In vitro blood compatibility evaluation method: incubating while rotating hemodialyzers filled with fresh human blood
AbstractOne of the often-used methods for in vitro evaluation of the blood compatibility of hemodialysis membranes is the circulation of human blood through a miniaturized hemodialyzer. The use of a rather small amount of human blood in its evaluation is one advantage of this method. However, because it is manufactured by a different process than actual ones, a miniaturized hemodialyzer membrane cannot always preserve the properties of actual hemodialyzers. To address this problem, we established a new experimental method that uses a relatively small amount of human blood and actual dialyzers. In this method, a test hemodi...
Source: Journal of Artificial Organs - November 16, 2020 Category: Transplant Surgery Source Type: research

Extracorporeal membrane oxygenation in a patient with newly diagnosed acute myeloblastic leukaemia presenting with severe respiratory failure
We present a case of a 51-year-old female who attended her local hospital with symptoms suggestive of community-acquired pneumonia. Within a few days, there was progression to severe respiratory failure, initially managed with invasive mechanical ventilation but rapidly deteriorating respiratory failure triggered referral for ECMO support. Initial investigations on ECMO demonstrated features of acute myeloblastic leukaemia with a superimposed community-acquired pneumonia. This was successfully managed with supportive treatment alongside mechanical respiratory therapy and targeted chemotherapy, achieving complete remission ...
Source: Journal of Artificial Organs - November 12, 2020 Category: Transplant Surgery Source Type: research

Utility of bedside artificial pancreas for postoperative glycemic control in cardiac surgery
In this study, we investigated whether the bedside artificial pancreas STG-55 is useful for postoperative glycemic control in cardiac surgery. Methods: In the present single-center retrospective study, we analyzed arterial blood glucose levels for 15  h after surgery in 69 patients treated using the bedside artificial pancreas and in 160 patients treated with continuous intravenous insulin infusion using a scale that adjusts for current blood glucose level, glycemic fluctuation, and insulin dose. Results: Hypoglycemia (arterial blood glucose le vel 
Source: Journal of Artificial Organs - November 5, 2020 Category: Transplant Surgery Source Type: research

Suitable hemolysis index for low-flow rotary blood pumps
AbstractA suitable index is needed for hemolysis tests that use low-flow pumps, such as pediatric blood pumps or blood purification pumps. To create such an index, the present study investigates the change of plasma-free hemoglobin in the pump circuit with time and the change of the hemolysis rate with flow rate and impeller rotational speed. The results show that the hemolysis rate or the increase rate of the total free hemoglobin are suitable measures for hemolysis evaluation for low-flow pumps. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - November 2, 2020 Category: Transplant Surgery Source Type: research

Acknowledgements to reviewers
(Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - November 2, 2020 Category: Transplant Surgery Source Type: research

Plasma skimming efficiency of human blood in the spiral groove bearing of a centrifugal blood pump
AbstractThis work investigates the plasma skimming effect in a spiral groove bearing within a hydrodynamically levitated centrifugal blood pump when working with human blood having a hematocrit value from 0 to 40%. The present study assessed the evaluation based on a method that clarified the limitations associated with such assessments. Human blood was circulated in a closed-loop circuit via a pump operating at 4000  rpm at a flow rate of 5 L/min. Red blood cells flowing through a ridge area of the bearing were directly observed using a high-speed microscope. The hematocrit value in the ridge area was calculated usin...
Source: Journal of Artificial Organs - October 28, 2020 Category: Transplant Surgery Source Type: research

Untwist the twist: instant hemodynamic improvement in known HeartMate 3 complication
AbstractThe HeartMate 3 [HM3 (Abbott, Abbott Park, Illinois)] is a left-ventricular assist device (LVAD) with excellent clinical results. Outflow graft occlusion as a complication secondary to outflow graft twisting was reported to occur in 1.6% within the MOMENTUM 3 trial.  The anti-twist metal clip or modified bend relief is made to prevent this complication currently, however, there remain large numbers of early implanted HM3 which may develop this complication. There are limited reports illustrating diagnosis, surgical repair, and post-repair hemodynamic changes o f these complications. Thus, we present a cas...
Source: Journal of Artificial Organs - October 23, 2020 Category: Transplant Surgery Source Type: research

Comparison of supportive regulatory measures for pediatric medical device development in Japan and the United States
AbstractFurther development of medical devices for children is required in Japan, but the development of such devices is delayed compared to that of medical devices for adults. Herein, we investigated policies for advancing the development of pediatric medical devices in Japan and the United States. Considering the achievements of each policy, we proposed a strategy to promote further development of pediatric medical devices in Japan. We investigated policies for supporting the development of pediatric medical devices and approved cases in Japan and the United States by searching contents of websites of regulatory bodies a...
Source: Journal of Artificial Organs - October 20, 2020 Category: Transplant Surgery Source Type: research

Adsorption of vancomycin, gentamycin, ciprofloxacin and tygecycline on the filters in continuous renal replacement therapy circuits: in full blood in vitro study
AbstractThe aim of this study was to assess the in vitro adsorption of antibiotics: vancomycin, gentamicin, ciprofloxacin and tigecycline on both polyethyleneimine-treated polyacrylonitrile membrane of AN69ST filter and polysulfone membrane of AV1000 filter using porcine blood as a model close to in vivo conditions. The porcine blood with antibiotic dissolved in it was pumped into hemofiltration circuit (with AN69ST or AV1000 filter), ultrafiltration fluid was continuously returned to the reservoir containing blood with antibiotic. Blood samples to determine antibiotic concentrations were taken at minutes 0, 5, 15, 30, 45,...
Source: Journal of Artificial Organs - October 8, 2020 Category: Transplant Surgery Source Type: research

Preserved peritoneal function by short-term two-day peritoneal rest in hemodialysis combination therapy patients
We examined the effect of the two-day PR on peritoneal permeability. We observed and compared the daily PD ultrafiltration changes in the four PD and hemodialysis (HD) combination patients from the start of dialysis therapy throughout the total observation period of each case. Next, 6  months after the initiation of dialysis therapy we performed a set of peritoneal equilibrium tests (PET) before and after the 2-day PR. D/P creatinine, daily urine volume, daily ultrafiltration volume in PD, weekly residual renal creatinine clearance, and weekly PD creatinine clearance were measur ed. The daily PD ultrafiltration volume...
Source: Journal of Artificial Organs - October 2, 2020 Category: Transplant Surgery Source Type: research

Ten-year outcomes of extracorporeal life support for in-hospital cardiac arrest at a tertiary center
AbstractExtracorporeal cardiopulmonary resuscitation (ECPR) is controversial, given both the lack of evidence for improved outcomes and clarity on appropriate candidacy during time-sensitive cardiac arrest situations. The primary objective of our study was to identify factors predicting successful outcomes in ECPR patients.Between March 2007 and November 2018, 112 patients were placed on extracorporeal life support (ECLS) during active CPR (ECPR) at our institution. The primary outcome was survival to hospital discharge. Survivors and non-survivors were compared in terms of pre-cannulation comorbidities, laboratory values,...
Source: Journal of Artificial Organs - October 2, 2020 Category: Transplant Surgery Source Type: research

Hypo-attenuated leaflet thickening and reduced leaflet motion after the implantation of the Perceval S sutureless bioprosthesis
AbstractHypo-attenuated leaflet thickening (HALT) is gaining attention as a relatively common issue after surgical or transcatheter aortic valve replacement (AVR). However, only a few reports have described HALT in sutureless bioprosthesis, which has emerged as a promising tool with excellent hemodynamics and enhanced implantability. We herein report a 75-year-old woman who underwent quintuple coronary artery bypass grafting and sutureless AVR with a Perceval S bioprosthesis (LivaNova PLC, London, UK). Despite an uneventful perioperative course, her recovery was slow with persistent pleural effusion. Echocardiography revea...
Source: Journal of Artificial Organs - September 20, 2020 Category: Transplant Surgery Source Type: research

Mobile ECMO in COVID-19 patient: case report
AbstractAt July 25, 2020, WHO had recorded more than 16.1 million confirmed COVID-19 cases, 1% of them developed critical illness. These patients can experience rapid progression to profound hypoxemia and severe acute respiratory distress syndrome (ARDS). Some patients, despite receiving lung-protective ventilation and maximal medical therapy, develop refractory hypoxemia, rendering candidates for extracorporeal membrane oxygenation (ECMO) support. Centers with experience in this technique are available only in a few reference hospitals and some patients are too ill to be transferred with conventional mechanical ventilatio...
Source: Journal of Artificial Organs - September 18, 2020 Category: Transplant Surgery Source Type: research

Clinical potential of hemodynamic ramp test by simultaneous echocardiography and right heart catheterization for aortic insufficiency in a patient with continuous-flow left ventricular assist device
In conclusion, a hemodynamic ramp test with simultaneous echocardiography and RHC was useful for the evaluation of the causal relationship between AI and low CO, and for selection of surgical treatment for AI in a patient with CF-LVAD. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - September 16, 2020 Category: Transplant Surgery Source Type: research

Development and accuracy evaluation of a degree of occlusion visualization system for roller pumps used in cardiopulmonary bypass
In this study, we have developed a degree of occlusion quantification system which constructs the flow channel shape within an occluded tube from red optical density images, and we have verified the validity of this system. Utilizing a linear actuator, an acrylic roller and raceway, a solution colored with simulated blood powder, and a 3/8-inch vinyl chloride tube, this system uses a camera to capture red optical density images within an occluded tube and constructs the tube flow channel shape using a formula manipulation system. To verify the accuracy of this system, we compared the thickness of a cross-section of the flo...
Source: Journal of Artificial Organs - September 14, 2020 Category: Transplant Surgery Source Type: research

Early venoarterial extracorporeal membrane oxygenation improves outcomes in post-cardiotomy shock
AbstractPost-cardiotomy shock (PCS) is associated with substantial morbidity and mortality. We reviewed our 12-year experience of venoarterial extracorporeal membrane oxygenation (VA-ECMO) therapy for PCS. Between July 2007 and June 2018, 156 consecutive patients underwent VA-ECMO for PCS. We retrospectively investigated patient characteristics, indications, and management to determine factors affecting outcomes. Secondary analysis was performed by dividing the cohort into Era 1 (2007 –2012,n = 52) and Era 2 (2013–2018,n = 104) for comparison. After a median of 4.70 days (interq...
Source: Journal of Artificial Organs - September 13, 2020 Category: Transplant Surgery Source Type: research

Electrophysiological insights into the relationship between calcium dynamics and cardiomyocyte beating function in chronic hemodialysis treatment
AbstractFor patients in which the Ca2+ concentration of dialysis fluid is lower than that in plasma, chronic hemodialysis treatment often leads to cardiac beating dysfunction. By applying these conditions to an electrophysiological mathematical model, we evaluated the impact of body fluid Ca2+ dynamics during treatment on cardiomyocyte beating and, moreover, explored measures that may prevent cardiomyocyte beating dysfunction. First, Ca2+ concentrations in both plasma and interstitial fluid were decreased with treatment time, which induced both a slight decline in beating rhythm on a sinoatrial nodal cell and a wane in con...
Source: Journal of Artificial Organs - September 9, 2020 Category: Transplant Surgery Source Type: research

Pediatric patient with restrictive cardiomyopathy on staged biventricular assist device support with Berlin Heart EXCOR ® underwent heart transplantation successfully: the first case in Japan
AbstractAbstractPure restrictive cardiomyopathy is a strong risk factor for poor outcomes in children with cardiomyopathy on ventricular assist devices. Owing to concomitant right heart failure, children with end-staged restrictive cardiomyopathy who are supported with a ventricular assist device often require a biventricular assist device, which is another risk factor for waitlist mortality in heart transplantation candidates. Herein, we report the case of a 3-year-old boy with pure restrictive cardiomyopathy who successfully underwent heart transplantation after 12  months of support with staged biventricular assist...
Source: Journal of Artificial Organs - September 9, 2020 Category: Transplant Surgery Source Type: research

Accuracy of acetabular cup insertion in an anterolateral supine approach using an accelerometer-based portable navigation system
AbstractThe purpose of this study was to determine the accuracy of acetabular cup insertion during total hip arthroplasty (THA) in a supine position using an accelerometer-based portable navigation system. A single-surgeon study was conducted in which 62 prospective patients with navigation and 42 retrospective patients without navigation as historical controls were compared. The patients underwent THA via an anterolateral supine approach. The absolute values of errors of radiographic inclination and anteversion were calculated. The navigation error was also calculated. The factors that affected the absolute values of erro...
Source: Journal of Artificial Organs - September 1, 2020 Category: Transplant Surgery Source Type: research

Extracorporeal membrane oxygenation  as a bridge to lung transplantation in a Turkish lung transplantation program: our initial experience
AbstractLung transplantation is a life-saving treatment for patients with end-stage lung disease. Although the number of lung transplants has increased over the years, the number of available donor lungs has not increased at the same rate, leading to the death of transplant candidates on waiting lists. In this paper, we presented our initial experience with the use of extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation. Between December 2016 and August 2018, we retrospectively reviewed the use of ECMO as a bridge to lung transplantation. Thirteen patients underwent preparative ECMO for bridging t...
Source: Journal of Artificial Organs - August 26, 2020 Category: Transplant Surgery Source Type: research

Correction to: New treatment strategy for severe heart failure: combination of ventricular assist device and regenerative therapy
In the original publication of the article, the following description was missed in the footnote and it has been given in this correction. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - August 17, 2020 Category: Transplant Surgery Source Type: research

Biventricular assistance with 2 hm3 in a small chest patient: extra-pericardial implant
We describe the clinical course and treatment of a 53-year-old female, with small chest dimensions, referred to our institution for a primary cardiogenic shock. The patient underwent an on-pump left ventricular assist-device (VAD) implantation with the aid of immediate post-operative paracorporeal right-VAD assistance for an acute right ventricular failure. After two unsuccessful weaning attempts, she underwent extrapericardial HM 3 RVAD implantation. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - August 16, 2020 Category: Transplant Surgery Source Type: research

Minimally invasive central venoarterial extracorporeal membrane oxygenation for long-term ambulatory support as a bridge to heart –lung transplant
AbstractExtracorporeal membrane oxygenation (ECMO) is becoming a key tool for bridge to heart, lung, or heart –lung transplantation, and ambulatory ECMO support offers many advantages to prepare the patients. We here present a case of successful en bloc heart and lung transplantation after long-term ambulatory support with a minimally invasive central venoarterial ECMO approach as bridge to transplant. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - August 15, 2020 Category: Transplant Surgery Source Type: research

Heparin-induced thrombocytopenia in COVID-19 patients with severe acute respiratory distress syndrome requiring extracorporeal membrane oxygenation: two case reports
We report herein two cases of laboratory-confirmed HIT in COVID-19 patients with severe ARDS admitted to our intensive care unit for VV-ECMO support and the successful use of argatroban as an alternative therapy. We also provide a brief literature review of best evidence for managing such patients. The diagnosis and management of HIT is particularly challenging in COVID-19 patients receiving ECMO support. An increased awareness is warranted in those patients who already present a procoagulant state leading to higher rates of thrombotic events which can confuse the issues. Argatroban seems to be an appropriate and safe ther...
Source: Journal of Artificial Organs - August 11, 2020 Category: Transplant Surgery Source Type: research

External compression due to seroma of ventricular assist device outflow graft
AbstractA 45-year-old woman with repaired complex congenital heart disease, who underwent placement of Jarvik 2000, a ventricular assist device (VAD) for 4  years, experienced abdominal pain due to outflow graft compression caused by seroma formation between the outflow graft and ringed Gore-Tex graft. We exchanged the pump of Jarvik 2000 and punched several small holes in the new ringed Gore-Tex graft. Seroma formation between the two grafts should b e considered as a cause of outflow graft obstruction in patients with the long-term support of VAD, and additional surgical interventions to the ringed Gore-Tex graft ma...
Source: Journal of Artificial Organs - August 9, 2020 Category: Transplant Surgery Source Type: research

A case of spontaneous rectus sheath hematoma induced by lateral semi-prone positional changes during extracorporeal membrane oxygenation
In conclusion, spontaneous abdominal wall hematoma is a rare and important complication that might occur during ECMO. Thus, careful physical examination should be routinely conducted when the patient is semi-prone during ECMO. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - August 8, 2020 Category: Transplant Surgery Source Type: research

Total percutaneous biventricular assist device implantation for fulminant myocarditis
We report an effective therapeutic approach of mechanical circulatory support for a patient with cardiogenic shock and respiratory insufficiency due to fulminant myocarditis. An Impella® 5.0 was utilized as a left ventricular assist device (VAD) and percutaneous veno-pulmonary extracorporeal membrane oxygenation (ECMO) as a right VAD. These devices were implanted without sternotomy or thoracotomy. Although a combination of Impella and veno-arterial ECMO has been reported as percutaneous biventricular support, there are concerns that this combination is not beneficial for myocardial recovery in patients with respiratory...
Source: Journal of Artificial Organs - August 3, 2020 Category: Transplant Surgery Source Type: research

Does difference in stem design affect accuracy of stem alignment in total hip arthroplasty with a CT-based navigation system?
AbstractThe efficacy of a computed tomography (CT)-based navigation system to accurately position the stem for intended alignment is unclear. In addition, the influence of stem design on the accuracy of insertion is unknown. We therefore retrospectively compared the accuracy and precision for the intended alignment of two different designs of femoral stem which were implanted with or without the navigation system. Forty-nine total hip arthroplasties (THAs) using a tapered wedge stem and 91 THAs using an anatomic stem were evaluated for the navigation group. Thirty-three THAs using the tapered wedge stem and 15 THAs using t...
Source: Journal of Artificial Organs - July 23, 2020 Category: Transplant Surgery Source Type: research

Post-CABG sternum sparing biventricular assist device implantation technique using the right pulmonary artery for right ventricular assist device outflow cannulation
(Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - July 15, 2020 Category: Transplant Surgery Source Type: research

Letter to the Editor of the Journal of Artificial Organs : The flaws in the detail of describing methods, comparing patient cohorts and interpreting results
AbstractWe read with great interest the article written by Murphy et al. (J Artif Organs 22:286 –293, 2019). We acknowledge the authors contribution. However, the results presented may be difficult to interpret due to several missing information and therefore may not support the conclusions. Therefore, the results of this publication should be viewed very critically. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - July 14, 2020 Category: Transplant Surgery Source Type: research

Huge thrombus formation in the left ventricle during bilateral CentriMag ventricular assist device with successful bridging to heart transplantation: a case report and review of the literature
AbstractOwing to shortage of donor hearts, the ventricular assist device is used as a bridging therapy to heart transplantation. However, thrombus formation is a critical complication during ventricular assist device circulatory support that might result in ischemic infarction of end organs. Here, we report a patient diagnosed with decompensated dilated cardiomyopathy and cardiogenic shock who underwent emergent extracorporeal life support, and subsequent temporary bilateral ventricular assistance with the CentriMag device (Levitronix LLC, Waltham, MA). Daily transthoracic echocardiography did not detect any thrombus forma...
Source: Journal of Artificial Organs - July 13, 2020 Category: Transplant Surgery Source Type: research

Recovery of human mesenchymal stem cells grown on novel microcarrier coated with thermoresponsive polymer
AbstractThe cultivation of cells on microcarriers (MCs) in stirred suspension system is useful method for the large-scale culture of human mesenchymal stem cells (hMSCs) for allogenic transplantation. To harvest hMSCs from MCs without using proteolytic enzyme treatment but by lowering temperature, polystyrene MCs coated with a copolymer called CAT having zwitterionic and thermoresponsive characteristics, which has a lower critical solution temperature (LCST) in the range of 28 –32 ℃, were developed and compared with those coated with poly(N-isopropylacrylamide) (PNIPAM), which has an LCST almost the same as th...
Source: Journal of Artificial Organs - July 11, 2020 Category: Transplant Surgery Source Type: research

Correction to: A subcostal approach is favorable compared to sternotomy for left ventricular assist device exchange
In the original publication, the title of the article was published incorrectly. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - July 7, 2020 Category: Transplant Surgery Source Type: research

Connector sensors for permittivity-based thrombus monitoring in extracorporeal life support
This study fabricated and evaluated a connector sensor for real-time permittivity-based thrombus monitoring at tube –connector interface. Computational simulations were initially done to pre-evaluate the applicability of connector sensor. The sensor was fabricated by incorporating two stainless steel electrodes on acrylic tube for measuring permittivity changes at the tube–connector interface. OCT images were also taken from the interface at intervals for comparisons. Results show that the sensor was able to detect thrombus formation at the interface in form of sudden rise in permittivity after timet =&t...
Source: Journal of Artificial Organs - July 6, 2020 Category: Transplant Surgery Source Type: research

Prosthetic valve replacement for aortic leaflet tear secondary to Impella device placement
AbstractWe experienced a case of aortic regurgitation secondary to tear in the non-coronary cusp of the aortic valve after percutaneous mechanical circulatory support by Impella 2.5 placement, which was resolved with aortic valve replacement. Our patient, a 72-year-old man, developed non-ST elevation myocardial infarction and cardiogenic shock, which was treated with the implantation of Impella 2.5 prior to percutaneous coronary intervention. He eventually required prosthetic valve replacement for progressive aortic regurgitation after removing the Impella device. From intraoperative photographs, multiple lacerations were ...
Source: Journal of Artificial Organs - July 5, 2020 Category: Transplant Surgery Source Type: research

Improved viability of murine skin flaps using a gelatin hydrogel sheet impregnated with bFGF
In this study, the effects of gelatin hydrogel sheets impregnated with bFGF on flap survival and angiogenesis were examined in a murine skin flap model. A flap of 1  × 3 cm was generated on the backs of 60 C57BL/6 mice. The mice were divided into five groups (n = 12/group): Group I, untreated; Group II, treated with a gelatin hydrogel sheet impregnated with saline; Group III, treated with bFGF (50 µg) without sheets; Groups IV and V, treated with gelatin hydrogel sheets impregnated with 50 and 100 µg of bFGF, respectively. On the seventh day after surgery, the fl...
Source: Journal of Artificial Organs - July 5, 2020 Category: Transplant Surgery Source Type: research

The effect of roller head pump on platelet deterioration during the simulated extracorporeal circulation
AbstractRoller pumping results in hemolysis and adverse effects on coagulation, but there are few reports on the influence of roller heads on platelets. Here, we evaluate the interaction between roller pumping and platelet function using a simulated extracorporeal circuit incorporating a vinyl chloride tube and roller head pump with 30  min recirculation. Platelet aggregation, platelet count, microparticle, P-selectin, Phosphatidylserine (PS) exposure and Ricinus Communis Agglutinin 1 (RCA-1) were measured before, 5, 10, 20, and 30 min after the recirculation using 100 ml of fresh human blood that had obtain...
Source: Journal of Artificial Organs - July 3, 2020 Category: Transplant Surgery Source Type: research

Higher skin autofluorescence detection using AGE-Reader ™ technology as a measure of increased tissue accumulation of advanced glycation end products in dialysis patients with diabetes: a meta-analysis
AbstractThis meta-analysis was conducted to compare skin autofluorescence (SAF) levels as a measure of advanced glycation end products (AGEs) accumulation between diabetic and non-diabetic dialysis patients. Relevant studies were identified primarily by searching PubMed/MEDLINE and other online databases and manual searching of cross-references. Random-effects model was used to obtain standardized mean differences (SMD) as a summary statistic. Heterogeneity was tested with meta-regression and sub-group analyses. Publication bias and robustness of this meta-analysis were tested using funnel plot and sensitivity analyses. A ...
Source: Journal of Artificial Organs - June 30, 2020 Category: Transplant Surgery Source Type: research

New treatment strategy for severe heart failure: combination of ventricular assist device and regenerative therapy
AbstractHeart transplantation and ventricular assist device for the patients with end-stage heart failure are limited by availability and durability due to limited donor or device-related complication. Thus, complementation or a new alternative is needed for the treatment of severe heart failure. Based on the results of basic experiments, we applied skeletal myoblast cell sheet transplantation in a clinical setting using cell-sheet methods with temperature-responsive dish for the treatment of heart failure patient from 2007. After confirming the safety of this treatment, we started a clinical trial of myoblast cell sheet t...
Source: Journal of Artificial Organs - June 19, 2020 Category: Transplant Surgery Source Type: research

Aortic insufficiency associated with Impella that required surgical intervention upon implantation of the durable left ventricular assist device
In this report, we describe two patients who developed aortic insufficiency (AI) associated with Impella and required surgical intervention upon implantation of the durable left ventricular assist device (LVAD). Both patients presented with cardiogenic shock and underwent insertion of Impella 5.0 as a bridge to decision. The cardiac function in these patients did not improve and obtaining approval for heart transplantation required time. They were managed with Impella for 91 and 98  days, respectively. In both cases, moderate AI that was not present before Impella insertion was observed when the Impella was removed. T...
Source: Journal of Artificial Organs - June 18, 2020 Category: Transplant Surgery Source Type: research

Clinical course of a critically ill patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
AbstractAlthough several studies have reported on the clinical and epidemiological characteristics of the patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), clinical course of the most severe cases requiring treatment in ICU have been insufficiently reported. A 73-year-old man traveling on a cruise ship with history of hypertension and dyslipidemia developed high fever, dyspnea and cough after 7  days of steroid treatment for sudden sensorineural hearing loss, and tested positive for SARS-CoV-2 in sputa polymerase chain reaction (PCR) examination. His respiratory function deteriorated despite t...
Source: Journal of Artificial Organs - June 15, 2020 Category: Transplant Surgery Source Type: research

Preclinical biocompatibility study of ultra-compact durable ECMO system in chronic animal experiments for 2  weeks
AbstractAlthough the innovation has come in ECMO field, many problems remain unresolved. One of the main problems is about long-term durability and biocompatibility. Another is the system ’s size, weight, and its complicated equipment. For the former problem, we have previously developed ECMO system which consists of a tiny, hydrodynamically levitated centrifugal pump (BIOFLOAT-NCVC), a membrane oxygenator with hollow polyolefin fibers (BIOCUBE-NCVC), and the circuit treated with a heparin-bonding material (T-NCVC coating), and reported three cases of animal experiments for 30-day heparin-free drive. For the latter p...
Source: Journal of Artificial Organs - June 7, 2020 Category: Transplant Surgery Source Type: research

Training the component steps of an extra-corporeal membrane oxygenation (ECMO) cannulation outside the clinical setting
AbstractExtra-corporeal membrane oxygenation (ECMO) cannulation can be a stressful procedure because a fast cannulation is vital for the patient ’s survival. Therefore, it is important to train the steps of cannulation outside the clinical setting. A relatively low budget, easy to use model, was developed to train the most important steps of an ECMO cannulation. Following this, it was evaluated by experts and target group participants. The y all completed a questionnaire regarding their experience and opinions on the ECMO model on general aspects and the training of the component steps, rated on a 5-point Likert scal...
Source: Journal of Artificial Organs - June 7, 2020 Category: Transplant Surgery Source Type: research

Sutureless aortic valve replacement with concomitant aortic arch reconstruction
AbstractSutureless aortic valve replacement (AVR) offers an alternative approach to the standard AVR in aortic valve disease. We herein report a case of an 82-year-old woman with severe aortic insufficiency and a persistent type 1 endoleak following a thoracic endovascular aortic repair, who underwent successful combined aortic arch reconstruction and sutureless AVR. The bioprosthesis, Perceval (LivaNova PLC, London, UK), a self-anchoring, self-expanding, sutureless valve, which can be implanted in selected patients with aortic insufficiency was used. Although the patient was frail and at a high risk of open-heart surgery,...
Source: Journal of Artificial Organs - June 6, 2020 Category: Transplant Surgery Source Type: research

Spinal cord infarction during venoarterial-extracorporeal membrane oxygenation support
AbstractSpinal cord infarction (SCI) is a rare disease among central nervous system vascular diseases. Only a little is known about venoarterial extracorporeal membrane oxygenation (VA-ECMO)-related SCI. Retrospective observational study conducted, from 2006 to 2019, in a tertiary referral center on patients who developed VA-ECMO-related neurovascular complications, focusing on SCI. During this period, among the 1893 patients requiring VA-ECMO support, 112 (5.9%) developed an ECMO-related neurovascular injury: 65 (3.4%) ischemic strokes, 40 (2.1%) intracranial bleeding, one cerebral thrombophlebitis (0.05%) and 6 (0.3%) sp...
Source: Journal of Artificial Organs - May 29, 2020 Category: Transplant Surgery Source Type: research

Twisting and constriction of a HeartMate II driveline in the area of a repair site
AbstractThe driveline ’s durability is crucial for optimal long-term support with a left-ventricular assist device (LVAD). The incidence of percutaneous driveline fracture after HeartMate II LVAD implantation is low. For the first time, we describe a patient with an already repaired driveline and a massive constriction and twisting of the driveline in the area of the repair site. This dramatic finding necessitates a renewed exchange of the external part of the driveline by the manufacturer. Due to the increasing number of patients with elongated LVAD support, the stability of the driveline and possible repairs in clu...
Source: Journal of Artificial Organs - May 29, 2020 Category: Transplant Surgery Source Type: research

Posterolateral lumbar spine fusion with unidirectional porous beta-tricalcium phosphate in a canine model
AbstractWe investigated the use of the autologous iliac bone and unidirectional porous beta-tricalcium phosphate (UDPTCP) in posterolateral lumbar spine fusion (PLF). Ten canine PLF models were prepared. Using only the autologous bone as the control group, 100%, 75%, 50%, and 25% groups were prepared according to the mixing ratios of UDPTCP. Radiological evaluation and histological analysis were performed 12  weeks after surgery. Bone fusion was evaluated according to anteroposterior plain X-rays and coronal reconstruction CT views using four grades: 0 = no osteogenesis, 1 = only slight dis...
Source: Journal of Artificial Organs - May 24, 2020 Category: Transplant Surgery Source Type: research

Regional thigh tissue oxygen saturation during cardiopulmonary bypass predicts acute kidney injury after cardiac surgery
In conclusion, the regional oxygen saturation at the thigh during cardiopulmonary bypass is a crucial marker to predict postoperative acute kidney in jury in adults undergoing cardiac surgery. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - May 23, 2020 Category: Transplant Surgery Source Type: research

Correction to: Extracorporeal membrane oxygenation support for postcardiotomy cardiogenic shock in adult patients: predictors of in ‑hospital mortality and failure to be weaned from extracorporeal membrane oxygenation
In the original publication of the article, author group affiliation was published incorrectly. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - May 19, 2020 Category: Transplant Surgery Source Type: research

Long term CentriMag biventricular support using hybrid cannulation as a bridge to transplant in a pediatric patient
We describe the long-term use of the CentriMag biventricular assist device with multiple pump changes in a 9-year-old boy with idiopathic-dilated cardiomyopathy. The initially implanted Berlin Heart EXCOR pumps were replaced by CentriMag due to thromboembolic complications. The CentriMag pumps were exchanged 15 times due to clot and fibrin formation or when the pumps reached their expiration dates. Connecting CentriMag to Berlin Heart EXCOR cannulae effectively served as an alternative long-term hybrid bridge to transplantation for 235  days. The patient successfully underwent a transplant after 284 days. Judicio...
Source: Journal of Artificial Organs - May 19, 2020 Category: Transplant Surgery Source Type: research