Human Monocytic Ehrlichiosis presenting as Guillain-Barre syndrome (P3.315)
Conclusion:CNS manifestations are relatively common in patients with HME but GBS has not been previously reported. Our case illustrates the importance of a high index of clinical suspicion which will facilitate early diagnosis and initiate timely therapy, thus avoiding potentially life-threatening complications.Background:Not applicableDesign/Methods:Not applicableResults:Not applicableConclusions:Not applicableDisclosure: Dr. Zhu, MD has nothing to disclose. Dr. Arukala, MD has nothing to disclose. Dr. Sheikh, MD has nothing to disclose. Dr. Uprety, MD has nothing to disclose. Dr. McCrary, MD has nothing to disclose. Dr. ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Zhu, H., Arukala, V., Sheikh, S., Uprety, A., McCrary, D., Silverman, T., Cranston, H. Tags: Fungal and Parasitic Disease of the Nervous System Source Type: research
Tick-Borne Emerging Infections
This article reviews recent advances in the understanding of HME and HGA. (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - March 25, 2017 Category: Laboratory Medicine Authors: Nahed Ismail, Jere W. McBride Source Type: research
Cytopenias and clonal expansion of gamma/delta T-cells in a patient with anaplasmosis: a potential diagnostic pitfall.
Authors: Marko D, Perry AM, Ponnampalam A, Nasr MR
Abstract
Human granulocytic anaplasmosis is a rare, tick-borne infectious disease caused by Anaplasma phagocytophilum. Herein, we report a rare case of human granulocytic anaplasmosis associated with cytopenias and clonal expansion of gamma/delta T-cells in the bone marrow. A 77-year old man presented multiple times to the emergency department complaining of muscle weakness. Complete blood count detected cytopenias and peripheral blood smear showed pseudo Pelger-Huet neutrophils. These findings prompted bone marrow evaluation with ancillary studies includi...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 24, 2017 Category: Hematology Tags: J Clin Exp Hematop Source Type: research
The Eurasian otter ( < i > Lutra lutra < /i > ) as a potential host for rickettsial pathogens in southern Italy
This study is the first report on the evidence of infection by rickettsial pathogens in the Eurasian otter. The present result prompts some inquiries into the pathogenic role of those bacteria for the isolated sub-populations of the endangered Eurasian otter in southern Italy. (Source: PLoS One)
Source: PLoS One - March 6, 2017 Category: Biomedical Science Authors: Mario Santoro Source Type: research
Canine pancytopoenia in a Mediterranean region: a retrospective study of 119 cases (2005 to 2013)
ObjectivesTo further clarify the causes of pancytopoenia and to investigate whether underlying cause or severity were associated with survival in an area endemic for vector‐borne pathogens.
MethodsRetrospective review of medical records of 119 dogs with and 238 dogs without pancytopoenia.
ResultsMixed‐breed dogs and dogs younger than one year had higher odds of being pancytopoenic. The most common diagnoses included monocytic ehrlichiosis (n=42), leishmaniasis (n=28) and parvoviral enteritis (n=19). The mean white blood cell counts were lower in dogs with ehrlichiosis and parvoviral enteritis compared to dogs with leis...
Source: The Journal of Small Animal Practice - February 28, 2017 Category: Veterinary Research Authors: P. S. Frezoulis, E. Angelidou, D. Karnezi, I. L. Oikonomidis, M. Kritsepi ‐Konstantinou, D. Kasabalis, M. E. Mylonakis Tags: PAPER Source Type: research
Genetic profiling for Anaplasma and Ehrlichia species in ticks collected in the Eastern Cape Province of South Africa
Anaplasma and Ehrlichia are emerging tick-borne pathogens that cause anaplasmosis and ehrlichiosis in humans and other animals worldwide. Infections caused by these pathogens are deadl... (Source: BMC Microbiology)
Source: BMC Microbiology - February 27, 2017 Category: Microbiology Authors: Benson C. Iweriebor, Elia J. Mmbaga, Abiodun Adegborioye, Aboi Igwaran, Larry C. Obi and Anthony I. Okoh Source Type: research
Detection of Borrelia miyamotoi and other tick-borne pathogens in human clinical specimens and Ixodes scapularis ticks in New York State, 2012 –2015
Publication date: Available online 16 January 2017 Source:Ticks and Tick-borne Diseases Author(s): Danielle Wroblewski, Linda Gebhardt, Melissa A. Prusinski, Lisa J. Meehan, Tanya A. Halse, Kimberlee A. Musser Borrelia miyamotoi (Bm) is a recently emerging bacterial agent transmitted by several species of ixodid ticks. Diagnosis of Bm infection can be challenging, as the organism is not easily cultivable. We have developed and validated a multiplex real-time PCR to simultaneously identify Bm infection and the agents causing human granulocytic anaplasmosis and human monocytic ehrlichiosis, Anaplasma phagocytophilum ...
Source: Ticks and Tick borne Diseases - January 16, 2017 Category: Zoology Source Type: research
Scoring clinical signs can help diagnose canine visceral leishmaniasis in a highly endemic area in Brazil.
This study proposes a score with the potential to distinguish positive CVL cases from negative ones. We studied 265 dogs that tested positive for CVL on ELISA and parasitological tests. A score ranging between 0 and 19 was recorded on the basis of clinical signs. Dogs with CVL had an overall higher positivity of the majority of clinical signs than did dogs without CVL or with ehrlichiosis. Clinical signs such as enlarged lymph nodes (83.93%), muzzle/ear lesions (55.36%), nutritional status (51.79%), bristle condition (57.14%), pale mucosal colour (48.21%), onychogryphosis (58.93%), skin lesion (39.28%), bleeding (12.50%), ...
Source: Memorias do Instituto Oswaldo Cruz - December 31, 2016 Category: Infectious Diseases Authors: Silva KR, Mendonça VR, Silva KM, Nascimento LF, Mendes-Sousa AF, Pinho FA, Barral-Netto M, Barral AM, Cruz MD Tags: Mem Inst Oswaldo Cruz Source Type: research
Early diagnosis of Ehrlichia ewingii infection in a lung transplant recipient by peripheral blood smear
This article is protected by copyright. All rights reserved. (Source: Transplant Infectious Disease)
Source: Transplant Infectious Disease - December 29, 2016 Category: Transplant Surgery Authors: Hariharan Regunath, Christian Rojas ‐Moreno, Juan P. Olano, Richard D. Hammer, William Salzer Tags: Short Communication Source Type: research
Awareness of tick-borne disease and compliance with using tick preventive products of dog owners in Hong Kong
This study investigated knowledge of ticks and tick-borne disease and use of tick preventive agents by a large sample of dog owners in Hong Kong. A total of 492 valid questionnaires were completed by owners attending veterinary practices, approached by researchers at common dog-walking areas, or targeted via local social media sites for pet owners. A high proportion of respondents were aware of tick-borne disease (79%) and this correlated well with use of preventive products. However, 18% of owners did not use any protection, mainly due to lack of knowledge of the risk of disease. Targeted advice stressing the importance o...
Source: Preventive Veterinary Medicine - December 21, 2016 Category: Veterinary Research Source Type: research
Tick-Borne Diseases in Turkey: A Review Based on One Health Perspective
by Abdullah Inci, Alparslan Yildirim, Onder Duzlu, Mehmet Doganay, Serap Aksoy
The importance of tick-borne diseases is increasing all over the world, including Turkey. Global warming, environmental and ecological changes and the existence of suitable habitats increase the impact of ticks and result in frequent emergence or re-emergence of tick-borne diseases (TBDs) with zoo notic characteristics. In Turkey, almost 19 TBDs have been reported in animals and men, involving four protozoa (babesiosis, theileriosis, cytauxzoonosis, hepatozoonosis), one filarial nematode (acanthocheilonemasis), ten bacterial agents (anaplasmosi...
Source: PLoS Neglected Tropical Diseases - December 14, 2016 Category: Tropical Medicine Authors: Abdullah Inci Source Type: research
Molecular prevalence and haemato-biochemical profile of canine monocytic ehrlichiosis in dogs in and around Hisar, Haryana, India
AbstractThe present study was planned to investigate the molecular prevalence of canine monocytic ehrlichiosis (CME) in dogs in and around Hisar and to evaluate the haemato-biochemical profile for its better management. A total of 60 dogs presented to Medicine Section, TVCC, LUVAS, Hisar with the history of naturally acquired tick infestation and clinical signs consistent with CME were screened on the basis of blood smear examination, followed by molecular detection by nested PCR assay targeting a portion of 16S rRNA gene ofEhrlichia canis. Nested PCR detected 18 cases positive forE. canis with estimated 30% percent positi...
Source: Journal of Parasitic Diseases - November 8, 2016 Category: Parasitology Source Type: research
Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase.
Abstract
Ehrlichia chaffeensis is an obligatory intracellular bacterium that causes a potentially fatal emerging zoonosis, human monocytic ehrlichiosis. E. chaffeensis has a limited capacity for biosynthesis and metabolism and thus depends mostly on host-synthesized nutrients for growth. Although the host cell cytoplasm is rich with these nutrients, as E. chaffeensis is confined within the early endosome-like membrane-bound compartment, only host nutrients that enter the compartment can be used by this bacterium. How this occurs is unknown. We found that ehrlichial replication depended on autophagy inducti...
Source: Autophagy - October 31, 2016 Category: Cytology Authors: Lin M, Liu H, Xiong Q, Niu H, Cheng Z, Yamamoto A, Rikihisa Y Tags: Autophagy Source Type: research
Emerging Vector-Borne Diseases.
Abstract
Several mosquito-borne viral infections have recently emerged in North America; West Nile virus is the most common in the United States. Although West Nile virus generally causes a self-limited, flulike febrile illness, a serious neuroinvasive form may occur. Dengue is the most common vector-borne viral disease worldwide, and it has been a significant public health threat in the United States since 2009. Known as breakbone fever for its severe myalgias and arthralgias, dengue may cause a hemorrhagic syndrome. Chikungunya also causes flulike febrile illness and disabling arthralgias. Although menin...
Source: American Family Physician - September 30, 2016 Category: Primary Care Authors: Huntington MK, Allison J, Nair D Tags: Am Fam Physician Source Type: research
Use of Extracorporeal Support in Hemophagocytic Lymphohistiocytosis Secondary to Ehrlichiosis
We describe a child with HLH secondary to ehrlichiosis who developed multiorgan failure and was successfully managed with extracorporeal membrane oxygenation (ECMO). A 9-year-old boy developed headaches, fever, and sore throat after suspected tick exposure. He presented with pancytopenia, elevated ferritin, and soluble interleukin-2 receptor levels, all consistent with HLH. Bone marrow biopsy revealed hemophagocytosis. Polymerase chain reaction was positive for E chaffeensis. He developed acute kidney injury, coagulation failure, hepatic insufficiency, and progressive respiratory failure requiring intubation. Due to refrac...
Source: PEDIATRICS - September 29, 2016 Category: Pediatrics Authors: Cheng, A., Williams, F., Fortenberry, J., Preissig, C., Salinas, S., Kamat, P. Tags: Critical Care, Hematology/Oncology, Blood Disorders Case Report Source Type: research
