Discussing the final size and shape of the reconstructed tissues in tissue engineering
AbstractTissue engineering (TE) has made a revolution in repairing, replacing, or regenerating tissues or organs, but it has still a long way ahead. The mechanical properties along with suitable physicochemical and biological characteristics are the initial criteria for scaffolds in TE that should be fulfilled. This research will provide another point of view toward TE challenges concerning the morphological and geometrical aspects of the reconstructed tissue and which parameters may affect it. Based on our survey, there is a high possibility that the final reconstructed tissue may be different in size and shape compared t...
Source: Journal of Artificial Organs - September 20, 2022 Category: Transplant Surgery Source Type: research
ECPELLA as the bridge to surgery in patients with cardiogenic shock due to post-infarct papillary muscle rupture: management of mechanical circulatory support during operation
AbstractPapillary muscle rupture is a fatal complication with a high operative mortality. Most patients experience cardiogenic shock and hypoxia due to pulmonary edema caused by severe mitral regurgitation. Although preoperative stabilization using a mechanical assist device potentially improves surgical outcomes, an appropriate strategy has not yet been established. ECPELLA, combining venoarterial extracorporeal membrane oxygenation and Impella, has the potential to stabilize preoperative status and improve outcome in patients with refractory cardiogenic shock due to papillary muscle rupture. Herein, we present 3 cases in...
Source: Journal of Artificial Organs - September 16, 2022 Category: Transplant Surgery Source Type: research
Application of mathematical analysis on dialysis
AbstractHemodialysis is a blood purification method based on solute removal by diffusion and incorporates filtration to improve the efficiency of water removal and removal of high molecular weight substances. It is now a well-established treatment, due to the improved performance of dialyzers. This review outlines the development process of dialyzers, focusing on the application based on the mathematical analysis. First, phenomena occurring in the vicinity of the dialysis membrane are explained using a film model for diffusion and a gel polarization model for filtration. Then, currently established dialyzer designs are int...
Source: Journal of Artificial Organs - September 10, 2022 Category: Transplant Surgery Source Type: research
Effectiveness of combination of heat water disinfection, continuous water circulation, and minimalized dead space for dialysis piping in maintaining ultrapure dialysis fluid and preventing biofilm formation in a central dialysis fluid delivery system
This study aimed to develop sustainable cleaning strategies to solve the complicated dialysis fluid piping, which is a weakness of the central dialysis fluid delivery system, and provide ultrapure dialysis fluid for a long term. Combination of heat water disinfection, continuous water circulation, and minimalized dead space in the dialysis piping were designed for a central dialysis fluid delivery system and used in a clinic for 6 years. As an index of water purification, endotoxin concentrations and microbial colony counts in reverse osmosis water and dialysis fluid were measured. In addition, we performed scanning elec...
Source: Journal of Artificial Organs - September 8, 2022 Category: Transplant Surgery Source Type: research
Methods for confirming the safety of radiation therapy in patients with left ventricular assist device: a case of extranodal NK/T-cell lymphoma, nasal type
AbstractA left ventricular assist device (LVAD) is a treatment option for patients with end-stage heart failure; however, a certain number of patients on durable LVADs are diagnosed with malignancy. Radiation therapy (RT) for patients with durable LVADs has safety concerns, because RT may interfere with the device. Herein, we report a case of RT during durable LVAD management. A 48-year-old man with a durable LVAD was diagnosed with sinusitis. As his symptoms were resistant to drug therapy, endoscopic sinus surgery was performed, and extranodal NK/T-cell lymphoma, nasal type (ENKL) was pathologically detected. Since RT was...
Source: Journal of Artificial Organs - September 1, 2022 Category: Transplant Surgery Source Type: research
Transcatheter closure of patent foramen ovale accompanying right-to-left shunt during Impella support
AbstractWe experienced a 65-year-old woman who was diagnosed as fulminant myocarditis and transferred on mechanical ventilator and veno-arterial extracorporeal membrane oxygenation (ECMO) supports. Impella 5.0 support was additionally initiated to improve pulmonary edema and unload left ventricle. We found a patent foramen ovale (PFO) at the time of Impella insertion by transesophageal echocardiography. Follow-up transesophageal echocardiography found a development of right-to-left shunt flow through PFO accompanying central hypoxia during Impella P8 support. Veno-arterial ECMO was converted to veno-arterio-venous ECMO and...
Source: Journal of Artificial Organs - September 1, 2022 Category: Transplant Surgery Source Type: research
Fracture of dual lumen cannula leading to cerebrovascular accident in a patient supported with ECMO
AbstractExtended duration extracorporeal membrane oxygenation (ECMO), using dual-lumen cannulas, is being used with increased frequency to support patients, including those with COVID-19; both as a bridge to transplant and lung recovery. During such an extended duration of support, there are several factors that might lead to the attrition of the physical structure of the ECMO cannulas, predisposing them to the risk of fracture. Although rare, fracture of the ECMO cannula can be a potentially lethal event. Here, we present a case where fracture of a dual lumen cannula during veno-venous (VV) ECMO support resulted in a cere...
Source: Journal of Artificial Organs - September 1, 2022 Category: Transplant Surgery Source Type: research
Single-pass albumin dialysis and hemoadsorption for bilirubin and bile acids removal for a child with hyperbilirubinemia after ventricular assist device implantation
We report the successful management of hyperbilirubinemia using two different modalities of extracorporeal bilirubin removal therapy for a pediatric patient. A 13-year-old boy with dilated cardiomyopathy requiring veno-arterial extracorporeal membrane oxygenation (VA-ECMO) developed acute kidney injury and was dependent on continuous renal replacement therapy. He developed hyperbilirubinemia with a peak total bilirubin level of 786 μmol/L after implantation of biventricular assist device (BiVAD). Extracorporeal bilirubin and bile acids removal using single-pass albumin dialysis (SPAD) with 4% albumin as dialysate brough...
Source: Journal of Artificial Organs - September 1, 2022 Category: Transplant Surgery Source Type: research
Advances in tissue engineering technology for kidney regeneration and construction
AbstractTissue engineering is a highly interdisciplinary research field aiming at repairing, replacing, and regenerating the defective tissues. Over several decades of research, a variety of methods have been developed. The technical methods can be categorized into scaffold-based and scaffold-free strategies. In this mini review, the discussion will be focused on the technical methods of tissue engineering for kidney regeneration and construction. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - September 1, 2022 Category: Transplant Surgery Source Type: research
Usefulness of hybrid veno-arterial extracorporeal membrane oxygenation for lung ischemia –reperfusion injury after biventricular assist device implantation
AbstractWe experienced a case of fulminant myocarditis complicated by severe lung ischemia –reperfusion injury after switching from veno-arterial extracorporeal membrane oxygenation to biventricular assist device. We controlled lung blood flow by hybrid veno-arterial extracorporeal membrane oxygenation, which was established by modifying the biventricular assist device circuit without r esternotomy, blood delivery to the pulmonary artery and blood removal from the left ventricle in addition to central veno-arterial extracorporeal membrane oxygenation, and accelerated lung recovery. The patient’s lung damage and cardiac...
Source: Journal of Artificial Organs - September 1, 2022 Category: Transplant Surgery Source Type: research
A simple predictive marker of inflammation: systemic immune ‑inflammation index
(Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - August 29, 2022 Category: Transplant Surgery Source Type: research
