Cardiorenal Amyloidosis.
Authors: N M, Soni P, Anand R, Bali S, Hari Abstract Amyloidosis is a conglomeration of diseases due to production and deposition of amyloid, a proteinaceous substance, into organs, tissues, nerves and other places in the body affecting their normal function. This case report is of a 65 year old gentleman, resident of Bihar admitted with a short history of two months. He came with chief complaints of swelling in both lower limbs associated with heaviness in legs, shortness of breath, dizziness, fatigue and passage of frothy urine for two months. He was investigated and found to have proteinuria, low voltage ECG, Ec...
Source: Journal of the Association of Physicians of India - July 2, 2020 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

Relationship between malnutrition and coronary microvascular dysfunction in patients with nonischemic dilated cardiomyopathy.
Authors: Kul Ş, GÜvenÇ TS, ÇaliŞkan M Abstract Background/ aim: Malnutrition is common in patients with nonischemic dilated cardiomyopathy (DCM), especially in the end-stages of the disease where heart failure symptoms predominate. Malnutrition has been associated with atherosclerosis in patients with chronic kidney disease, but it is unknown whether a similar relationship exist between malnutrition and coronary microvascular dysfunction (CMD). In the present study, we aimed to analyze whether indices of malnutrition were associated with coronary flow reserve (CFR) in patients with DCM. MAT...
Source: Turkish Journal of Medical Sciences - July 2, 2020 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Left ventricular midwall fibrosis as a predictor of sudden cardiac death in non ‐ischaemic dilated cardiomyopathy: a meta‐analysis
AbstractIdentification of patients with non ‐ischaemic dilated cardiomyopathy (NICM) who are at risk of sudden cardiac death (SCD) and could benefit from an implantable cardioverter defibrillator (ICD) is challenging. The study aims to systematically assess the prognostic value of left ventricular (LV) midwall late gadolinium enhancement (L GE) pattern in patients with NICM and further explore its value on predicting SCD events. The study was prospectively registered in PROPSERO (CRD42019138468). We systematically searched PubMed, Ovid Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov to identify studies t...
Source: ESC Heart Failure - June 30, 2020 Category: Cardiology Authors: Jie Wang, Fuyao Yang, Ke Wan, David Mui, Yuchi Han, Yucheng Chen Tags: Review Source Type: research

A Korean child diagnosed with malonic aciduria harboring a novel start codon mutation following presentation with dilated cardiomyopathy
ConclusionsMA can be diagnosed using newborn screening; however, negative results do not exclude the possibility of disease. Metabolic screening for differential diagnosis of infantile DCMP is recommended to rule out rare, but manageable, metabolic cardiomyopathies. (Source: Molecular Genetics & Genomic Medicine)
Source: Molecular Genetics & Genomic Medicine - June 30, 2020 Category: Genetics & Stem Cells Authors: Seung Hoon Lee, Jung Min Ko, Mi ‐Kyoung Song, Junghan Song, Kyung Sun Park Tags: ORIGINAL ARTICLE Source Type: research

Commentary: Searching for simpler parameters in the context of non-ischemic dilated cardiomyopathy
Secondary functional mitral regurgitation (FMR) in patients with non-ischemic dilated cardiomyopathy (NIDCM) is associated with worse prognosis and poor survival,1 and results after mitral valve (MV) surgery are still controversial. The main reason is that FMR is not an intrinsic disease of the valve, but instead it mirrors a ventricular disease. In NIDCM, progressive left ventricular (LV) remodeling causes papillary muscle displacement and mitral annular dilation. Both conditions cause leaflet tethering and reduce leaflet coaptation. (Source: Seminars in Thoracic and Cardiovascular Surgery)
Source: Seminars in Thoracic and Cardiovascular Surgery - June 29, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Francesco Formica, Francesco Nicolini Tags: ADULT – Commentary Source Type: research

Practice makes perfect: improved long ‐term survival in nonischaemic dilated cardiomyopathy with contemporary treatment
European Journal of Heart Failure, Accepted Article. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - June 29, 2020 Category: Cardiology Authors: Petar M Seferovi ć, Milika Ašanin, Marija Polovina Tags: Editorial Comment Source Type: research

Cardiovascular Magnetic Resonance Imaging Tissue Characterization in Non-ischemic Cardiomyopathies
AbstractPurpose of reviewIn this review, we will focus the role of CMR in dilated cardiomyopathy and genetic cardiomyopathy.Recent findingsNon-invasive imaging plays a crucial rule in the diagnostic workup of cardiomyopathies. In these entities, echocardiography is the first-line imaging tool for diagnostic assessment, but CMR has the unique capability to identify and differentiate the underlying pathology, mainly through tissue characterization, even if the EF is preserved. Myocardial tissue characterization is crucial for adequate prognostication and guiding of therapy. Visual, semi-quantitative, and quantitative methods...
Source: Current Treatment Options in Cardiovascular Medicine - June 27, 2020 Category: Cardiology Source Type: research

Identification of Target Genes and Transcription Factors in Mice with LMNA-Related Dilated Cardiomyopathy by Integrated Bioinformatic Analyses.
CONCLUSIONS Our study used integrated bioinformatic analyses and revealed some important genes in mice with LMNA-related DCM, which could provide novel insights into the mechanism underlying human LMNA-related DCM. PMID: 32581210 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 26, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Association of S100B 3’UTR polymorphism with risk of chronic heart failure in a Chinese Han population
To study the correlation between single nucleotide polymorphism (SNP) of the 3′ untranslated region (UTR) rs9722 locus in S100B and the risk of chronic heart failure (CHF), plasma levels of S100B protein as well as has-miR-340-3p in a Chinese Han population. A total of 215 patients with CHF (124 ischemic cardiomyopathy (ICM) and 91 dilated cardiomyopathy (DCM)) and 215 healthy controls were recruited to analyze the S100B rs9722 genotype by Sanger sequencing. The levels of hsa-miR-340-3p in the plasma were detected by RT-PCR, and S100B levels were detected by ELISA. The risk of CHF in S100B rs9722 locus T allele car...
Source: Medicine - June 26, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Contemporary survival trends and aetiological characterization in non ‐ischaemic dilated cardiomyopathy
AbstractAimContemporary survival trends in dilated cardiomyopathy (DCM) are largely unknown. The aim of this study is to investigate clinical descriptors, survival trends and the prognostic impact of aetiological characterization in DCM patients.Methods and resultsDilated cardiomyopathy patients were consecutively enrolled and divided into four groups according to the period of enrolment (1978 –1984; 1985–1994; 1995–2004; and 2005–2015). A subset of patients with DCM of specific aetiology, enrolled from 2005 to 2015, was also analysed. Over a mean follow‐up of 12 ± 8 ye...
Source: European Journal of Heart Failure - June 26, 2020 Category: Cardiology Authors: Marco Merlo, Antonio Cannat à, Carola Pio Loco, Davide Stolfo, Giulia Barbati, Jessica Artico, Piero Gentile, Valerio De Paris, Federica Ramani, Massimo Zecchin, Marta Gigli, Bruno Pinamonti, Renata Korcova, Andrea Di Lenarda, Mauro Giacca, Tags: Research Article Source Type: research

Prognostic value of free triiodothyronine in patients with dilated cardiomyopathy.
Abstract BACKGROUND: The association between free triiodothyronine (FT3) and long-term prognosis in dilated cardiomyopathy (DCM) patients has not been evaluated. The purpose of this study was to determine whether the level of FT3 could provide prognostic value in patients with DCM. METHODS: Data of consecutive patients diagnosed with DCM were collected from October 2009 to December 2014. FT3 was measured by fluoroimmunoassay. Other biochemical markers, such as free thyroxin (FT4), thyroid-stimulating hormone, red blood cell, hemoglobin, blood urea nitrogen, and serum creatinine, were tested at the same time. ...
Source: Chinese Medical Journal - June 26, 2020 Category: General Medicine Authors: Zhao HY, Sun L, Zhu YQ, Chen QS, Zhu WW, Toorabally MB, Chen XG, Zhang FX Tags: Chin Med J (Engl) Source Type: research

Cushing syndrome cardiomyopathy: an unusual manifestation of small ‐cell lung cancer
We describe a patient presenting with acute heart failure, new cardiomyopathy, refractory hypokalaemia, severe hyperglycaemia, and uncontrolled hypertension who was found to have hypercortisolism secondary to an ectopic adrenocorticotropic hormone ‐secreting primary lung neoplasm. This case highlights the effects of hypercortisolism on the myocardium. The finding of a non‐dilated cardiomyopathy in this case is unique because the majority of previously reported Cushing syndrome cardiomyopathy cases have described left ventricular dilatatio n or significant left ventricular hypertrophy. In addition, small‐cell lung can...
Source: ESC Heart Failure - June 23, 2020 Category: Cardiology Authors: Srinath ‐Reddi Pingle, Tanvi Shah, Wassim Mosleh, Agnes S. Kim Tags: Case Report Source Type: research

CFTR deficiency causes cardiac dysplasia during zebrafish embryogenesis and is associated with dilated cardiomyopathy
Publication date: Available online 20 June 2020Source: Mechanisms of DevelopmentAuthor(s): Yanyan Liu, Ziyuan Lin, Mingfeng Liu, Huijuan Liao, Yan Chen, Xiaohu Zhang, Hsiao Chang Chan, Bin Zhou, Li Rao, Huaqin Sun (Source: Mechanisms of Development)
Source: Mechanisms of Development - June 22, 2020 Category: Biology Source Type: research

Prevalence and prognostic relevance of myocardial inflammation and cardiotropic viruses in non-ischemic dilated cardiomyopathy.
CONCLUSIONS: This study has shown that two markers - cardiotropic viruses and myocardial inflammation - are prevalent among DCM patients. They are also helpful in identifying sub-groups of DCM. An increased number of T-lymphocytes in the myocardium is a predictor of poor mid-term and long-term prognosis. PMID: 32567670 [PubMed - as supplied by publisher] (Source: Cardiology Journal)
Source: Cardiology Journal - June 22, 2020 Category: Cardiology Authors: Kažukauskienė I, Baltrūnienė V, Jakubauskas A, Žurauskas E, Maneikienė VV, Daunoravičius D, Čelutkienė J, Ručinskas K, Grabauskienė V Tags: Cardiol J Source Type: research

Cardiac hypertrophic risk markers of left ventricle and left atrium in chronic heart failure due to aortic and mitral valve disease.
Abstract BACKGROUND: Chronic valvular heart disease leads to systolic dysfunction and left atrial enlargement that ultimately results in heart failure. PURPOSE: To investigate prognostic importance of Echocardiography and plasma natriuretic peptide levels that increase as a compensatory response and can be used as predictive markers for cardiac hypertrophy. MATERIAL AND METHODS: The patients were divided into three groups: 51 with left ventricle hypertrophy due to aortic valve disease; 126 with left atrial enlargement due to mitral valve dysfunction; and 76 with both conditions. Atrial natriuretic peptid...
Source: Acta Radiologica - June 22, 2020 Category: Radiology Authors: Jan MI, Khan RA, Khan N, Mahak A, Shah AUHA, Hussain ST, Kakakhel AU, Murtaza I Tags: Acta Radiol Source Type: research

Management of pediatric cardiac transplantation candidates with pulmonary hypertension and high pulmonary vascular resistance.
In this study we aimed to evaluate management strategies in our pediatric cardiac transplantation candidates with PH and high PVR prior to OHT. METHOD: Twenty-six cardiac transplantation candidates (age: 10.2 ± 4.6, 1-17 years) underwent cardiac catheterization for the determination of PVR and pulmonary arterial pressure. They were admitted to the hospital and received 1-3 days of intravenous (IV) vasodilator therapy; 0.5-3 μg/kg/min nitroglyserin and/or 0.5-3 μg/kg/min nitroprusside, 5-15 μg/kg/min dobutamin and/or dopamin to keep systolic blood pressure above 80 mmHg. RESULTS: Thirteen patients ...
Source: The Turkish Journal of Pediatrics - June 21, 2020 Category: Pediatrics Authors: Yakut K, Varan B, Erdoğan İ, Cindik N, Gökdemir M, Gümüş A, Tokel NK, Sezgin A Tags: Turk J Pediatr Source Type: research

Troponin T amino acid mutation ( ΔK210) knock-in mice as a neonatal dilated cardiomyopathy model.
CONCLUSIONS: TNNT2ΔK210/ΔK210 mice have already developed DCM at birth, indicating that they should be an excellent animal model to identify early progression factors of DCM. IMPACT: TNNT2ΔK210/ΔK210 mice are excellent animal model for DCM.TNNT2ΔK210/ΔK210 mice are excellent animal model to identify early progression factors of DCM.KEGG PATHWAY analysis revealed that several important pathways such as cancer and focal adhesion might be associated with the pathogenesis and development of neonatal DCM. PMID: 32563186 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - June 20, 2020 Category: Pediatrics Authors: Tanihata J, Fujii T, Baba S, Fujimoto Y, Morimoto S, Minamisawa S Tags: Pediatr Res Source Type: research

Alterations of the renin angiotensin system in human end-stage heart failure before and after mechanical cardiac unloading by LVAD support.
Abstract Heart transplantation is often an unrealizable therapeutic option for end-stage heart failure, which is why mechanical left ventricular assist devices (LVADs) become an increasingly important therapeutic alternative. Currently, there is a lack of information about molecular mechanisms which are influenced by LVADs, particularly regarding the pathophysiologically critical renin angiotensin system (RAS). We, therefore, determined regulation patterns of key components of the RAS and the β-arrestin signaling pathways in left ventricular (LV) tissue specimens from 8 patients with end-stage ischemic cardio...
Source: Molecular and Cellular Biochemistry - June 20, 2020 Category: Biochemistry Authors: Messmann R, Dietl A, Wagner S, Domenig O, Jungbauer C, Luchner A, Maier LS, Schopka S, Hirt S, Schmid C, Birner C Tags: Mol Cell Biochem Source Type: research

Computational Studies on the Effects of Applied Apical Torsion for Cardiac Assist on Regional Wall Mechanics
Conclusion: Maximum principal stresses greater than 100 kPa were observed at multiple nodes along the epicardium and endocardium of the ventricular base and in the endocardium at the device base. Maximum principal strains greater than 0.60 were observed at multiple nodes along the epicardium and endocardium of the ventricular base. Significance: This suggests that while AAT has the potential to provide meaningful returns to hemodynamic function in failing hearts, the large deformations produced by this approach with the upper bounds of applied rotation angle realistically excludes supra-physiological rotations as a me...
Source: IEEE Transactions on Biomedical Engineering - June 19, 2020 Category: Biomedical Engineering Source Type: research

Hemolysis and methemoglobinemia in a child with left ventricular assist Levitronix PediMag.
o Lozano MJ Abstract A 5-month-old male was treated with left ventricular assist device due to cardiac failure secondary to dilated cardiomyopathy. The patient developed acute severe intravascular hemolysis with methemoglobinemia and renal failure, related to a mechanical problem due to pump cylinder misalignment. Secondary severe methemoglobinemia has not been previously described in patients undergoing ventricular assist device. Early detection of the signs and symptoms of hemolysis is crucial to prevent further complications. PMID: 32552341 [PubMed - as supplied by publisher] (Source: The International Jou...
Source: The International Journal of Artificial Organs - June 18, 2020 Category: Transplant Surgery Authors: Butragueño Laiseca L, Estepa Pedregosa L, Sánchez Galindo AC, Santiago Lozano MJ Tags: Int J Artif Organs Source Type: research

Delayed-type Hypersensitivity to Metals in Newly Diagnosed Patients with Nonischemic Dilated Cardiomyopathy.
nar J Abstract The causes of nonischemic dilated cardiomyopathy are classified as genetic or nongenetic, but environmental factors such as metal pollutants may interact with genetic susceptibility. The presence of metal particles has been detected in the myocardium, including in those patients with dilated cardiomyopathy. It is also known that hypersensitivity reactions can induce inflammation in tissue. The present study aimed to verify if metal-induced delayed-type hypersensitivity is present in patients with nonischemic dilated cardiomyopathy. The patient group consisted of 30 patients with newly diagnosed dila...
Source: Cardiovascular Toxicology - June 15, 2020 Category: Cardiology Authors: Manousek J, Felsoci M, Miklik R, Parenica J, Krejci J, Bjørklund G, Klanova J, Mlejnek D, Miklikova M, Lokaj P, Chirumbolo S, Spinar J Tags: Cardiovasc Toxicol Source Type: research

EP News: Allied Professionals
Using a national registry of patients with cardiac inherited disease (CID), the authors (Rucinski et al. J Am Coll Cardiol. 2020;75:2698-2707. PMID:32466885) sought to describe the profile of patients presenting with resuscitated sudden cardiac death (RSCD). People in New Zealand presenting with RSCD are evaluated using a standardized approach and those determined to have CID are included in the registry. Patients were classified based on standard diagnostic criteria for each diagnostic category including long QT syndrome (LQTS), Brugada syndrome (BrS), hypertrophic cardiomyopathy (HCM), catecholaminergic polymorphic ventr...
Source: Heart Rhythm - June 14, 2020 Category: Cardiology Authors: Erica S. Zado Source Type: research

Impact of diabetes mellitus on left ventricular longitudinal function of patients with non-ischemic dilated cardiomyopathy
Left ventricular (LV) longitudinal dysfunction has been identified in type 2 diabetes mellitus (T2DM) patients with preserved LV ejection fraction (LVEF). However, the impact of T2DM on LV longitudinal functio... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 13, 2020 Category: Cardiology Authors: Hidekazu Tanaka, Kazuhiro Tatsumi, Hiroki Matsuzoe, Kensuke Matsumoto and Ken-ichi Hirata Tags: Original investigation Source Type: research

Treatment of Dilated Cardiomyopathy in a Mouse Model of Friedreich’s Ataxia using N-acetylcysteine and Identification of Alterations in MicroRNA Expression that Could be Involved in its Pathogenesis
Publication date: Available online 10 June 2020Source: Pharmacological ResearchAuthor(s): S. Chiang, M.L.H. Huang, D.R. Richardson (Source: Pharmacological Research)
Source: Pharmacological Research - June 11, 2020 Category: Drugs & Pharmacology Source Type: research

Pre-excitation cardiac problems in children: recognition and treatment
Conclusion: For ventricular pre-excitation co-exists with dilated cardiomyopathy, differential diagnosis of tachycardiomyopathy or accessory pathway-induced dilated cardiomyopathy should be considered. Catheter ablation (radiofrequency and cryoablation) is a relatively safe and effective treatment option and has become the first choice to treat children with ventricular pre-excitation.What is Known:• Persistent atrioventricular reentrant tachycardia in children can lead to tachycardiomyopathy;• Antiarrhythmic drugs that can be chosen for children are quite limited.What is New:• The anterograde conduction of ...
Source: European Journal of Pediatrics - June 11, 2020 Category: Pediatrics Source Type: research

Global analysis of histone modifications and long-range chromatin interactions revealed the differential cistrome changes and novel transcriptional players in human dilated cardiomyopathy
Acetylation and methylation of histones alter the chromatin structure and accessibility that affect transcriptional regulators binding to enhancers and promoters. The binding of transcriptional regulators enables the interaction between enhancers and promoters, thus affecting gene expression. However, our knowledge of these epigenetic alternations in patients with heart failure remains limited. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - June 10, 2020 Category: Cytology Authors: Chia-Feng Liu, Armen Abnousi, Peter Bazeley, Ying Ni, Michael Morley, Christine S. Moravec, Ming Hu, W.H. Wilson Tang Source Type: research

Rare intronic mutation between Exon 62 and 63 (c.9225-285A > G) of the dystrophin gene associated with atypical BMD phenotype: a case report
X-linked dystrophinopathies represent the most common pediatric muscular disorders. These include Duchenne muscular dystrophy (DMD; incidence 1:3800 –6000 live male births), Becker muscular dystrophy (BMD; 1:15000), and a rare X-linked dilated cardiomyopathy (1, 2). Whereas DMD is associated with a rapidly progressive loss of muscular function, with symptoms onset at 3–5 years old, and loss of ambulation at 9-11 years old, BMD is clinically less severe. Affected males remain ambulatory beyond the age of 16 (2). (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - June 10, 2020 Category: Neurology Authors: SC Sch üssler, T Gerhalter, A Abicht, W Müller-Felber, AM Nagel, R Trollmann Source Type: research

Bi-allelic missense disease-causing variants in RPL3L associate neonatal dilated cardiomyopathy with muscle-specific ribosome biogenesis
In conclusion, we report that bi-allelic pathogenic variants inRPL3L are causative of an early-onset, severe neonatal form of dilated cardiomyopathy, and we show for the first time that cytoplasmic ribosomal proteins are involved in the pathogenesis of non-syndromic cardiomyopathies. (Source: Human Genetics)
Source: Human Genetics - June 8, 2020 Category: Genetics & Stem Cells Source Type: research

X-linked dilated cardiomyopathy: the important role of genetic tests and imaging in the early diagnosis and treatment
Future Cardiology, Ahead of Print. (Source: Future Cardiology)
Source: Future Cardiology - June 8, 2020 Category: Cardiology Authors: Sotirios Tsalamandris Evangelos Oikonomou Georgia Vogiatzi Antigoni Miliou George Lazaros Christos Georgakopoulos Elias Gialafos Skevos Sideris Charalampos Vlachopoulos Dimitris Tousoulis Source Type: research

Sudden onset of thyrotoxicosis induced by amiodarone mimicking low cardiac output syndrome in a patient with dilated cardiomyopathy
Publication date: Available online 6 June 2020Source: Journal of Cardiology CasesAuthor(s): Keita Iyama, Hiroaki Kawano, Takao Ando, Satoshi Ikeda, Koji Maemura (Source: Journal of Cardiology Cases)
Source: Journal of Cardiology Cases - June 7, 2020 Category: Cardiology Source Type: research

Tead1 is essential for mitochondrial function in cardiomyocytes.
Abstract Mitochondrial dysfunction occurs in most forms of heart failure. We have previously reported that TEAD1, the transcriptional effector of Hippo pathway, is critical for maintaining adult cardiomyocyte function and its deletion in adult heart results in lethal acute dilated cardiomyopathy. Growing lines of evidence indicate that Hippo pathway plays a role in regulating mitochondrial function, though its role in cardiomyocytes is unknown. Here we show that TEAD1 plays a critical role in regulating mitochondrial OXPHOS in cardiomyocytes. Assessment of mitochondrial bioenergetics in isolated mitochondria from ...
Source: American Journal of Physiology. Heart and Circulatory Physiology - June 5, 2020 Category: Physiology Authors: Liu R, Jagannathan R, Sun L, Li F, Yang P, Lee J, Negi V, Perez-Garcia EM, Shiva S, Yechoor VK, Moulik M Tags: Am J Physiol Heart Circ Physiol Source Type: research

The prevalence of atrial premature complexes in healthy Doberman Pinschers and their role in the diagnosis of occult dilated cardiomyopathy
Publication date: Available online 3 June 2020Source: The Veterinary JournalAuthor(s): J. Eberhard, G. Wess (Source: The Veterinary Journal)
Source: The Veterinary Journal - June 4, 2020 Category: Veterinary Research Source Type: research

Generation of two patient-derived iPSC lines from siblings (LIBUCi001-A and LIBUCi002-A) and a genetically modified iPSC line (JMUi001-A-1) to mimic dilated cardiomyopathy with ataxia (DCMA) caused by a homozygous DNAJC19 mutation
Publication date: Available online 2 June 2020Source: Stem Cell ResearchAuthor(s): Anna Janz, Ruping Chen, Martina Regensburger, Yuichiro Ueda, Simone Rost, Eva Klopocki, Katharina Günther, Frank Edenhofer, Henry J. Duff, Süleyman Ergün, Brenda Gerull (Source: Stem Cell Research)
Source: Stem Cell Research - June 3, 2020 Category: Stem Cells Source Type: research

Hypertrophic and Dilated Cardiomyopathy-Associated Troponin T Mutations R130C and ΔK210 Oppositely Affect Length-Dependent Calcium Sensitivity of Force Generation
Length-dependent activation of calcium-dependent myocardial force generation provides the basis for the Frank-Starling mechanism. To directly compare the effects of mutations associated with hypertrophic cardiomyopathy and dilated cardiomyopathy, the native troponin complex in skinned trabecular fibers of guinea pigs was exchanged with recombinant heterotrimeric, human, cardiac troponin complexes containing different human cardiac troponin T subunits (hcTnT): hypertrophic cardiomyopathy-associated hcTnTR130C, dilated cardiomyopathy-associated hcTnTΔK210 or the wild type hcTnT (hcTnTWT) serving as control. Force-calci...
Source: Frontiers in Physiology - June 3, 2020 Category: Physiology Source Type: research

A retooled drug that restores ionic balance and cardiac function in dystrophin deficient hearts
Duchenne muscular dystrophy (DMD) is a devastating and fatal disease affecting ~1 in 3500 boys with dystrophin gene mutations [1,2]. Dystrophin plays important roles in sarcolemma stability and cell signaling in skeletal, smooth, and cardiac muscles [1,2]. DMD patients often die at a young age from dilated cardiomyopathy (DCM) or respiratory dysfunction. The use of ventilators has reduced respiratory failure in DMD patients and DCM associated heart failure (HF) is now a major cause of DMD patient death [1,2]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 3, 2020 Category: Cardiology Authors: Ryan D. Wuebbles, Dean J. Burkin Source Type: research

Elevated plasma levels of asymmetric dimethylarginine and the risk for arrhythmic death in ischemic and non-ischemic, dilated cardiomyopathy - a prospective, controlled long-term study.
Abstract INTRODUCTION: Elevated plasma levels of asymmetric dimethylarginine (ADMA), an inhibitor of NO synthase, are associated with adverse outcome. There is no data available, whether ADMA levels are associated with arrhythmic death (AD) in patients with ischemic cardiomyopathy (ICM) or non-ischemic, dilated cardiomyopathy (DCM). METHODS AND RESULTS: A total of 110 ICM, 52 DCM and 30 control patients were included. Primary outcome parameter of this prospective study was arrhythmic death (AD) or resuscitated cardiac arrest (RCA). Plasma levels of ADMA were significantly higher in ICM (p
Source: Clinical Biochemistry - June 3, 2020 Category: Biochemistry Authors: Leo Burger A, Stojkovic S, Diedrich A, Demyanets S, Wojta J, Pezawas T Tags: Clin Biochem Source Type: research

Cardiac magnetic resonance in cocaine-induced myocardial damage: cocaine, heart, and magnetic resonance
AbstractThe use of cocaine constitutes a major health problem. Cocaine use is associated with acute and chronic complications that might involve any system, the most common being the cardiovascular system. The precise incidence of cocaine-induced cardiomyopathy remains mysterious and probably underreported. Cocaine use should be considered in young patients presenting with chest pain or heart failure without other underlying risk factors. Cocaine-related cardiovascular complications can be acute or chronic and include ischemic and non-ischemic events. Frequent cocaine users have a seven-fold higher risk of myocardial infar...
Source: Heart Failure Reviews - June 2, 2020 Category: Cardiology Source Type: research

An unusual case of tropical pyomyositis: cryptococcal pyomyositis.
Abstract The more common manifestations of cryptococcal infections are restricted to the central nervous system and lungs. A young man, suffering from idiopathic dilated cardiomyopathy with a left ventricular ejection fraction of 20%, presented with subacute, painful tender swelling in both legs initially attributed to congestive cardiac failure. No response to diuretics was achieved. Metabolically active lesions in the muscles of both lower limbs suggestive of muscle abscesses were found. A diagnosis of tropical pyomyositis was therefore made, but aspiration surprisingly revealed gram-positive yeast cells, staini...
Source: Tropical Doctor - June 2, 2020 Category: Tropical Medicine Authors: Ramesh V, Polati VR, Prakasham PS, Narreddy S, Saidulu G, Varahala S Tags: Trop Doct Source Type: research

High expression levels and localization of Sox5 in dilated cardiomyopathy.
Authors: Liu Y, Jiang B, Cao Y, Chen W, Yin L, Xu Y, Qiu Z Abstract Dilated cardiomyopathy (DCM) is a disease that can lead to heart expansion and severe heart failure, but the specific pathogenesis remains unclear. Sox5 is a member of the Sox family with a key role in cardiac function. However, the role of Sox5 in DCM remains unclear. In the present study, wild‑type mice were intraperitoneally injected with doxorubicin (Dox) to induce DCM, and heart specimens from human patients with DCM were used to investigate the preliminary role of Sox5 in DCM. The present study demonstrated that, compared with control human...
Source: Molecular Medicine Reports - May 31, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

SCN5a overlap syndromes. This episode: long QT syndrome type 3 meets multifocal ectopic Purkinje-related premature contractions.
The SCN5a gene encodes the ion-conducting subunit (Nav1.5) of the cardiac sodium channel. The main function of Nav1.5 is to enable a large and rapid, but transient, influx of sodium ions (INa) during the upstroke phase of the cardiac action potential. By doing so, Nav1.5 is responsible for the initiation of the cardiac action potential and thereby cardiac excitability. SCN5a mutations have been associated with inheritable syndromes, long QT syndrome type 3 (LQT3) in 1995, Brugada syndrome (BrS) in 1998, and several other diseases in the years thereafter, e.g., cardiac conduction disease, sick sinus syndrome, atrial fibrill...
Source: Heart Rhythm - May 31, 2020 Category: Cardiology Authors: Ahmad S. Amin Source Type: research

Ruptured cerebral mycotic aneurysm in a left ventricular assist device patient with bacteremia.
Abstract A 50-year-old male with a history of nonischemic dilated cardiomyopathy presented in cardiogenic shock and ultimately underwent durable left ventricular assist device implantation. He recovered well initially but developed persistent bacteremia. His indwelling pacemaker leads were extracted due to evidence of vegetation. Shortly thereafter, around 3 months post-left ventricular assist device, he succumbed to a massive intracranial hemorrhage due to ruptured cerebral mycotic aneurysm. This case highlights the potential importance of brain imaging in left ventricular assist device patients with persi...
Source: The International Journal of Artificial Organs - May 30, 2020 Category: Transplant Surgery Authors: Fisher B, Seese L, Mathier MA, Sultan I, Kilic A Tags: Int J Artif Organs Source Type: research

Serum alarmin S100A8/S100A9 levels and its potential role as biomarker in myocarditis
AbstractAimsThe alarmin S100A8/S100A9 (S100A8/A9) is released by activated monocytes/macrophages and neutrophils in the setting lymphocytic myocarditis (MC). We recently demonstrated its therapeutic potential in experimental acute MC. Now, we investigated the diagnostic relevance of S100A8/A9 serum levels in patients with suspected acute and chronic MC and in patients with heart failure without cardiac inflammation.Methods and ResultsSerum S100A8/A9 levels were analysed in patients with a recent onset of MC [ ≤ 30 days,n = 32; ejection fraction (EF): 45.4 ± 12.9%], dilated cardiomyopathy ...
Source: ESC Heart Failure - May 28, 2020 Category: Cardiology Authors: Irene M üller, Thomas Vogl, Uwe Kühl, Alexander Krannich, Aron Banks, Tobias Trippel, Michel Noutsias, Alan S. Maisel, Sophie Linthout, Carsten Tschöpe Tags: Original Research Article Source Type: research

A Novel Extracorporeal Continuous-Flow Ventricular Assist System for Patients With Advanced Heart Failure  - Initial Clinical Experience.
CONCLUSIONS: This novel extracorporeal VAD system with a hydrodynamically levitated centrifugal pump can safely and successfully bridge patients with advanced heart failure to subsequent therapeutic stages. PMID: 32461539 [PubMed - as supplied by publisher] (Source: Circulation Journal)
Source: Circulation Journal - May 28, 2020 Category: Cardiology Authors: Seguchi O, Fujita T, Kitahata N, Iwasaki K, Kuroda K, Nakajima S, Watanabe T, Yanase M, Fukushima S, Tsukiya T, Katagiri N, Mizuno T, Takewa Y, Hamasaki T, Onda K, Hayashi T, Yamamoto H, Tatsumi E, Kobayashi J, Fukushima N Tags: Circ J Source Type: research

Development of severe heart failure in a patient with squamous non-small-cell lung cancer during nivolumab treatment.
Authors: Samejima Y, Iuchi A, Kanai T, Noda Y, Nasu S, Tanaka A, Morishita N, Suzuki H, Okamoto N, Harada H, Ezumi A, Ueda K, Kawahara K, Hirashima T Abstract Cardiac side effects associated with immune checkpoint inhibitors (ICIs) are an uncommon but serious complication with a relatively high mortality. We experienced a case of cardiomyopathy induced by nivolumab. Echocardiography showed diffuse hypo-kinesis of the left ventricular cardiac wall and a significant decrease in the ejection fraction, like dilated cardiomyopathy. The myocardial biopsy showed non-inflammatory change; cardiac function gradually improved...
Source: Internal Medicine - May 27, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

Parameters of left ventricular systolic and diastolic dyssynchrony on radionuclide imaging to improve cardiac resynchronization therapy in heart failure patients with dilated cardiomyopathy
(Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 26, 2020 Category: Nuclear Medicine Source Type: research

Contemporary Survival Trends and etiological characterization in non ‐ischemic Dilated Cardiomyopathy
AbstractBackgroundContemporary survival trends of Dilated Cardiomyopathy (DCM) patients are largely unknown. The aims of this study are to describe clinical descriptors, survival trends and the prognostic impact of etiological characterization in DCM patients.MethodsDCM patients were consecutively enrolled and divided into 4 groups according to the period of enrolment: 1st: 1978 ‐1984; 2nd: 1985 ‐1994; 3rd: 1995 ‐2004; 4th: 2005 ‐2015. A cohort of patients with DCM with specific etiology, enrolled from 2005 to 2015, was also analyzed.ResultsOver a mean follow ‐up of 12±8 years, 1284 DCM patients (52...
Source: European Journal of Heart Failure - May 25, 2020 Category: Cardiology Authors: M Merlo, A Cannat à, C Pio Loco, D Stolfo, G Barbati, J Artico, P Gentile, V De Paris, F Ramani, M Zecchin, M Gigli, B Pinamonti, R Korcova, A Di Lenarda, M Giacca, L Mestroni, PG Camici, G Sinagra Tags: Research Article Source Type: research

Protein-protein correlations based variable dimension expansion algorithm for high efficient serum biomarker discovery.
In this study, we constructed a high specific and efficient serum biomarker discovery pipeline. We utilized dysregulated proteins identified in primary tissue and potentially secreted into the blood as biomarker candidates. The scheduled multiple reaction monitoring method was performed to accurately quantify and verify these candidates directly in serum, thus circumventing the effects of high-abundance proteins. We then generated new variables through assigning values to protein-protein correlations to extend the dimensionality of the dataset (PPC-VDE), and the specificity of disease classification. We successfully applie...
Source: Analytica Chimica Acta - May 23, 2020 Category: Chemistry Authors: Xie J, Zhang L, Chen Z, Hu A, Liu S, Lu D, Xia Y, Qian J, Yang P, Shen H Tags: Anal Chim Acta Source Type: research

A new perspective of an old tool: an everlasting benefit of the electrocardiogram in dilated cardiomyopathy
European Journal of Heart Failure, EarlyView. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - May 21, 2020 Category: Cardiology Authors: Petar M. Seferovi ć, Marija M. Polovina Tags: Editorial Comment Source Type: research

Unmasking features of the auto ‐epitope essential for β1‐adrenoceptor activation by autoantibodies in chronic heart failure
ConclusionsThe conformational auto ‐epitope targeted by cardio‐pathogenic β1‐receptor autoantibodies is faithfully conserved in cyclopeptide homologues of the β1ECII loop bearing the NDPK211 –214 motif and the C209↔C215 bridge while lacking cysteine C216. Such molecules provide promising tools for novel diagnostic and therapeutic approaches in β1‐autoantibody‐positive CHF. (Source: ESC Heart Failure)
Source: ESC Heart Failure - May 21, 2020 Category: Cardiology Authors: Angela W ölfel, Mathias Sättele, Christina Zechmeister, Viacheslav O. Nikolaev, Martin J. Lohse, Fritz Boege, Roland Jahns, Valérie Boivin‐Jahns Tags: Original Research Article Source Type: research