Glutathione Synthesis Regulated by CtrA Protects Ehrlichia chaffeensis From Host Cell Oxidative Stress
Ehrlichia chaffeensis, a small Gram-negative obligatory intracellular bacterium, infects human monocytes or macrophages, and causes human monocytic ehrlichiosis, one of the most prevalent, life-threatening emerging zoonoses. Reactive oxygen species are produced by the host immune cells in response to bacterial infections. The mechanisms exploited by E. chaffeensis to resist oxidative stress have not been comprehensively demonstrated. Here, we found that E. chaffeensis encodes two functional enzymes, GshA and GshB, to synthesize glutathione that confers E. chaffeensis the oxidative stress resistance, and that the expression...
Source: Frontiers in Microbiology - March 30, 2022 Category: Microbiology Source Type: research
Ehrlichiosis and Anaplasmosis among Transfusion and Transplant Recipients in the United States
No abstract available (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - January 19, 2022 Category: Infectious Diseases Tags: Current Abstracts Source Type: research
The “Biological Weapons” of Ehrlichia chaffeensis: Novel Molecules and Mechanisms to Subjugate Host Cells
Ehrlichia chaffeensis is an obligatory intracellular bacterium that causes human monocytic ehrlichiosis, an emerging, potentially fatal tick-borne infectious disease. The bacterium enters human cells via the binding of its unique outer-membrane invasin EtpE to the cognate receptor DNase X on the host-cell plasma membrane; this triggers actin polymerization and filopodia formation at the site of E. chaffeensis binding, and blocks activation of phagocyte NADPH oxidase that catalyzes the generation of microbicidal reactive oxygen species. Subsequently, the bacterium replicates by hijacking/dysregulating host-cell functions us...
Source: Frontiers in cellular and infection microbiology - January 14, 2022 Category: Microbiology Source Type: research
Tick-Borne Disease–Associated Thrombocytopenia: Epidemiological Description Among United States Veterans and Tick Surveillance Data From Suffolk County, Long Island, New York
Conclusions
Based on current epidemiologic trends, and local tick surveillance data, coinfections with tick-borne diseases need to be considered. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - January 1, 2022 Category: Infectious Diseases Tags: Original Articles Source Type: research
Ehrlichiosis and Anaplasmosis among Transfusion and Transplant Recipients in the United States
Emerg Infect Dis. 2021 Nov;27(11):2768-2775. doi: 10.3201/eid2711.211127.ABSTRACTEhrlichiosis and anaplasmosis are emerging tickborne diseases that can also be transmitted through blood transfusions or organ transplants. Since 2000, ehrlichiosis and anaplasmosis cases in the United States have increased substantially, resulting in potential risk to transplant and transfusion recipients. We reviewed ehrlichiosis and anaplasmosis cases among blood transfusion and solid organ transplant recipients in the United States from peer-reviewed literature and Centers for Disease Control and Prevention investigations. We identified 13...
Source: Emerging Infectious Diseases - October 21, 2021 Category: Infectious Diseases Authors: Sanjida J Mowla Naomi A Drexler Cara C Cherry Pallavi D Annambholta Ian T Kracalik Sridhar V Basavaraju Source Type: research
Ehrlichiosis and Anaplasmosis among Transfusion and Transplant Recipients in the United States
Emerg Infect Dis. 2021 Nov;27(11):2768-2775. doi: 10.3201/eid2711.211127.ABSTRACTEhrlichiosis and anaplasmosis are emerging tickborne diseases that can also be transmitted through blood transfusions or organ transplants. Since 2000, ehrlichiosis and anaplasmosis cases in the United States have increased substantially, resulting in potential risk to transplant and transfusion recipients. We reviewed ehrlichiosis and anaplasmosis cases among blood transfusion and solid organ transplant recipients in the United States from peer-reviewed literature and Centers for Disease Control and Prevention investigations. We identified 13...
Source: Emerging Infectious Diseases - October 21, 2021 Category: Infectious Diseases Authors: Sanjida J Mowla Naomi A Drexler Cara C Cherry Pallavi D Annambholta Ian T Kracalik Sridhar V Basavaraju Source Type: research
Ehrlichiosis and Anaplasmosis among Transfusion and Transplant Recipients in the United States
Emerg Infect Dis. 2021 Nov;27(11):2768-2775. doi: 10.3201/eid2711.211127.ABSTRACTEhrlichiosis and anaplasmosis are emerging tickborne diseases that can also be transmitted through blood transfusions or organ transplants. Since 2000, ehrlichiosis and anaplasmosis cases in the United States have increased substantially, resulting in potential risk to transplant and transfusion recipients. We reviewed ehrlichiosis and anaplasmosis cases among blood transfusion and solid organ transplant recipients in the United States from peer-reviewed literature and Centers for Disease Control and Prevention investigations. We identified 13...
Source: Emerging Infectious Diseases - October 21, 2021 Category: Infectious Diseases Authors: Sanjida J Mowla Naomi A Drexler Cara C Cherry Pallavi D Annambholta Ian T Kracalik Sridhar V Basavaraju Source Type: research
Ehrlichiosis and Anaplasmosis among Transfusion and Transplant Recipients in the United States
Emerg Infect Dis. 2021 Nov;27(11):2768-2775. doi: 10.3201/eid2711.211127.ABSTRACTEhrlichiosis and anaplasmosis are emerging tickborne diseases that can also be transmitted through blood transfusions or organ transplants. Since 2000, ehrlichiosis and anaplasmosis cases in the United States have increased substantially, resulting in potential risk to transplant and transfusion recipients. We reviewed ehrlichiosis and anaplasmosis cases among blood transfusion and solid organ transplant recipients in the United States from peer-reviewed literature and Centers for Disease Control and Prevention investigations. We identified 13...
Source: Emerging Infectious Diseases - October 21, 2021 Category: Infectious Diseases Authors: Sanjida J Mowla Naomi A Drexler Cara C Cherry Pallavi D Annambholta Ian T Kracalik Sridhar V Basavaraju Source Type: research
Ehrlichiosis and Anaplasmosis among Transfusion and Transplant Recipients in the United States
S. J. Mowla et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - October 13, 2021 Category: Infectious Diseases Source Type: research
Hyalomma spp. ticks and associated Anaplasma spp. and Ehrlichia spp. on the Iran-Pakistan border
Anaplasmosis and ehrlichiosis are tick-borne diseases affecting humans and livestock, particularly in tropical and subtropical regions. Animal husbandry is the main activity of people on the borders of Iran an... (Source: Parasites and Vectors)
Source: Parasites and Vectors - September 14, 2021 Category: Microbiology Authors: Nayyereh Choubdar, Fateh Karimian, Mona Koosha, Jalil Nejati and Mohammad Ali Oshaghi Tags: Research Source Type: research
The Epidemiology of Human Ehrlichiosis in Texas, 2008-2017
Publication date: Available online 12 July 2021Source: Ticks and Tick-borne DiseasesAuthor(s): Timothy Erickson, Bonny Mayes, Kristy O. Murray, Sarah Gunter (Source: Ticks and Tick borne Diseases)
Source: Ticks and Tick borne Diseases - July 14, 2021 Category: Zoology Source Type: research
Rhabdomyolysis and Multisystem Organ Failure Due to Fulminant Ehrlichiosis Infection
Publication date: June 2021Source: Wilderness & Environmental Medicine, Volume 32, Issue 2Author(s): Alex C. Overmiller, Cindy C. Bitter (Source: Wilderness and Environmental Medicine)
Source: Wilderness and Environmental Medicine - June 12, 2021 Category: Environmental Health Source Type: research
Iron robbery by intracellular pathogen via bacterial effector-induced ferritinophagy [Microbiology]
Iron is essential for survival and proliferation of Ehrlichia chaffeensis, an obligatory intracellular bacterium that causes an emerging zoonosis, human monocytic ehrlichiosis. However, how Ehrlichia acquires iron in the host cells is poorly understood. Here, we found that native and recombinant (cloned into the Ehrlichia genome) Ehrlichia translocated factor-3 (Etf-3),... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 1, 2021 Category: Science Authors: Qi Yan, Wenqing Zhang, Mingqun Lin, Omid Teymournejad, Khemraj Budachetri, Jeffrey Lakritz, Yasuko Rikihisa Tags: Microbiology Biological Sciences Source Type: research
Fever, pancytopenia, and elevated D-dimer in a 95 ‐year‐old woman with ehrlichiosis: a case report
Pancytopenia, fever, and elevated D-dimer are significant clinical findings. The differential diagnosis includes hematological malignancies, severe coronavirus disease 2019 (COVID-19), tick-borne illnesses, an... (Source: BMC Geriatrics)
Source: BMC Geriatrics - March 12, 2021 Category: Geriatrics Authors: Christopher Radcliffe, Cynthia Tsay, Kimberly Glerum, Jane Liao, George Goshua and Gerard Kerins Tags: Case report Source Type: research
Multi-Locus Sequence Typing of Ehrlichia chaffeensis Reveals Extensive Genotypic Variation across the United States
In this study, a molecular typing system was developed that allows for the genetic differentiation of E. chaffeensis isolates. This multi-locus typing system included sequencing and analyzing intergenic regions ECH0033-ECH0035 and ECH0217-ECH0218, plus, variable genes variable length PCR target, 28-kDa, 120-kDa, and hemE. We examined a total of 31 unique isolates from humans and white-tailed deer, and eight DNA samples extracted from infected A. americanum collected from multiple states. This is the largest evaluation of E. chaffeensis isolates and their genotypes. Our findings show that when sequences of all six loci were...
Source: Am J Trop Med Hyg - March 1, 2021 Category: Infectious Diseases Authors: Maria L Zambrano Christopher D Paddock Sandor E Karpathy Source Type: research
