Fingers on the Wrist and Taming the Funny Current, Rejuvenate the Wounded Heart: Ivabradine-Responsive Atrial Tachycardia
Turk Kardiyol Dern Ars. 2023 Dec;51(8):580-583. doi: 10.5543/tkda.2023.60296.ABSTRACTA 19-year-old male presented with dyspnea on exertion (New York Heart Association [NYHA] class II) and occasional palpitations for six months. He had initially been evaluated at another facility and diagnosed with dilated cardiomyopathy. Despite treatment, there was no improvement in his symptoms. On evaluation at our centre, his previous electrocardiograms appeared normal. However, palpation of his radial pulse for one minute revealed runs of regular tachycardia, interspersed with a normal pulse rate. A 30-second rhythm strip electrocardi...
Source: Turk Kardiyoloji Dernegi arsivi - January 2, 2024 Category: Cardiology Authors: A Shaheer Ahmed Gauravkumar Divani Nitish Rai Anwar Hussain Ansari Source Type: research
Fingers on the Wrist and Taming the Funny Current, Rejuvenate the Wounded Heart: Ivabradine-Responsive Atrial Tachycardia
Turk Kardiyol Dern Ars. 2023 Dec;51(8):580-583. doi: 10.5543/tkda.2023.60296.ABSTRACTA 19-year-old male presented with dyspnea on exertion (New York Heart Association [NYHA] class II) and occasional palpitations for six months. He had initially been evaluated at another facility and diagnosed with dilated cardiomyopathy. Despite treatment, there was no improvement in his symptoms. On evaluation at our centre, his previous electrocardiograms appeared normal. However, palpation of his radial pulse for one minute revealed runs of regular tachycardia, interspersed with a normal pulse rate. A 30-second rhythm strip electrocardi...
Source: Turk Kardiyoloji Dernegi arsivi - January 2, 2024 Category: Cardiology Authors: A Shaheer Ahmed Gauravkumar Divani Nitish Rai Anwar Hussain Ansari Source Type: research
Fingers on the Wrist and Taming the Funny Current, Rejuvenate the Wounded Heart: Ivabradine-Responsive Atrial Tachycardia
Turk Kardiyol Dern Ars. 2023 Dec;51(8):580-583. doi: 10.5543/tkda.2023.60296.ABSTRACTA 19-year-old male presented with dyspnea on exertion (New York Heart Association [NYHA] class II) and occasional palpitations for six months. He had initially been evaluated at another facility and diagnosed with dilated cardiomyopathy. Despite treatment, there was no improvement in his symptoms. On evaluation at our centre, his previous electrocardiograms appeared normal. However, palpation of his radial pulse for one minute revealed runs of regular tachycardia, interspersed with a normal pulse rate. A 30-second rhythm strip electrocardi...
Source: Turk Kardiyoloji Dernegi arsivi - January 2, 2024 Category: Cardiology Authors: A Shaheer Ahmed Gauravkumar Divani Nitish Rai Anwar Hussain Ansari Source Type: research
The clinical profile, genetic basis and survival of childhood cardiomyopathy: a single-center retrospective study
Conclusions: This study demonstrates that CM, especially RCM, is related to a high incidence of death. NYHA/Ross class III or IV is a predictor of mortality in the patients and gene mutations may be a common cause.Trial registration: MR-50-23-011798.What is Known:• Cardiomyopathy (CM) is a heterogeneous group of myocardial diseases and one of the leading causes of heart failure in children due to the lack of effective treatments.• There remains scarce data on Asian pediatric populations though emerging studies have assessed the clinical characteristics and outcomes of CM.What is New:• A retrospective study was conduc...
Source: European Journal of Pediatrics - January 2, 2024 Category: Pediatrics Source Type: research
Association of MBL2 gene polymorphisms and MBL levels with dilated cardiomyopathy in a Chinese Han population
This study aimed to investigate the potential association between MB... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - January 2, 2024 Category: Genetics & Stem Cells Authors: Yujie Mao, Hong Wei, Yugang Gong, Lei Peng and Yu Chen Tags: Research Source Type: research
GSE222952 BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma drives human dilated cardiomyopathy
Contributors : Yuliang Feng ; Liuyang Cai ; Chao-Hui Chang ; Feng Liu ; Lei Jiang ; Siim PauklinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensBy using a small molecule compound library targeting epigenetic enzymes we have identified BRD9 enzyme for eliminating CSCs. Genomic and proteomic studies revealed that BRD9/BAF complex regulates expression of stemness factors and chemoresistance by cooperating with TGF β/Activin-SMAD2/3 signalling pathway. Chemical inhibition and genetic loss of function of BDR9 blocks the self-renewal of CSCs, reduces CSC invasiveness and resensitizes...
Source: GEO: Gene Expression Omnibus - January 1, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
PTPN11 Mutation, A Heartbreaking Revelation
Dilated cardiomyopathy (DCM) exhibits an annual incidence of 5-7 cases per 100,000 persons and a worldwide prevalence of 1:2500 individuals, with a genetic involvement in 35% of all cases (TTN and LMNA gene mutation accounting for the majority). Amongst the numerous genetic mutations, prior research has linked PTPN11 gene mutations to hypertrophic cardiomyopathy. Our case sheds light on the association between PTPN11 mutation and the development of isolated DCM. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Hashim M. AlHammouri, Nora AbuAmouneh, Zaid A. Al-Abed, Ahmad Z. Turk Tags: 324 Source Type: research
National Trends In Racial Disparities Among Hospitalizations And Outcomes In Patients With Dilated Cardiomyopathy
Dilated cardiomyopathy (DCM) is usually progressive, leading to a decline in ventricular function, followed by conduction system abnormalities, ventricular arrhythmias, thromboembolism, renal failure, depression, and progression to chronic heart failure. Our study aimed to decipher the recent trends in hospitalization and in-hospital mortality attributable to dilated cardiomyopathy in the United States. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: OVIE OKORARE, Anderson Ariaga, Chikodili Nebuwa, Sunam Kafle, Endurance Evbayekha, Olushola Ogunleye, Ather Kashif Tags: 183 Source Type: research
β1-adrenergic Receptor (β1AR) Autoantibodies Endogenously Bias β1AR Signaling
Autoimmune response to self-antigens results in autoantibodies (AAbs), wherein AAbs against extra cellular loop 2 (ECL2) of β1AR is known to underlie dilated cardiomyopathy (DCM). Contrarily, recent studies show that patients with β1AR AAbs belonging to the IgG3 subclass have beneficial outcomes. However, the signaling mechanisms that underlie the beneficial outcomes are not well understood. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Maradumane Mohan, Chia-Feng Liu, Khuraijam Dhanachandra Singh, Sadashiva S. Karnik, Wai Hong Tang, Sathyamangla V. Naga Prasad Tags: 066 Source Type: research
One Pump For Two Hearts - A Single-center Experience With An Impella 5.5 Micro-axial Pump In A Peripartum Patient With Cardiogenic Shock
We describe using an Impella 5.5 micro-axial pump to successfully support a pregnancy complicated by DCMP and cardiogenic shock(CS). (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Ashwin Pillai, Mai Badr, Xingchen Mai, Jennifer Bell Tags: 043 Source Type: research
Evidence Of Genetic Testing In A Large, Real-world DCM Cohort And Association With Heart Failure Risk
Dilated Cardiomyopathy (DCM) is a significant cause of congestive heart failure (HF). Understanding the etiology of the left ventricular dysfunction leading to DCM may inform clinical care and prevent subsequent progression to HF. Current clinical guidelines recommend genetic testing for all patients with a diagnosis of DCM or with a family history of DCM; however, the association between guideline-directed genetic testing and progression to clinical HF in DCM patients has yet to be determined. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Kanchan Bhasin, Mauro Longoni, Andrew Ward, McKenna Nisson, Brent White, Donghyun Lee, Sucheta Bhatt, Fatima Rodriguez, Rajesh Dash Tags: 014 Source Type: research
Perivascular Basal Echogenicity in the Fetal Heart: An Unconventional Marker of Maternal Autoimmune Antibodies
We present two cases where recognition of isolated basal echogenicity of the fetal heart, an unconventional manifestation of anti-SSA antibodies during pregnancy, led to a suspicion and ultimately diagnosis of antibody positivity in the mother. These cases highlight the importance of being aware of this rare manifestation of anti-SSA antibodies during pregnancy, as early recognition of antibody positivity may lead to improve fetal and maternal outcomes. (Source: Mammalian Genome)
Source: Mammalian Genome - January 1, 2024 Category: Genetics & Stem Cells Source Type: research
Perivascular Basal Echogenicity in the Fetal Heart: An Unconventional Marker of Maternal Autoimmune Antibodies
We present two cases where recognition of isolated basal echogenicity of the fetal heart, an unconventional manifestation of anti-SSA antibodies during pregnancy, led to a suspicion and ultimately diagnosis of antibody positivity in the mother. These cases highlight the importance of being aware of this rare manifestation of anti-SSA antibodies during pregnancy, as early recognition of antibody positivity may lead to improve fetal and maternal outcomes. (Source: Pediatric Cardiology)
Source: Pediatric Cardiology - January 1, 2024 Category: Cardiology Source Type: research
A nomogram to predict ventricular thrombus in dilated cardiomyopathy patients
Conclusions: The novel nomogram demonstrated better than presenting scores and showed an improvement in predicting VT in DCM patients. (Source: Journal of Thrombosis and Thrombolysis)
Source: Journal of Thrombosis and Thrombolysis - January 1, 2024 Category: Hematology Source Type: research
