Expression and Potential Significance of miR-499 and IL-1 β in Serum of Dilated Cardiomyopathy Patients with Atrial Fibrillation
CONCLUSIONS: A close relationship exists between the abnormal expression of serum miR-499 and IL-1β and DCM complicated with AF, which will be of great importance in future research. In addition, the data of patients with DCM are related to the occurrence and development of AF, and clinicians should actively perform early drug interventions to reduce myocardial remodeling, so as to reduce the incidence of AF.PMID:38551417 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 29, 2024 Category: Complementary Medicine Authors: Zhiwei Xu Lijuan Zhang Quanhua Pan Yang Gao Su Huang Source Type: research
Deciphering the role of SMARCA4 in cardiac disorders: Insights from single-cell studies on dilated cardiomyopathy and coronary heart disease
CONCLUSION: This study provides a clearer understanding of cell-type dynamics in heart diseases, emphasizing the role of fibroblasts and the significance of SMARCA4 in their function. Our results offer insights into the cellular mechanisms underlying DCM and CHD, potentially guiding future therapeutic strategies.PMID:38552892 | DOI:10.1016/j.cellsig.2024.111150 (Source: Cellular Signalling)
Source: Cellular Signalling - March 29, 2024 Category: Cytology Authors: Li Liu Chengban Li Linxing Yu Yubo Wang Xingshou Pan Jianjun Huang Source Type: research
Resveratrol Delays Diabetic Cardiomyopathy Fibrosis by Regulating Mitochondrial Autophagy
CONCLUSION: Resveratrol postpones dilated cardiomyopathy fibrosis by regulating the mitochondrial autophagy response through the AMP-activated protein kinase (AMPK)/silent mating type information regulation 2 homolog 1 (SIRT1)-mediated inositol-requiring enzyme 1 alpha (IRE1α)/PTEN-induced putative kinase 1 (PINK) signaling pathway.PMID:38551444 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 29, 2024 Category: Complementary Medicine Authors: Liqun Yang Zhe Gao Hang Zhao Zhimei Zhang Guangyao Song Source Type: research
Expression and Potential Significance of miR-499 and IL-1 β in Serum of Dilated Cardiomyopathy Patients with Atrial Fibrillation
CONCLUSIONS: A close relationship exists between the abnormal expression of serum miR-499 and IL-1β and DCM complicated with AF, which will be of great importance in future research. In addition, the data of patients with DCM are related to the occurrence and development of AF, and clinicians should actively perform early drug interventions to reduce myocardial remodeling, so as to reduce the incidence of AF.PMID:38551417 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 29, 2024 Category: Complementary Medicine Authors: Zhiwei Xu Lijuan Zhang Quanhua Pan Yang Gao Su Huang Source Type: research
Resveratrol Delays Diabetic Cardiomyopathy Fibrosis by Regulating Mitochondrial Autophagy
CONCLUSION: Resveratrol postpones dilated cardiomyopathy fibrosis by regulating the mitochondrial autophagy response through the AMP-activated protein kinase (AMPK)/silent mating type information regulation 2 homolog 1 (SIRT1)-mediated inositol-requiring enzyme 1 alpha (IRE1α)/PTEN-induced putative kinase 1 (PINK) signaling pathway.PMID:38551444 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 29, 2024 Category: Complementary Medicine Authors: Liqun Yang Zhe Gao Hang Zhao Zhimei Zhang Guangyao Song Source Type: research
Expression and Potential Significance of miR-499 and IL-1 β in Serum of Dilated Cardiomyopathy Patients with Atrial Fibrillation
CONCLUSIONS: A close relationship exists between the abnormal expression of serum miR-499 and IL-1β and DCM complicated with AF, which will be of great importance in future research. In addition, the data of patients with DCM are related to the occurrence and development of AF, and clinicians should actively perform early drug interventions to reduce myocardial remodeling, so as to reduce the incidence of AF.PMID:38551417 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 29, 2024 Category: Complementary Medicine Authors: Zhiwei Xu Lijuan Zhang Quanhua Pan Yang Gao Su Huang Source Type: research
Resveratrol Delays Diabetic Cardiomyopathy Fibrosis by Regulating Mitochondrial Autophagy
CONCLUSION: Resveratrol postpones dilated cardiomyopathy fibrosis by regulating the mitochondrial autophagy response through the AMP-activated protein kinase (AMPK)/silent mating type information regulation 2 homolog 1 (SIRT1)-mediated inositol-requiring enzyme 1 alpha (IRE1α)/PTEN-induced putative kinase 1 (PINK) signaling pathway.PMID:38551444 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 29, 2024 Category: Complementary Medicine Authors: Liqun Yang Zhe Gao Hang Zhao Zhimei Zhang Guangyao Song Source Type: research
Expression and Potential Significance of miR-499 and IL-1 β in Serum of Dilated Cardiomyopathy Patients with Atrial Fibrillation
CONCLUSIONS: A close relationship exists between the abnormal expression of serum miR-499 and IL-1β and DCM complicated with AF, which will be of great importance in future research. In addition, the data of patients with DCM are related to the occurrence and development of AF, and clinicians should actively perform early drug interventions to reduce myocardial remodeling, so as to reduce the incidence of AF.PMID:38551417 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 29, 2024 Category: Complementary Medicine Authors: Zhiwei Xu Lijuan Zhang Quanhua Pan Yang Gao Su Huang Source Type: research
Resveratrol Delays Diabetic Cardiomyopathy Fibrosis by Regulating Mitochondrial Autophagy
CONCLUSION: Resveratrol postpones dilated cardiomyopathy fibrosis by regulating the mitochondrial autophagy response through the AMP-activated protein kinase (AMPK)/silent mating type information regulation 2 homolog 1 (SIRT1)-mediated inositol-requiring enzyme 1 alpha (IRE1α)/PTEN-induced putative kinase 1 (PINK) signaling pathway.PMID:38551444 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 29, 2024 Category: Complementary Medicine Authors: Liqun Yang Zhe Gao Hang Zhao Zhimei Zhang Guangyao Song Source Type: research
Ferroptosis in Cardiovascular Disease and Cardiomyopathies: Therapeutic Implications of Glutathione and Iron Chelating Agents
Biomedicines. 2024 Mar 1;12(3):558. doi: 10.3390/biomedicines12030558.ABSTRACTThis review explores ferroptosis, a form of regulated cell death reliant on iron-induced phospholipid peroxidation, in diverse physiological and pathological contexts, including neurodegenerative disorders, and ischemia-reperfusion. In the realm of cardiovascular diseases, it significantly contributes to cardiomyopathies, including dilated cardiomyopathy, hypertrophic cardiomyopathy, and restrictive cardiomyopathy. Ferroptosis involves intricate interactions within cellular iron metabolism, lipid peroxidation, and the balance between polyunsatura...
Source: Atherosclerosis - March 28, 2024 Category: Cardiology Authors: John Dawi Scarlet Affa Edgar Gonzalez Yura Misakyan David Nikoghosyan Karim Hajjar Samuel Kades Sabrina Fardeheb Hayk Mirzoyan Vishwanath Venketaraman Source Type: research
Ferroptosis in Cardiovascular Disease and Cardiomyopathies: Therapeutic Implications of Glutathione and Iron Chelating Agents
Biomedicines. 2024 Mar 1;12(3):558. doi: 10.3390/biomedicines12030558.ABSTRACTThis review explores ferroptosis, a form of regulated cell death reliant on iron-induced phospholipid peroxidation, in diverse physiological and pathological contexts, including neurodegenerative disorders, and ischemia-reperfusion. In the realm of cardiovascular diseases, it significantly contributes to cardiomyopathies, including dilated cardiomyopathy, hypertrophic cardiomyopathy, and restrictive cardiomyopathy. Ferroptosis involves intricate interactions within cellular iron metabolism, lipid peroxidation, and the balance between polyunsatura...
Source: Atherosclerosis - March 28, 2024 Category: Cardiology Authors: John Dawi Scarlet Affa Edgar Gonzalez Yura Misakyan David Nikoghosyan Karim Hajjar Samuel Kades Sabrina Fardeheb Hayk Mirzoyan Vishwanath Venketaraman Source Type: research
LncRNA H19: A Novel Biomarker in Cardiovascular Disease
Acta Cardiol Sin. 2024 Mar;40(2):172-181. doi: 10.6515/ACS.202403_40(2).20230925A.ABSTRACTCardiovascular disease is a major cause of death and disability worldwide. Recently, increasing evidence has demonstrated that long non-coding RNAs (lncRNAs) play critical roles in the pathogenesis of cardiovascular diseases, including atherosclerosis, coronary artery disease, dilated cardiomyopathy, diabetic cardiomyopathy, aortic dissection, and more. LncRNA H19 was the first to be described as a non-protein-coding mRNA-like molecule. A large number of studies have found that lncRNA H19 is related to the pathophysiological processes...
Source: Atherosclerosis - March 27, 2024 Category: Cardiology Authors: Xiaojun Li Yugui Zhang Zhaoran Ding Yijun Chen Wei Wang Source Type: research
Temporal progression of replacement and interstitial fibrosis in optimally managed dilated cardiomyopathy patients: A prospective study
Background: To prospectively examine the dynamic evolution of fibrotic processes within a one-year in patients with dilated cardiomyopathy (DCM). Methods: Between May 2019 and September 2020, 102 DCM patients (mean age 45.2 ± 11.8 years, EF 29.9 ± 11.6%) underwent cardiac magnetic resonance (CMR-1). After 13.9 ± 2.9 months, 92 of these patients underwent a follow-up CMR (CMR-2). Replacement fibrosis was assessed via late gadolinium enhancement (LGE), quantified in terms of LGE mass and extent. Inter stitial fibrosis was evaluated via T1-mapping and expressed as extracellular volume fraction (ECV). (Sour...
Source: International Journal of Cardiology - March 26, 2024 Category: Cardiology Authors: Pawel Rubi ś, Paweł Banyś, Maciej Krupiński, Małgorzata Mielnik, Sylwia Wiśniowska-Śmiałek, Ewa Dziewięcka, Małgorzata Urbańczyk-Zawadzka Source Type: research
Left ventricular assist device temporary explantation as a strategy for infection control in a pediatric patient
We report a case of temporary Berlin Heart EXCOR ® explantation in a pediatric patient with idiopathic dilated cardiomyopathy who suffered an uncontrollable inflow cannulation site infection while on bridge-to-transplantation. Despite failure to thrive and catheter-related infections, once free of the device, the patient was cured of infection us ing systemic antibiotics and surgical debridement. The patient underwent EXCOR® reimplantation after four months, and is awaiting heart transplantation in stable condition. A life-threatening ventricular assist device-related infection may require device explantation under condi...
Source: Journal of Artificial Organs - March 23, 2024 Category: Transplant Surgery Source Type: research
HTRA1-driven detachment of type I collagen from endoplasmic reticulum contributes to myocardial fibrosis in dilated cardiomyopathy
The aberrant secretion and excessive deposition of type I collagen (Col1) are important factors in the pathogenesis of myocardial fibrosis in dilated cardiomyopathy (DCM). However, the precise molecular mechan... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 22, 2024 Category: Research Authors: Hongjie Shi, Ming Yuan, Jie Cai, Lan Lan, Yumou Wang, Wei Wang, Jianliang Zhou, Bin Wang, Wenjun Yu, Zhe Dong, Dawei Deng, Qiaofeng Qian, Yang Li, Xianwu Zhou and Jinping Liu Tags: Research Source Type: research
