Total percutaneous biventricular assist device implantation for fulminant myocarditis
We report an effective therapeutic approach of mechanical circulatory support for a patient with cardiogenic shock and respiratory insufficiency due to fulminant myocarditis. An Impella® 5.0 was utilized as a left ventricular assist device (VAD) and percutaneous veno-pulmonary extracorporeal membrane oxygenation (ECMO) as a right VAD. These devices were implanted without sternotomy or thoracotomy. Although a combination of Impella and veno-arterial ECMO has been reported as percutaneous biventricular support, there are concerns that this combination is not beneficial for myocardial recovery in patients with respiratory...
Source: Journal of Artificial Organs - August 4, 2020 Category: Transplant Surgery Source Type: research

Does difference in stem design affect accuracy of stem alignment in total hip arthroplasty with a CT-based navigation system?
AbstractThe efficacy of a computed tomography (CT)-based navigation system to accurately position the stem for intended alignment is unclear. In addition, the influence of stem design on the accuracy of insertion is unknown. We therefore retrospectively compared the accuracy and precision for the intended alignment of two different designs of femoral stem which were implanted with or without the navigation system. Forty-nine total hip arthroplasties (THAs) using a tapered wedge stem and 91 THAs using an anatomic stem were evaluated for the navigation group. Thirty-three THAs using the tapered wedge stem and 15 THAs using t...
Source: Journal of Artificial Organs - July 24, 2020 Category: Transplant Surgery Source Type: research

Post-CABG sternum sparing biventricular assist device implantation technique using the right pulmonary artery for right ventricular assist device outflow cannulation
(Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - July 16, 2020 Category: Transplant Surgery Source Type: research

Letter to the Editor of the Journal of Artificial Organs : The flaws in the detail of describing methods, comparing patient cohorts and interpreting results
AbstractWe read with great interest the article written by Murphy et al. (J Artif Organs 22:286 –293, 2019). We acknowledge the authors contribution. However, the results presented may be difficult to interpret due to several missing information and therefore may not support the conclusions. Therefore, the results of this publication should be viewed very critically. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - July 15, 2020 Category: Transplant Surgery Source Type: research

Huge thrombus formation in the left ventricle during bilateral CentriMag ventricular assist device with successful bridging to heart transplantation: a case report and review of the literature
AbstractOwing to shortage of donor hearts, the ventricular assist device is used as a bridging therapy to heart transplantation. However, thrombus formation is a critical complication during ventricular assist device circulatory support that might result in ischemic infarction of end organs. Here, we report a patient diagnosed with decompensated dilated cardiomyopathy and cardiogenic shock who underwent emergent extracorporeal life support, and subsequent temporary bilateral ventricular assistance with the CentriMag device (Levitronix LLC, Waltham, MA). Daily transthoracic echocardiography did not detect any thrombus forma...
Source: Journal of Artificial Organs - July 14, 2020 Category: Transplant Surgery Source Type: research

Recovery of human mesenchymal stem cells grown on novel microcarrier coated with thermoresponsive polymer
AbstractThe cultivation of cells on microcarriers (MCs) in stirred suspension system is useful method for the large-scale culture of human mesenchymal stem cells (hMSCs) for allogenic transplantation. To harvest hMSCs from MCs without using proteolytic enzyme treatment but by lowering temperature, polystyrene MCs coated with a copolymer called CAT having zwitterionic and thermoresponsive characteristics, which has a lower critical solution temperature (LCST) in the range of 28 –32 ℃, were developed and compared with those coated with poly(N-isopropylacrylamide) (PNIPAM), which has an LCST almost the same as th...
Source: Journal of Artificial Organs - July 12, 2020 Category: Transplant Surgery Source Type: research

Correction to: A subcostal approach is favorable compared to sternotomy for left ventricular assist device exchange
In the original publication, the title of the article was published incorrectly. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - July 8, 2020 Category: Transplant Surgery Source Type: research

Connector sensors for permittivity-based thrombus monitoring in extracorporeal life support
This study fabricated and evaluated a connector sensor for real-time permittivity-based thrombus monitoring at tube –connector interface. Computational simulations were initially done to pre-evaluate the applicability of connector sensor. The sensor was fabricated by incorporating two stainless steel electrodes on acrylic tube for measuring permittivity changes at the tube–connector interface. OCT images were also taken from the interface at intervals for comparisons. Results show that the sensor was able to detect thrombus formation at the interface in form of sudden rise in permittivity after timet =&t...
Source: Journal of Artificial Organs - July 7, 2020 Category: Transplant Surgery Source Type: research

Prosthetic valve replacement for aortic leaflet tear secondary to Impella device placement
AbstractWe experienced a case of aortic regurgitation secondary to tear in the non-coronary cusp of the aortic valve after percutaneous mechanical circulatory support by Impella 2.5 placement, which was resolved with aortic valve replacement. Our patient, a 72-year-old man, developed non-ST elevation myocardial infarction and cardiogenic shock, which was treated with the implantation of Impella 2.5 prior to percutaneous coronary intervention. He eventually required prosthetic valve replacement for progressive aortic regurgitation after removing the Impella device. From intraoperative photographs, multiple lacerations were ...
Source: Journal of Artificial Organs - July 6, 2020 Category: Transplant Surgery Source Type: research

Improved viability of murine skin flaps using a gelatin hydrogel sheet impregnated with bFGF
In this study, the effects of gelatin hydrogel sheets impregnated with bFGF on flap survival and angiogenesis were examined in a murine skin flap model. A flap of 1  × 3 cm was generated on the backs of 60 C57BL/6 mice. The mice were divided into five groups (n = 12/group): Group I, untreated; Group II, treated with a gelatin hydrogel sheet impregnated with saline; Group III, treated with bFGF (50 µg) without sheets; Groups IV and V, treated with gelatin hydrogel sheets impregnated with 50 and 100 µg of bFGF, respectively. On the seventh day after surgery, the fl...
Source: Journal of Artificial Organs - July 6, 2020 Category: Transplant Surgery Source Type: research

The effect of roller head pump on platelet deterioration during the simulated extracorporeal circulation
AbstractRoller pumping results in hemolysis and adverse effects on coagulation, but there are few reports on the influence of roller heads on platelets. Here, we evaluate the interaction between roller pumping and platelet function using a simulated extracorporeal circuit incorporating a vinyl chloride tube and roller head pump with 30  min recirculation. Platelet aggregation, platelet count, microparticle, P-selectin, Phosphatidylserine (PS) exposure and Ricinus Communis Agglutinin 1 (RCA-1) were measured before, 5, 10, 20, and 30 min after the recirculation using 100 ml of fresh human blood that had obtain...
Source: Journal of Artificial Organs - July 4, 2020 Category: Transplant Surgery Source Type: research

Higher skin autofluorescence detection using AGE-Reader ™ technology as a measure of increased tissue accumulation of advanced glycation end products in dialysis patients with diabetes: a meta-analysis
AbstractThis meta-analysis was conducted to compare skin autofluorescence (SAF) levels as a measure of advanced glycation end products (AGEs) accumulation between diabetic and non-diabetic dialysis patients. Relevant studies were identified primarily by searching PubMed/MEDLINE and other online databases and manual searching of cross-references. Random-effects model was used to obtain standardized mean differences (SMD) as a summary statistic. Heterogeneity was tested with meta-regression and sub-group analyses. Publication bias and robustness of this meta-analysis were tested using funnel plot and sensitivity analyses. A ...
Source: Journal of Artificial Organs - July 1, 2020 Category: Transplant Surgery Source Type: research

New treatment strategy for severe heart failure: combination of ventricular assist device and regenerative therapy
AbstractHeart transplantation and ventricular assist device for the patients with end-stage heart failure are limited by availability and durability due to limited donor or device-related complication. Thus, complementation or a new alternative is needed for the treatment of severe heart failure. Based on the results of basic experiments, we applied skeletal myoblast cell sheet transplantation in a clinical setting using cell-sheet methods with temperature-responsive dish for the treatment of heart failure patient from 2007. After confirming the safety of this treatment, we started a clinical trial of myoblast cell sheet t...
Source: Journal of Artificial Organs - June 20, 2020 Category: Transplant Surgery Source Type: research

Aortic insufficiency associated with Impella that required surgical intervention upon implantation of the durable left ventricular assist device
In this report, we describe two patients who developed aortic insufficiency (AI) associated with Impella and required surgical intervention upon implantation of the durable left ventricular assist device (LVAD). Both patients presented with cardiogenic shock and underwent insertion of Impella 5.0 as a bridge to decision. The cardiac function in these patients did not improve and obtaining approval for heart transplantation required time. They were managed with Impella for 91 and 98  days, respectively. In both cases, moderate AI that was not present before Impella insertion was observed when the Impella was removed. T...
Source: Journal of Artificial Organs - June 19, 2020 Category: Transplant Surgery Source Type: research

Clinical course of a critically ill patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
AbstractAlthough several studies have reported on the clinical and epidemiological characteristics of the patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), clinical course of the most severe cases requiring treatment in ICU have been insufficiently reported. A 73-year-old man traveling on a cruise ship with history of hypertension and dyslipidemia developed high fever, dyspnea and cough after 7  days of steroid treatment for sudden sensorineural hearing loss, and tested positive for SARS-CoV-2 in sputa polymerase chain reaction (PCR) examination. His respiratory function deteriorated despite t...
Source: Journal of Artificial Organs - June 16, 2020 Category: Transplant Surgery Source Type: research

Preclinical biocompatibility study of ultra-compact durable ECMO system in chronic animal experiments for 2  weeks
AbstractAlthough the innovation has come in ECMO field, many problems remain unresolved. One of the main problems is about long-term durability and biocompatibility. Another is the system ’s size, weight, and its complicated equipment. For the former problem, we have previously developed ECMO system which consists of a tiny, hydrodynamically levitated centrifugal pump (BIOFLOAT-NCVC), a membrane oxygenator with hollow polyolefin fibers (BIOCUBE-NCVC), and the circuit treated with a heparin-bonding material (T-NCVC coating), and reported three cases of animal experiments for 30-day heparin-free drive. For the latter p...
Source: Journal of Artificial Organs - June 8, 2020 Category: Transplant Surgery Source Type: research

Training the component steps of an extra-corporeal membrane oxygenation (ECMO) cannulation outside the clinical setting
AbstractExtra-corporeal membrane oxygenation (ECMO) cannulation can be a stressful procedure because a fast cannulation is vital for the patient ’s survival. Therefore, it is important to train the steps of cannulation outside the clinical setting. A relatively low budget, easy to use model, was developed to train the most important steps of an ECMO cannulation. Following this, it was evaluated by experts and target group participants. The y all completed a questionnaire regarding their experience and opinions on the ECMO model on general aspects and the training of the component steps, rated on a 5-point Likert scal...
Source: Journal of Artificial Organs - June 8, 2020 Category: Transplant Surgery Source Type: research

Sutureless aortic valve replacement with concomitant aortic arch reconstruction
AbstractSutureless aortic valve replacement (AVR) offers an alternative approach to the standard AVR in aortic valve disease. We herein report a case of an 82-year-old woman with severe aortic insufficiency and a persistent type 1 endoleak following a thoracic endovascular aortic repair, who underwent successful combined aortic arch reconstruction and sutureless AVR. The bioprosthesis, Perceval (LivaNova PLC, London, UK), a self-anchoring, self-expanding, sutureless valve, which can be implanted in selected patients with aortic insufficiency was used. Although the patient was frail and at a high risk of open-heart surgery,...
Source: Journal of Artificial Organs - June 7, 2020 Category: Transplant Surgery Source Type: research

Spinal cord infarction during venoarterial-extracorporeal membrane oxygenation support
AbstractSpinal cord infarction (SCI) is a rare disease among central nervous system vascular diseases. Only a little is known about venoarterial extracorporeal membrane oxygenation (VA-ECMO)-related SCI. Retrospective observational study conducted, from 2006 to 2019, in a tertiary referral center on patients who developed VA-ECMO-related neurovascular complications, focusing on SCI. During this period, among the 1893 patients requiring VA-ECMO support, 112 (5.9%) developed an ECMO-related neurovascular injury: 65 (3.4%) ischemic strokes, 40 (2.1%) intracranial bleeding, one cerebral thrombophlebitis (0.05%) and 6 (0.3%) sp...
Source: Journal of Artificial Organs - May 30, 2020 Category: Transplant Surgery Source Type: research

Twisting and constriction of a HeartMate II driveline in the area of a repair site
AbstractThe driveline ’s durability is crucial for optimal long-term support with a left-ventricular assist device (LVAD). The incidence of percutaneous driveline fracture after HeartMate II LVAD implantation is low. For the first time, we describe a patient with an already repaired driveline and a massive constriction and twisting of the driveline in the area of the repair site. This dramatic finding necessitates a renewed exchange of the external part of the driveline by the manufacturer. Due to the increasing number of patients with elongated LVAD support, the stability of the driveline and possible repairs in clu...
Source: Journal of Artificial Organs - May 30, 2020 Category: Transplant Surgery Source Type: research

Posterolateral lumbar spine fusion with unidirectional porous beta-tricalcium phosphate in a canine model
AbstractWe investigated the use of the autologous iliac bone and unidirectional porous beta-tricalcium phosphate (UDPTCP) in posterolateral lumbar spine fusion (PLF). Ten canine PLF models were prepared. Using only the autologous bone as the control group, 100%, 75%, 50%, and 25% groups were prepared according to the mixing ratios of UDPTCP. Radiological evaluation and histological analysis were performed 12  weeks after surgery. Bone fusion was evaluated according to anteroposterior plain X-rays and coronal reconstruction CT views using four grades: 0 = no osteogenesis, 1 = only slight dis...
Source: Journal of Artificial Organs - May 25, 2020 Category: Transplant Surgery Source Type: research

Regional thigh tissue oxygen saturation during cardiopulmonary bypass predicts acute kidney injury after cardiac surgery
In conclusion, the regional oxygen saturation at the thigh during cardiopulmonary bypass is a crucial marker to predict postoperative acute kidney in jury in adults undergoing cardiac surgery. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - May 24, 2020 Category: Transplant Surgery Source Type: research

Correction to: Extracorporeal membrane oxygenation support for postcardiotomy cardiogenic shock in adult patients: predictors of in ‑hospital mortality and failure to be weaned from extracorporeal membrane oxygenation
In the original publication of the article, author group affiliation was published incorrectly. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - May 20, 2020 Category: Transplant Surgery Source Type: research

Long term CentriMag biventricular support using hybrid cannulation as a bridge to transplant in a pediatric patient
We describe the long-term use of the CentriMag biventricular assist device with multiple pump changes in a 9-year-old boy with idiopathic-dilated cardiomyopathy. The initially implanted Berlin Heart EXCOR pumps were replaced by CentriMag due to thromboembolic complications. The CentriMag pumps were exchanged 15 times due to clot and fibrin formation or when the pumps reached their expiration dates. Connecting CentriMag to Berlin Heart EXCOR cannulae effectively served as an alternative long-term hybrid bridge to transplantation for 235  days. The patient successfully underwent a transplant after 284 days. Judicio...
Source: Journal of Artificial Organs - May 20, 2020 Category: Transplant Surgery Source Type: research

Amino acid losses are lower during pre-dilution on-line HDF than HD of the same Kt/V for urea
In this study, we investigated differences in amino acid losses between HD and pre-dilution on-line HDF with equal Kt/V for urea to determine which modality removes less amino acids from extravascular pools and ensures better nutrition. The subjects were patients receiving pre-dilution on-line HDF (n = 10) or HD (n = 10) at this hospital. Dialysis time was 4 h for all patients. In patients on HD, the blood flow rate was 200 mL/min and the dialysate flow rate was 463 ± 29.3 mL/min. In patients on pre-dilution on-line HDF, the blood flow rate was 240 &plu...
Source: Journal of Artificial Organs - May 16, 2020 Category: Transplant Surgery Source Type: research

Impact of the angle between aortic and mitral annulus on the occurrence of hemolysis during Impella support
In this study, we investigated the pre-procedural factors, including the echocardiographic narrow angle between aortic and mitral annulus, associating with the occurrence of refractory hemolysis following Impella insertion. We enrolled 26 patients (71  years, 65% male) who received Impella insertion between March 2018 and November 2019. Among baseline characteristics, the angle between aortic and mitral annulus, 
Source: Journal of Artificial Organs - May 14, 2020 Category: Transplant Surgery Source Type: research

Involvement of ionic interactions in cytokine adsorption of polyethyleneimine-coated polyacrylonitrile and polymethyl methacrylate membranes in vitro
This study investigated the involvement of ionic interactions in cytokine adsorption to a negatively charged AN69ST membrane and neutral-charged PMMA membrane. Experimental hemofiltration was performed for 30  min in a closed-loop circulation system using AN69ST and PMMA hemofilters. Tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-8 concentrations in the test solutions were measured at baseline and at 10 min and 30 min into hemofiltration. To investigate the involvement of ionic interaction s in cytokine adsorption, cytokine clearance (CL) was calculated at 10 min into hemofiltration and...
Source: Journal of Artificial Organs - May 11, 2020 Category: Transplant Surgery Source Type: research

Review and reflections about pulsatile ventricular assist devices from history to future: concerning safety and low haemolysis —still needed
AbstractSince the first use of a ventricular assist device in 1963 many extracorporeal and implantable pulsatile blood pumps have been developed. After the invention of continuous flow blood pumps the implantable pulsatile pumps are not available anymore. The new rotary pumps spend a better quality of life because many of the patients can go home. Nevertheless, the extracorporeal pulsatile pumps have some advantages. They are low-cost systems, produce less haemolysis and heart-recovery can be tested easily. Pump failure is easy to realize because the pumps can be observed visually. Pump exchange can be done easily without ...
Source: Journal of Artificial Organs - May 4, 2020 Category: Transplant Surgery Source Type: research

A preliminary implementation of an active intraocular prosthesis as a new image acquisition device for a cortical visual prosthesis
In conclusion, the feasibility of the active intraocular prosthesis to cooperate with a cortical visual prosthesis is discussed. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - April 27, 2020 Category: Transplant Surgery Source Type: research

Using hydrophilic introducer sheath for peripheral vaECMO cannulation in highly calcified vessels: the bailout solution
(Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - April 27, 2020 Category: Transplant Surgery Source Type: research

Professor Kazuhiiko Atsumi, MD: reflections on a half-century friendship
(Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - April 18, 2020 Category: Transplant Surgery Source Type: research

Remembering Professor Kazuhiko Atsumi
(Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - April 16, 2020 Category: Transplant Surgery Source Type: research

Evaluation of low-volume post-dilution online hemodiafiltration with Japanese high-performance hemodiafilters
AbstractTo assess the removal performance of low-volume post-hemodiafiltration (HDF) with Japanese hemodiafilters and the removal performance with 20  % reduction in the total dialysate flow rate (Qdtotal). Subjects were 8 patients undergoing pre-HDF. Study 1: Post-HDF was performed at a blood flow rate (Qb) of 250  mL/min and a total volume of substitution fluid (Vs) of 12 L/session(s) for 4 hrs using Fineflux-210Seco (FIX), ABH-21PA (ABH), and NVF-21H (NVF). We assessed removal efficiency of small molecular solutes, low-molecular-weight-proteins and the amount of albumin loss. Study 2: Post-HDF was pe...
Source: Journal of Artificial Organs - April 7, 2020 Category: Transplant Surgery Source Type: research

Therapeutic effect of high-efficiency online hemodiafiltration for recurrent restless legs syndrome in dialysis patients
AbstractTwo dialysis patients developed recurrent restless legs syndrome. The clinical courses and the association between the α1-microglobulin removal rate and the therapeutic effects of hemodiafiltration were analyzed. Case 1: a middle-aged woman was switched from predilution online hemodiafiltration to hemodialysis, following which the α1-microglobulin removal rate decreased from 39.1 to 29.9%. A month later, the severe restless legs syndrome occurred. The treatment was then switched to high-efficiency hemodiafiltration and 2  weeks later, these symptoms were resolved. The α1-microglobulin removal...
Source: Journal of Artificial Organs - March 30, 2020 Category: Transplant Surgery Source Type: research

Impella support as a bridge to scheduled surgical repair of ventricular septal rupture
Abstract We studied the experience of a 69-year-old woman with acute decompensated heart failure due to post-infarction ventricular septal rupture. She received mechanical hemodynamic support by Impella 2.5 (Abiomed, Danvers, MA, USA), percutaneous axial-flow left ventricular assist device, which improved intra-cardiac pressure, maintaining end-organ function. She was successfully bridged to the scheduled surgical repair of ventricular septal rupture following the 9-day Impella support and discharged on foot on the 32nd day. Impella might be a useful mechanical circulatory support device as a bridge tool to the scheduled...
Source: Journal of Artificial Organs - March 27, 2020 Category: Transplant Surgery Source Type: research

Effect of a modular neck hip prosthesis on anteversion and hip rotation in total hip arthroplasty for developmental dysplasia of the hip
AbstractTotal hip arthroplasty (THA) is often required to decrease the excessive anatomical femoral anteversion (AA) in developmental dysplasia of the hip. Studies have recommended decreasing the AA via the use of a retroverted modular neck. However, hip rotation after THA may strengthen or weaken the effect of changing the AA. Thus, the present study analyzed the effect of a retroverted neck on AA and hip rotation. Patients who underwent THA using a straight neck (ST group) or a 15 ° retroverted neck (RV group) in a version changeable dual modular system (Mainstay stem, Kyocera, Kyoto, Japan) were retrospectively revi...
Source: Journal of Artificial Organs - March 2, 2020 Category: Transplant Surgery Source Type: research

Future development of artificial organs related with cutting edge emerging technology and their regulatory assessment: PMDA ’s perspective
AbstractFuture development of innovative artificial organs is closely related with cutting edge emerging technology. These technologies include brain machine or computer interface, organs made by three dimensional bioprinting, organs designed from induced-pluripotent stem cell for personalized tissue or organ, and xenotransplantation. To bridge the gap between scientific innovation and regulatory product review, pharmaceuticals and medical devices agency of Japan (PMDA) started the science board to discuss about the new scientific topics regarding medical products including medical device and regenerative products with ext...
Source: Journal of Artificial Organs - February 28, 2020 Category: Transplant Surgery Source Type: research

Extracorporeal membrane oxygenation support for postcardiotomy cardiogenic shock in adult patients: predictors of in-hospital mortality and failure to be weaned from extracorporeal membrane oxygenation
AbstractPostcardiotomy cardiogenic shock (PCCS) is a rare clinical entity associated with substantial morbidity and mortality. It is characterized by heart failure that results in an inability to be weaned from cardiopulmonary bypass (CPB). The aim of this study was to analyze the outcomes of extracorporeal membrane oxygenation (ECMO) in patients with PCCS and to identify predictors of in-hospital mortality and failure to be weaned from ECMO. From January 2002 to August 2016, 3248 patients underwent cardiac surgery in our hospital. Of these, 29 patients (0.89%) required ECMO because of an inability to be weaned from cardio...
Source: Journal of Artificial Organs - February 25, 2020 Category: Transplant Surgery Source Type: research

Recent developments in strontium-based biocomposites for bone regeneration
AbstractRecent advances in biomaterial designing techniques offer immense support to tailor biomimetic scaffolds and to engineer the microstructure of biomaterials for triggering bone regeneration in challenging bone defects. The current review presents the different categories of recently explored strontium-integrated biomaterials, including calcium silicate, calcium phosphate, bioglasses and polymer-based synthetic implants along with their in vivo bone formation efficacies and/or in vitro cell responses. The role and significance of controlled drug release scaffold/carrier design in strontium-triggered osteogenesis was ...
Source: Journal of Artificial Organs - February 25, 2020 Category: Transplant Surgery Source Type: research

Central conversion from peripheral extracorporeal life support for patients with refractory congestive heart failure
This study enrolled an institutional consecutive surgical series of 24 patients with refractory congestive heart failure under peripheral ECLS, related to fulminant myocarditis (n = 15), dilated cardiomyopathy (n = 5), or acute myocardial infarction (n = 4). They were converted to central Y-extracorporeal membrane oxygenation (ECMO,n = 6), extracorporeal ventricular assist device (EC-VAD,n = 12), or pump catheter (n = 6), dependent upon the degree of multiorgan failure. Despite the different degree of multiorgan failure prior to the convers...
Source: Journal of Artificial Organs - February 19, 2020 Category: Transplant Surgery Source Type: research

Journal of Artificial Organs 2019: the year in review
(Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - February 19, 2020 Category: Transplant Surgery Source Type: research

Does a computed tomography-based navigation system reduce the risk of dislocation after total hip arthroplasty in patients with osteonecrosis of the femoral head? A propensity score analysis
This study aimed to investigate whether use of a computed tomography (CT)-based navigation system reduce the risk of dislocation after total hip arthroplasty (THA) in patients with osteonecrosis of the femoral head (ONFH). A total of 271 hips from 192 consecutive patients that underwent primary THA for ONFH were included. There were 110 hips in non-navigation group, and 161 hips in navigation group. After applying exclusion criteria, 209 hips from 149 patients were selected for analysis. Clinical outcomes and complication rates were evaluated, and implant alignments were also calculated. To identify whether the navigation ...
Source: Journal of Artificial Organs - February 18, 2020 Category: Transplant Surgery Source Type: research

A simulation tool for mechanical circulatory support device interaction with diseased states
This article describes the mathematical core of the in silico simulation system and shows examples of simulation output imitating various disease states and of selected in vitro and clinical data from the literature. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - February 14, 2020 Category: Transplant Surgery Source Type: research

Pneumopericardium suggesting left ventricular assist device-related gastrointestinal complication
We report an uncommon case of ventricular assist device-related infection and resultant fistula formation into the gastrointestinal tract. A 69-year-old man, who had undergone implantation of a HeartMate II 1  year earlier secondary to ischemic cardiomyopathy, presented to our hospital with a high fever. Computed tomography showed unusual gas collection around the heart apex (i.e., pneumopericardium), which had not been detected before. The patient developed sudden melena with fresh blood without abdomi nal symptoms 1 month after beginning antibiotic therapy. Emergent colonoscopy showed that the HeartMate II stra...
Source: Journal of Artificial Organs - January 25, 2020 Category: Transplant Surgery Source Type: research

Gerbode defect and left ventricular-aortic discontinuity in prosthetic valve endocarditis
AbstractCommunication between the left ventricle and right atrium is known as the Gerbode defect. The defect is usually congenital but can be acquired secondary to infective endocarditis. Left ventricular-aortic discontinuity is another serious complication of extensive infective endocarditis. Here, we report a rare case of prosthetic valve endocarditis complicated with both acquired Gerbode defect and left ventricular-aortic discontinuity. We successfully performed reconstructive surgery involving patch closure of the Gerbode defect and reconstruction of the circumferential left ventricular outflow tract with a xenoperica...
Source: Journal of Artificial Organs - January 8, 2020 Category: Transplant Surgery Source Type: research

A case of left ventricular assist device application for chemotherapy-related cardiomyopathy caused by trastuzumab and anthracycline
AbstractLeft ventricular assist device (LVAD) is an established therapy for patients with severe heart failure. Because the incidence of cardiotoxicity owing to anticancer agents is low, it is difficult to predict the recovery prospects when the cause of heart failure is due to anticancer agents. In this context, cancer patients who present with severe symptoms of heart failure and who fail medical therapy for heart failure may pose a dilemma, especially in countries such as Japan where implantable LVADs are not approved for purposes other than bridging to transplant. Recently, we encountered a 32-year-old woman with chemo...
Source: Journal of Artificial Organs - January 2, 2020 Category: Transplant Surgery Source Type: research

Decellularization of submillimeter-diameter vascular scaffolds using peracetic acid
In this study, rat tail arteries (inner diameter, 0.6  mm) were decellularized with peracetic acid (PAA) and DNase I. PAA treatment is expected not only to disrupt cell membranes which improves the decellularization efficiency in the subsequent DNase treatment, but also to sterilize vascular scaffolds. We succeeded in adequate cell removal by immersin g in 0.3% isotonic PAA solution and subsequent washing with DNase solution. For the DNase washing process, the perfusion method was superior in terms of cell removal to the static immersion method. Graft lumen was modified with a peptide composed of a collagen binding se...
Source: Journal of Artificial Organs - January 1, 2020 Category: Transplant Surgery Source Type: research

Impella RP in hemodynamically unstable patients with acute pulmonary embolism
AbstractOver the last years, different case reports/studies have demonstrated that in patients with acute pulmonary embolism (PE) and refractory shock mechanical circulatory support (MCS) with Impella RP® (Abiomed, Inc, Danvers, Mass) increases the chances of survival, significantly unloading the right ventricle and improving both the cardiac output and the mean pulmonary artery pressure. We reviewed the medical literature about the use of Impella RP in patients with acute PE and refractory shock using PubMed (MEDLINE), Scopus, Cochrane library, and Google Scholar databases. The final research was conducted in July 201...
Source: Journal of Artificial Organs - December 23, 2019 Category: Transplant Surgery Source Type: research

Continuous monitoring of changes in cerebral oxygenation during hemodialysis in a patient with acute congestive heart failure
AbstractA 71-year-old man undergoing hemodialysis (HD) was admitted to our hospital with congestive heart failure (CHF) and pneumonia. After admission, ultrafiltration with HD was urgently performed because of a lack of respiratory improvement despite the use of noninvasive positive pressure ventilation. During HD, cerebral regional saturation of oxygen (rSO2) was monitored by INVOS 5100c oxygen saturation monitor (Covidien Japan, Japan) to evaluate changes in tissue oxygenation. At HD initiation, cerebral rSO2 was very low at 34% under the fraction of inspiratory oxygen (FiO2) of 0.4. Ultrafiltration was performed at the ...
Source: Journal of Artificial Organs - December 19, 2019 Category: Transplant Surgery Source Type: research

Acquired factor XIII deficiency in two patients with bleeding events during veno-venous extracorporeal membrane oxygenation treatment
We report two cases of acquired factor XIII deficiency with bleeding events during veno-venous extracorporeal membrane oxygenation (ECMO). Case 1: A 76-year-old man diagnosed with aspiration pneumonia after near-drowning was started on ECMO. Later, the patient presented with hemoptysis and anemia. Blood tests showed a decreased factor XIII activity of 29%. Although the patient recovered after receiving 1200 International Units of factor XIII concentrate, the patient had another episode of decreased factor XIII activity and bloody stool and was treated again with factor XIII concentrate. Case 2: A 48-year-old female diagnos...
Source: Journal of Artificial Organs - December 13, 2019 Category: Transplant Surgery Source Type: research