) in premature ovarian insufficiency (POI). Methods: One-hundred forty-six women with POI participated in this stratified, randomized, double-blind, placebo-controlled clinical trial. Participants in two groups (n = 73 in each)—the YYSG group and control group—underwent treatment for 12 weeks. Outcome measures included the Chinese version Menopause-Specific Quality of Life questionnaire (CMS), serum levels of basal follicle-stimulating hormone (bFSH), basal estra...
Source: Menopause - July 26, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Older women do not have seasonal variations of vitamin D levels: a study from a southern country
Objective: The aim was to study whether the seasonal variation of vitamin D [25(OH)-D or calcidiol] is similar or different in younger and older women living in a southern country. Methods: Measurement of serum 25(OH)-D concentration in 739 Chilean women aged 20 to 87 years, residents of Santiago (latitude: 33.4° South) who, during a routine gynaecological checkup, agreed to be evaluated. Results: The mean serum concentration of 25(OH)-D for the group was 24.1 ± 10.5 ng/mL. In women 20 to 39 years, the mean was significantly different from the mean of the ≥60 years old group (25.8 ± 1...
Source: Menopause - July 26, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Association between waist-to-height ratio and anxiety in middle-aged women: a secondary analysis of a cross-sectional multicenter Latin American study
Conclusions: In this series, WHtR was associated with anxiety in middle-aged women. It is advisable to further study this anthropometric measure in order for it to be incorporated in the routine clinical practice and evaluation of middle-aged women. (Source: Menopause)
Source: Menopause - July 26, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Isolated vitamin D supplementation improves the immune-inflammatory biomarkers in younger postmenopausal women: a randomized, double-blind, placebo-controlled trial
Objective: The aim of this study was to evaluate the effect of vitamin D (VitD) supplementation on immune-inflammatory biomarkers in younger postmenopausal women. Methods: In this double-blind, placebo-controlled trial, 160 postmenopausal women aged 50 to 65 years with amenorrhea ≥12 months were randomized into two groups: VitD group, oral supplementation with 1000 IU VitD3/day (n = 80) or placebo group (n = 80). The intervention time was 9 months, and the women were assessed at baseline and endpoint. Serum levels of interleukins (ILs)-1β, IL-5, IL-6, IL-10, IL-12ρ70, IL-17α, tumor necrosis...
Source: Menopause - July 26, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Climacteric-related symptoms in menopause transition and beyond: a prospective 19-year follow-up study on previously hysterectomized women
Conclusions: The only symptom with notable decrease was vasomotor symptoms. The etiology of other symptoms, commonly connected to menopause transition, is probably multifactorial and not substantially dependent on the climacteric. (Source: Menopause)
Source: Menopause - July 26, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Risk factors for 5-year prospective height loss among postmenopausal women
Conclusions: This set of available variables may be useful in predicting the 5-year risk of height loss of 1 inch or more in postmenopausal women. These findings may help to target older women at risk of height loss who may benefit most from prevention strategies for fracture and mortality. (Source: Menopause)
Source: Menopause - July 26, 2018 Category: OBGYN Tags: Original Articles Source Type: research

SLCO1B1 genetic variation and hormone therapy in menopausal women
Conclusions: Individual variation in sulfated estrogens is explained, in part, by genetic variation in SLCO1B1. Bioavailability of sulfated estrogens may contribute to relief of night sweats. (Source: Menopause)
Source: Menopause - July 26, 2018 Category: OBGYN Tags: Original Articles Source Type: research