Association of uncertain significance genetic variants with myocardial mechanics and morphometrics in patients with nonischemic dilated cardiomyopathy
Careful interpretation of the relation between phenotype changes of the heart and gene variants detected in dilated cardiomyopathy (DCM) is important for patient care and monitoring. (Source: BMC Cardiovascular Disorders)
Source: BMC Cardiovascular Disorders - April 25, 2024 Category: Cardiology Authors: Karolina M ėlinytė-Ankudavičė, Marius Šukys, Gabrielė Kasputytė, Ričardas Krikštolaitis, Eglė Ereminienė, Grytė Galnaitienė, Vaida Mizarienė, Gintarė Šakalytė, Tomas Krilavičius and Renaldas Jurkevičius Tags: Research Source Type: research
Integrated machine learning and multimodal data fusion for patho-phenotypic feature recognition in iPSC models of dilated cardiomyopathy
Biol Chem. 2024 Apr 24. doi: 10.1515/hsz-2024-0023. Online ahead of print.ABSTRACTIntegration of multiple data sources presents a challenge for accurate prediction of molecular patho-phenotypic features in automated analysis of data from human model systems. Here, we applied a machine learning-based data integration to distinguish patho-phenotypic features at the subcellular level for dilated cardiomyopathy (DCM). We employed a human induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) model of a DCM mutation in the sarcomere protein troponin T (TnT), TnT-R141W, compared to isogenic healthy (WT) control iPSC-CMs. ...
Source: Biological Chemistry - April 23, 2024 Category: Chemistry Authors: Ruheen Wali Hang Xu Cleophas Cheruiyot Hafiza Nosheen Saleem Andreas Janshoff Michael Habeck Antje Ebert Source Type: research
Cardiac MRI for clinical dilated cardiomyopathy: Improved diagnostic power via combined T1, T2, and ECV
This study will examine whether the combination of MRI T1 and T2 mapping offers greater advantages in the diagnosis of DCM. (Source: Radiography)
Source: Radiography - April 23, 2024 Category: Radiology Authors: S-q. Jia, S-y. Lv, Y.-H. Jin, Y. Zhao, L-p. Tian, M-m. Chang, C-l. Yan, X-l. Qi Source Type: research
Minimally-Invasive Approach in the Setting of a Malignant Primary Cardiac Tumor
Thorac Cardiovasc Surg Rep 2024; 13: e16-e19 DOI: 10.1055/a-2298-0497A 71-year-old man with dilated cardiomyopathy without clinical complaints revealed a suspicious finding in checkup. After a multimodality cardiac imaging, the suspicion of a malignant primary cardiac tumor in the left ventricle was substantiated and the patient underwent minimally-invasive cardiac surgery for tumor resection. Postoperative chemotherapy with multiple cycles of liposomal doxorubicin was established and supported by proton beam radiotherapy. Two-year follow-up revealed no disease recurrence. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 7...
Source: The Thoracic and Cardiovascular Surgeon Reports - April 23, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Polat, Emre Stock, Sina Owais, Tamer Girdauskas, Evaldas Tags: Case Report: Cardiac Source Type: research
Is the detection of late gadolinium enhancement sufficient for assessing fibrosis in cardiomyopathies?
In recent years Cardiac magnetic resonance (CMR) imaging has become a fundamental tool for evaluating patients with Dilated Cardiomyopathy (DCM). Indeed, CMR has revolutionized the diagnostic approach to different cardiomyopathies, not only providing detailed information about ventricular dimension and function but also allowing visualization and quantification of scarring using late gadolinium enhancement (LGE) [1]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 22, 2024 Category: Cardiology Authors: Marika Martini, Barbara Bauce Source Type: research
Left Ventricular Segmentation, Warping, and Myocardial Registration for Automated Strain Measurement
AbstractThe left ventricular global longitudinal strain (LVGLS) is a crucial prognostic indicator. However, inconsistencies in measurements due to the speckle tracking algorithm and manual adjustments have hindered its standardization and democratization. To solve this issue, we proposed a fully automated strain measurement by artificial intelligence-assisted LV segmentation contours. The LV segmentation model was trained from echocardiograms of 368 adults (11,125 frames). We compared the registration-like effects of dynamic time warping (DTW) with speckle tracking on a synthetic echocardiographic dataset in experiment-1. ...
Source: Journal of Digital Imaging - April 19, 2024 Category: Radiology Source Type: research
The role of cardiac magnetic resonance in sports cardiology: results from a large cohort of athletes
ConclusionCMR is more efficient in identifying a pathologic cardiac substrate in athletes in case of VAs (i.e., polymorphic beats), abnormal ECG repolarisation (negative T-waves in inferolateral leads), and borderline echocardiographic findings (LV hypertrophy, mildly depressed LV function). On the other hand, CMR is associated with a large proportion of negative results. Therefore, a careful clinical selection is needed to indicate CMR in athletes appropriately.Graphical AbstractClinical indications for CMR and positive CMR findings.The left panel shows clinical indications for CMR in our athletic cohort and the percentag...
Source: Clinical Research in Cardiology - April 15, 2024 Category: Cardiology Source Type: research
Loss of ADAM15 in female mice does not worsen pressure overload cardiomyopathy, independent of ovarian hormones
Am J Physiol Heart Circ Physiol. 2024 Apr 12. doi: 10.1152/ajpheart.00116.2024. Online ahead of print.ABSTRACTCardiac hypertrophy is a common feature in several cardiomyopathies. We previously reported that loss of ADAM15 (disintegrin and metalloproteinase 15) worsened cardiac hypertrophy and dilated cardiomyopathy following cardiac pressure overload. Here, we investigated the impact of ADAM15 loss in female mice following cardiac pressure overload induced by transverse aortic constriction (TAC). Female Adam15-/-mice developed the same degree of cardiac hypertrophy, dilation and dysfunction as the parallel female wildtype ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 12, 2024 Category: Physiology Authors: Vidhya Krishnan Nikki Atanasova Preetinder K Aujla Devon Hupka Caroline A Owen Zamaneh Kassiri Source Type: research
Loss of ADAM15 in female mice does not worsen pressure overload cardiomyopathy, independent of ovarian hormones
Am J Physiol Heart Circ Physiol. 2024 Apr 12. doi: 10.1152/ajpheart.00116.2024. Online ahead of print.ABSTRACTCardiac hypertrophy is a common feature in several cardiomyopathies. We previously reported that loss of ADAM15 (disintegrin and metalloproteinase 15) worsened cardiac hypertrophy and dilated cardiomyopathy following cardiac pressure overload. Here, we investigated the impact of ADAM15 loss in female mice following cardiac pressure overload induced by transverse aortic constriction (TAC). Female Adam15-/-mice developed the same degree of cardiac hypertrophy, dilation and dysfunction as the parallel female wildtype ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 12, 2024 Category: Physiology Authors: Vidhya Krishnan Nikki Atanasova Preetinder K Aujla Devon Hupka Caroline A Owen Zamaneh Kassiri Source Type: research
Loss of ADAM15 in female mice does not worsen pressure overload cardiomyopathy, independent of ovarian hormones
Am J Physiol Heart Circ Physiol. 2024 Apr 12. doi: 10.1152/ajpheart.00116.2024. Online ahead of print.ABSTRACTCardiac hypertrophy is a common feature in several cardiomyopathies. We previously reported that loss of ADAM15 (disintegrin and metalloproteinase 15) worsened cardiac hypertrophy and dilated cardiomyopathy following cardiac pressure overload. Here, we investigated the impact of ADAM15 loss in female mice following cardiac pressure overload induced by transverse aortic constriction (TAC). Female Adam15-/-mice developed the same degree of cardiac hypertrophy, dilation and dysfunction as the parallel female wildtype ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 12, 2024 Category: Physiology Authors: Vidhya Krishnan Nikki Atanasova Preetinder K Aujla Devon Hupka Caroline A Owen Zamaneh Kassiri Source Type: research
Loss of ADAM15 in female mice does not worsen pressure overload cardiomyopathy, independent of ovarian hormones
Am J Physiol Heart Circ Physiol. 2024 Apr 12. doi: 10.1152/ajpheart.00116.2024. Online ahead of print.ABSTRACTCardiac hypertrophy is a common feature in several cardiomyopathies. We previously reported that loss of ADAM15 (disintegrin and metalloproteinase 15) worsened cardiac hypertrophy and dilated cardiomyopathy following cardiac pressure overload. Here, we investigated the impact of ADAM15 loss in female mice following cardiac pressure overload induced by transverse aortic constriction (TAC). Female Adam15-/-mice developed the same degree of cardiac hypertrophy, dilation and dysfunction as the parallel female wildtype ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 12, 2024 Category: Physiology Authors: Vidhya Krishnan Nikki Atanasova Preetinder K Aujla Devon Hupka Caroline A Owen Zamaneh Kassiri Source Type: research
Loss of ADAM15 in female mice does not worsen pressure overload cardiomyopathy, independent of ovarian hormones
Am J Physiol Heart Circ Physiol. 2024 Apr 12. doi: 10.1152/ajpheart.00116.2024. Online ahead of print.ABSTRACTCardiac hypertrophy is a common feature in several cardiomyopathies. We previously reported that loss of ADAM15 (disintegrin and metalloproteinase 15) worsened cardiac hypertrophy and dilated cardiomyopathy following cardiac pressure overload. Here, we investigated the impact of ADAM15 loss in female mice following cardiac pressure overload induced by transverse aortic constriction (TAC). Female Adam15-/-mice developed the same degree of cardiac hypertrophy, dilation and dysfunction as the parallel female wildtype ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 12, 2024 Category: Physiology Authors: Vidhya Krishnan Nikki Atanasova Preetinder K Aujla Devon Hupka Caroline A Owen Zamaneh Kassiri Source Type: research
Dilated cardiomyopathy due to hypocalcaemia: a case report
ConclusionThis adds to literature of this rare cause of reversible cardiomyopathy secondary to hypocalcemia reported from the South Asian region of the world. This case highlights the impact of proper treatment improving the heart failure in patients with hypocalcemic cardiomyopathy. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - April 11, 2024 Category: General Medicine Source Type: research
