Response to “Letter to the editor in response to: Associations of sleep and female sexual function: good sleep quality matters”
No abstract available (Source: Menopause)
Source: Menopause - November 1, 2021 Category: OBGYN Tags: Letters to the Editor Source Type: research

Letter to the editor in response to: Associations of sleep and female sexual function: good sleep quality matters
No abstract available (Source: Menopause)
Source: Menopause - November 1, 2021 Category: OBGYN Tags: Letters to the Editor Source Type: research

Vaginal CO2 laser therapy versus sham for genitourinary syndrome of menopause management: a systematic review and meta-analysis of randomized controlled trials
Importance: The research of new therapeutic modalities, especially with energy-based devices, has been increasing nowadays for genitourinary syndrome of menopause (GSM) management. Microablative fractional CO2 laser has been used for pelvic floor dysfunction management. Objective: To conduct a systematic review and meta-analysis of randomized controlled trials to compare fractional CO2 laser therapy versus sham therapy for GSM management. Evidence Review: We searched for the available randomized clinical trials in Cochrane Library, PubMed, ISI web of science, and Scopus during March 2021. We included rand...
Source: Menopause - November 1, 2021 Category: OBGYN Tags: Review Article Source Type: research

Addressing intimate partner violence with midlife women: awareness, support, empowerment
Intimate partner violence (IPV) is a prevalent women's health problem that affects the health and well-being of midlife women. Clinicians who provide care to women have a responsibility to address IPV with their patients. Given the complexities surrounding IPV disclosure, the latest recommendations for IPV move beyond prior approaches that emphasize IPV screening and identification to that of universal education about IPV. Women experiencing IPV have indicated the utility of receipt of IPV information and resources regardless of disclosure. Further, a universal-education approach raises awareness about IPV for all patients...
Source: Menopause - November 1, 2021 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research

The effect of hormone therapy on breast density following risk-reducing salpingo-oophorectomy in women with an increased risk for breast and ovarian cancer
Conclusions: A decline in breast density is seen after premenopausal RRSO despite the use of both CEE + MPA or tibolone, although lower breast density is seen after tibolone use. (Source: Menopause)
Source: Menopause - November 1, 2021 Category: OBGYN Tags: Brief Report Source Type: research

Obesity and metabolic syndrome induce hyperfiltration, glomerulomegaly, and albuminuria in obese ovariectomized female mice and obese male mice
Conclusions: In mice, there is a clear interplay between obesity, metabolic syndrome, and menopause in the induction of kidney damage. Video Summary:http://links.lww.com/MENO/A803. (Source: Menopause)
Source: Menopause - November 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Estrogens influence differentially on the pelvic floor muscles activation at somatovisceral reflexes involved in micturition of rabbits
Objective: To determine the estrogen-dependency of the bladder and urethral function and the coordinated activation of pelvic floor muscles (PFM) during micturition. Methods: We allocated age-matched female rabbits to control, 1-month ovariectomized (OVX), and OVX plus 2-week estradiol benzoate (EB) groups to record cystometry, urethral pressure, and electromyograms of bulbospongiosus (Bsm), and pubococcygeus muscles (Pcm) simultaneously. We also measured serum estradiol levels and myofiber cross-sectional area. We assessed urodynamic and urethral variables, categorized the Bsm-Pcm activation patterns at storage...
Source: Menopause - November 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

A predictive model of choosing pessary type for women with symptomatic pelvic organ prolapse
Objective: To investigate clinical factors including translabial ultrasound parameters, which are predictive for choosing pessary type (Ring or Gellhorn) in the fitting trial, and to establish a predictive model. Methods: A retrospective study was conducted on symptomatic women with pelvic organ prolapse (POP) at the Pelvic Floor Disease Diagnosis and Treatment Center (Liaoning Province, China) between May 2018 and December 2020 who were successfully fitted with pessaries. This retrospective study was supplemented with a prospective cohort study on women seeking pessary for first-line treatment of POP at the abo...
Source: Menopause - November 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Prevalence and risk factors for menopausal symptoms in middle-aged Chinese women: a community-based cross-sectional study
Objectives: To examine the prevalence and risk factors of menopausal symptoms in middle-aged Chinese women. Methods: A cross-sectional, community-based study recruited 6,745 women aged 40 to 55 years in the eastern, central, and western regions of China during 2018. Menopausal status was categorized into reproductive stage (defined as regular menstruation or subtle changes in menstrual cycle characteristics), menopausal transition (the beginning of a persistent difference of 7 d in the length of consecutive cycles, or the last menstruation having occurred no more than 12 mo), or postmenpause (the end of th...
Source: Menopause - November 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Effect of free androgen index on blood pressure variability and target organ damage in postmenopausal hypertensive women: findings from a cross-sectional study
Objective: The present study investigated the effects of free androgen index (FAI) on ambulatory blood pressure (ABP) and target organ function in postmenopausal hypertensive women. Methods: A total of 285 postmenopausal hypertensive women (mean age 54.06 ± 3.61) were admitted to the Department of Hypertension of Lanzhou University Second Hospital between December 2018 and December 2020. According to the serum FAI level, the participants were divided into a low-FAI (0.2) group. The relationship of FAI with 24-hour ABP, left ventricular mass index (LVMI), and cardio-ankle vascular index (CAVI) was anal...
Source: Menopause - November 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Association of lifestyle factors with osteoporosis and fracture in postmenopausal women: a Japanese cohort study
Conclusions: Osteoporosis and fracture showed different association patterns with lifestyle factors, and no factors were correlated with an increase in both osteoporosis and fracture. (Source: Menopause)
Source: Menopause - November 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Midwifery-oriented group counseling based on the GATHER approach on quality of life of women during the transition to menopause: a randomized controlled trial
Conclusions: The results of this study suggest that midwifery-oriented group counseling based on the GATHER approach may improve the life quality of women during the transition to menopause. Video Summary:http://links.lww.com/MENO/A816. (Source: Menopause)
Source: Menopause - November 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Healthcare provider knowledge, attitudes, and preferences in management of genitourinary syndrome of menopause in the Mid-South
Conclusion: This study identifies gaps in Mid-South healthcare providers’ awareness of the boxed warning on low-dose vaginal estrogen as well as their comfort level in providing counseling regarding the risks, benefits, and alternatives to vaginal estrogen. Integrated practice between physicians and Advanced Practice Registered Nurses can lead to a significant benefit to patients experiencing menopause as shared experience and knowledge are shared between each group. Our survey does reveal gaps in knowledge and practice for optimal outcomes for patients experiencing genitourinary syndrome of menopause. These resu...
Source: Menopause - November 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Physical activity domains are differently related with quality of life in breast cancer survivors: a cross-sectional study
Conclusions: Sports practice and leisure time/commuting PA were positively related to QoL in BC survivors, while occupational PA was negatively related to QoL, independently of age, marital status, and socioeconomic condition. (Source: Menopause)
Source: Menopause - November 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Effects of menopausal hormone therapy on cardiovascular diseases and type 2 diabetes in middle-aged postmenopausal women: analysis of the Korea National Health Insurance Service Database
Conclusions: Although protective effects of MHT against CVDs or type 2 diabetes were not observed among postmenopausal women who had screened underlying diseases, our results may contribute to reducing the current concerns about the use of MHT for middle-aged postmenopausal women in Korea. Video Summary:http://links.lww.com/MENO/A807. (Source: Menopause)
Source: Menopause - November 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Estrogen modulates metabolic risk profile after resistance training in early postmenopausal women: a randomized controlled trial
Objective: Women experience an unhealthy change in metabolic risk profile at menopause. The purpose of the present study was to determine effects of resistance training with or without transdermal estrogen therapy (ET) on adipose tissue mass and metabolic risk profile in early postmenopausal women. Methods: A double-blinded randomized controlled trial, where healthy, untrained postmenopausal women were allocated to supervised resistance training with placebo (PLC, n = 16) or transdermal ET (n = 15) for 12 weeks. Endpoints with prespecified hypotheses were the change in total fat mass (FM) (main endpoin...
Source: Menopause - November 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Growth of surgically confirmed leiomyomas in postmenopausal women: analysis of the influencing factors
Objectives: The aim of this study was to examine the growth of uterine leiomyomas in postmenopausal women and evaluate the influencing factors associated with fibroid growth. Methods: We retrospectively analyzed the medical records of postmenopausal women with fibroids between 2015 and 2020. All women received at least 2 transvaginal ultrasound examinations within a 6-month interval. All fibroids were verified via surgery. The postoperative pathology of all tumors was uterine fibroid. We calculated the fibroid volume using the ellipsoid volume formula and evaluated the growth rate of fibroids within 6 months s...
Source: Menopause - November 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Menopausal hormone therapy and risk of incident hypertension: role of the route of estrogen administration and progestogens in the E3N cohort
Conclusions: MHT was associated with a modest but significant increased risk of incident hypertension, especially when using oral estrogen in combination with a progestogen such as pregnane and norpregnane derivatives. Surveillance of blood pressure should be added to the medical surveillance of MHT users. Video Summary:http://links.lww.com/MENO/A802. (Source: Menopause)
Source: Menopause - November 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Fibroids after menopause: they never stop growing
No abstract available (Source: Menopause)
Source: Menopause - November 1, 2021 Category: OBGYN Tags: Editorials Source Type: research

Menopausal hormone therapy and hypertension: minimizing risk
No abstract available (Source: Menopause)
Source: Menopause - November 1, 2021 Category: OBGYN Tags: Editorials Source Type: research

Influencing factors on women's attitudes toward menopause: a systematic review
Conclusion and relevance: The findings showed that menopausal stage, menopausal symptoms, and psychological and socioeconomic status can influence the attitude of women toward menopause. Therefore, these factors should be considered in interventions that aim to improve women's attitudes toward menopause. (Source: Menopause)
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Review Article Source Type: research

Menopause preparedness: perspectives for patient, provider, and policymaker consideration
Conclusions: To improve care and quality of life for individuals during the menopause transition and after menopause, the working group recommends developing a more standardized approach to menopause preparedness that includes education for both patients and providers, as well as considering policy solutions to address regulatory barriers to care. Providers also need to factor in the diverse needs of individuals experiencing menopause in the development of their personalized care. (Source: Menopause)
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Personal Perspective Source Type: research

Different cutoff points to diagnose low muscle mass and prediction of osteoporosis in postmenopausal women
This study aimed to verify which of the different cutoff points of low muscle mass (LMM) based on appendicular lean mass (ALM) is associated with osteoporosis in postmenopausal women (PMW). Methods: Cross-sectional study. PMW (n = 355) were classified for the presence of osteoporosis (score (Source: Menopause)
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Brief Reports Source Type: research

Impact of sleep disturbances on employment and work productivity among midlife women in the US SWAN database: a brief report
Conclusions: New-onset sleep problems in midlife women are associated with significant increases in risk of unemployment and ∼$2 billion/yr in lost productivity nationwide. Video Summary:http://links.lww.com/MENO/A798. (Source: Menopause)
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Brief Reports Source Type: research

Associations between menopause, cardiac remodeling, and diastolic function: the CARDIA study
Objectives: Heart failure with preserved ejection fraction (HFpEF) affects more women than men. Menopause may influence HFpEF development in women. We assessed cross-sectional and longitudinal associations between menopause and echocardiographic measures of left ventricular (LV) function and cardiac remodeling. Methods: We studied 1,723 women with available echo data from at least two of: year 5 (Y5) (1990-1991), Y25 (2010-2011), or Y30 (2015-2016) in the Coronary Artery Risk Development in Young Adults study. Cardiac structure and function were measured using 2D and Doppler echocardiography. Cross-sectional ass...
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Association between higher serum uric acid levels within the normal physiological range and changes of lumbar spine bone mineral density in healthy Chinese postmenopausal women: a longitudinal follow-up study
Objectives: The aim of this study was to investigate whether higher serum uric acid (SUA) levels within the physiological range were associated with changes in lumbar spine bone mineral density (LBMD) in postmenopausal women without existing lumbar spine osteoporosis after a longitudinal follow-up of 3.09 years, and to further confirm the relationship between SUA and bone mineral density (BMD) in other sites such as femoral neck, total hip, and trochanter at follow-up. Methods: A longitudinal study of 175 healthy postmenopausal women without osteoporosis was conducted in Shenyang, China. BMD of the lumbar spin...
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

The Women's Study for the Alleviation of Vasomotor Symptoms (WAVS): a randomized, controlled trial of a plant-based diet and whole soybeans for postmenopausal women
This study aimed to assess the effects of the combination of a low-fat plant-based diet and soybeans on the frequency and severity of menopausal hot flashes. Methods: Postmenopausal women (n = 38) reporting two or more hot flashes/day were randomly assigned to a low-fat, vegan diet, including ½ cup (86 g) of cooked soybeans daily, or to no diet changes for 12 weeks. Frequency and severity of hot flashes were recorded using a mobile application, and vasomotor, psychosocial, physical, and sexual symptoms were assessed using the Menopause-Specific Quality of Life Questionnaire. Significance was assessed ...
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

The mediating effect of skeletal muscle index on the relationship between menarcheal age and bone mineral density in premenopausal women by race/ethnicity
Conclusions: SMI, as a full mediator, affected the relationship between menarcheal age and BMD among premenopausal women, and the mediating effects varied by race/ethnicity. To prevent or slow down the loss of hip/spine BMD and the development of osteoporosis, measures aiming at minimizing the risk for muscle mass loss should be recommended, especially for White and African-American women with late menarcheal age. (Source: Menopause)
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Factors related to age at natural menopause in China: results from the China Kadoorie Biobank
Objectives: The aim of this study was to investigate the potentially modifiable factors affecting age at natural menopause (ANM) in Chinese women. Methods: We used cross-sectional data from the China Kadoorie Biobank study which that recruited 0.5 million (0.3 million women) Chinese adults aged 30 to 79 from 2004 to 2008. Multinomial logistic regression models were used to examine the relationships between ANM and various factors recorded at baseline. Results: Among 87,349 postmenopausal women, the mean ANM (SD) was 48.7 (4.3) years. Older age, being a housewife, earlier menarche, and passive smoking were...
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Comparative venous thromboembolic safety of oral and transdermal postmenopausal hormone therapies among women Veterans
Conclusions: Among women veterans, the risk of VTE was similar in users of oral CEE, oral E2, and transdermal E2. These findings do not confirm the previously observed greater safety of transdermal and oral E2 over CEE. (Source: Menopause)
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Dance practice modifies functional fitness, lipid profile, and self-image in postmenopausal women
Objective: The aim of the present study was to analyze the effects of dance practice on body composition, metabolic profile, functional fitness, and self-image/self-esteem in postmenopausal women. Methods: A total of 36 postmenopausal participants (mean age 57 years) danced three times per week for 90 minutes each day and were evaluated before and after 16 weeks. The parameters evaluated were body composition (body fat and lean mass), blood lipids, functional fitness, self-image, and self-esteem. Results: Statistical analysis was done using Student t test for paired samples and the Wilcoxon test with ...
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Hormone therapy formulation, dose, route of delivery, and risk of hypertension: findings from the Women's Health Initiative Observational Study (WHI-OS)
Objective: Using data from the Women's Health Initiative Observational Study (WHI-OS), to determine the role of estrogen formulation, dose, route of delivery, and its combination with different progestogens on the risk for hypertension in the WHI-OS. Methods: After excluding women with diagnosed hypertension, receiving antihypertensive medication, presenting with elevated blood pressure ( ≥ 140/90), and those not taking menopausal hormone therapy at baseline, 19,986 women remained eligible for the analyses. Using hierarchal modeling, proportional hazard rate calculation, and linear and logistic regression...
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Reproductive period and preclinical cerebrospinal fluid markers for Alzheimer disease: a 25-year study
Conclusions: Our findings suggest that longer exposure to endogenous estrogen may be associated with increased levels of AD biomarkers in the preclinical phase of AD. These findings, however, need to be confirmed in larger samples. Video Summary:http://links.lww.com/MENO/A804. (Source: Menopause)
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Obesity increases endometrial cancer risk in Chinese women with postmenopausal bleeding
We examined the relationship between body mass index (BMI) at referral and subsequent diagnosis of endometrial cancer in a cohort of Chinese women presenting with postmenopausal bleeding, to determine whether BMI of 25 kg/m2 would serve to delineate women at increased risk of endometrial cancer. Methods: This cohort included 4,164 Chinese women referred for postmenopausal bleeding from 2002 to 2013. For all women, a medical history was taken, and physical examination, BMI measurement, transvaginal pelvic ultrasonography, and endometrial sampling were performed. Additional investigations were performed as indicated...
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Impact of menopausal status on risk of metastatic recurrence of breast cancer
Conclusions: Women with earlier age at menopause, and ER+ and/or PR+ stage I-III breast cancer were more likely to develop metastatic breast cancer. Age increased the risk of metastatic relapse for women with ER− and PR− disease, but not for ER+ and/or PR+ cancers. (Source: Menopause)
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Reproductive aging and Alzheimer disease biomarkers: an evolving field
No abstract available (Source: Menopause)
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Editorials Source Type: research

Is obesity predictive of endometrial cancer for women with postmenopausal bleeding?
No abstract available (Source: Menopause)
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Editorials Source Type: research

Menopausal status at diagnosis of breast cancer and risk of metastatic recurrence
No abstract available (Source: Menopause)
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Editorials Source Type: research

Preeclampsia and cancer risk in women in later life: a systematic review and meta-analysis of cohort studies
Conclusions and Relevance: Overall, women with preeclampsia have a decreased BC risk and increased ovarian cancer risk compared with the normal population. A subgroup analysis stratified by reproductive factors demonstrated that BC risk decreased in the preeclampsia population in parous women, women with full-term pregnancies, and women with increasing parity regardless of their menopausal status and the sex of their offspring. (Source: Menopause)
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Review Article Source Type: research

Statin therapy in midlife women
The menopause transition is associated with adverse changes to the lipid profile. Although there are no specific treatment guidelines for women, current evidence supports the use of statin therapy in women with 1) established clinical atherosclerotic cardiovascular disease (ASCVD); 2) primary hypercholesterolemia, with low-density lipoprotein cholesterol of 190 mg/dL (4.9 mmol/L) or higher; 3) diabetes mellitus regardless of ASCVD risk category (ages 40-75 y); and 4) for primary prevention of ASCVD in women at high risk (10-y risk, ≥20%) or intermediate risk (10-y risk, ≥7.5-20%) with the presence of guideline-de...
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research

Preparing women experiencing symptoms of menopause for shared decision making about treatment
Objective: To develop a decision support intervention that can be used with women experiencing menopausal symptoms to facilitate treatment shared decision making. Methods: Our research team contacted patients with reported menopausal symptoms by telephone to obtain consent and administer a baseline survey. Subsequently, we sent participants a booklet on the treatment of menopausal symptoms. A nurse educator then contacted participants by telephone to review the booklet and guide them through a structured decision counseling exercise designed to help clarify treatment preference. A 60-day endpoint telephone surve...
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Is climacterium by the mid-40s associated with thyroid dysfunction or autoimmunity? A population-based study
Objective: We investigated whether more advanced climacteric stage in the mid-40s is associated with thyroid autoimmunity and dysfunction. Methods: This cross-sectional cohort study included 2,569 46-year-old women. Thyroid hormone, thyroid peroxidase antibodies, and follicle-stimulating hormone levels were determined. Using menstrual history and follicle-stimulating hormone levels, the participants were divided into climacteric (n = 340) and preclimacteric (n = 2,229) groups. Women diagnosed with premature ovarian insufficiency (menopause by 40 y of age) were excluded. The use of thyroid medication wa...
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Effects of oral versus transdermal estradiol plus micronized progesterone on thyroid hormones, hepatic proteins, lipids, and quality of life in menopausal women with hypothyroidism: a clinical trial
Objective: The aim of the study was to evaluate the effects of usual doses of oral estradiol with transdermal estradiol and the effects of these estrogens plus micronized progesterone (MP) in menopausal women with primary hypothyroidism. Methods: Twenty women were randomized to 12 weeks of treatment with estradiol 1 mg tablets or estradiol 1 mg gel. Then, women with a uterus received a 100 mg capsule of oral MP. Thyroid function, thyroxine-binding globulin (TBG), sex hormone-binding globulin (SHBG), insulin-like growth factor 1 (IGF-1), lipid profiles, and quality of life were measured at baseline and af...
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Differences in menopausal symptoms and female sexual function by region and ethnicity in West Texas and Central Arizona: a cross-sectional survey
Objective: To evaluate menopausal symptoms and sexual problems in Hispanic and non-Hispanic women in two Southwest areas. Methods: An anonymous survey including the Green Climacteric Scale (GCS), Female Sexual Function Index (FSFI), and demographics was distributed to English and Spanish-speaking women age 40 to 60 in Scottsdale, Arizona, and West Texas. FSFI for sexually active women and GCS scores for the Hispanic and non-Hispanic women in Texas were analyzed with multivariable analysis and compared between Texas and Arizona for Non-Hispanic participants. Results: Predominantly non-Hispanic women (70%),...
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Risk of de novo severe carpal tunnel syndrome after bilateral oophorectomy: a population-based cohort study
Conclusions: The risk of severe CTS, common in perimenopausal women, is increased after bilateral oophorectomy. The association may be causal or due to confounding. Therefore, the precise biological mechanisms explaining the association and the absence of a mitigating effect of estrogen therapy should be further investigated. (Source: Menopause)
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Symptom experience during the late reproductive stage and the menopausal transition: observations from the Women Living Better survey
Conclusions: Women in the LRS experience symptoms strikingly similar to those often associated with the MT. Women do not expect these changes until the age of 50 years or later and are surprised by such symptoms before cycle irregularity. Research about the epidemiology and management of LRS symptoms, anticipatory guidance for women, and education for clinicians who care for them warrant increased attention. (Source: Menopause)
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

The role of multiparity and maternal age at first pregnancy in the association between early menarche and metabolic syndrome among middle-aged and older women
Conclusions: Age at first pregnancy may partially contribute to the association between early menarche and metabolic syndrome among middle-aged and older women who had experienced a pregnancy over their lifetime. (Source: Menopause)
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Evaluation of endometrial progesterone receptor expression after 12 weeks of exposure to a low-dose vaginal estradiol insert
Conclusions: No meaningful differences in endometrial PGR expression were observed with the vaginal E2 (4- and 10-μg) inserts at week 12 from baseline, supporting the hypothesis that local exposure to E2 from a low-dose, vaginal insert placed near the vaginal introitus will not be sufficient to upregulate endometrial PGR expression. Coupled with the lack of histologic changes and systemic absorption, our data suggest that these softgel vaginal E2 inserts would not be expected to stimulate endometrial hyperplasia leading to a potential endometrial safety issue in postmenopausal women with moderate to severe dyspareun...
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Management of osteoporosis in postmenopausal women: the 2021 position statement of The North American Menopause Society
Conclusions: Osteoporosis is a common disorder in postmenopausal women. Management of skeletal health in postmenopausal women involves assessing risk factors for fracture, reducing modifiable risk factors through dietary and lifestyle changes, and the use of pharmacologic therapy for patients at significant risk of osteoporosis or fracture. For women with osteoporosis, lifelong management is necessary. Treatment decisions occur continuously over the lifespan of a postmenopausal woman. Decisions must be individualized and should include the patient in the process of shared decision-making. (Source: Menopause)
Source: Menopause - September 1, 2021 Category: OBGYN Tags: NAMS Position Statement Source Type: research

A path to a healthier middle age in adolescents with early menarche: avoid teen pregnancy?
No abstract available (Source: Menopause)
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Editorials Source Type: research