Impact of evening primrose oil consumption on psychological symptoms of postmenopausal women: a randomized double-blinded placebo-controlled clinical trial

Objective: The purpose of this study was to determine the efficacy and safety of evening primrose oil on women's psychological symptoms during menopause. Methods: A double-blinded randomized placebo-controlled trial carried out from September 2018 to February 2019 in Bandar Abbas, Iran. Eligible women randomly received either 1,000 mg of evening primrose oil capsules daily or matching placebo for 8 weeks. The Main outcome measures were psychological symptoms based on the psychological subscale of the Menopause Rating Scale. Independent samples t test was used for intergroup comparisons and paired samples t test for pre- and post-treatment comparisons. P ≤ 0.05 was considered statistically significant. Results: The 8-week treatment was completed by 189 women. The mean baseline psychological score did not differ among the two groups. After intervention, the psychological score, however, differed significantly among groups (P 
Source: Menopause - Category: OBGYN Tags: Original Studies Source Type: research

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Conclusions: Given that estrogen-alone therapy has been shown to be associated with increased risk of ovarian cancer, these findings are consistent with the hypothesis that adding a progestin each day ameliorates the carcinogenic effects of estrogen on the cells of origin for all histotypes of ovarian cancer.
Source: Epidemiology - Category: Epidemiology Tags: Women’s Health Source Type: research
ConclusionsSerum HE4 levels can potentially be used as a marker to differentiate between benign and malignant ovarian disease with elevated serum CA125 levels. The high specificity of HE4 was superior in identifying benign ovarian disease. We recommend increasing the cutoff values of HE4 in premenopausal patients and decreasing the cutoff values in postmenopausal patients for increased accuracy in the differential diagnosis of patients with elevated CA125 levels.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
This study was conducted on 22 patients hospitalized for different stages of bone necrosis for a period of two years. The prevalence of osteonecrosis is higher in menopausal women and also after a certain period after the bisphosphonate therapy is closed. PMID: 32239099 [PubMed - in process]
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
CONCLUSIONS: The serum levels of CA125 and HE4, ROMA index and IHC markers for surgical tissue fragments play a very important role in discriminating and reporting borderline ovarian tumors, as well as benign or malignant ovarian forms. Due to the superior sensitivity and specificity of CA125 and HE4, we can consider these markers as an alternative or additional diagnostic criterion to the ROMA index. PMID: 32239091 [PubMed - in process]
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
CONCLUSIONS: Our study showed that BTMs correlated negatively with lumbar BMD and positively with each other. Resorption markers levels increase with duration of estradiol deprivation period. PMID: 32239087 [PubMed - in process]
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
Conclusion: Enhanced masticatory force affected the expression of OPG, RANKL, and MGF in alveolar bone of ovariectomized rats, improved the quality of jaw bone of ovariectomized rats, and delayed oral bone loss by ovariectomy.
Source: Journal of Applied Oral Science - Category: Dentistry Source Type: research
Park The fruit of Schisandra chinensis (SC) is a well-known traditional herb used for pharmacological purposes in Asian countries (e.g., Korea, China, and Japan). In animal studies, SC extract supplementation had beneficial effects on muscle strength and lactate level. However, the effect of SC extract supplementation on skeletal muscle strength and lactate at rest in humans remains unclear. The purpose of this study was to evaluate the effect of SC extract supplementation on quadriceps muscle strength (QMS) and lactate at rest in adult women. Forty five healthy post-menopausal middle-aged women (61.9 ± 8....
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Publication date: Available online 31 March 2020Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Joanna Owsianowska, Magdalena Sylwia Kamińska, Mateusz Bosiacki, Dariusz Chlubek, Beata Karakiewicz, Anna Jurczak, Marzanna Stanisławska, Katarzyna Barczak, Elżbieta Grochans
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
This article reviews sex differences in stroke risk and presentation, with a particular emphasis on the unique risk factors women experience throughout the lifespan. RECENT FINDINGS Although prior studies suggested women have worse outcomes after stroke, it is now clear that age, prestroke functional status, and comorbidities explain many of the differences between men and women in stroke severity, functional outcomes, and mortality. Several meta-analyses and large cohort studies have evaluated the risk factors for women related to reproductive factors and found that fewer years between menarche and menopause, pregnancy...
Source: CONTINUUM: Lifelong Learning in Neurology - Category: Neurology Tags: REVIEW ARTICLES Source Type: research
(University of Jyv ä skyl ä - Jyv ä skyl ä n yliopisto) Late menopausal status is associated with an elevated level of depressive symptoms that indicate the negative dimension of mental well-being. However, menopause was not linked to positive dimensions of mental well-being in women aged 47 to 55. The results also suggest that a high level of physical activity was linked to fewer depressive symptoms, higher satisfaction with life and higher positive affectivity in menopausal women.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
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