Navigating the Complex Landscape of Atrial Functional Mitral Regurgitation: Insights, Challenges, and Emerging Interventions
Functional or secondary mitral valve regurgitation occurs as a consequence of abnormalities in left-sided cardiac geometry and function, in the setting of structurally normal mitral valve leaflets and chordal apparatus. It is frequently associated with left ventricular enlargement or regional dysfunction causing mitral leaflet tethering and annular dilatation, as seen in dilated cardiomyopathy or ischemic heart disease. Atrial functional mitral regurgitation (AFMR) has sparked increasing interest in recent years and is characterized by left atrial and mitral annular dilatation despite normal left ventricular size and systo...
Source: The American Journal of Cardiology - January 10, 2024 Category: Cardiology Authors: Sushil Allen Luis, Hector I. Michelena, Vuyisile T. Nkomo Tags: Editorial Source Type: research
Severity of Left Ventricular Dysfunction in Patients With Tachycardia-Induced Cardiomyopathy: Impacts on Remodeling After Atrial Flutter Ablation
Tachycardia-induced cardiomyopathy (TIC) is a unique cause of nonischemic dilated cardiomyopathy, defined as reversible left ventricular (LV) systolic dysfunction resulting from a sustained fast heart rate.1 It has been reported in patients with incessant or very frequent tachyarrhythmias with an incidence ranging from 3% to 50%, depending on the arrhythmia type and population.2 –6 Although atrial fibrillation is the most common and most studied tachyarrhythmia associated with arrhythmia-induced cardiomyopathy, atrial flutter is also a common etiology. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 10, 2024 Category: Cardiology Authors: Hugo De Larochelli ère, François Brouillette, Patrick Lévesque, Nicolas Dognin, Raphaël St-Germain, Goran Rimac, Sylvain Lemay, François Philippon, Mario Sénéchal Source Type: research
Characterization of cardiac involvement in patients with LMNA splice-site mutation –related dilated cardiomyopathy and sudden cardiac death
Discussion: Above all, Cardiaccardiac involvement in patients with LMNA splice-site mutation presented with a high rate of SCD. Implanting a pacemaker significantly reduced the SCD rate in non-DCM patients with AVB. The pathogenic characterization was not only haveinvolved suppressed the expression of the healthy LMNA allele, but was also associated with abnormal expression and distribution of desmin and Cx43. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - January 8, 2024 Category: Genetics & Stem Cells Source Type: research
The outcomes of a standardized protocol for extracorporeal mechanical circulatory support selection-left ventricular challenge protocol
AbstractThere are no criteria for surgical mechanical circulatory system (MCS) selection for acute heart failure. Since 2021, we have utilized cardiopulmonary bypass system to assess patients ’ heart and lung condition to inform surgical MCS selection. we aimed to retrospectively analyze the outcomes of treatments administered using our protocol. We analyzed the data of 19 patients who underwent surgical MCS implantation. We compared patients’ characteristics across the biventricular -assist device (BiVAD), central Y-Y extracorporeal membrane oxygenation (ECMO), central ECMO, and left VAD (LVAD) systems. Patients' diag...
Source: Journal of Artificial Organs - January 8, 2024 Category: Transplant Surgery Source Type: research
Generation of CRISPR-Cas9 edited human induced pluripotent stem cell line carrying BAG3 V468M mutation in its BAG domain
Stem Cell Res. 2023 Dec 21;74:103294. doi: 10.1016/j.scr.2023.103294. Online ahead of print.ABSTRACTBCL2-Associated Athanogene 3 (BAG3) gene was identified mutated in patients with dilated cardiomyopathy (DCM), an important cause of heart failure and premature death. BAG3 is a cytoprotective co-chaperonne protein involved in many cellular process with a central role in the maintenance of protostasis. We generated two human induced pluripotent stem cell lines (hiPSc), one carrying the heterozygous, the other the homozygous p.V468M mutation identified in DCM familial cases. All lines expressed pluripotent markers, had normal...
Source: Cell Research - January 6, 2024 Category: Cytology Authors: Laetitia Duboscq-Bidot B énédicte Hoareau Flavie Ader Vincent Fontaine Eric Villard Source Type: research
Circulating biomarker- and magnetic resonance-based nomogram predicting long-term outcomes in dilated cardiomyopathy
CONCLUSIONS: We established and validated a circulating biomarker- and CMRI-based nomogram that could provide a personalized prediction of ACM/HTx for DCM patients, which might help risk stratification and decision-making in clinical practice.PMID:38178323 | DOI:10.1097/CM9.0000000000002688 (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2024 Category: General Medicine Authors: Yupeng Liu Wenyao Wang Jingjing Song Jiancheng Wang Yi Fu Yida Tang Source Type: research
Circulating biomarker- and magnetic resonance-based nomogram predicting long-term outcomes in dilated cardiomyopathy
CONCLUSIONS: We established and validated a circulating biomarker- and CMRI-based nomogram that could provide a personalized prediction of ACM/HTx for DCM patients, which might help risk stratification and decision-making in clinical practice.PMID:38178323 | DOI:10.1097/CM9.0000000000002688 (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2024 Category: General Medicine Authors: Yupeng Liu Wenyao Wang Jingjing Song Jiancheng Wang Yi Fu Yida Tang Source Type: research
Circulating biomarker- and magnetic resonance-based nomogram predicting long-term outcomes in dilated cardiomyopathy
CONCLUSIONS: We established and validated a circulating biomarker- and CMRI-based nomogram that could provide a personalized prediction of ACM/HTx for DCM patients, which might help risk stratification and decision-making in clinical practice.PMID:38178323 | PMC:PMC10766284 | DOI:10.1097/CM9.0000000000002688 (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 5, 2024 Category: General Medicine Authors: Yupeng Liu Wenyao Wang Jingjing Song Jiancheng Wang Yi Fu Yida Tang Source Type: research
Case report: Clinical profile, molecular genetics, and neuroimaging findings presenting in a patient with Kearns-Sayre syndrome associated with inherited thrombophilia
ConclusionThe genetic tests performed on KSS patients should also include those for inherited thrombophilia. By detecting these mutations, we can prevent major complications such as cerebral venous sinus thrombosis, coronary accidents, or sudden death. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - January 5, 2024 Category: Neurology Source Type: research
A comparative study of synthetic and venous hematocrit for calculating cardiovascular magnetic resonance-derived extracellular volume
AbstractThe extracellular volume (ECV) fraction derived from cardiac magnetic resonance (CMR) can reflect various pathologies. The application of ECVs was limited by the strict requirement that hematocrit (Hct0) should be obtained within 24 hours of CMR scan. The aim of this study was to obtain accurate and convenient ECV calculated from the venous Hct and synthetic Hct in CMR. A total of 839 subjects were retrospectively enrolled. The subjects were divided into derivation cohort for local sex-specific models and validation cohort for assessing the accuracy of different ECVs. In the validation cohort, venous Hcts from 7 da...
Source: The International Journal of Cardiovascular Imaging - January 4, 2024 Category: Radiology Source Type: research
Fingers on the Wrist and Taming the Funny Current, Rejuvenate the Wounded Heart: Ivabradine-Responsive Atrial Tachycardia
Turk Kardiyol Dern Ars. 2023 Dec;51(8):580-583. doi: 10.5543/tkda.2023.60296.ABSTRACTA 19-year-old male presented with dyspnea on exertion (New York Heart Association [NYHA] class II) and occasional palpitations for six months. He had initially been evaluated at another facility and diagnosed with dilated cardiomyopathy. Despite treatment, there was no improvement in his symptoms. On evaluation at our centre, his previous electrocardiograms appeared normal. However, palpation of his radial pulse for one minute revealed runs of regular tachycardia, interspersed with a normal pulse rate. A 30-second rhythm strip electrocardi...
Source: Turk Kardiyoloji Dernegi arsivi - January 2, 2024 Category: Cardiology Authors: A Shaheer Ahmed Gauravkumar Divani Nitish Rai Anwar Hussain Ansari Source Type: research
Fingers on the Wrist and Taming the Funny Current, Rejuvenate the Wounded Heart: Ivabradine-Responsive Atrial Tachycardia
Turk Kardiyol Dern Ars. 2023 Dec;51(8):580-583. doi: 10.5543/tkda.2023.60296.ABSTRACTA 19-year-old male presented with dyspnea on exertion (New York Heart Association [NYHA] class II) and occasional palpitations for six months. He had initially been evaluated at another facility and diagnosed with dilated cardiomyopathy. Despite treatment, there was no improvement in his symptoms. On evaluation at our centre, his previous electrocardiograms appeared normal. However, palpation of his radial pulse for one minute revealed runs of regular tachycardia, interspersed with a normal pulse rate. A 30-second rhythm strip electrocardi...
Source: Turk Kardiyoloji Dernegi arsivi - January 2, 2024 Category: Cardiology Authors: A Shaheer Ahmed Gauravkumar Divani Nitish Rai Anwar Hussain Ansari Source Type: research
Fingers on the Wrist and Taming the Funny Current, Rejuvenate the Wounded Heart: Ivabradine-Responsive Atrial Tachycardia
Turk Kardiyol Dern Ars. 2023 Dec;51(8):580-583. doi: 10.5543/tkda.2023.60296.ABSTRACTA 19-year-old male presented with dyspnea on exertion (New York Heart Association [NYHA] class II) and occasional palpitations for six months. He had initially been evaluated at another facility and diagnosed with dilated cardiomyopathy. Despite treatment, there was no improvement in his symptoms. On evaluation at our centre, his previous electrocardiograms appeared normal. However, palpation of his radial pulse for one minute revealed runs of regular tachycardia, interspersed with a normal pulse rate. A 30-second rhythm strip electrocardi...
Source: Turk Kardiyoloji Dernegi arsivi - January 2, 2024 Category: Cardiology Authors: A Shaheer Ahmed Gauravkumar Divani Nitish Rai Anwar Hussain Ansari Source Type: research
Fingers on the Wrist and Taming the Funny Current, Rejuvenate the Wounded Heart: Ivabradine-Responsive Atrial Tachycardia
Turk Kardiyol Dern Ars. 2023 Dec;51(8):580-583. doi: 10.5543/tkda.2023.60296.ABSTRACTA 19-year-old male presented with dyspnea on exertion (New York Heart Association [NYHA] class II) and occasional palpitations for six months. He had initially been evaluated at another facility and diagnosed with dilated cardiomyopathy. Despite treatment, there was no improvement in his symptoms. On evaluation at our centre, his previous electrocardiograms appeared normal. However, palpation of his radial pulse for one minute revealed runs of regular tachycardia, interspersed with a normal pulse rate. A 30-second rhythm strip electrocardi...
Source: Turk Kardiyoloji Dernegi arsivi - January 2, 2024 Category: Cardiology Authors: A Shaheer Ahmed Gauravkumar Divani Nitish Rai Anwar Hussain Ansari Source Type: research
