Characterizing Patients with Inherited Dilated Cardiomyopathy Requiring Heart Transplantation
Purpose: Inherited cardiomyopathies constitute a significant proportion of advanced heart failure and malignant arrhythmias requiring heart transplantation. We sought to determine the baseline characteristics and post-transplant outcomes of patients with pathogenic variants who underwent heart transplantation at Stanford Health Care. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: A. Elezaby, T. Moscarello, L. Tran, , V.N. Parikh, F. Haddad, W. Hiesinger, K. Khush, J. Teuteberg, K. Sallam Source Type: research
Hybrid Palliation as Bridge to Heart Transplantation in Neonatal Dilated Cardiomyopathy
We present an infant with DCM successfully palliated with hybrid procedure as a bridge to heart transplantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , R.K. Singh, M. Argilla, S. Chakravarti, A. Ludomirsky, M. Martinez, J. McKinstry, R.S. Mosca, R.M. Rogoff, S. Saharan, T. Kumar Source Type: research
To VAD or Not VAD? How to Get to Heart Transplant in a Child with Duchenne Muscular Dystrophy
We present a clinical case dilemma of a 9-year-old child with DMD and dilated cardiomyopathy. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Joong, K. Gambetta, M. Monge, P. Thrush Source Type: research
Initial Experience of Sodium-Glucose Cotransporter 2 Inhibitors in Adolescents with Heart Failure Due to Muscular Dystrophy
Introduction: Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are novel agents in the management of adult heart failure (HF) with proven mortality benefit in large, randomized control trials. Now the standard of care in adult guideline-directed medical therapy (GDMT), SGLT2i are increasingly being used off-label in pediatric patients. Patients with Duchene muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), progressive X-linked myopathies that primarily affect males in their early teenage years, can develop HF secondary to dilated cardiomyopathy (DCM). (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , E. Kramer, D. Weber, H. Ahmed, M.J. O'Connor, J.B. Edelson, J.J. Edwards, K.Y. Lin, J.W. Rossano, C.A. Wittlieb-Weber, J.H. Berger Source Type: research
Genetic Signatures in Heart Transplant and LVAD Patients: Unraveling Their Association with Hypertrophic and Dilated Cardiomyopathy Subtypes
This study evaluates genetic testing outcomes in a cohort of 40 HTx patients and 20 LVAD patients for bridge to transplantation, with a focus on hypertrophic cardiomyopathy (HCMP) and dilated cardiomyopathy (DCMP) subgroups. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: K. Kim Source Type: research
Genome-Wide DNA Methylation Profiling in Human Dilated Cardiomyopathy
Purpose: DNA methylation controls transcriptional expression. The role of DNA methylation in heart failure (HF) and response to left ventricular assist devices (LVAD) is unknown. Here, we examined genome-wide DNA methylation in end stage dilated cardiomyopathy (DCM) and response to LVAD therapy. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , D. Liescheski, M. Urban, A. Burdorf, J. Um, B. Lowes Source Type: research
Exception Requests and Approval Rates After Implementation of the National Heart Review Board for Pediatrics
Purpose: The OPTN Guidance for pediatric heart transplant exception requests addresses dilated cardiomyopathy (DCM), hypertrophic or restrictive cardiomyopathy (HCM/RCM), single ventricle congenital heart disease (1V CHD), and cardiac allograft vasculopathy (CAV). The purpose of our study was to evaluate the use and approval rates of exception requests after the implementation of the National Heart Review Board (NHRB) for Pediatrics. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , D. Bearl, L. Wright Source Type: research
Causal Relationship Between Immune Cells/Cytokines and Dilated Cardiomyopathy
This study aimed to investigate the causal relationship between the levels of various types of immune cells/cytokines and DCM. Herein, two-sample Mendelian randomization (MR) (TSMR) using R software was conducted. Single nucleotide polymorphisms (SNPs) related to the levels of various types of immune cells/cytokines and DCM were screened based on the genome-wide association studies (GWAS) obtained from open-source databases. The TSMR was conducted using inverse variance weighted (IVW), method, MR-Egger regression, weighted median method, and simple estimator based on mode to explore the causal association between the level...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Bin Qi Nan Huang Zhi-Jie Yang Wen-Bo Zheng Chun Gui Source Type: research
A novel gene-trap line reveals the dynamic patterns and essential roles of cysteine and glycine-rich protein 3 in zebrafish heart development and regeneration
In this study, we characterized a novel zebrafish gene-trap line, gSAIzGFFM218A, which harbors an insertion in the csrp3 genomic locus, heterozygous fish served as a csrp3 expression reporter line and homozygous fish served as a csrp3 mutant line. We discovered that csrp3 is specifically expressed in larval ventricular cardiomyocytes (CMs) and that csrp3 deficiency leads to excessive trabeculation, a common feature of CSRP3-related HCM and DCM. We further revealed that csrp3 expression increased in response to different cardiac injuries and was regulated by several signaling pathways vital for heart regeneration. Csrp3 def...
Source: Cellular and Molecular Life Sciences : CMLS - March 31, 2024 Category: Cytology Authors: Shuzhang Liang Yating Zhou Yue Chang Jiayi Li Min Zhang Peng Gao Qi Li Hong Yu Koichi Kawakami Jinmin Ma Ruilin Zhang Source Type: research
Causal Relationship Between Immune Cells/Cytokines and Dilated Cardiomyopathy
This study aimed to investigate the causal relationship between the levels of various types of immune cells/cytokines and DCM. Herein, two-sample Mendelian randomization (MR) (TSMR) using R software was conducted. Single nucleotide polymorphisms (SNPs) related to the levels of various types of immune cells/cytokines and DCM were screened based on the genome-wide association studies (GWAS) obtained from open-source databases. The TSMR was conducted using inverse variance weighted (IVW), method, MR-Egger regression, weighted median method, and simple estimator based on mode to explore the causal association between the level...
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Bin Qi Nan Huang Zhi-Jie Yang Wen-Bo Zheng Chun Gui Source Type: research
