Cardiac Proteome Profiling in Ischemic and Dilated Cardiomyopathy Mouse Models
Heart failure is a worldwide pandemic with an unacceptable high level of morbidity and mortality. Understanding the different pathophysiological mechanisms will contribute to prevention and individualized therapy of heart failure. We established mouse models for ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) by inducing myocardial infarction and Coxsackievirus B3 infection respectively. Isobaric tags for relative and absolute quantitation and liquid chromatography coupled with tandem mass spectrometry technology was used to identify the protein expression profiles in control and failing hearts. A total of 1...
Source: Frontiers in Physiology - June 18, 2019 Category: Physiology Source Type: research

Characterization of a Mouse Model of Hypereosinophilia-Associated Heart Disease.
Abstract Hypereosinophilic syndrome is characterized by sustained and marked eosinophilia leading to tissue damage and organ dysfunction. Morbidity and mortality occur primarily due to cardiac and thromboembolic complications. Understanding the cause and mechanism of disease would aid in the development of targeted therapies with greater efficacy and fewer side effects. We discovered a spontaneous mouse mutant in our colony with a hypereosinophilic phenotype. Mice develop peripheral blood eosinophilia, infiltration of lungs, spleen and heart by eosinophils, and extensive myocardial damage and remodeling. This ulti...
Source: American Journal of Physiology. Heart and Circulatory Physiology - June 14, 2019 Category: Physiology Authors: Prows DR, Klingler A, Gibbons WJ, Homan SM, Zimmermann N Tags: Am J Physiol Heart Circ Physiol Source Type: research

Limb-Girdle Muscular Dystrophies (LGMDs): The Clinical Application of NGS Analysis, a Family Case Report
The diagnosis of LGMD2A (calpainopathy) can be challenging due to genetic heterogeneity and to high similarity with other LGMDs or neuromuscular disorders. In this setting, NGS panels are highly recommended to perform differential diagnosis, identify new causative mutations and enable genotype-phenotype correlations. In this manuscript, the case of a patient affected by LGMD2A is reported, for which the application of a defined custom designed NGS panel allowed to confirm the diagnosis of calpainopathy linked with two heterozygous variants in CAPN3, namely c.550delA and c.1813G>C. The first variant has been extensively ...
Source: Frontiers in Neurology - June 13, 2019 Category: Neurology Source Type: research

Trends in the use of implantable cardioverter ‐defibrillators for prevention of sudden cardiac arrest: A South Korean nationwide population‐based study
AbstractBackgroundThe benefits of implantable cardioverter ‐defibrillators (ICDs) for the prevention of sudden cardiac arrest (SCA) are well established. However, a significant knowledge gap remains regarding current indications and utilization of ICDs in real‐world settings in Asia.MethodsPatients who underwent ICD implantation in South Korea from 2007 to 2015 were identified using the Health Insurance Review and Assessment Service database. We investigated trends in use of ICD for prevention of SCA.ResultsA total of 4,649 ICDs were implanted during the 9 years. ICDs were implanted in 1,448 (31.2%) patients for primar...
Source: Pacing and Clinical Electrophysiology : PACE - June 13, 2019 Category: Cardiology Authors: Seung ‐Young Roh, Jong‐Il Choi, Min Sun Kim, Eun Young Cho, Yun Gi Kim, Kwang‐No Lee, Yong‐Soo Baek, Jaemin Shim, Jin Seok Kim, Sang‐Weon Park, Sumeet S. Chugh, Young‐Hoon Kim Tags: DEVICES Source Type: research

Genetic Variants Are Not Rare in ICD Candidates with Dilated Cardiomyopathy: Time for Next-Generation Sequencing?
Conclusion: In patients with DCM and ICD, genetic variants could be identified in a significant proportion of patients in several genes, highlighting the potential role of genetics in DCM SCD risk stratification. PMID: 31179125 [PubMed] (Source: Cardiology Research and Practice)
Source: Cardiology Research and Practice - June 12, 2019 Category: Cardiology Authors: Sousa A, Canedo P, Campelo M, Moura B, Leite S, Baixia M, Belo A, Rocha-Gonçalves F, Machado JC, Silva-Cardoso J, Martins E, Fatima Investigators Tags: Cardiol Res Pract Source Type: research

Diagnostic Value of Different Noninvasive Criteria of Latent Myocarditis in Comparison with Myocardial Biopsy
Conclusion: AHA have the greatest significance in the diagnosis of latent myocarditis in patients with “idiopathic” arrhythmias and DCM. The use of a complex of noninvasive criteria allows the probability of myocarditis to be estimated and the indications for EMB to be determined.Cardiology (Source: Cardiology)
Source: Cardiology - June 12, 2019 Category: Cardiology Source Type: research

Using Machine Learning to Predict One-year Cardiovascular Events in Patients with Severe Dilated Cardiomyopathy
ConclusionsML effectively predicted risk in patients with severe DCM in 1-year follow-up, and this may direct risk stratification and patient management in the future. (Source: European Journal of Radiology)
Source: European Journal of Radiology - June 12, 2019 Category: Radiology Source Type: research

ECG in dilated cardiomyopathy: specific findings and long-term prognostic significance
Conclusion The exhaustive systematic evaluation of ECG has an incremental impact in the prognostication of a large cohort of DCM patients, also regarding the arrhythmic stratification. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - June 11, 2019 Category: Cardiology Tags: Research articles: Heart failure Source Type: research

Stem cell therapy in heart failure: Where do we stand today?
This article is part of a Special Issue entitled: Stem Cells and Their Applications to Human Diseases edited by Hemachandra Reddy. (Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease)
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - June 11, 2019 Category: Molecular Biology Source Type: research

Dilated cardiomyopathy in a national paediatric population
This study aims to review the aetiology and associated outcomes of DCM. The median age at diagnosis was 6  months (0–42 months);n = 23 (43.3%) were idiopathic;n = 11 (20.9%) secondary to a viral infection;n = 12 (22.6%) genetic disorders andn = 7 (13.2%) as a result of vitamin D deficiency. There was a significant correlation between aetiology and mortality,r = 0.85, with a lower survival rate in idiopathic and genetic cohorts. Males were significantly less likely to survive to 1 year of age,p = 0.035. The age at diagno...
Source: European Journal of Pediatrics - June 11, 2019 Category: Pediatrics Source Type: research

Heterozygous Mylk3 Knockout Mice Partially Recapitulate Human DCM With Heterozygous MYLK3 Mutations
Conclusion: Heterozygous Mylk3 knockout mice show mild reduction of cardiac contractility by 4 months of age, and proteins reduced by approximately 75% relative to the control wild-type mice. These mice partly resemble human with the heterozygous MYLK3 mutation, but the reduction in cardiac contractility was milder. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - June 6, 2019 Category: Physiology Source Type: research

Cardiovascular magnetic resonance with parametric mapping in long-term ultra-marathon runners
ConclusionsUltra-marathon runner's hearts demonstrate a high degree of structural remodelling, but there is no significant increase in focal or diffuse myocardial fibrosis. (Source: European Journal of Radiology)
Source: European Journal of Radiology - June 4, 2019 Category: Radiology Source Type: research

Cardio-embolic stroke: Lessons from a single centre in Sub-Saharan Africa.
CONCLUSION: CES accounted for 1/4 of ischemic stroke with a high risk of early death and long-term recurrence. Atrial fibrillation was the leading cause of CES. The association of VKA and anti-platelet agent should be avoided to reduce early death during acute stroke. PMID: 31155304 [PubMed - as supplied by publisher] (Source: Revue Neurologique)
Source: Revue Neurologique - June 4, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Left bundle branch block-induced cardiomyopathy: a diagnostic proposal for a poorly explored pathological entity
Despite being increasingly recognized as a specific disease, at the present time left bundle branch block (LBBB)-induced cardiomyopathy is neither formally included among unclassified cardiomyopathies nor among the acquired/non-genetic forms of dilated cardiomyopathy (DCM). Currently, a post-hoc diagnosis of LBBB-induced cardiomyopathy is possible when evaluating patients' response to cardiac resynchronization therapy (CRT). However, an early detection of a LBBB-induced cardiomyopathy could have significant clinical and therapeutic implications. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 4, 2019 Category: Cardiology Authors: Giuseppe D. Sanna, Marco Merlo, Eleonora Moccia, Enrico Fabris, Stefano L. Masia, Gherardo Finocchiaro, Guido Parodi, Gianfranco Sinagra Source Type: research

Ventricular fibrillation undersensing due to air entrapment in a patient implanted with a subcutaneous cardioverter defibrillator
This article is protected by copyright. All rights reserved. (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - June 4, 2019 Category: Cardiology Authors: Carmen Adduci, Loris Spadoni, Francesca Palano, Pietro Francia Tags: EP IMAGE Source Type: research

Successful treatment with voriconazole combined with amphotericin B-liposome for fluconazole-resistant pulmonary cryptococcosis after renal transplantation
In conclusion, this case shows the efficacy of VRCZ combined with L-AMB for refractory pulmonary cryptococcosis. (Source: CEN Case Reports)
Source: CEN Case Reports - June 3, 2019 Category: Urology & Nephrology Source Type: research

Targeted Mono-Therapy for Newly Diagnosed Dilated Cardiomyopathy
In patients with Stage C heart failure with reduced ejection fraction (HFrEF), guidelines recommend initiating combined therapy with angiotensin-converting enzyme inhibition (ACEI) or angiotensin receptor blockade (ARB) and specific beta adrenergic receptor blockade (BARB).1 However, mono-therapy with BARB may be preferable to combined ACEI/ARB and BARB therapy in a subset of patients with newly diagnosed dilated cardiomyopathy. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - May 31, 2019 Category: Cardiology Authors: Indranee Rajapreyar, Rohan Samson, Pierre Vladimir Ennezat, Thierry H Le Jemtel Source Type: research

Sex differences in the long-term prognosis of dilated cardiomyopathy
Publication date: Available online 30 May 2019Source: Canadian Journal of CardiologyAuthor(s): Antonio Cannatà, Enrico Fabris, Marco Merlo, Jessica Artico, Piero Gentile, Carola Pio Loco, Andrea Ballaben, Federica Ramani, Giulia Barbati, Gianfranco SinagraAbstractBackgroundDilated Cardiomyopathy (DCM) represents a specific phenotype of heart failure (HF). Sex differences in the long-term prognosis of patients with DCM are unknown. Aim of this study is to investigate the long-term prognostic role of gender in a large cohort of DCM patients.Methods1113 DCM patients have been prospectively enrolled. To investigate the ...
Source: Canadian Journal of Cardiology - May 30, 2019 Category: Cardiology Source Type: research

Association of Soluble ST2 Serum Levels With Outcomes in Pediatric Dilated Cardiomyopathy
This study aimed to assess the prognostic value of sST2 in PDCM.MethodsNinety-four patients with PDCM were enrolled after admission from 2 centres in China and followed up for adverse events (death, cardiac transplantation, and heart-failure–related rehospitalization). B-type natriuretic peptide (BNP) and sST2 levels were measured.ResultsOver a median of 678 (interquartile range [IQR]: 533-785) days, 28 (29.8%) adverse events occurred. Patients in the highest tertile of sST2 levels had increased risk of short-term (
Source: Canadian Journal of Cardiology - May 30, 2019 Category: Cardiology Source Type: research

Higher Body Mass Index in Adolescence Predicts Cardiomyopathy Risk in Midlife: Long-Term Follow-Up Among Swedish Men.
M, Rosengren A Abstract BACKGROUND: Modifiable lifestyle factors in relation to risk for cardiomyopathy, a common and increasing cause of heart failure in the young, have not been widely studied. We sought to investigate a potential link between obesity, a recognized predictor of early heart failure, in adolescence and being diagnosed with cardiomyopathy in adulthood. METHODS: This was a nationwide register-based prospective cohort study of 1 668 893 adolescent men (mean age, 18.3 years; SD, 0.7 years) who enlisted for compulsory military service from 1969 to 2005. At baseline, body mass index (BMI), blood pr...
Source: Circulation - May 28, 2019 Category: Cardiology Authors: Robertson J, Schaufelberger M, Lindgren M, Adiels M, Schiöler L, Torén K, McMurray J, Sattar N, Åberg M, Rosengren A Tags: Circulation Source Type: research

Ultimate Third Heart Sound.
Authors: Shono A, Mori S, Yatomi A, Kamio T, Sakai J, Soga F, Tanaka H, Hirata KI Abstract A 79-year-old man with dilated cardiomyopathy and severe functional mitral regurgitation presented with general fatigue and dyspnea. Auscultation revealed a systolic regurgitant murmur with a minimized second heart sound due to a low output. On the other hand, the third heart sound was ultimately enhanced, being visible and palpable as a pulsatile knock of the precordium. Phonocardiography and echocardiography successfully confirmed early-diastolic rapid distension of the left ventricle along with rapid ventricular filling an...
Source: Internal Medicine - May 24, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

Rapidly Progressive Heart Failure in a Female Carrier of Becker Muscular Dystrophy with No Skeletal Muscle Symptoms.
Authors: Komoriyama H, Fukushima A, Takahashi Y, Kinugawa S, Sera F, Ohtani T, Nakamura A, Sakata Y, Anzai T Abstract Becker muscular dystrophy (BMD) carriers are at risk to developing cardiac dysfunction. The prevalence of female BMD carriers remains underestimated, and the disease progression varies. We herein report the case of a young female BMD carrier who developed dilated cardiomyopathy (DCM) and heart failure without any skeletal muscle signs. Her cardiac dysfunction progressed over a mere two months, resulting in the need for left ventricular assist device implantation. Her case demonstrates that progressi...
Source: Internal Medicine - May 24, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

Relationships between left ventricular geometry (sphericity index) and remodeling in dilated cardiomyopathy.
Authors: Dziewięcka E, Wiśniowska-Śmiałek S, Khachatryan L, Karabinowska A, Szymonowicz M, Podolec P, Rubiś P Abstract BACKGROUND: Since left ventricular reverse remodeling (LVRR) and sphericity index (SI) are correlated with DCM patients' survival, we attempted to establish the relationship between LVRR, SI and left ventricle (LV) dimensions. METHODS: In 70 DCM patients, we measured EF, LV transverse (sLVd) and longitudinal (lLVd) diameters at hospital admission, then after 3 and 12 months. SI was assessed thus: SI=sLVd/lLVd. RESULTS: LVRR was present in 32 patients (52%). SI measurements were similar...
Source: Minerva Cardioangiologica - May 24, 2019 Category: Cardiology Tags: Minerva Cardioangiol Source Type: research

Analysis of Cre-mediated genetic deletion of Gdf11 in cardiomyocytes of young mice.
Abstract Administration of active growth differentiation factor 11 (GDF11) to aged mice can reduce cardiac hypertrophy, and low serum levels of GDF11 measured together with the related protein, myostatin (also known as GDF8), predict future morbidity and mortality in coronary heart patients. Using mice with a loxP-flanked ("floxed") allele of Gdf11 and Myh6-driven expression of Cre recombinase to delete Gdf11 in cardiomyocytes, we tested the hypothesis that cardiac-specific Gdf11 deficiency might lead to cardiac hypertrophy in young adulthood. We observed that targeted deletion of Gdf11 in cardiomyocytes...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 24, 2019 Category: Physiology Authors: Garbern J, Kristl AC, Bassaneze V, Vujic A, Schoemaker H, Sereda R, Peng L, Ricci-Blair EM, Goldstein JM, Walker RG, Bhasin S, Wagers AJ, Lee RT Tags: Am J Physiol Heart Circ Physiol Source Type: research

Rare indication for cardioverter ‑defibrillator implantation: propionic acidemia complicated by dilated cardiomyopathy and prolonged QT interval.
Rare indication for cardioverter‑defibrillator implantation: propionic acidemia complicated by dilated cardiomyopathy and prolonged QT interval. Kardiol Pol. 2019 May 24;77(5):584-585 Authors: Peregud-Pogorzelska M, Kaźmierczak J, Zielska M, Pobłocki J, Walczak M, Giżewska M PMID: 31125033 [PubMed - in process] (Source: Polish Heart Journal)
Source: Polish Heart Journal - May 24, 2019 Category: Cardiology Authors: Peregud-Pogorzelska M, Kaźmierczak J, Zielska M, Pobłocki J, Walczak M, Giżewska M Tags: Kardiol Pol Source Type: research

Coronary angiographic findings in dilated cardiomyopathy in a sub-Saharan African population.
Abstract AIM: To describe the coronary angiographic aspects observed in patients with dilated cardiomyopathies (DCM) in a sub-Saharan African country in order to improve their management. METHODS: This was a cross-sectional study conducted from 1 January 2010 to 31 March 2016. All patients aged 18 years and older, presenting with DCM and admitted to Abidjan Heart Institute, who underwent coronary angiography were included. One hundred and eight patients were selected. We analysed and compared the coronary angiographic features observed. RESULTS: The median age of our patients was 52 years (46-61). There ...
Source: Cardiovascular Journal of Africa - May 24, 2019 Category: Cardiology Authors: N'Guetta R, Yao H, Ehouman E, Ekou A, Anzouan-Kacou JB, Coulibaly I, Hauhouot-Attoungbre ML, Kramoh E, Yapobi Y, Seka R Tags: Cardiovasc J Afr Source Type: research

SCN5A Variant R222Q generated abnormal changes in cardiac sodium current and action potentials in murine myocytes and Purkinje cells
The cardiac sodium channel (SCN5A) mutation, R222Q, neutralizes a positive charge in the domain I voltage sensor. Mutation carriers display very frequent ectopy and dilated cardiomyopathy (DCM). (Source: Heart Rhythm)
Source: Heart Rhythm - May 21, 2019 Category: Cardiology Authors: Laura L. Daniel, Tao Yang, Brett Kroncke, Lynn Hall, Dina Stroud, Dan M. Roden Source Type: research

Preliminary Study on the Diagnostic Value of 11C-PIB PET/MR in cardiac amyloidosis
Conclusions: 11C-PIB PET/MR may be valuable in the noninvasive diagnosis of CA. Further study with a larger cohort of patients would be needed to confirm it. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 21, 2019 Category: Nuclear Medicine Authors: Bi, X., Liu, J., Dong, W., Guan, Z., Zhang, X., An, J., Xu, B., Tian, J. Tags: Cardiovascular YIA Symposium Source Type: research

Myocardial extracellular volume fraction measurements with MOLLI 5(3)3 by cardiovascular MRI for the discrimination of healthy volunteers from dilated and hypertrophic cardiomyopathy patients
To investigate the diagnostic performance of myocardial native T1 time and the extracellular volume fraction (ECV) for differentiating dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM) patients from healthy volunteers. (Source: Clinical Radiology)
Source: Clinical Radiology - May 20, 2019 Category: Radiology Authors: Y. Cui, Y. Chen, Y. Cao, J. Liu, J. Song, S. Zhang, X. Kong, P. Han, H. Shi Source Type: research

Irish Wolfhounds with Subclinical Atrial Fibrillation: Progression of Disease and Causes of Death
ConclusionIW with subclinical AF commonly develop DCM and die from cardiac death. (Source: Journal of Veterinary Cardiology)
Source: Journal of Veterinary Cardiology - May 17, 2019 Category: Veterinary Research Source Type: research

Risk of adverse events related to prolonged antibiotic use in patients diagnosed with Baggio-Yoshinari syndrome, or autochthonous Lyme-like disease, in Brazil
We report the case of a 67-year-old man with a consumptive syndrome with two subpleural pulmonary opacities. A transthoracic lung biopsy revealed a Dirofilaria worm. Myocardial nuclear magnetic resonance (NMR) demonstrated dilated cardiomyopathy after myocarditis related to dirofilariasis. Human infection is rare and occurs accidentally. The most common radiological alteration is a mainly subpleural coin lesion. Dirofilariasis is a neglected emergent disease and knowledge about it is important for differential diagnoses from neoplastic pulmonary nodules. (Source: Revista da Sociedade Brasileira de Medicina Tropical)
Source: Revista da Sociedade Brasileira de Medicina Tropical - May 17, 2019 Category: Tropical Medicine Source Type: research

Treatment of hepatic alveolar echinococcosis infringing the inferior vena cava
We report the case of a 67-year-old man with a consumptive syndrome with two subpleural pulmonary opacities. A transthoracic lung biopsy revealed a Dirofilaria worm. Myocardial nuclear magnetic resonance (NMR) demonstrated dilated cardiomyopathy after myocarditis related to dirofilariasis. Human infection is rare and occurs accidentally. The most common radiological alteration is a mainly subpleural coin lesion. Dirofilariasis is a neglected emergent disease and knowledge about it is important for differential diagnoses from neoplastic pulmonary nodules. (Source: Revista da Sociedade Brasileira de Medicina Tropical)
Source: Revista da Sociedade Brasileira de Medicina Tropical - May 17, 2019 Category: Tropical Medicine Source Type: research

Scorpionism in Brazil: exponential growth of accidents and deaths from scorpion stings
We report the case of a 67-year-old man with a consumptive syndrome with two subpleural pulmonary opacities. A transthoracic lung biopsy revealed a Dirofilaria worm. Myocardial nuclear magnetic resonance (NMR) demonstrated dilated cardiomyopathy after myocarditis related to dirofilariasis. Human infection is rare and occurs accidentally. The most common radiological alteration is a mainly subpleural coin lesion. Dirofilariasis is a neglected emergent disease and knowledge about it is important for differential diagnoses from neoplastic pulmonary nodules. (Source: Revista da Sociedade Brasileira de Medicina Tropical)
Source: Revista da Sociedade Brasileira de Medicina Tropical - May 17, 2019 Category: Tropical Medicine Source Type: research

Human pulmonary dirofilariasis with secondary myocarditis
We report the case of a 67-year-old man with a consumptive syndrome with two subpleural pulmonary opacities. A transthoracic lung biopsy revealed a Dirofilaria worm. Myocardial nuclear magnetic resonance (NMR) demonstrated dilated cardiomyopathy after myocarditis related to dirofilariasis. Human infection is rare and occurs accidentally. The most common radiological alteration is a mainly subpleural coin lesion. Dirofilariasis is a neglected emergent disease and knowledge about it is important for differential diagnoses from neoplastic pulmonary nodules. (Source: Revista da Sociedade Brasileira de Medicina Tropical)
Source: Revista da Sociedade Brasileira de Medicina Tropical - May 17, 2019 Category: Tropical Medicine Source Type: research

Dilated Cardiomyopathy.
PMID: 31082299 [PubMed - in process] (Source: Circulation)
Source: Circulation - May 14, 2019 Category: Cardiology Authors: Knowlton KU Tags: Circulation Source Type: research

A Quality Bundle to Support High-Risk Pediatric Ventricular Assist Device Implantation
AbstractPediatric ventricular assist device (VAD) implantation outcomes are increasingly promising for children with dilated cardiomyopathy and advanced decompensated heart failure (ADHF). VAD placement in patients with clinical features such as complex congenital cardiac anatomy, small body size, or major comorbidities remains problematic. These comorbidities have been traditionally prohibitive for VAD consideration leaving these children as a treatment-orphaned population. Here we describe the quality bundle surrounding these patients with ADHF considered high risk for VAD implantation at our institution. Over a 7-year p...
Source: Pediatric Cardiology - May 13, 2019 Category: Cardiology Source Type: research

Endovascular treatment of stroke in children under 2 years with heart failure and ventricular assist device.
CONCLUSION: As a result of the difficulty in performing arterial puncture, the small vessel calibre and the limitation in the use of iodated contrast, there are certain limitations to endovascular treatment of strokes in children that can lead to complications. A multidisciplinary approach to managing such cases would be helpful. PMID: 31072251 [PubMed - as supplied by publisher] (Source: Interventional Neuroradiology)
Source: Interventional Neuroradiology - May 12, 2019 Category: Radiology Tags: Interv Neuroradiol Source Type: research

Protosappanin A protects against experimental autoimmune myocarditis, and induces metabolically reprogrammed tolerogenic DCs
In conclusion, PrA endows DC with a tolerogenic profile via glycolytic reprogramming, thereby inducing expansion of immunosuppressive Tregs, and preventing EAM progress. Our results suggested that PrA may confer immunosuppressive and protective effects on EAM by metabolically reprogramming DCs, which could contribute to the development of a new potential immunotherapy for the treatment of EAM and immune-related disorders. (Source: Pharmacological Research)
Source: Pharmacological Research - May 11, 2019 Category: Drugs & Pharmacology Source Type: research

Effect and safety of treatment with ACE-inhibitor Enalapril and β-blocker metoprolol on the onset of left ventricular dysfunction in Duchenne muscular dystrophy - a randomized, double-blind, placebo-controlled trial
X-linked Duchenne muscular dystrophy (DMD), the most frequent human hereditary skeletal muscle myopathy, inevitably leads to progressive dilated cardiomyopathy. We assessed the effect and safety of a combined ... (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - May 10, 2019 Category: Internal Medicine Authors: Sven Dittrich, Erika Graf, Regina Trollmann, Ulrich Neudorf, Ulrike Schara, Antje Heilmann, Maja von der Hagen, Brigitte Stiller, Janbernd Kirschner, Robert Dalla Pozza, Wolfgang M üller-Felber, Katja Weiss, Katja von Au, Markus Khalil, Reinald Motz, Chr Tags: Research Source Type: research

Outcomes and Effect of Treatment According to Etiology in HFrEF: An Analysis of PARADIGM-HF
ConclusionsJust under half of patients in this global trial had nonischemic HF with reduced ejection fraction, with idiopathic and hypertensive the most commonly ascribed etiologies. Adjusted outcomes were similar across etiologic categories, as was the benefit of sacubitril/valsartan over enalapril. (Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality of Patients With Chronic Heart Failure; NCT01035255)Central Illustration (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - May 9, 2019 Category: Cardiology Source Type: research

Dilated cardiomyopathy and limb-girdle muscular dystrophy-dystroglycanopathy due to novel pathogenic variants in the DPM3 gene
Abnormalities of the N-glycosylation and O-mannosylation pathways are respectively involved in congenital disorders of glycosylation (CDG) and alpha-dystroglycanopathies [1 –4]. Dolichol-P-mannose (DPM) is produced by the DPM synthase and plays an important role, as a mannosyl donor, in four different glycosylation pathways (N-glycosylation, C-mannosylation, glycosyl-phosphatidylinositol anchor assembly, and O-mannosylation) [1]. DPM synthase is composed of three sub units; DPM3 anchors the cytoplasmic catalytic subunit DPM1 to the endoplasmic reticulum membrane, and DPM2 stabilizes the complex [5–7]. (Source: ...
Source: Neuromuscular Disorders - May 9, 2019 Category: Neurology Authors: J. Svahn, P. Lafor êt, C. Vial, N. Streichenberger, N. Romero, C. Bouchet-Séraphin, A. Bruneel, T. Dupré, N. Seta, R. Menassa, L. Michel-Calemard, T. Stojkovic Tags: Case report Source Type: research

2019 HRS Expert Consensus Statement on Evaluation, Risk Stratification, and Management of Arrhythmogenic Cardiomyopathy
Arrhythmogenic cardiomyopathy (ACM) is an arrhythmogenic disorder of the myocardium not secondary to ischemic, hypertensive or valvular heart disease. ACM incorporates a broad spectrum of genetic, systemic, infectious, and inflammatory disorders. This designation includes, but is not limited to, arrhythmogenic right/left ventricular cardiomyopathy, cardiac amyloid and sarcoidosis, Chagas ’ disease and left ventricular noncompaction. The ACM phenotype overlaps with other cardiomyopathies, particularly dilated cardiomyopathy with arrhythmia presentation which may be associated with ventricular dilatation and/or impaire...
Source: Heart Rhythm - May 9, 2019 Category: Cardiology Authors: Jeffrey A. Towbin, William J. McKenna, Dominic J. Abrams, Michael J. Ackerman, Hugh Calkins, Francisco C.C. Darrieux, James P. Daubert, Christian de Chillou, Eugene C. DePasquale, Milind Y. Desai, N.A. Mark Estes, Wei Hua, Julia H. Indik, Jodie Ingles, Cy Source Type: research

Left Ventricular Relaxation Half-Time as a Predictor of Cardiac Events in Idiopathic Dilated Cardiomyopathy and Hypertrophic Cardiomyopathy with Left Ventricular Systolic and /or Diastolic Dysfunction
Diastolic dysfunction preceding systolic dysfunction is considered an important interaction in cardiomyopathy with poor prognosis. The aim of this study was to compare left ventricular (LV) isovolumic relaxation with the other parameters as a potential prognostic marker for patients with idiopathic dilated cardiomyopathy (IDC) and hypertrophic cardiomyopathy (HC). (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - May 9, 2019 Category: Cardiology Authors: Tsuyoshi Yokoi, Ryota Morimoto, Hideo Oishi, Hiroo Kato, Yoshihito Arao, Shogo Yamaguchi, Tasuku Kuwayama, Tomoaki Haga, Hiroaki Hiraiwa, Toru Kondo, Kenji Furusawa, Kenji Fukaya, Akinori Sawamura, Takahiro Okumura, Akihiro Hirashiki, Toyoaki Murohara Source Type: research

Dilated cardiomyopathy as a rare presentation of the pulmonary sequestration: A case report with aberrant vessel from aorta to left lower pulmonary lobe
In conclusion, pulmonary sequestration and aberrant pulmonary supply from aorta should be considered as a rare cause of dilated cardiomyopathy which can be reversible by proper intervention. (Source: Journal of Cardiology Cases)
Source: Journal of Cardiology Cases - May 8, 2019 Category: Cardiology Source Type: research

Advances in research on treatment of heart failure with nitrosyl hydrogen
AbstractHeart failure is the end stage of various heart diseases such as ischemic heart disease, dilated cardiomyopathy, valvular heart disease, congenital heart disease, and hypertensive myocardial damage. It is characterized by a decrease in myocardial contractility, but there is currently no ideal treatment. Nitroxyl hydrogen (HNO) is considered to be a protonated form of NO. It has special chemical properties compared to other nitrogen oxides. In the body of organisms, HNO can participate in all aspects of the occurrence and development of heart failure (HF) and react with some proteins closely related to cardiac activ...
Source: Heart Failure Reviews - May 8, 2019 Category: Cardiology Source Type: research

Reduced hybrid/complex N-glycosylation disrupts cardiac electrical signaling and calcium handling in a model of dilated cardiomyopathy
Dilated cardiomyopathy (DCM) is the third most common cause of heart failure, with ~70% of DCM cases considered idiopathic. We showed recently, through genetic ablation of the MGAT1 gene, which encodes an essential glycosyltransferase (GlcNAcT1), that prevention of cardiomyocyte hybrid/complex N-glycosylation was sufficient to cause DCM that led to heart failure and early death. Our findings are consistent with increasing evidence suggesting a link between aberrant glycosylation and heart diseases of acquired and congenital etiologies. (Source: Journal of Molecular and Cellular Cardiology)
Source: Journal of Molecular and Cellular Cardiology - May 6, 2019 Category: Cytology Authors: Andrew R. Ednie, Austin R. Parrish, Martha J. Sonner, Eric S. Bennett Source Type: research

Characteristics of ventricular tachycardia and long-term treatment outcome in patients with dilated cardiomyopathy complicated by lamin A/C gene mutations.
CONCLUSIONS: These results demonstrate that patients with LMNA-related cardiomyopathy are characterized by VTs refractory to RFCA probably because of the deep intramural focus at the basal ventricular septum, resulting in poor prognosis with progressive severe heart failure despite all available optimized therapies. Thus, we should consider heart transplantation in their early 50s when several VT events begin to occur. PMID: 31060954 [PubMed - as supplied by publisher] (Source: Journal of Cardiology)
Source: Journal of Cardiology - May 3, 2019 Category: Cardiology Authors: Hasebe Y, Fukuda K, Nakano M, Kumagai K, Karibe A, Fujishima F, Satake H, Kondo M, Wakayama Y, Shimokawa H Tags: J Cardiol Source Type: research

Clinical efficacy of carvedilol treatment for dilated cardiomyopathy: A meta-analysis of randomized controlled trials
Background: Clinical trials examining the therapeutic benefit of carvedilol on patients with dilated cardiomyopathy have reported inconsistent results. The aim of this study was to evaluate the clinical efficacy of carvedilol on patients with dilated cardiomyopathy. Methods: PubMed, Embase, Cochrane Library, web of science, China National Knowledge Infrastructure (CNKI), Wanfang, and Chinese Scientific and Technological Journal (VIP) databases were searched for randomized controlled trials (RCTs) before March 2018. Weighted mean differences (WMDs) and 95% confidence intervals (CIs) were used to evaluate the effects of...
Source: Medicine - May 1, 2019 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Erdheim-Chester Disease
A 58-year-old man presented to the emergency department with cardiac tamponade and dilated cardiomyopathy of unknown origin. Chest radiography demonstrated cardiomegaly and pleural effusion. Computed tomography scan revealed pericardial masses of soft tissue-density between the atria and between the right atrium and ventricle (Figure  1); pericardial effusion; pleural effusion; enlarged and ill-defined adrenal glands; perirenal stranding (Figure 2); and sclerosed osseous lesions in the diaphysis of both humeri, both femoral necks, and the left os ilium. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - May 1, 2019 Category: Internal Medicine Authors: Alexander Poellinger, Joris Hrycyk Tags: Medical images Source Type: research

Superoxide dismutase activity as a predictor of adverse outcomes in patients with nonischemic dilated cardiomyopathy.
In conclusion, the present study shows that serum SOD activity may be a useful predictor of adverse outcome in HF. PMID: 31041645 [PubMed - as supplied by publisher] (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - May 1, 2019 Category: Cytology Authors: Romuk E, Jacheć W, Kozielska-Nowalany E, Birkner E, Zemła-Woszek A, Wojciechowska C Tags: Cell Stress Chaperones Source Type: research