Genes, Vol. 15, Pages 53: Exploring the Regulation and Function of Rpl3l in the Development of Early-Onset Dilated Cardiomyopathy and Congestive Heart Failure Using Systems Genetics Approach
Conclusions: RPL3L is highly expressed in the heart tissue of humans and mice. Expression of Rpl3l and its upstream regulators, Myl4 and Sdha, correlate with multiple cardiac function traits in murine GRPs of BXD mice, while RPL3L and SDHA correlate with immune cell infiltration in DCM patient hearts, suggesting important roles for RPL3L in DCM and CHF pathogenesis via immune inflammation, necessitating experimental validations of Myl4 and Sdha in Rpl3l regulation. (Source: Genes)
Source: Genes - December 29, 2023 Category: Genetics & Stem Cells Authors: Akhilesh K. Bajpai Qingqing Gu Buyan-Ochir Orgil Neely R. Alberson Jeffrey A. Towbin Hugo R. Martinez Lu Lu Enkhsaikhan Purevjav Tags: Article Source Type: research
Echocardiographic values and prevalence of cardiac abnormalities in clinically healthy adult Borzoi dogs
Am J Vet Res. 2024 Jan 2:1-10. doi: 10.2460/ajvr.23.11.0255. Online ahead of print.ABSTRACTOBJECTIVE: To develop breed-specific echocardiographic values for normal Borzoi and to report the prevalence of structural cardiac abnormalities.ANIMALS: 146 clinically healthy, adult Borzoi dogs.METHODS: Cardiac auscultation and standard echocardiograms were performed. Longitudinal follow-up was described in a subset of dogs (n = 25).RESULTS: Most Borzoi were structurally normal (119/146, 81.5%), with breed-specific echocardiographic values generated independently for each sex, as females weighed significantly less than males (30.4 ...
Source: American Journal of Veterinary Research - December 28, 2023 Category: Veterinary Research Authors: Sonya Wesselowski K Tess Sykes Ashley B Saunders Stephen R Werre Source Type: research
Echocardiographic values and prevalence of cardiac abnormalities in clinically healthy adult Borzoi dogs
Am J Vet Res. 2024 Jan 2:1-10. doi: 10.2460/ajvr.23.11.0255. Online ahead of print.ABSTRACTOBJECTIVE: To develop breed-specific echocardiographic values for normal Borzoi and to report the prevalence of structural cardiac abnormalities.ANIMALS: 146 clinically healthy, adult Borzoi dogs.METHODS: Cardiac auscultation and standard echocardiograms were performed. Longitudinal follow-up was described in a subset of dogs (n = 25).RESULTS: Most Borzoi were structurally normal (119/146, 81.5%), with breed-specific echocardiographic values generated independently for each sex, as females weighed significantly less than males (30.4 ...
Source: American Journal of Veterinary Research - December 28, 2023 Category: Veterinary Research Authors: Sonya Wesselowski K Tess Sykes Ashley B Saunders Stephen R Werre Source Type: research
Echocardiographic values and prevalence of cardiac abnormalities in clinically healthy adult Borzoi dogs
Am J Vet Res. 2024 Jan 2:1-10. doi: 10.2460/ajvr.23.11.0255. Online ahead of print.ABSTRACTOBJECTIVE: To develop breed-specific echocardiographic values for normal Borzoi and to report the prevalence of structural cardiac abnormalities.ANIMALS: 146 clinically healthy, adult Borzoi dogs.METHODS: Cardiac auscultation and standard echocardiograms were performed. Longitudinal follow-up was described in a subset of dogs (n = 25).RESULTS: Most Borzoi were structurally normal (119/146, 81.5%), with breed-specific echocardiographic values generated independently for each sex, as females weighed significantly less than males (30.4 ...
Source: American Journal of Veterinary Research - December 28, 2023 Category: Veterinary Research Authors: Sonya Wesselowski K Tess Sykes Ashley B Saunders Stephen R Werre Source Type: research
Echocardiographic values and prevalence of cardiac abnormalities in clinically healthy adult Borzoi dogs
Am J Vet Res. 2024 Jan 2:1-10. doi: 10.2460/ajvr.23.11.0255. Online ahead of print.ABSTRACTOBJECTIVE: To develop breed-specific echocardiographic values for normal Borzoi and to report the prevalence of structural cardiac abnormalities.ANIMALS: 146 clinically healthy, adult Borzoi dogs.METHODS: Cardiac auscultation and standard echocardiograms were performed. Longitudinal follow-up was described in a subset of dogs (n = 25).RESULTS: Most Borzoi were structurally normal (119/146, 81.5%), with breed-specific echocardiographic values generated independently for each sex, as females weighed significantly less than males (30.4 ...
Source: American Journal of Veterinary Research - December 28, 2023 Category: Veterinary Research Authors: Sonya Wesselowski K Tess Sykes Ashley B Saunders Stephen R Werre Source Type: research
Echocardiographic values and prevalence of cardiac abnormalities in clinically healthy adult Borzoi dogs
Am J Vet Res. 2024 Jan 2:1-10. doi: 10.2460/ajvr.23.11.0255. Online ahead of print.ABSTRACTOBJECTIVE: To develop breed-specific echocardiographic values for normal Borzoi and to report the prevalence of structural cardiac abnormalities.ANIMALS: 146 clinically healthy, adult Borzoi dogs.METHODS: Cardiac auscultation and standard echocardiograms were performed. Longitudinal follow-up was described in a subset of dogs (n = 25).RESULTS: Most Borzoi were structurally normal (119/146, 81.5%), with breed-specific echocardiographic values generated independently for each sex, as females weighed significantly less than males (30.4 ...
Source: American Journal of Veterinary Research - December 28, 2023 Category: Veterinary Research Authors: Sonya Wesselowski K Tess Sykes Ashley B Saunders Stephen R Werre Source Type: research
Mechanical Dispersion is Associated with Ventricular Arrhythmias and Sudden Cardiac Death in Non-ischemic Dilated Cardiomyopathy
(Source: Journal of the American Society of Echocardiography)
Source: Journal of the American Society of Echocardiography - December 28, 2023 Category: Cardiology Authors: Eduard R ódenas-Alesina, Jordi Lozano-Torres, Rosa Vila, Maria Calvo-Barceló, Clara Badia-Molins, Pablo Eduardo Tobías-Castillo, Ignacio Ferreira-González, José Rodríguez-Palomares Tags: Brief Research Communication Source Type: research
Mechanical Dispersion Is Associated With Ventricular Arrhythmias and Sudden Cardiac Death in Nonischemic Dilated Cardiomyopathy
Patients with nonischemic dilated cardiomyopathy (NIDCM) are at higher risk of ventricular arrhythmias (VAs) and sudden cardiac death (SCD), but the use of implantable cardioverter-defibrillators (ICDs) is not recommended in all-comers.1 Risk stratification is paramount when deciding ICD implantation in primary prevention before VAs occur. Although late gadolinium enhancement (LGE) using cardiac magnetic resonance (CMR) has been demonstrated to be strongly associated with VA during follow-up,2 CMR is not widely available for repeated assessments and myocardial substrate may vary with time. (Source: Journal of the American ...
Source: Journal of the American Society of Echocardiography - December 28, 2023 Category: Cardiology Authors: Eduard R ódenas-Alesina, Jordi Lozano-Torres, Rosa Vila-Olives, Maria Calvo-Barceló, Clara Badia-Molins, Pablo Eduardo Tobías-Castillo, Ignacio Ferreira-González, José Rodríguez-Palomares Tags: Brief Research Communication Source Type: research
Striated preferentially expressed gene deficiency leads to mitochondrial dysfunction in developing cardiomyocytes
AbstractA deficiency of striated preferentially expressed gene (Speg), a member of the myosin light chain kinase family, results in abnormal myofibril structure and function of immature cardiomyocytes (CMs), corresponding with a dilated cardiomyopathy, heart failure and perinatal death. Mitochondrial development plays a role in cardiomyocyte maturation. Therefore, this study investigated whetherSpeg deficiency ( – / – ) in CMs would result in mitochondrial abnormalities.Speg wild-type andSpeg−/− C57BL/6 littermate mice were utilized for assessment of mitochondrial structure by transmission electron and confocal m...
Source: Basic Research in Cardiology - December 26, 2023 Category: Cardiology Source Type: research
Generation of an RBM20-mutation-associated left-ventricular non-compaction cardiomyopathy iPSC line (UMGi255-A) into a DCM genetic background to investigate monogenetic cardiomyopathies
Stem Cell Res. 2023 Dec 16;74:103290. doi: 10.1016/j.scr.2023.103290. Online ahead of print.ABSTRACTRBM20 mutations account for 3 % of genetic cardiomypathies and manifest with high penetrance and arrhythmogenic effects. Numerous mutations in the conserved RS domain have been described as causing dilated cardiomyopathy (DCM), whereas a particular mutation (p.R634L) drives development of a different cardiac phenotype: left-ventricular non-compaction cardiomyopathy. We generated a mutation-induced pluripotent stem cell (iPSC) line in which the RBM20-LVNC mutation p.R634L was introduced into a DCM patient line with rescued RB...
Source: Cell Research - December 23, 2023 Category: Cytology Authors: Hanna Eberl Sabine Rebs Stefanie Hoppe Farbod Sedaghat-Hamedani Elham Kayvanpour Benjamin Meder Katrin Streckfuss-B ömeke Source Type: research
Enteral N-acetylcysteine to reduce serum cobalt concentrations secondary to prosthetic knee-associated metallosis: A case report
CONCLUSION: This case report contributes to the body of literature suggesting that administration of N-acetylcysteine can reduce serum cobalt concentrations, without notable adverse effects, in the context of prosthetic knee-associated metallosis.PMID:38141216 | DOI:10.1093/ajhp/zxad312 (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - December 23, 2023 Category: Drugs & Pharmacology Authors: Connor A Floyd John Carr Logan Brock Dustin Orvin Source Type: research
Generation of an RBM20-mutation-associated left-ventricular non-compaction cardiomyopathy iPSC line (UMGi255-A) into a DCM genetic background to investigate monogenetic cardiomyopathies
Stem Cell Res. 2023 Dec 16;74:103290. doi: 10.1016/j.scr.2023.103290. Online ahead of print.ABSTRACTRBM20 mutations account for 3 % of genetic cardiomypathies and manifest with high penetrance and arrhythmogenic effects. Numerous mutations in the conserved RS domain have been described as causing dilated cardiomyopathy (DCM), whereas a particular mutation (p.R634L) drives development of a different cardiac phenotype: left-ventricular non-compaction cardiomyopathy. We generated a mutation-induced pluripotent stem cell (iPSC) line in which the RBM20-LVNC mutation p.R634L was introduced into a DCM patient line with rescued RB...
Source: Cell Research - December 23, 2023 Category: Cytology Authors: Hanna Eberl Sabine Rebs Stefanie Hoppe Farbod Sedaghat-Hamedani Elham Kayvanpour Benjamin Meder Katrin Streckfuss-B ömeke Source Type: research
Enteral N-acetylcysteine to reduce serum cobalt concentrations secondary to prosthetic knee-associated metallosis: A case report
CONCLUSION: This case report contributes to the body of literature suggesting that administration of N-acetylcysteine can reduce serum cobalt concentrations, without notable adverse effects, in the context of prosthetic knee-associated metallosis.PMID:38141216 | DOI:10.1093/ajhp/zxad312 (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - December 23, 2023 Category: Drugs & Pharmacology Authors: Connor A Floyd John Carr Logan Brock Dustin Orvin Source Type: research
Enteral N-acetylcysteine to reduce serum cobalt concentrations secondary to prosthetic knee-associated metallosis: A case report
CONCLUSION: This case report contributes to the body of literature suggesting that administration of N-acetylcysteine can reduce serum cobalt concentrations, without notable adverse effects, in the context of prosthetic knee-associated metallosis.PMID:38141216 | DOI:10.1093/ajhp/zxad312 (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - December 23, 2023 Category: Drugs & Pharmacology Authors: Connor A Floyd John Carr Logan Brock Dustin Orvin Source Type: research
Extracellular vesicles (EVs): A promising therapeutic tool in the heart tissue regeneration
Extracellular vesicles paracrine effects play a primary role in the regenerative ability. EVs and the bioactive molecules contained in the human dental pulp stem cells influence the differentiation process toward cardiomyogenic lineage. Differentiation of dental pulp stem cells into cardiomyocytes induced by EVs derived modulating the differentiation process toward cardiomyogenic lineage. AbstractMesenchymal stem cells (MSCs) treatment has been widely explored as a therapy for myocardial infarction, peripheral ischemic vascular diseases, dilated cardiomyopathy, and pulmonary hypertension. Latest in vitro studies suggest th...
Source: BioFactors - December 22, 2023 Category: Biochemistry Authors: Francesca Diomede,
Simone Guarnieri,
Paola Lanuti,
Fani Konstantinidou,
Valentina Gatta,
Thangavelu Soundara Rajan,
Sante D. Pierdomenico,
Oriana Trubiani,
Guya Diletta Marconi,
Jacopo Pizzicannella Tags: RESEARCH ARTICLE Source Type: research
