In Reply
No abstract available (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Letters to the Editor Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Letters to the Editor Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Letters to the Editor Source Type: research

Intracrinology and menopause: the science describing the cell-specific intracellular formation of estrogens and androgens from DHEA and their strictly local action and inactivation in peripheral tissues
The secretion of estrogens by the ovaries stops at menopause. Afterward, dehydroepiandrosterone (DHEA) becomes the only source of both estrogens and androgens during all the postmenopausal years. To maintain very low and biologically inactive concentrations of estrogens and androgens in the circulation, DHEA is transformed intracellularly into cell-specific small amounts of estrogens and androgens (except in the endometrium) which then act and are inactivated locally in the same cells, thus avoiding biologically significant systemic exposure to active sex steroids. The secretion of DHEA, however, mainly of adrenal origin, ...
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Personal Perspective Source Type: research

Clinical management of hypoactive sexual desire disorder
Although a woman's healthcare provider has the best opportunity to address hypoactive sexual desire disorder (HSDD), most women are reluctant to discuss their loss of sexual desire. The feeling is often mutual, because limited education and misunderstanding persist, leaving few providers feeling competent to assess and treat this condition. The purpose of this Practice Pearl is to improve the clinician's understanding of and confidence in discussing HSDD, including symptoms, etiology, burden, diagnosis, and treatment. (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research

Factors associated with age at natural menopause among elderly women in São Paulo, Brazil
Conclusions: We found significant associations of age at natural menopause with reproductive and lifestyle factors similar to some studies of women from developed countries. (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Validation of the 10-item Cervantes Scale in middle-aged Portuguese women: paper-and-pencil and online format assessment of menopause-related symptoms
Conclusions: The Portuguese language version of the CS-10 rendered data with good psychometric properties in a sample of middle-aged Portuguese women. Therefore, it can be used in both clinical and community settings. The weak association between both instruments (UQoLS and CS-10) might be due to the different conceptualization of the quality of life construct: the CS-10 focuses on symptom severity, whereas the UQoLS assesses domains such as work-related or health-related behaviors. (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Hormone therapy in postmenopausal women associated with risk of stroke and venous thromboembolism: a population-based cohort study in Taiwan
Conclusions: In postmenopausal Taiwanese women, HT may be associated with an increased risk of cardiovascular disease. Although the women in our population receiving HT were near menopausal age, their risk of cardiovascular disease was still higher than in the non-HT group. (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Demands for perimenopausal health care in women aged 40 to 60 years—a hospital-based cross-sectional study in Shanghai, China
Objectives: The aim of the study was to describe the major complaints of menopausal symptoms among middle-aged women who initiated healthcare seeking for menopausal symptoms and to understand the factors influencing women's decisions to seek perimenopausal health care in Shanghai, China. Methods: A cross-sectional study was performed in five hospitals in Shanghai. Women aged 40 to 60 years at their first visit to the perimenopausal outpatient departments/clinics were investigated in person over a 3-month period. Information on sociodemographics, menopausal symptoms, and experiences in seeking perimenopausal health car...
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Status of bone strength and factors associated with vertebral fracture in postmenopausal women with type 2 diabetes
Conclusions: Low bone mass and deteriorated TBS were noted in approximately two-thirds of T2DM women and was also associated with vertebral fracture. In addition to aging, poor glycemic control may play an important role in bone remodeling, which may be associated with changes in bone strength in T2DM women. Bone strength together with clinical risk factors has the strongest association with fracture, and may potentially be useful to identify women with T2DM at risk. (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Bazedoxifene-induced vasodilation and inhibition of vasoconstriction is significantly greater than estradiol
Conclusion: Bazedoxifene and bazedoxifene + estradiol relaxed mesenteric arteries and opposed vasoconstriction to a greater degree than estradiol or medroxyprogesterone + estradiol. These effects were independent of sex and G-protein-coupled estrogen receptor expression. We conclude that bazedoxifene may provide vascular benefits over estrogen alone or estrogen plus progestogen combinations in postmenopausal women. (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Changes in adiposity and other factors in relation to age at natural menopause: analyses from the coronary artery risk development (CARDIA) study
Conclusion: These findings show that age at natural menopause is partly determined by modifiable factors such as premenopausal hypertension and baseline adiposity. These results highlight the importance of both control and prevention of cardiovascular risk factors such as excess weight in early to mid-adulthood before menopause onset. (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Decreasing sleep-related symptoms through increasing physical activity among Asian American midlife women
Conclusions: The WPAPP is potentially beneficial in decreasing Asian American midlife women's sleep-related symptoms and promoting their lifestyle physical activity. (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Successful long-term use of Gellhorn pessary and the effect on symptoms and quality of life in women with symptomatic pelvic organ prolapse
Conclusions: More than half of the patients continued long-term use of the pessary. The Gellhorn pessary can resolve prolapse and voiding difficulty symptoms effectively. In addition, the Gellhorn pessary can significantly improve the QOL of women via long-term use. However, the Gellhorn pessary has a limited effect on defecatory symptoms. (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Postmenopausal hormone therapy is accompanied by elevated risk for uterine prolapse
Objective: Receptors for estrogen and progesterone are present in the pelvic floor, and therefore, postmenopausal hormone therapy may affect its function. We compared the former use of estradiol-progestogen postmenopausal hormone therapy in nonhysterectomized women with a uterine prolapse surgery (N = 12,072) and control women (N = 33,704). Methods: The women with a history of uterine prolapse operation were identified from the Finnish National Hospital Discharge Register, and the control women from the Finnish Central Population Register. The use of hormone therapy was traced from the national drug reimbursem...
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Risk factors for sexual dysfunction in BRCA mutation carriers after risk-reducing salpingo-oophorectomy
Objective: The aim of the study was to identify risk factors for sexual dysfunction in BRCA mutation carriers who have undergone risk-reducing salpingo-oophorectomy (RRSO). Methods: A cross-sectional study was performed. BRCA1/2 mutation carriers with and without RRSO were surveyed to determine sexual function (Female Sex Function Index [FSFI]), demographics, medical history, sleep quality, depression, and anxiety scores. Characteristics of patients with the lowest quartile of FSFI scores ( (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

WISDOM survey: attitudes and behaviors of physicians toward vulvar and vaginal atrophy (VVA) treatment in women including those with breast cancer history
Conclusions: More OB/GYNs than PCPs prescribed VVA treatment, especially vaginal estrogens, for menopausal women, but both groups generally had similar attitudes and behaviors regarding VVA treatment. Physician comfort was low when prescribing to women with a history of breast cancer, despite women's health medical societies supporting vaginal estrogen use in women with a history of estrogen-dependent breast cancer who were unresponsive to nonhormonal therapies when offered in consultation with their oncologist. (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Original Articles Source Type: research

Sleep: suicide's tipping point? Time for menopausal practitioners to act
No abstract available (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Editorials Source Type: research

Pelvic organ prolapse: from estrogen to pessary
No abstract available (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Editorials Source Type: research

The unintended sexual health consequences of risk-reducing surgery: we must do more!
No abstract available (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Editorials Source Type: research

The WISDOM survey: toward wiser care of women with vulvovaginal atrophy
No abstract available (Source: Menopause)
Source: Menopause - January 29, 2019 Category: OBGYN Tags: Editorials Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Letters to the Editor Source Type: research

The mysteries of menopause and urogynecologic health: clinical and scientific gaps
Conclusions: Innovative human studies, focused on the independent effects of menopausal estrogen levels, uncoupled from tissue and cellular senescence, are needed. (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Clinical Corner: Invited Review Source Type: research

Association between metabolic profiles in urine and bone mineral density of pre- and postmenopausal Chinese women
Conclusions: Based on the GC–MS metabolomic platform, four typical pathological phases during the progression of postmenopausal osteoporosis were described. Several differentiating metabolites and metabolic pathways were found to be closely related to the pathology of postmenopausal osteoporosis. Our results provided a solid foundation for further studies on early diagnosis and pathomechanistic evaluation. (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Serum androgen profiles in women with premature ovarian insufficiency: a systematic review and meta-analysis
Objective: This meta-analysis aims to investigate serum androgen profiles (testosterone, dehydroepiandrosterone sulfate, androstenedione, and sex hormone-binding globulin) in women with premature ovarian failure and to establish if there is evidence of diminished androgen levels in these women. Methods: Various Internet sources of PubMed, Cochrane library, and Medline were searched systematically until February, 2018. Out of a pool of 2,461 studies, after applying the inclusion/exclusion criterion, 14, 8, 10, and 9 studies were chosen for testosterone, dehydroepiandrosterone sulfate, androstenedione, and sex hormone-b...
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Original Articles Source Type: research

The histological microstructure and in vitro mechanical properties of the human female postmenopausal perineal body
Conclusions: We determined the structural and mechanical parameters of the perineal body. The resultant data could be used as input for models simulating pelvic floor prolapse or dysfunction. (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Original Articles Source Type: research

The many menopauses: searching the cognitive research literature for menopause types
Conclusions: This review revealed that although some clinical studies differentiated between the many menopauses, most did not. This may limit their relevance to clinical practice. We found that when menopause types are distinguished, the differing cognitive outcomes of each type are clarified, yielding the strongest evidence, which in turn will be able to inform best clinical practice for treating all women. (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Difference in carotid intima-media thickness between pre and postmenopausal women
Conclusions: Our findings indicate that postmenopausal status is a significant factor of high mean CIMT. These findings add to the growing evidence showing that menopause transition is a critical period for subclinical atherosclerosis development. (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Original Articles Source Type: research

A prospective study of inflammatory biomarker levels and risk of early menopause
Conclusions: The observation of lower risk of early menopause among women with moderate sTNFR2 levels compared with women with lower and higher levels warrants further prospective study. (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Changes in carotid artery intima-media thickness 3 years after cessation of menopausal hormone therapy: follow-up from the Kronos Early Estrogen Prevention Study
Conclusions: Cessation of MHT at the lower doses and formulations used in KEEPS did not appear to alter the trajectory of CIMT over a 3-year follow-up period. CIMT, however, increased in all groups over the entire 7-year timeframe as expected with age and timing of menopause possibly key contributors. (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Physical activity and weight gain after smoking cessation in postmenopausal women
Conclusions: Our data demonstrate that even a modest increase in PA (equivalent to current recommendations) can attenuate weight gain after quitting smoking among postmenopausal women, especially in combination with improved diet. (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Apolipoprotein E4 genotype in combination with poor metabolic profile is associated with reduced cognitive performance in healthy postmenopausal women: implications for late onset Alzheimer's disease
Conclusions: In a general population of postmenopausal women, association between poor metabolic profile with reduction in cognitive performance is more apparent in women who carry an ApoE4 allele. These data indicate a window of opportunity for interventions to reverse the trajectory of the preclinical phase of Alzheimer's disease. (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Hormone therapy and carotid intima-media thickness: the thick and thin of it
No abstract available (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Editorials Source Type: research

Preventing postsmoking cessation weight gain: exercise helps, even if previously inactive
No abstract available (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Editorials Source Type: research

Toward a personalized lifestyle intervention approach to prevent Alzheimer's disease
No abstract available (Source: Menopause)
Source: Menopause - December 28, 2018 Category: OBGYN Tags: Editorials Source Type: research

29th Annual Meeting of The North American Menopause Society October 3-6, 2018, San Diego, CA
No abstract available (Source: Menopause)
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Abstracts Source Type: research

Subject Index
No abstract available (Source: Menopause)
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Index Source Type: research

Author Index
No abstract available (Source: Menopause)
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Index Source Type: research

Abstract Author Index
No abstract available (Source: Menopause)
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Abstracts Source Type: research

Acknowledgment of Reviewers
No abstract available (Source: Menopause)
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Acknowledgment of Reviewers Source Type: research

Appropriate evaluation of postmenopausal bleeding
In clinical practice, although only 3% to 7% of women with postmenopausal bleeding (PMB) will ultimately be found to have cancer, it is the clinician's responsibility to ensure that endometrial cancer is not present. The diagnostic evaluation of PMB has evolved greatly. This Practice Pearl addresses the appropriate evaluation of women with PMB. (Source: Menopause)
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research

Anxiety, depressive symptoms, and cardiac autonomic function in perimenopausal and postmenopausal women with hot flashes: a brief report
Objective: The aim of the study was to examine whether anxiety and depressive symptoms are associated with an adverse cardiac autonomic profile among midlife women with hot flashes. Methods: Anxiety and depressive symptoms were evaluated by validated self-administered questionnaires among peri- and postmenopausal women in a randomized trial of slow-paced respiration for hot flashes. Pre-ejection period (PEP), a marker of sympathetic activation, and respiratory sinus arrhythmia (RSA), a marker of parasympathetic activation, were measured at baseline and 12 weeks using impedance cardiography and electocardiography. Mult...
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Brief Report Source Type: research

The naturally derived small compound Osthole inhibits osteoclastogenesis to prevent ovariectomy-induced bone loss in mice
This study was to determine the bone protective effects and underlying mechanisms of Osthole (OT) in ovariectomized (OVX) mice. We found that the inhibitory effects of OT on receptor activator of nuclear factor kappa-B ligand (RANKL)-activated osteoclastogenesis are responsible for its bone protective effects in OVX mice. Methods: Eight-week-old mice were ovariectomized and OT (10 mg/kg/d) was intraperitoneally administrated to OVX mice 7 days after the surgery and were sacrificed at the end of the 3 months. Osteoclasts were generated from primary bone marrow macrophages (BMMs) to investigate the inhibitory effects of...
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Ovariectomy and obesity have equal impact in causing mitochondrial dysfunction and impaired skeletal muscle contraction in rats
Objective: Previous studies have demonstrated that either an obese-insulin resistance condition or a condition involving loss of estrogen impaired skeletal muscle function as indicated by a decrease in muscle contraction. The differing effects of combined estrogen deficiency over obese-insulin resistance on skeletal muscle function have, however, not yet been determined. Our hypothesis was that estrogen deficiency aggravates skeletal muscle dysfunction in obese-insulin resistant rats, via increased muscle oxidative stress and mitochondrial dysfunction. Methods: Twenty-four female Wistar rats were divided into 2 groups...
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Original Articles Source Type: research

Effect of combined circuit exercise on arterial stiffness in hypertensive postmenopausal women: a local public health center-based pilot study
This study examined the effect of combined circuit exercise on arterial stiffness in hypertensive postmenopausal women. Furthermore, it ascertained whether performing this exercise program is feasible in local public health centers with better accessibility than research and commercial facilities. Methods: Among 24 hypertensive postmenopausal women, 16 finished this study in either the control (n = 8) or exercise (n = 8) group. Except for one participant who withdrew from the study due to the difficulty of the exercise program, seven participants withdrew due to reasons unrelated to the study. Circuit-type exerc...
Source: Menopause - November 29, 2018 Category: OBGYN Tags: Original Articles Source Type: research