Association between opioid use disorder and palliative care: a cohort study using linked health administrative data in Ontario, Canada
CMAJ. 2024 Apr 28;196(16):E547-E557. doi: 10.1503/cmaj.231419.ABSTRACTBACKGROUND: People with opioid use disorder (OUD) are at risk of premature death and can benefit from palliative care. We sought to compare palliative care provision for decedents with and without OUD.METHODS: We conducted a cohort study using health administrative databases in Ontario, Canada, to identify people who died between July 1, 2015, and Dec. 31, 2021. The exposure was OUD, defined as having emergency department visits, hospital admissions, or pharmacologic treatments suggestive of OUD within 3 years of death. Our primary outcome was receipt of...
Source: Canadian Medical Association Journal - April 29, 2024 Category: General Medicine Authors: Jenny Lau Mary M Scott Karl Everett Tara Gomes Peter Tanuseputro Sheila Jennings Rebecca Bagnarol Camilla Zimmermann Sarina R Isenberg Source Type: research
Medicinal chemistry strategies toward broad-spectrum antiviral agents to prevent next pandemics
Eur J Med Chem. 2024 Apr 25;271:116442. doi: 10.1016/j.ejmech.2024.116442. Online ahead of print.ABSTRACTThe pandemic and tremendous impact of severe acute respiratory syndrome coronavirus 2 alert us, despite great achievements in prevention and control of infectious diseases, we still lack universal and powerful antiviral strategies to rapidly respond to the potential threat of serious infectious disease. Various highly contagious and pathogenic viruses, as well as other unknown viruses may appear or reappear in human society at any time, causing a catastrophic epidemic. Developing broad-spectrum antiviral drugs with high...
Source: European Journal of Medicinal Chemistry - April 29, 2024 Category: Chemistry Authors: Zirui L ü Xiandong Dai Jianjie Xu Zhenming Liu Yongbiao Guo Zhenhua Gao Fanhua Meng Source Type: research
Autoimmune encephalitis mediated by postvaccination and infection of SARS-CoV-2 in a patient with a narcolepsy type 1
CONCLUSION: The patient fulfilled the diagnostic criteria for autoimmune encephalitis with subacute onset. COVID-19 infection and vaccination could constitute a risk in a patient with narcolepsy as in this case and, could help to provide better understanding of the implication of immune-mediated processes in the pathophysiology of the diseases.PMID:38682764 | DOI:10.33588/rn.7809.2023306 (Source: Revista de Neurologia)
Source: Revista de Neurologia - April 29, 2024 Category: Neurology Authors: R Peraita-Adrados N Bravo-Quelle Source Type: research
Urgent one-stage endoscopic treatment for choledocholithiasis related moderate to severe acute cholangitis: A propensity score-matched analysis
CONCLUSION: Urgent one-stage ERCP provides the advantages of a shorter ICU stay, a shorter duration of antibiotic use, and a shorter hospital stay.PMID:38681983 | PMC:PMC11045478 | DOI:10.3748/wjg.v30.i15.2118 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Yang Zhou Yin-Qiu Zhang Shuai-Jing Huang Yan Liang Xiao Liang Masoom Wali Ya-Dong Feng Source Type: research
Appendectomy versus antibiotic treatment for acute appendicitis
CONCLUSIONS: Antibiotics may be associated with higher rates of unsuccessful treatment for 76 per 1000 people, although differences may not be clinically significant. It is uncertain if antibiotics increase length of hospital stay by half a day. Antibiotics may reduce wound infections. A third of the participants initially treated with antibiotics required subsequent appendectomy or two-thirds avoided surgery within one year, but the evidence is very uncertain. There were too few data from the included studies to comment on major complications.PMID:38682788 | DOI:10.1002/14651858.CD015038.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - April 29, 2024 Category: General Medicine Authors: Brett Doleman Siv Fonnes Jon N Lund Hannah Boyd-Carson Hannah Javanmard-Emamghissi Susan Moug Marianne Hollyman Gillian Tierney Samson Tou John P Williams Source Type: research
"Emergency Room Incision and Drainage of Perirectal Abscess is Equivalent to Incision and Drainage in the Operating Room"
In this study, for patients presenting to the ED, bedside drainage was found to be an adequate management strategy to achieve complete drainage without a significant increase in the rate of complications when compared to operative drainage.PMID:38684322 | DOI:10.1177/00031348241248785 (Source: The American Surgeon)
Source: The American Surgeon - April 29, 2024 Category: Surgery Authors: Seija A Maniskas Mallory I Jebbia Dena Nasir Gabriel Akopian Howard S Kaufman Juliane Y Golan Source Type: research
Management of Injuries to the Parenchymal Abdominal Organs
Zentralbl Chir. 2024 Apr 29. doi: 10.1055/a-2301-7951. Online ahead of print.ABSTRACTThe most common organs affected by abdominal trauma are the spleen and the liver, often in combination. Pancreatic injuries are rare. In the case of blunt abdominal trauma, which is much more common, a clinical and laboratory examination as well as sonography should be performed. In the initial assessment, the circulatory situation must be screened. If there is haemodynamic instability and presentation of free fluid, an emergency laparotomy is indicated. If the situation is stable or stabilised and a pathological sonography is present, it ...
Source: Zentralblatt fur Chirurgie - April 29, 2024 Category: Surgery Authors: Stina Schild-Suhren Elif Yilmaz Lorenz Biggemann Ali Seif Giovanni Federico Torsello Annemarie Uhlig Michael Ghadimi Florian B ösch Source Type: research
Evaluating the impact of the Community Helpers Program on adolescents 12-18 years old in Edmonton, Canada
CONCLUSION: Findings show contextual effect of CHP; i.e., being potentially exposed to the program reduced the likelihood of anxiety- and depression-related visits. Costs of CHP implementation could be compared with the avoided costs to assess economic benefits of implementing CHP.PMID:38683287 | DOI:10.17269/s41997-024-00878-6 (Source: Canadian Journal of Public Health)
Source: Canadian Journal of Public Health - April 29, 2024 Category: International Medicine & Public Health Authors: Mohammad Habibullah Pulok Arthur Novaes de Amorim Sandra Johansen Kristin Pilon Christina Lucente Vineet Saini Source Type: research
The health economic-industrial complex: production and innovation for universal health access, Brazil
Bull World Health Organ. 2024 May 1;102(5):352-356. doi: 10.2471/BLT.23.290838. Epub 2024 Apr 17.ABSTRACTPROBLEM: The coronavirus disease 2019 (COVID-19) pandemic has highlighted global disparities in accessing essential health products, demonstrating the critical need for low- and middle-income countries to develop local production and innovation capabilities.APPROACH: The health economic-industrial complex approach changed the values that guided innovation and industrial policies in Brazil. The approach directed health production and innovation to universal access; the health ministry led a whole-of-government approach; ...
Source: Bulletin of the World Health Organization - April 29, 2024 Category: International Medicine & Public Health Authors: Carlos Ag Gadelha Gabriela Maretto Marco Ac Nascimento Felipe Kamia Source Type: research
Giraffes and Zebras on the Runway: the AMREF Flying Doctors (AFD) of Africa
This article follows a volunteer doctor and the author on the exciting journey to the Flying Doctors of Africa, based at Wilson Airport/Nairobi who reach out to a patient in medical needs from a rural airstrip within the Maasai Mara on which wild animals roam to medical evacuations which can span the entire globe.PMID:38684161 | DOI:10.1055/a-2148-3336 (Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS)
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - April 29, 2024 Category: Intensive Care Authors: Malte Sebastian Struckmeyer Source Type: research
Resuscitation Update - What's New?
Anasthesiol Intensivmed Notfallmed Schmerzther. 2024 Apr;59(4):214-225. doi: 10.1055/a-2082-8685. Epub 2024 Apr 29.ABSTRACTPerfect, uninterrupted basic life support (BLS) is the key for successful cardiopulmonary resuscitation (CPR) in out-of-hospital cardiac arrest (OHCA). Time plays an important role in the treatment of OHCA. This applies both to the time until the start of BLS and the reduction of all pauses during resuscitation, especially chest compressions. In 2022, the rate of bystander-CPR showed an absolute increase of 4% compared to previous years. The bystander-CPR rate is currently above 50%. Compared to OHCA i...
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - April 29, 2024 Category: Intensive Care Authors: Jan-Thorsten Gr äsner Stephan Katzenschlager Leonie Hannappel Jan Wnent Source Type: research
Urgent one-stage endoscopic treatment for choledocholithiasis related moderate to severe acute cholangitis: A propensity score-matched analysis
CONCLUSION: Urgent one-stage ERCP provides the advantages of a shorter ICU stay, a shorter duration of antibiotic use, and a shorter hospital stay.PMID:38681983 | PMC:PMC11045478 | DOI:10.3748/wjg.v30.i15.2118 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Yang Zhou Yin-Qiu Zhang Shuai-Jing Huang Yan Liang Xiao Liang Masoom Wali Ya-Dong Feng Source Type: research
Transfusion management and hemoglobin-based oxygen carrier treatment in a patient with anti-Rh17 antibody
DISCUSSION: Overall difficulties in this case included the challenge of finding compatible units, dilemma of transfusing incompatible units in a patient with severe anemia and obtaining alternatives to blood products. This case report demonstrates the successful use of HBOC-21 in treating life-threatening anemia.PMID:38682958 | DOI:10.1111/trf.17855 (Source: Transfusion)
Source: Transfusion - April 29, 2024 Category: Hematology Authors: Noah Mehr Christine Fuja Cody Simon Timothy Carll Rahaf Alkhateb Sulin Wu Anand A Patel Fatima Aldarweesh Source Type: research
Emergency Department Use in Adolescent and Young Adult Cancer Early Survivors from 2006 to 2020
Conclusion: ED utilization declined as time from diagnosis elapsed, but higher utilization was associated with social determinants of health and cancer types.PMID:38682323 | DOI:10.1089/jayao.2023.0174 (Source: Ann Oncol)
Source: Ann Oncol - April 29, 2024 Category: Cancer & Oncology Authors: Karen J Wernli Eric C Haupt Neetu Chawla Thearis Osuji Ernest Shen Andrew B Smitherman Mallory Casperson Anne C Kirchhoff Bradley J Zebrack Theresa H M Keegan Lawrence Kushi Christopher Baggett Heydon K Kaddas Kathryn J Ruddy Candice A M Sauder Theodore W Source Type: research
Unpacking Sociotechnical Discourses on Telehealth Use and Data Protection: A Path Towards Digital Health Value Creation
CONCLUSION: Our study revealed the importance of the COVID-19 pandemic in telehealth use, highlighting the move towards 'good faith' and responsible use of telehealth.PMID:38682506 | DOI:10.3233/SHTI240013 (Source: Studies in Health Technology and Informatics)
Source: Studies in Health Technology and Informatics - April 29, 2024 Category: Information Technology Authors: Javad Pool Farhad Fatehi Salma Sharifi Morteza Namvar Saeed Akhlaghpour Source Type: research
