Ehrlichiosis and Anaplasmosis
Canine ehrlichiosis and anaplasmosis are zoonotic tick-borne diseases with broad distribution. Advances in diagnostics have enhanced our understanding of the species of rickettsial organisms involved, their expanding geographic distribution, and their impact on the health of dogs, cats, and people. While clinical remission can be achieved with appropriate antimicrobial therapy, optimal treatment modalities for the elimination of infection remain somewhat uncertain. Protection through vaccines for ehrlichiosis or anaplasmosis remains elusive. This review provides practicing veterinarians with the most current information ab...
Source: Veterinary Clinics of North America: Small Animal Practice - November 1, 2022 Category: Veterinary Research Authors: Pedro Paulo V.P. Diniz, Daniel Moura de Aguiar Source Type: research
Serologic Evidence of Human Exposure to Ehrlichiosis Agents in Japan
Emerg Infect Dis. 2022 Nov;28(11):2355-2357. doi: 10.3201/eid2811.212566.ABSTRACTIn retrospective analyses, we report 3 febrile patients in Japan who had seroconversion to antibodies against Ehrlichia chaffeensis antigens detected by using an immunofluorescence and Western blot. Our results provide evidence of autochthonous human ehrlichiosis cases and indicate ehrlichiosis should be considered a potential cause of febrile illness in Japan.PMID:36286246 | DOI:10.3201/eid2811.212566 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - October 26, 2022 Category: Infectious Diseases Authors: Hongru Su Kenji Kubo Shigetoshi Sakabe Shinsuke Mizuno Nobuhiro Komiya Shigehiro Akachi Hiromi Fujita Kozue Sato Hiroki Kawabata Hiromi Nagaoka Shuji Ando Norio Ohashi Source Type: research
Serologic Evidence of Human Exposure to Ehrlichiosis Agents in Japan
Emerg Infect Dis. 2022 Nov;28(11):2355-2357. doi: 10.3201/eid2811.212566.ABSTRACTIn retrospective analyses, we report 3 febrile patients in Japan who had seroconversion to antibodies against Ehrlichia chaffeensis antigens detected by using an immunofluorescence and Western blot. Our results provide evidence of autochthonous human ehrlichiosis cases and indicate ehrlichiosis should be considered a potential cause of febrile illness in Japan.PMID:36286246 | DOI:10.3201/eid2811.212566 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - October 26, 2022 Category: Infectious Diseases Authors: Hongru Su Kenji Kubo Shigetoshi Sakabe Shinsuke Mizuno Nobuhiro Komiya Shigehiro Akachi Hiromi Fujita Kozue Sato Hiroki Kawabata Hiromi Nagaoka Shuji Ando Norio Ohashi Source Type: research
Serologic Evidence of Human Exposure to Ehrlichiosis Agents in Japan
Emerg Infect Dis. 2022 Nov;28(11):2355-2357. doi: 10.3201/eid2811.212566.ABSTRACTIn retrospective analyses, we report 3 febrile patients in Japan who had seroconversion to antibodies against Ehrlichia chaffeensis antigens detected by using an immunofluorescence and Western blot. Our results provide evidence of autochthonous human ehrlichiosis cases and indicate ehrlichiosis should be considered a potential cause of febrile illness in Japan.PMID:36286246 | DOI:10.3201/eid2811.212566 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - October 26, 2022 Category: Infectious Diseases Authors: Hongru Su Kenji Kubo Shigetoshi Sakabe Shinsuke Mizuno Nobuhiro Komiya Shigehiro Akachi Hiromi Fujita Kozue Sato Hiroki Kawabata Hiromi Nagaoka Shuji Ando Norio Ohashi Source Type: research
Serologic Evidence of Human Exposure to Ehrlichiosis Agents in Japan
Emerg Infect Dis. 2022 Nov;28(11):2355-2357. doi: 10.3201/eid2811.212566.ABSTRACTIn retrospective analyses, we report 3 febrile patients in Japan who had seroconversion to antibodies against Ehrlichia chaffeensis antigens detected by using an immunofluorescence and Western blot. Our results provide evidence of autochthonous human ehrlichiosis cases and indicate ehrlichiosis should be considered a potential cause of febrile illness in Japan.PMID:36286246 | DOI:10.3201/eid2811.212566 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - October 26, 2022 Category: Infectious Diseases Authors: Hongru Su Kenji Kubo Shigetoshi Sakabe Shinsuke Mizuno Nobuhiro Komiya Shigehiro Akachi Hiromi Fujita Kozue Sato Hiroki Kawabata Hiromi Nagaoka Shuji Ando Norio Ohashi Source Type: research
Serologic Evidence of Human Exposure to Ehrlichiosis Agents in Japan
Emerg Infect Dis. 2022 Nov;28(11):2355-2357. doi: 10.3201/eid2811.212566.ABSTRACTIn retrospective analyses, we report 3 febrile patients in Japan who had seroconversion to antibodies against Ehrlichia chaffeensis antigens detected by using an immunofluorescence and Western blot. Our results provide evidence of autochthonous human ehrlichiosis cases and indicate ehrlichiosis should be considered a potential cause of febrile illness in Japan.PMID:36286246 | DOI:10.3201/eid2811.212566 (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - October 26, 2022 Category: Infectious Diseases Authors: Hongru Su Kenji Kubo Shigetoshi Sakabe Shinsuke Mizuno Nobuhiro Komiya Shigehiro Akachi Hiromi Fujita Kozue Sato Hiroki Kawabata Hiromi Nagaoka Shuji Ando Norio Ohashi Source Type: research
Serologic Evidence of Human Exposure to Ehrlichiosis Agents in Japan
H. Su et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - October 14, 2022 Category: Infectious Diseases Source Type: research
Human case of Anaplasma phagocytophilum infection in Eastern Taiwan
In this study, we report an indigenous case of clinically diagnosed HGA. The patient was a 41-year-old man who experienced a tick bite and later developed fever, chills, myalgia, malaise, thrombocytopenia, leukocytosis with a left shift, elevated hepatic transaminase levels, and splenomegaly upon admission to the hospital. Immunofluorescence assays detected seroconversion against A. phagocytophilum, whereas tests for spotted fever group rickettsiae, murine typhus, scrub typhus, Q fever, and ehrlichiosis were negative. ELISA and Western blot analysis using recombinant MSP2 protein confirmed the exposure to A. phagocytophilu...
Source: J Formos Med Assoc - September 12, 2022 Category: General Medicine Authors: Feng-Yee Chang Ruo-Yu Wang Tsai-Ying Yen Pei-Yun Shu Su-Lin Yang Source Type: research
Use of a recombinant positive control in the diagnostic of canine Ehrlichiosis from 16sRNA gen of Ehrlichia canis in Mexico City
Arch Microbiol. 2022 Sep 12;204(10):616. doi: 10.1007/s00203-022-03227-8.ABSTRACTEhrlichia canis has gained importance over the years as a zoonotic bacterium, nevertheless in Mexico is unknown the extent of the problem in animals and public health. The country had a few studies carried out locally using serology and molecular tests as diagnostic methods. Ehrlichiosis is not considered endemic in the central valley of Mexico, because the climatic conditions in the region have not allowed the vector (Rhipicephalus sanguineus) to establish itself adequately, therefore, diagnosis is not used in clinical practice in this area. ...
Source: Archives of Microbiology - September 12, 2022 Category: Microbiology Authors: S E Acevedo-Monroy J M M éndez-Alemán I Castro-Mendoza M A Mojica-S ánchez A Verdugo-Rodr íguez Source Type: research
Human case of Anaplasma phagocytophilum infection in Eastern Taiwan
In this study, we report an indigenous case of clinically diagnosed HGA. The patient was a 41-year-old man who experienced a tick bite and later developed fever, chills, myalgia, malaise, thrombocytopenia, leukocytosis with a left shift, elevated hepatic transaminase levels, and splenomegaly upon admission to the hospital. Immunofluorescence assays detected seroconversion against A. phagocytophilum, whereas tests for spotted fever group rickettsiae, murine typhus, scrub typhus, Q fever, and ehrlichiosis were negative. ELISA and Western blot analysis using recombinant MSP2 protein confirmed the exposure to A. phagocytophilu...
Source: J Formos Med Assoc - September 12, 2022 Category: General Medicine Authors: Feng-Yee Chang Ruo-Yu Wang Tsai-Ying Yen Pei-Yun Shu Su-Lin Yang Source Type: research
Genome-Wide Subtraction Analysis and Reverse Vaccinology to Detect Novel Drug Targets and Potential Vaccine Candidates Against Ehrlichia chaffeensis
This study is comprised of two major phases. First, the common proteins retrieved through subtractive analysis and potential drug targets were evaluated by subcellular localization, homology prediction, metabolic pathways, druggability, essentiality, protein-protein interaction networks, and protein data bank availability. In the second phase, surface-exposed proteins were assessed based on antigenicity, allergenicity, physiochemical properties, B cell and T cell epitopes, conserved domains, and protein-protein interaction networks. A multi-epitope vaccine was designed and characterized using molecular dockings and immune ...
Source: Applied Biochemistry and Biotechnology - September 2, 2022 Category: Biochemistry Authors: Samira Sabzi Shahla Shahbazi Narjes Noori Goodarzi Fatemeh Haririzadeh Jouriani Mehri Habibi Negin Bolourchi Amir Mirzaie Farzad Badmasti Source Type: research
Novel Ehrlichia canis genogroup in dogs with canine ehrlichiosis in Cuba
Canine monocytic ehrlichiosis (CME) is caused by the tick-borne pathogen Ehrlichia canis, an obligate intracellular Gram-negative bacterium of the family Anaplasmataceae with tropism for canine monocytes and macr... (Source: Parasites and Vectors)
Source: Parasites and Vectors - August 23, 2022 Category: Microbiology Authors: Maylin Gonz ález Navarrete, Adnan Hodžić, Belkis Corona-González, Matheus Dias Cordeiro, Claudia Bezerra da Silva, Liani Coronado Báez, Dasiel Obregón, Daniel Moura de Aguiar, Amanda Noeli da Silva Campos, Ísis Indaiara Gonçalves Granjeiro Taques, Tags: Research Source Type: research
“Leopards do not change their spots:” tick borne disease symptomology case report
Human Monocytic Ehrlichiosis is caused by infection with the bacteria Ehrlichia chaffeensis through the bite of an infected lone star tick (Amblyomma americanum). Patients infected with Human Monocytic Ehrlichios... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - August 19, 2022 Category: Infectious Diseases Authors: Haley Abernathy, Aidin Alejo, Victor Arahirwa, Odai Mansour, Amanda Brown-Marusiak, Dana Giandomenico and Ross M. Boyce Tags: Case report Source Type: research
Evaluation of a multi-species Protein A-ELISA assay for plague serologic diagnosis in humans and other mammal hosts
ConclusionsAltogether, the Protein A-ELISA showed high performance when compared both to HA and Anti-IgG ELISA, with a polyvalent single protocol that requires reduced amounts of antigen and can be employed to any plague hosts. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - May 12, 2022 Category: Tropical Medicine Authors: Matheus Filgueira Bezerra Source Type: research
Diagnostic value of procalcitonin, C-reactive protein, and leukocyte count in canine ehrlichiosis and canine demodicosis
AbstractCanine ehrlichiosis (E. canis) is an obligate intracellular organism that resides as a microcolony within a membrane-lined intracellular vacuole (morulae), primarily within monocytes and macrophages of dogs. Canine demodicosis (D. canis) is an inflammatory parasitic skin disease associated with the presence of excessive numbers ofDemodex mites. We aimed to conduct a comprehensive study on blood procalcitonin (PCT), C-reactive protein (CRP), leukocytes count alterations along with hemato-biochemical, and the clinical observations including clinical history and physical examination in dogs infected with canine ehrlic...
Source: Comparative Clinical Pathology - May 6, 2022 Category: Pathology Source Type: research
