To the Editor:
No abstract available (Source: Menopause)
Source: Menopause - August 28, 2020 Category: OBGYN Tags: Letters to the Editor Source Type: research

In Reply:
No abstract available (Source: Menopause)
Source: Menopause - August 28, 2020 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor:
No abstract available (Source: Menopause)
Source: Menopause - August 28, 2020 Category: OBGYN Tags: Letters to the Editor Source Type: research

Fractional Pixel CO2 laser treatment for decubitus ulcer in advanced pelvic organ prolapse: a case report
Conclusions: This case demonstrates that fractional Pixel CO2 laser treatment is a viable option for managing decubitus ulcers before definitive surgery in postmenopausal women with advanced pelvic organ prolapse. (Source: Menopause)
Source: Menopause - August 28, 2020 Category: OBGYN Tags: Case Report Source Type: research

Effects of phytoestrogen supplementation on intermediate cardiovascular disease risk factors among postmenopausal women: a meta-analysis of randomized controlled trials
Conclusions and Relevance: Phytoestrogen supplementation seems to modestly improve the CVD risk profile of postmenopausal women by influencing blood lipids and parameters of endothelial function. In women with an increased risk of atherosclerosis, although modest, a harmful effect on CIMT progression may be present. Because of limited quality and the heterogeneous nature of the current evidence, additional rigorous studies are needed to explore the role of phytoestrogens in menopausal cardiovascular health. Video Summary: http://links.lww.com/MENO/A593. (Source: Menopause)
Source: Menopause - August 28, 2020 Category: OBGYN Tags: Review Articles Source Type: research

Variation in outcome reporting and measurement tools in clinical trials of treatments for genitourinary symptoms in peri- and postmenopausal women: a systematic review
Conclusions and Relevance: There is heterogeneity in reported outcomes and measures used in clinical trials of treatments for genitourinary symptoms at menopause and uncertainty as to which outcomes best reflect patient priorities and symptoms. The findings from this systematic review have informed an international survey of stakeholders to determine priorities for outcome selection and reporting. This survey will then inform the development of a Core Outcome Set for use in future clinical trials by the COMMA (Core OutcoMes in MenopAuse) consortium. Video Summary:http://links.lww.com/MENO/A599. (Source: Menopause)
Source: Menopause - August 28, 2020 Category: OBGYN Tags: Review Articles Source Type: research

Changes in kidney function during the menopausal transition: the Study of Women's Health Across the Nation (SWAN) – Michigan site
Conclusions: Kidney function declines during the MT. Although associated with levels of FSH and SHBG, the rate of decline in eGFR is consistent with what would be expected of age alone. (Source: Menopause)
Source: Menopause - August 28, 2020 Category: OBGYN Tags: Brief Report Source Type: research

Blood pressure and cardiovascular risk factors in women treated for climacteric symptoms with acupuncture, phytoestrogens, or hormones
Objective: To evaluate the response of cardiovascular risk factors to the treatment of climacteric symptoms. Methods: In this prospective study, women reporting climacteric symptoms were randomized to 3 months of treatment with either acupuncture (n = 19), phytoestrogens (75 mg soy isoflavones, BID; n = 22), or low-dose hormone therapy (HT; 0.3 mg conjugated equine oestrogens plus 1.5 mg medroxyprogesterone acetate; n = 20). Greene's climacteric scale, blood pressure (BP), lipids, glucose, insulin, and homeostatic model assessment of insulin resistance were assessed before and after treatment. Observ...
Source: Menopause - August 28, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Validation of the Chinese version of the Pelvic Organ Prolapse Symptom Score (POP-SS)
The objective of the present study was to translate the Pelvic Organ Prolapse Symptom Score (POP-SS) into Chinese and validate it in a population of Chinese women. Methods: The POP-SS questionnaire was translated into simplified Chinese language following an intercultural adaptation procedure. One hundred forty-six patients who met the inclusion criteria were recruited. Among the enrolled patients, 63 underwent surgery for POP and 50 underwent pessary management. They completed the questionnaires at baseline (T1), 1 to 2 weeks later (T2), and 3 months after intervention (T3). Evaluation for psychometric properties was c...
Source: Menopause - August 28, 2020 Category: OBGYN Tags: Original Studies Source Type: research

What do Spanish men know about menopause?
Objective: The aim of this study is to evaluate the level of knowledge men have about menopause and to analyze whether sociodemographic aspects influence this knowledge. Methods: A total of 560 consecutive surveys were collected during 2019. Surveys were completed by men anonymously, voluntarily, and without incentives. A maximum score of 45 points was considered for the knowledge analysis. Results: The mean age was 49.13 ± 11.1 years. The most frequent source of information to obtain knowledge about menopause was friends (61.4%). The mean of the questionnaire score was 20.69 ± 6.1 (R: 0-45). ...
Source: Menopause - August 28, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Serum phosphorus levels are associated with carotid intima-media thickness in asymptomatic postmenopausal women
This study aimed to compare the relationship between serum phosphorous concentration and carotid intima-media thickness in healthy asymptomatic postmenopausal women. Methods: A retrospective review of the medical records from a health checkup center in Gangnam Severance hospital between March 2007 and September 2017 was conducted. We examined asymptomatic postmenopausal female patients with age range between 56 and 66 (N = 361) who underwent measurement of carotid intima-media thickness by B-mode ultrasonography. The physiological variables analyzed included mean blood pressure, body mass index, renal function (seru...
Source: Menopause - August 28, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Mediatory role of abdominal obesity in the association of early menopause with diabetes among middle-aged and older Chinese women
Objective: The aim of this study was to assess the association of early menopause with diabetes and the mediating effect of abdominal obesity. Methods: This cross-sectional study was conducted among 5,693 participants. The data from the second follow-up (2015) of the China Health and Retirement Longitudinal Study were used. Participants self-reported their age at menopause and were divided into three age groups (54 years) according to the 10th, 10th to 90th, and 90th percentiles, with a menopausal age of 45 to 54 years serving as reference. The total effect was decomposed into direct and indirect (mediating) effects u...
Source: Menopause - August 28, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Depression, anxiety, and fear of death in postmenopausal women
Conclusion: Depression among postmenopausal women is an important health problem that needs to be studied further. No relation was found between depression and fear of death. These results will be beneficial for raising awareness about depression among postmenopausal women and conducting screening for early diagnosis. (Source: Menopause)
Source: Menopause - August 28, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Comparison of health-related habits and metabolic syndrome risk factors according to obesity type in Korean postmenopausal women
This study aimed to investigate the differences in health-related habits, metabolic syndrome risk factors, and related diseases prevalence according to obesity type in postmenopausal women. Methods: This cross-sectional study used a data set of 1,443 postmenopausal women who were 40 years or older (range = 45-80, mean = 64.10) from the 2016 Korean National Health and Nutrition Examination Survey VII-1. The participants were classified into normal group (body mass index [BMI] (Source: Menopause)
Source: Menopause - August 28, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Influence of dietary habits and Mediterranean diet adherence on menopausal symptoms. The FLAMENCO project
Objective: To explore the association of dietary habits and Mediterranean diet adherence with menopausal symptoms. Methods: The present study included 172 women recruited from the FLAMENCO project. Menopausal symptoms were assessed with the Kupperman Menopausal Index and the Cervantes Menopause and Health Subscale from the validated Cervantes Scale. A food frequency questionnaire was employed to evaluate dietary habits. Adherence to the Mediterranean diet was assessed with the Mediterranean diet score. Results: Intake of poultry and skimmed dairy products was associated with a worse Kupperman Menopausal Index score...
Source: Menopause - August 28, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Association between waist-hip ratio and coronary artery calcification in postmenopausal women
Objective: Many studies have reported that body composition might be associated with cardiovascular disease, but the issue has not been fully investigated in postmenopausal women. Methods: This retrospective study comprised 582 postmenopausal women without a history of cardiovascular disease who visited the Health Promotion Center between May 2008 and February 2018. All women were screened for body fat composition by bioelectrical impedance analysis and for degree of coronary artery calcification (CAC) by multidetector computed tomography. In addition, multivariate analysis, integrated discrimination improvement, and ...
Source: Menopause - August 28, 2020 Category: OBGYN Tags: Original Studies Source Type: research

The effect of menopause on metabolic syndrome: cross-sectional results from the Canadian Longitudinal Study on Aging
Objectives: Data were examined from women surveyed in the Canadian Longitudinal Study on Aging to evaluate whether menopause is an independent risk factor for the development of metabolic syndrome (MetS) or its components, including hypertension, central obesity, dyslipidemia, or elevated glycated hemoglobin. Methods: We conducted a cross-sectional analysis of women aged 45-85 years old that participated in the baseline data of the Canadian Longitudinal Study on Aging Comprehensive Cohort collected from 2012 to 2015. Modified Poisson regression with robust error variance was used to estimate the crude and adjusted rel...
Source: Menopause - August 28, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Prevalence of ocular surface disease symptoms in peri- and postmenopausal women
Conclusions: Sixty-four percent of the pre- and postmenopausal women studied had OSD symptoms. There was a correlation between OSD symptoms and age, postmenopause, and earlier age at menopause, which was associated with an increased prevalence. Video Summary:http://links.lww.com/MENO/A603. (Source: Menopause)
Source: Menopause - August 28, 2020 Category: OBGYN Tags: Original Studies Source Type: research

The 2020 genitourinary syndrome of menopause position statement of The North American Menopause Society
Conclusions: Clinicians can resolve many distressing genitourinary symptoms and improve sexual health and the quality of life of postmenopausal women by educating women about, diagnosing, and appropriately managing GSM. Choice of therapy depends on the severity of symptoms, the effectiveness and safety of treatments for the individual patient, and patient preference. Nonhormone therapies available without a prescription provide sufficient relief for most women with mild symptoms. Low-dose vaginal estrogens, vaginal DHEA, systemic estrogen therapy, and ospemifene are effective treatments for moderate to severe GSM. When l...
Source: Menopause - August 28, 2020 Category: OBGYN Tags: NAMS Position Statement Source Type: research

After menopause, is an enlarging middle, an enlarging cardiovascular risk factor?
No abstract available (Source: Menopause)
Source: Menopause - August 28, 2020 Category: OBGYN Tags: Editorials Source Type: research

What drives metabolic syndrome after menopause, and can we do anything about it?
No abstract available (Source: Menopause)
Source: Menopause - August 28, 2020 Category: OBGYN Tags: Editorials Source Type: research

The role of gynecologists in screening older women for ocular surface disease symptoms
No abstract available (Source: Menopause)
Source: Menopause - August 28, 2020 Category: OBGYN Tags: Editorials Source Type: research

Bruce Ettinger, MD (November 1938-June 2020)
No abstract available (Source: Menopause)
Source: Menopause - August 28, 2020 Category: OBGYN Tags: In Memoriam Source Type: research

The accuracy of ascites cytology in diagnosis of advanced ovarian cancer in postmenopausal women prior to neoadjuvant chemotherapy; Methodological issues - Answer
No abstract available (Source: Menopause)
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Letters to the Editor Source Type: research

The accuracy of ascites cytology in diagnosis of advanced ovarian cancer in postmenopausal women prior to neoadjuvant chemotherapy; Methodological issues
No abstract available (Source: Menopause)
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Letters to the Editor Source Type: research

Can walking exercise programs improve health for women in menopause transition and postmenopausal? Findings from a scoping review
Conclusion: The scoping review highlights the growing interest in walking programs as therapies for menopause and related symptoms and provides evidence of their possible benefit as a wellness option for women in menopause and beyond. Further research would be recommended to establish the therapeutic value of walking programs for women with specific focus on typical menopause symptoms at different stages of menopause. Video Summary:http://links.lww.com/MENO/A587. (Source: Menopause)
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Review Articles Source Type: research

Role of sex steroid hormones in pelvic organ prolapse
Conclusions: Because of the role that estrogen plays in maintaining the integrity of pelvic floor connective tissues, we propose that rigorous and well-controlled studies are needed on the role of exogenous estrogen administration as a form of POP prevention. Video Summary:http://links.lww.com/MENO/A583. (Source: Menopause)
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Review Articles Source Type: research

The effect of hormone therapy on the ocular surface and intraocular pressure for postmenopausal women: a systematic review and meta-analysis of randomized controlled trials
Objective: The aim of the study was to investigate the impact of hormone therapy (HT) on the ocular surface and intraocular pressure in postmenopausal women. Methods: This systematic review and meta-analysis was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses Statement. PubMed, EMBASE, Cochrane Library of Systematic Reviews, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure were searched from inception to November 2019 without language restrictions. Only randomized control...
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Review Articles Source Type: research

The Women's Health Initiative trials of menopausal hormone therapy: lessons learned
Objective: The Women's Health Initiative (WHI) assessed oral conjugated equine estrogens (CEE) taken with or without medroxyprogesterone acetate (MPA) for prevention of chronic disease in postmenopausal women aged 50-79 years. Methods: Women with an intact uterus (n = 16,608) were randomized to CEE+ MPA therapy or placebo for a median of 5.6 years; women with hysterectomy (n = 10,739) were randomized to CEE-alone therapy or placebo for a median of 7.2 years. Both cohorts have been followed for 18 years. Results: In the overall study population (mean age, 63 y), neither estrogen-progestin therapy (EPT) nor e...
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Clinical Corner: Review - Invited Source Type: research

Genetic predictors to acupuncture response for hot flashes: an exploratory study of breast cancer survivors
Conclusions: In this exploratory, proof of concept study, we identified six genotypes that may predict response to acupuncture for hot flashes in breast cancer survivors. If confirmed by future studies, these findings may inform the development of personalized acupuncture for managing hot flashes. (Source: Menopause)
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Brief Report Source Type: research

Retinol-binding protein 4 is associated with arterial stiffness in early postmenopausal women
Conclusions: RBP4 serum levels are associated with arterial stiffness, in a sample of healthy postmenopausal women. If this association is causative, serum RBP4 levels could serve as a marker of arterial stiffness. Prospective studies are required to investigate the significance of our findings. Video Summary:http://links.lww.com/MENO/A621. (Source: Menopause)
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

The effects of a new, improved Chinese medicine, Gengnianchun formula granules, on hot flushes, depression, anxiety, and sleep in Chinese peri- and postmenopausal women: a randomized placebo-controlled trial
Objective: The aim of the study was to investigate the effectiveness and safety of a new, improved herbal formula of a traditional Chinese medicine, improved Gengnianchun (I-GNC), on hot flushes, depression, anxiety, and sleep in peri- and postmenopausal women in China. Methods: A randomized, single-blind, placebo-controlled trial of peri- and postmenopausal women with Kupperman Index (KMI) scores of 15 or higher was conducted for 12 weeks. Hot flush frequencies, KMI scores, Hamilton depression scale scores, Hamilton anxiety scale scores, and Pittsburgh Sleep Quality Index scores were evaluated. Each outcome was evalu...
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Factors associated with counseling and postoperative hormone therapy use in surgically menopausal women
Conclusions: Within our cohort, 66% had no documentation of counseling about menopausal symptoms before surgical menopause. Most women experienced symptoms postoperatively, but less than one-third of symptomatic women received hormone therapy. We have an opportunity to improve anticipatory guidance and informed consent for women undergoing surgical menopause. (Source: Menopause)
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Association between osteoporosis and menopause in relation to SOX6 rs297325 variant in Taiwanese women
Conclusion: SOX6 rs297325 was not significantly associated with osteoporosis but might have modulated the association between menopause and osteoporosis. The risk of osteoporosis was higher in menopausal women with the TC + CC genotype but lower in premenopausal women with the TC + CC genotype. (Source: Menopause)
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Dairy intake is not associated with improvements in bone mineral density or risk of fractures across the menopause transition: data from the Study of Women's Health Across the Nation
Objective: Menopause represents a period in which bone deterioration is accelerated; thus, primary prevention strategies to address age-related bone loss are crucial. Dairy products contain more than a dozen essential nutrients, including calcium, phosphorus, vitamin D, and high-quality protein, as well as bioactive compounds that may promote bone mineralization. However, the relationship between dairy consumption and bone health across the menopause transition remains largely unknown. The purpose of this analysis was to estimate the change in lumbar spine and femoral neck bone mineral density and the risk of bone fractu...
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Associations of pituitary-ovarian hormones and white matter hyperintensities in recently menopausal women using hormone therapy
Conclusions: Circulating levels of pituitary-ovarian hormones associate with changes in WMH volume in recently menopausal women using HT. Whether these relationships would be influenced by different doses of tE2 or oCEE remains to be determined. Video Summary:http://links.lww.com/MENO/A590. (Source: Menopause)
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Incidence of venous thromboembolism among postmenopausal women prescribed ospemifene, selective estrogen receptor modulators for noncancer indications, or untreated vulvar and vaginal atrophy
Conclusions: This interim analysis of an ongoing study suggests a favorable safety profile for ospemifene with respect to VTE. Comparative analyses with covariate adjustment will be performed when data accrual is complete. (Source: Menopause)
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Treatment for vaginal atrophy using microablative fractional CO2 laser: a randomized double-blinded sham-controlled trial
Objective: The aim of this study was to evaluate the efficacy of vaginal CO2 laser for the treatment of vaginal atrophy compared to the sham procedure. Methods: Between June 2016 and May 2017, postmenopausal women with moderate to severe intensity of any vaginal atrophy symptoms (VAS) were invited to participate in the study. A total of 88 women were randomized to receive treatment with either vaginal CO2 laser or sham procedures every 4 weeks for three sessions. Both the participants and the evaluators were blinded to the treatment. Vaginal Health Index (VHI) score (primary outcome), VAS score, and the item for vagin...
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

A multicenter, randomized study to select the minimum effective dose of estetrol (E4) in postmenopausal women (E4Relief): part 1. Vasomotor symptoms and overall safety
Conclusions: Estetrol 15 mg is considered to be the minimum effective daily oral dose for treatment of vasomotor symptoms. Its current seemingly favorable safety profile is further to be confirmed in phase 3 clinical development. Video Summary:http://links.lww.com/MENO/A591. (Source: Menopause)
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Ospemifene: less venous thrombosis than other selective estrogen receptor modulators in postmenopausal women with vulvo vaginal atrophy
No abstract available (Source: Menopause)
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Editorials Source Type: research

How do we measure success in the treatment of genitourinary syndrome of menopause?
No abstract available (Source: Menopause)
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Editorials Source Type: research

Estetrol for menopause symptoms: the Cinderella of estrogens or just another fairy tale?
No abstract available (Source: Menopause)
Source: Menopause - August 1, 2020 Category: OBGYN Tags: Editorials Source Type: research

In Reply:
No abstract available (Source: Menopause)
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor:
No abstract available (Source: Menopause)
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Letters to the Editor Source Type: research

Effect of hormone therapy on muscle strength in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials
Conclusions: The use of HT was not associated with the improvement of muscle strength in postmenopausal women. This finding suggested that HT might not improve muscle strength or that the effect size was too small to identify significant therapeutic efficacy. (Source: Menopause)
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Review Articles Source Type: research

Relationship between age at menarche and risk of glucose metabolism disorder: a systematic review and dose-response meta-analysis
Conclusions: Older age at menarche (range 8-18 years old) is associated with reduced risk of glucose metabolism disorder. The strongest reduction in risk of GDM is observed at menarche age of 14.5 years. (Source: Menopause)
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Review Articles Source Type: research

Climate change and its potential impact on menopausal hot flashes: a commentary
Climate change is known to impact men and women differently and yet how it will change the health impact of menopause, specifically hot flashes, has not been well researched or understood. Given the duration of symptoms, the high number of women suffering from them, and the associated consequences, any marginal change in incidence due to climate change could result in a very large number of women being affected. Global health systems need to be prepared for this and ensure that gendered issues like menopause do not fall through the cracks as we prepare for our future climate. Video Summary:http://links.lww.com/MENO/A549. (Source: Menopause)
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Personal Perspective Source Type: research

Linguistic translation and validation of the Menopause-specific Quality of Life (MENQOL) questionnaire in Greek menopausal women
Conclusions: The Greek version of MENQOL is a reliable instrument for evaluating menopausal women. Availability of an online form will allow wider dissemination of the questionnaire. Further use of the questionnaire in Greece may lead to better understanding of the bothersome symptoms of menopause; a prerequisite to develop intervention studies for amelioration of quality of life. (Source: Menopause)
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Effect of Chinese herbal medicine on serum lipids in postmenopausal women with mild dyslipidemia: a randomized, placebo-controlled clinical trial
This study was aimed to evaluate the effect of Chinese herbal medicine, tonifying kidney and descending turbidity (TKDT) granule, on serum lipid profiles in postmenopausal women with dyslipidemia. Methods: A double-blind randomized, placebo-controlled trial was conducted among 104 postmenopausal Chinese women with mild dyslipidemia. Participants were randomized into treatment group (n = 53) and control group (n = 51). The participants in the treatment group received TKDT granule once per day for 24 weeks, whereas the control group received placebo in the same manner. All participants were subjected to healthy li...
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research

Changes in ultrasound uterine morphology and endometrial thickness during ovarian aging and possible associated factors: findings from a prospective study
Conclusions: The figures for uterine volume and endometrial thickness decrease around menopause using ultrasound measurments with large reductions in the first and second year after the final menstrual period. A higher body mass index is associated with increased endometrial thickness. (Source: Menopause)
Source: Menopause - July 1, 2020 Category: OBGYN Tags: Original Studies Source Type: research