The incidence, risk factors, and outcomes of gastrointestinal bleeding in patients with a left ventricular assist device: a Japanese single-center cohort study
AbstractContinuous flow-left ventricular assist devices (CF-LVADs) have become a therapeutic option in the management of advanced heart failure. Several studies show that patients with CF-LVAD are at an increased risk of gastrointestinal bleeding (GIB). However, few reports have presented the characteristics of GIB in Japanese populations. We investigated the incidence, etiology, and outcome of GIB in patients with CF-LVAD. Records of adult patients who received CF-LVADs between October 2008 and January 2017 were reviewed. GIB was defined as detection of bleeding sites by any type of diagnostic imaging. 54 patients receive...
Source: Journal of Artificial Organs - November 8, 2019 Category: Transplant Surgery Source Type: research

Correction to: Intermittent application of external positive pressure helps to preserve organ viability during ex vivo perfusion and culture
article Intermittent application (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - November 7, 2019 Category: Transplant Surgery Source Type: research

Impact of three-dimensional tortuous pore structure on polyethersulfone membrane morphology and mass transfer properties from a manufacturing perspective
We examined typical commercial poly(ethersulfone) (PESf) hemodialysis and hemoconcentration membranes successfully used in manufacturing, and employed scanning probe microscope (SPM) to achieve a structural observation of the pores in the inner membrane surfaces, as well as measure the pore diameters and their distribution, verifying the relationship between the typical mass transfer properties. We focused on the differences between the PESf membranes which were expected to further improve the advanced pore structure control and functional design for various medical uses. The three-dimensional tortuous capillary pores on t...
Source: Journal of Artificial Organs - November 5, 2019 Category: Transplant Surgery Source Type: research

Simple and efficient method for consecutive inactivation –cryopreservation of porcine skin grafts
In this study, we evaluated whether glycerol-cryopreservation could be applied in order to preserve inactivated skin by HHP using a porcine model. Twenty full-thickness skin grafts (1.5  × 1.5 cm) were prepared from a minipig. The skin samples were inactivated by the HHP in normal saline or glycerol/fructose solution, followed by cryopreservation for 5 weeks at − 80 °C in each same solution. Another 10 grafts immediately after inactivation were prepared as non-cryopres erved controls. Nine grafts in each group were randomly implanted on the fascia of a host pig and remove...
Source: Journal of Artificial Organs - November 3, 2019 Category: Transplant Surgery Source Type: research

Pre-clinical assessment of a prototype non-invasive diagnostic device to detect aortic aneurysms
This study aimed to examine how configuration and size of an aneurysm as well as endoluminal pressure affect our diagnostic device ’s ability to detect an aneurysm, using a pulsatile mock circulation. We created three different-sized (12, 16, and 20 mm) saccular and fusiform aneurysm models using silicone and incorporated them in a pulsatile perfusion circuit to evaluate vertical vessel wall velocity wave form at a location apart from the aneurysm. We also varied the pressure condition to evaluate the changes in the detected wave forms. In both fusiform and saccular aneurysm models, biphasic wave forms indicatin...
Source: Journal of Artificial Organs - November 2, 2019 Category: Transplant Surgery Source Type: research

Comparison of adsorption of selected antibiotics on the filters in continuous renal replacement therapy circuits: in vitro studies
AbstractThe aim of this study was to assess the adsorption of selected antibiotics: vancomycin, gentamicin, ciprofloxacine and tigecycline in an experimental continuous veno-venous hemofiltration circuit with the use of both polyethyleneimine-treated polyacrylonitrile (PAN) and the polysulfone (PS) filter membranes. The crystalloid fluid dosed with one of antibiotic was pumped from a reservoir through a hemofiltration circuit (with PAN or PS membrane) and back to reservoir. All ultrafiltrate was also returned to the reservoir. During the procedures samples were collected from the post-hemofilter port at 5, 15, 30, 45, 60, ...
Source: Journal of Artificial Organs - October 20, 2019 Category: Transplant Surgery Source Type: research

Pediatric ventricular assist device therapy for advanced heart failure-Hong Kong experience
We present a retrospective review of 13 consecutive children who underwent implantation of VAD between 2001 and 2018 in our center. The median age was 12  years (1–17 years), weight was 45 kg (10–82 kg). Etiologies of heart failure were dilated cardiomyopathy (CMP) (n = 8), myocarditis (n = 2), ischemic CMP (n = 1), restrictive CMP (n = 1) and congenital heart disease (n = 1). Pre-implantation ECMO was used in 5, mechanical ventilation in 4, renal replacement therapy in 2 and IABP in 1. Devices used were: Berlin Heart EXCO...
Source: Journal of Artificial Organs - October 17, 2019 Category: Transplant Surgery Source Type: research

Intermittent application of external positive pressure helps to preserve organ viability during ex vivo perfusion and culture
AbstractThe perfusion of medium through blood vessels allows the preservation of donor organs and culture of bioengineered organs. However, tissue damage due to inadequate perfusion remains a problem. We evaluated whether intermittent external pressurization would improve the perfusion and viability of organs in culture. A bioreactor system was used to perfuse and culture rat small intestine and femoral muscle preparations. Intermittent positive external pressure (10  mmHg) was applied for 20 s at intervals of 20 s. Intermittent pressurization resulted in uniform perfusion of small intestine preparations and...
Source: Journal of Artificial Organs - October 15, 2019 Category: Transplant Surgery Source Type: research

A CO 2 removal system using extracorporeal lung and renal assist device with an acid and alkaline infusion
AbstractThe patients with respiratory failure need high tidal volume by mechanical ventilation, which lead to the ventilator-induced lung injury. We developed an extracorporeal lung and renal assist device (ELRAD), comprising acid infusion, membrane lung, continuous hemodiafiltration and alkaline infusion. To evaluate this system, we conducted in vivo studies using experimental swine which were connected to the new system. In vivo experiments consist of four protocols; baseline  = hemodiafiltration only (no O2 gas flow to membrane lung); membrane lung  = “Baseline” plus O2 gas flow t...
Source: Journal of Artificial Organs - October 4, 2019 Category: Transplant Surgery Source Type: research

New chemistry supporting portable solutions for end-stage renal disease dialysis treatment
AbstractA new polymeric adsorbent to improve portable dialysis treatment by simplifying urea removal at the dialysate regeneration step is proposed. An adsorbent to remove urea was synthesized by molecular imprinting technology that can potentially overcome drawbacks existing in urease enzyme-based dialysate regeneration technology. Molecularly imprinted polymer (MIP) for urea generates cavities both in shape and in size targeted for urea. Using the synthesized MIP, we have shown removal of urea present in the dialysate buffer. Various experimental conditions such as choice of monomers, porogen, and template to monomer rat...
Source: Journal of Artificial Organs - September 30, 2019 Category: Transplant Surgery Source Type: research

Potential utility of new surgical hemostatic film using Hydrofit ® : a preliminary study
AbstractWe developed a surgical hemostatic film using Hydrofit® (Hydrofit® film). This film is prepared by reacting Hydrofit® with water in advance, and it can be used in the same way as an accessory silicone sheet. In addition, unlike the silicone sheet, there is no need to remove the Hydrofit® film from the body. In the present study, we describe the hemostatic effect of our new method using Hydrofit® film. We created a pulsatile flow circuit model using a ventricular assist device and a vascular graft. The circuit was filled with water, and the systolic pressure was adjusted to  ≥ 13...
Source: Journal of Artificial Organs - September 25, 2019 Category: Transplant Surgery Source Type: research

Proximal outflow graft extrinsic compression of the Heartmate 3 centrifugal flow left ventricular assist device resulting in pump dysfunction
This report underscores that this complication should be screened in case of persistent low-flow alarms with the Heartmate 3 centrifugal pump. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - September 25, 2019 Category: Transplant Surgery Source Type: research

Extracorporeal therapy for amlodipine poisoning
We report a rare case where both lifesaving extracorporeal therapies were used in a patient with a severe drug overdose. Stabilizing hemodynamics with ECMO combined with TPE for drug removal is a feasible strategy in unstable patients with amlodipine overdose. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - September 24, 2019 Category: Transplant Surgery Source Type: research

End-stage liver failure: filling the treatment gap at the intensive care unit
AbstractEnd-stage liver failure is a condition of collapsing liver function with mortality rates up to 80. Liver transplantation is the only lifesaving therapy. There is an unmet need for therapy to extend the waiting time for liver transplantation or regeneration of the native liver. Here we review the state-of-the-art of non-cell based and cell-based artificial liver support systems, cell transplantation and plasma exchange, with the first therapy relying on detoxification, while the others aim to correct also other failing liver functions and/or modulate the immune response. Meta-analyses on the effect of non-cell based...
Source: Journal of Artificial Organs - September 18, 2019 Category: Transplant Surgery Source Type: research

Recurrent short-to-shield phenomenon requiring LVAD exchange: a rare complication
We reported a case of 66-year-old man status post-implantation of HM II who presented with STS phenomenon. A tear at the distal end of the DL was found, and the patient underwent replacement of the extracorporeal part of DL twice. After the second repair, the pump functioned normally when tested in the hospital but the STS occurred again at home. The patient then underwent LVAD replacement surgery and insulation breach was found at one of the wires in intracorporeal part of the DL. After the surgery, the patient sustained recurrent episodes of STS and had to undergo a third extracorporeal DL repair surgery. Analysis of the...
Source: Journal of Artificial Organs - September 13, 2019 Category: Transplant Surgery Source Type: research

Jarvik 2000 with postauricular cable as destination therapy: first clinical case in Japan
AbstractCurrently in Japan, a left ventricular assist device powered by an abdominal driveline is the only type of left ventricular assist device available. The driveline is vulnerable to infection secondary to inappropriate fixation and the traditional Japanese custom of bathing is prohibited in patients with an abdominal driveline. The Jarvik 2000 with postauricular cable is a left ventricular assist device in which the driveline exits the body behind the ear (postauricular) instead of exiting through an abdominal site. This case report is the first to describe the implantation of Jarvik 2000 with postauricular cable as ...
Source: Journal of Artificial Organs - September 13, 2019 Category: Transplant Surgery Source Type: research

Early postoperative heparinization reduce hemolysis in patients with HeartMate II devices
AbstractHemolysis is closely related with pump thrombosis and thromboembolic events in patients with continuous flow left ventricular assist devices. We retrospectively investigated the impact of early postoperative heparinization on hemolysis in patients with HeartMate II devices. From April 2013 to August 2017, 83 patients (age 45  ± 12 years; 20 females; body surface area 1.6 ± 0.2 m2) underwent HeartMate II implantation. Postoperative heparinization was started when hemostasis was achieved and continued until full warfarinization. Hemolysis was defined in accordance with t...
Source: Journal of Artificial Organs - September 4, 2019 Category: Transplant Surgery Source Type: research

Patent foramen ovale-related complications in left ventricular assist device patients: a reappraisal for cardiovascular professionals
AbstractLeft ventricular assist device (LVAD) implantation is an important treatment option for patients with advanced heart failure. The presence of a patent foramen ovale (PFO) may elicit undesired consequences in LVAD patients: hypoxemia and paradoxical embolization. The variable physiological status of the patient with heart failure can make pre-LVAD implant identification of a PFO elusive. When identified pre- or intraoperatively, PFO is closed at time of LVAD implantation. In the case of delayed diagnosis, percutaneous PFO closure has proven to be a feasible and safe solution. As mechanical circulatory support gains ...
Source: Journal of Artificial Organs - August 28, 2019 Category: Transplant Surgery Source Type: research

Infective endocarditis of bovine pericardial patch in the aortic position in a patient with left ventricular assist device
AbstractA 53-year old woman, who had a history of left ventricular assist device implantation for acromegalic cardiomyopathy and aortic valve closure with bovine pericardial patch, was diagnosed with active endocarditis of aortic valve closure patch. The investigation revealed that infection was limited to the aortic valve closure patch; thus, redo aortic valve closure with a new bovine pericardial patch was performed. The postoperative course was uneventful and the infection was sufficiently controlled. Early surgical intervention is mandatory for a good result without spread of infection to the left ventricular assist de...
Source: Journal of Artificial Organs - August 24, 2019 Category: Transplant Surgery Source Type: research

Regional citrate anticoagulation and influence of recirculation on ionized calcium levels in the circuit
AbstractRegional citrate anticoagulation is now widely used during continuous renal replacement therapy (CRRT), and especially in patients at risk for hemorrhagic complications. A close monitoring is required to avoid citrate overload, leading to metabolic alkalosis or citrate intoxication causing metabolic acidosis. This case report describes a dysfunction of the regional citrate anticoagulation due to the development of a deep vein thrombosis close to the site of insertion of the venous CRRT catheter. The result was a local recirculation in the circuit with a local citrate overload (acidosis and non-measurable calcium). ...
Source: Journal of Artificial Organs - August 23, 2019 Category: Transplant Surgery Source Type: research

Initial perfusate purification during subnormothermic machine perfusion for porcine liver donated after cardiac death
In this study, the effects of initial purification perfusate with simple method of replacing the first 0.5-L perfusate during SNMP were investigated to consider installation effect of the filter or the dialyzer. Porcine liver grafts, which have 60-min warm ischemia time, were procured to imitate the DCD graft condition. Purified SNMP (PSNMP) results were compared with simple cold storage and conventional SNMP. In PSNMP, initial perfusate of 0.5  L was removed to substitute for purification. After preservation process, the preserved grafts were reperfused with diluted autologous blood for 2 h under normothermic ma...
Source: Journal of Artificial Organs - August 7, 2019 Category: Transplant Surgery Source Type: research

Jarvik 2000 axial flow ventricular assist device in right single ventricle after Fontan operation
We present a case of successful ventricular assist device support in a 13-year-old female diagnosed with right single ventricle, asplenia, dextrocardia, who had undergone a Fontan operation at 4  years old in an associated children hospital. She underwent placement of Jarvik 2000 axial flow ventricular assist device to the morphologic right ventricle which worked as systemic ventricle. The postoperative course was not eventful. She was waiting for heart transplantation attending high schoo l 3 years after implantation. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - August 7, 2019 Category: Transplant Surgery Source Type: research

Triboelectric charging of polytetrafluoroethylene antithrombotic catheters
This study proposes that a polytetrafluoroethylene (PTFE) electret tube charged by frictional electricity can prevent the solidification of the indwelling catheter in blood vessels. Coagulation in intravascular indwelling catheters may discontinue the treatment because of thrombus-derived bacteria –adhesion infections or poor blood removal. Current commercially available intravascular catheters lack complete antithrombotic measures, even with heparin or urokinase antithrombotic coatings. Herein, we tested the effectiveness of an antithrombotic treatment that prevents coagulation using a sta tic electric charge on the...
Source: Journal of Artificial Organs - August 2, 2019 Category: Transplant Surgery Source Type: research

Early continuous renal replacement therapy during infant extracorporeal life support is associated with decreased lung opacification
AbstractLung opacification on chest radiography (CXR) is common during extracorporeal life support (ECLS), often resulting from pulmonary edema or inflammation. Concurrent use of continuous renal replacement therapy (CRRT) during ECLS is associated with improved fluid balance and cytokine filtration; through modification of these pathologic states, CRRT may modulate lung opacification observed on CXRs. We hypothesize that early CRRT use during infant ECLS decreases lung opacification on CXR. We conducted a retrospective cohort study comparing CXRs from infants receiving ECLS and early CRRT (n = 7) to matched ...
Source: Journal of Artificial Organs - July 25, 2019 Category: Transplant Surgery Source Type: research

Differences in cerebral and hepatic oxygenation in response to intradialytic blood transfusion in patients undergoing hemodialysis
This study aimed to (i) monitor the differences in tissue oxygenation in the brain and liver during intradialytic blood transfusion, and (ii) elucidate the clinical factors affecting cerebral and hepatic oxygenation. Thirty-eight HD patients with severe anemia requiring intradialytic blood transfusion were included (27 men, 11 women; mean age, 70.2  ± 1.6 years). Cerebral and hepatic regional oxygen saturation (rSO2) values were monitored using near-infrared spectroscopy (INVOS 5100c oxygen saturation monitor). Cerebral and hepatic rSO2 were significantly higher after than before blood transfusion (p 
Source: Journal of Artificial Organs - July 24, 2019 Category: Transplant Surgery Source Type: research

Experience of the use of octreotide for refractory gastrointestinal bleeding in a patient with Jarvik2000 ® left ventricular assist device
AbstractGastrointestinal bleeding (GIB) is among the major complications affecting implantable continuous-flow left ventricular assist device (iLVAD) recipients and is the major cause of re-hospitalization. GIB in iLVAD recipients is sometimes critical, and controlling bleeding using conventional approaches is difficult. A 35-year-old woman developed refractory GIB from multiple gastric polyps and de novo angiodysplasia after Jarvik2000® iLVAD implantation. Discontinuation of anticoagulation and antiplatelet therapies had little effect on GIB; thus, multiple endoscopic hemostatic therapies were performed. However, blee...
Source: Journal of Artificial Organs - July 23, 2019 Category: Transplant Surgery Source Type: research

Mathematical evaluation of cardiac beat synchronization control used for a rotary blood pump
AbstractWe studied a control method of rotary blood pumps (RBPs), which is called as the cardiac beat synchronization (CBS) system. Usually, RBPs operate at constant target rotational speed, meanwhile, the CBS system modulates target speed synchronizing with cardiac beat. We built a computer simulation method to evaluate the CBS system. This simulator acquires a mathematical model of a circulatory system including a RBP and can provide us the theoretical hemodynamics when our control method is applied. We compared theoretical results with experimental ones with the model focusing on both pulsatility and aortic valve (AV) o...
Source: Journal of Artificial Organs - July 20, 2019 Category: Transplant Surgery Source Type: research

Angiogenesis and new bone formation in novel unidirectional porous beta-tricalcium phosphate: a histological study
This study examined angiogenesis and bone formation over time with unidirectional porous beta-TCP (UDPTCP). Ten Japanese White rabbits were used in this study. A 5  × 8-mm rectangular area of periosteum was resected, followed by preparation of a cortical bone defect using a high-speed bur. UDPTCP was embedded in the defect in the direction of the pores, parallel to the axis of the tibia. Tissue samples were harvested at 2 weeks (n = 3) and 6 weeks (n = 7) after implantation. Just before euthanasia, the vasculature of the lower limb was perfused with saline from the ...
Source: Journal of Artificial Organs - July 19, 2019 Category: Transplant Surgery Source Type: research

Risk of injury to the femoral blood vessels based on the extent of acetabular dysplasia in total hip arthroplasty
AbstractWe evaluated the course of the femoral blood vessels of patients with acetabular dysplasia. Patients were divided into five groups: those with Crowe type I, II, III, and IV dysplastic hips and those with normal hips. A computed tomography-based hip navigation software was used to measure the distance between the femoral blood vessels and the anterior pelvic wall in four axial planes located 10 –40 mm proximal to the pelvic teardrop. In Crowe Groups I through IV, the distance was shortest at a point 20 mm proximal to the pelvic teardrop. Furthermore, the distance decreased as the Crowe classification...
Source: Journal of Artificial Organs - July 5, 2019 Category: Transplant Surgery Source Type: research

Circulating endothelial progenitor cells in small-diameter artificial blood vessel
AbstractIn the tissue engineering research field, the presence of circulating endothelial progenitor cells (EPCs) in the peripheral blood of adults represents a promising cell source to grow autologous endothelium on blood-contacting devices. Materials functionalized with EPC-specific molecules are an intriguing strategy to induce the homing and differentiation of the trapped EPCs into endothelial cells to generate a non-thrombogenic surface. Although the EPCs have been identified in adult peripheral blood about 30  years ago, in the subsequent literatures, the term “EPCs” has encompassed different cell po...
Source: Journal of Artificial Organs - July 4, 2019 Category: Transplant Surgery Source Type: research

Interventricular dyssynchrony during continuous-flow left ventricular assist device support: observation using the conductance method
In this study, we evaluated this phenomenon in a normal heart model using the adult goat (n = 5, body weight 44.5 ± 2.9 kg). A centrifugal LVAD was implanted under general anesthesia. We inserted the conductance catheter into the RV and LV to obtain the pressure–volume relationship of the two ventricles simultaneously. We defined the dyssynchronous status as the sign (plus or minus) of the LV volume-change opposite to that of RV volume-change. Dyssynchronous phase of the cardiac cycle was observed in 5.6 ± 0.65% of hearts under LVAD pump-off and 25.3&thinsp...
Source: Journal of Artificial Organs - July 2, 2019 Category: Transplant Surgery Source Type: research

Clinical evaluation of performance, biocompatibility, and safety of vitamin E-bonded polysulfone membrane hemodialyzer compared to non-vitamin E-bonded hemodialyzer
In conclusion, this study provided performance and safety data of the ViE-21 for regulatory application. The data suggest that vitamin E-bonded hemodialyzers are beneficial in lowering platelet activation and frequency of intradialytic hypotension. Larger randomized controlled trials are needed to confirm these findings. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - June 26, 2019 Category: Transplant Surgery Source Type: research

Changes in acute blood purification therapy in critical care: republication of the article published in the Japanese Journal of Artificial Organs
AbstractAcute blood purification therapy is an essential artificial organ in critical care. In the review article, looking back on the history, we describe our present knowledge and techniques of acute blood purification therapy in critical care. The topics include continuous hemodiafiltration (CHDF), online HDF as an artificial liver support, blood purification therapy aiming to remove pathogenic substances of sepsis, a procedure for connecting a CRRT device into an extra-corporeal membrane oxygenation circuit, and replacement fluid for CHDF. We also raise remaining issues and clarify the future direction of acute blood p...
Source: Journal of Artificial Organs - June 24, 2019 Category: Transplant Surgery Source Type: research

Accuracy and reliability of continuous blood glucose monitoring during pediatric cardiopulmonary bypass
AbstractThe purpose of this study was to assess the accuracy and reliability of a continuous blood glucose monitoring system (artificial endocrine pancreas; STG-55, Nikkiso, Tokyo, Japan) during pediatric cardiopulmonary bypass surgery. Twenty-five pediatric patients scheduled to undergo cardiovascular surgery with cardiopulmonary bypass (age 4  months to 11 years; body weight 5.6–59.7 kg) were enrolled. The glucose sensor line of the artificial endocrine pancreas was connected to the venous side of the cardiopulmonary bypass circuit and used for continuous blood glucose monitoring. We obtained 192 sam...
Source: Journal of Artificial Organs - June 24, 2019 Category: Transplant Surgery Source Type: research

A case of Takotsubo cardiomyopathy with cardiogenic shock after influenza infection successfully recovered by IMPELLA support
AbstractWe recently experienced a case of cardiogenic shock due to influenza-related Takotsubo cardiomyopathy with atrial tachycardia and respiratory distress syndrome. Temporary mechanical circulatory support by IMPELLA 2.5 improved end-organ failure and resulted in cardiac recovery with sinus rhythm conversion. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - June 21, 2019 Category: Transplant Surgery Source Type: research

Quantification of interventricular dyssynchrony during continuous-flow left ventricular assist device support
In this study, we evaluated seven goats (body weight 44.5  ± 6.5 kg) with normal hearts. A centrifugal LVAD was implanted under general anesthesia. We inserted the conductance catheters into the left ventricle (LV) and right ventricle (RV) to assess the volume signal simultaneously. We defined the interventricular dyssynchrony as a signal (increase o r decrease) of LV volume (LVV) change opposite to that of RV volume (RVV) (i.e., (dLVV/dt)  × (dRVV/dt)  
Source: Journal of Artificial Organs - June 15, 2019 Category: Transplant Surgery Source Type: research

0.1  mm ePTFE versus autologous pericardium for hand-sewn trileaflet valved conduit: a comparative study
AbstractA hand-sewn trileaflet valved conduit is reportedly better than a bovine jugular graft. However, the comparative efficacy and safety between 0.1  mm ePTFE and autologous pericardium in this surgical procedure remained undetermined. This single-center cohort study included 46 patients aged 3–146 months who received implanted simplified hand-sewn trileaflet valved conduits: 31 patients (Group A) received 0.1 mm ePTFE valved conduits and 1 5 patients (Group B) received autologous pericardium valved conduits. Perioperative and follow-up outcomes up to 3 years after the surgeries were evaluated...
Source: Journal of Artificial Organs - June 1, 2019 Category: Transplant Surgery Source Type: research

The psoas muscle index as a predictor of long-term survival after cardiac surgery for hemodialysis-dependent patients
AbstractSarcopenia represented by skeletal muscle depletion is closely related to frailty and predicts prognoses in the general population. However, its predictive value for hemodialysis (HD)-dependent patients undergoing cardiac surgery has not been fully investigated. We aimed to clarify the impact of sarcopenia on the outcomes of HD-dependent patients after cardiac surgery. We retrospectively reviewed 138 HD-dependent patients who underwent cardiac surgery between January 2006 and December 2017. Sarcopenia was assessed using the psoas muscle index (PMI), which was calculated using values measured on preoperative compute...
Source: Journal of Artificial Organs - May 27, 2019 Category: Transplant Surgery Source Type: research

A novel evaluation system for whole-organ-engineered liver graft by ex vivo application to a highly reproducible hepatic failure rat model
AbstractIn recent years, studies on liver graft construction using the decellularized liver as a template for transplantation therapy have attracted much attention. However, the therapeutic effect of constructed liver grafts in hepatic failure has not been evaluated. Therefore, we aimed to develop a novel evaluation system demonstrating the curative effect of a constructed liver graft in animals with hepatic failure. First, we developed a highly reproducible rat model of hepatic failure by combining 80% partial hepatectomy with warm ischemia. In this model, severity could be controlled by the warm ischemic period. We also ...
Source: Journal of Artificial Organs - May 10, 2019 Category: Transplant Surgery Source Type: research

Continuous-flow total artificial heart: hemodynamic and pump-related changes associated with posture in a chronic calf model
This study aimed to evaluate the effects of posture (sitting [lying down]/standing) on hemodynamic and pump-related parameters in calves implanted with our institution ’s continuous-flow total artificial heart (CFTAH). These parameters were analyzed with posture information in four calves that had achieved the intended 14-, 30-, or 90-day durations of implantation. In each animal, postoperative hourly data gathered throughout the study were used to compare avera ge values with the animal sitting vs. standing. Pump flow became significantly higher in the standing than sitting position at the same pump speed (standing ...
Source: Journal of Artificial Organs - May 10, 2019 Category: Transplant Surgery Source Type: research

How to implant the Jarvik 2000 post-auricular driveline: evolution to a novel technique
AbstractThe post-auricular (PA) driveline positioning for percutaneous power delivery is a specific feature of the Jarvik 2000 FlowMaker LVAD. We applied several technical refinements to optimise the PA implant. Here, we present and discuss these modifications. We retrospectively reviewed all patients implanted with Jarvik 2000 at our Institution. Different PA implant techniques were described. A machine learning analysis was performed to evaluate the determinants of driveline infection. From December 2008 to December 2017, 62 patients were implanted with Jarvik 2000, at our Institution. The PA connection was managed throu...
Source: Journal of Artificial Organs - April 22, 2019 Category: Transplant Surgery Source Type: research

A subcostal approach is favorable compared to sternotomy for left ventricular assist device exchange field of research: artificial heart (clinical)
AbstractThis is a single-center retrospective study to summarize clinical outcomes of patients requiring surgical continuous-flow left ventricular assist device (HeartMate II) exchange. The patients who underwent HeartMate II exchange were divided into two groups either via a subcostal approach (SC group) or a full sternotomy (FS group). The exclusion criteria of a subcostal approach for device exchange included the presence of outflow graft obstruction, and/or the need for concomitant cardiac procedures. Among 277 consecutive patients who underwent HeartMate II implantation from July 2008 to December 2015, 25 patients (9....
Source: Journal of Artificial Organs - April 11, 2019 Category: Transplant Surgery Source Type: research

Safety and efficacy of a simple cardiotomy suction system as a blood salvage procedure during off-pump coronary artery bypass surgery
AbstractThe ideal blood-salvaging strategies for off-pump coronary artery bypass graft procedures have not been determined. We developed a new blood-salvaging system that uses a cardiotomy suction. The purpose of this study was to examine the efficacy of this novel method. This was a retrospective study involving 50 consecutive patients undergoing off-pump coronary artery bypass grafting. In 25 patients, a simple cardiotomy suction system was used (cardiotomy suction group). These individuals were compared with 25 historical cohorts who were treating with the conventional cell saver system (cell saver group). There was no ...
Source: Journal of Artificial Organs - April 9, 2019 Category: Transplant Surgery Source Type: research

Electrophysiological evaluation of a chronically implanted electrode for suprachoroidal transretinal stimulation in rabbit eyes
In this study, we aimed to determine the electrophysiological efficacy, safety, and electrical stability of a chronically implanted electrode for suprachoroidal transretinal stimulation (STS) in rabbit eyes. A platinum microelectrode was implanted into the scleral pocket of rabbit eyes (n = 5) and followed-up for 6 months. To evaluate the electrophysiological efficacy, electrically evoked potentials (EEPs) were measured every month after implantation. To evaluate safety, fundus examinations, fluorescein angiograms, electroretinograms (ERGs), and visually evoked potentials (VEPs ) were measured before and...
Source: Journal of Artificial Organs - April 3, 2019 Category: Transplant Surgery Source Type: research

A case of cardiogenic shock due to acute coronary syndrome successfully recovered by percutaneous and paracorporeal left ventricular assist device
AbstractWe recently experienced a 70-year-old woman with left main trunk-acute coronary syndrome who was initially supported by Impella 5.0 which converted to paracorporeal left ventricular assist device (LVAD) implantation as a bridge to recovery. Optimized guideline-directed medical therapy with cardiac rehabilitation resulted in successful explantation of LVAD and she discharged on foot. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - April 1, 2019 Category: Transplant Surgery Source Type: research

Restless legs syndrome effectively treated with constant-pressure predilution online hemodiafiltration
ConclusionsUsing the constant-pressure mode enabled achieved the clinical endpoint, namely, resolution of RLS with no need to manually reduce the flow rate. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - March 27, 2019 Category: Transplant Surgery Source Type: research

Hypoproteinemia as a factor in assessing malnutrition and predicting survival on hemodialysis
AbstractSeries of studies have described malnutrition as one of the main non-traditional risk factors associated with poor prognosis and treatment outcome in patients on hemodialysis (HD). The aims of this study were to evaluate the link between HD treatment quality and the nutritional status and to additionally investigate the association of malnutrition and overall survival. A total of 134 adult out-patients (56.4% male, mean age 60.8  ± 16.15 years) were enrolled in the study. Clinical and laboratory data were obtained from the medical records. Anthropometric measurements were performed prior t...
Source: Journal of Artificial Organs - March 9, 2019 Category: Transplant Surgery Source Type: research

Therapeutic hypothermia after global cerebral ischemia due to left ventricular assist device malfunction
AbstractHerein we report the case of a patient who suffered from global cerebral ischemia due to pump stoppage of Jarvik2000 Left ventricular assist device (LVAD) for unknown reason and fatal ventricular arrhythmia at home. Cardiopulmonary resuscitation was started by paramedics 6 –7 min after the patient fell down. The patient was transferred to our hospital after the restoration of the LVAD function by exchanging external cables. Mild therapeutic hypothermia was induced and body temperature was kept at 33 °C for 24 h. After rewarming, the patient recovered his conscio usness without any neurologi...
Source: Journal of Artificial Organs - March 2, 2019 Category: Transplant Surgery Source Type: research

Influence of albumin leakage on glycated albumin in patients with type 2 diabetes undergoing hemodialysis
In conclusion, GA was a reliable indicator, even with the change of hemodialysis modality. The influence of albumin leakage induced by hemodialysis on GA was negligible practically. We should recognize that the preferable glycemic indicator in patients undergoing hemodialysis depends on the hemoglobin and albumin metabolism of each patient. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - February 25, 2019 Category: Transplant Surgery Source Type: research

Journal of Artificial Organs 2018: the year in review
(Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - February 23, 2019 Category: Transplant Surgery Source Type: research