Expression and Potential Significance of miR-499 and IL-1 β in Serum of Dilated Cardiomyopathy Patients with Atrial Fibrillation
CONCLUSIONS: A close relationship exists between the abnormal expression of serum miR-499 and IL-1β and DCM complicated with AF, which will be of great importance in future research. In addition, the data of patients with DCM are related to the occurrence and development of AF, and clinicians should actively perform early drug interventions to reduce myocardial remodeling, so as to reduce the incidence of AF.PMID:38551417 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 29, 2024 Category: Complementary Medicine Authors: Zhiwei Xu Lijuan Zhang Quanhua Pan Yang Gao Su Huang Source Type: research
Resveratrol Delays Diabetic Cardiomyopathy Fibrosis by Regulating Mitochondrial Autophagy
CONCLUSION: Resveratrol postpones dilated cardiomyopathy fibrosis by regulating the mitochondrial autophagy response through the AMP-activated protein kinase (AMPK)/silent mating type information regulation 2 homolog 1 (SIRT1)-mediated inositol-requiring enzyme 1 alpha (IRE1α)/PTEN-induced putative kinase 1 (PINK) signaling pathway.PMID:38551444 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 29, 2024 Category: Complementary Medicine Authors: Liqun Yang Zhe Gao Hang Zhao Zhimei Zhang Guangyao Song Source Type: research
Ferroptosis in Cardiovascular Disease and Cardiomyopathies: Therapeutic Implications of Glutathione and Iron Chelating Agents
Biomedicines. 2024 Mar 1;12(3):558. doi: 10.3390/biomedicines12030558.ABSTRACTThis review explores ferroptosis, a form of regulated cell death reliant on iron-induced phospholipid peroxidation, in diverse physiological and pathological contexts, including neurodegenerative disorders, and ischemia-reperfusion. In the realm of cardiovascular diseases, it significantly contributes to cardiomyopathies, including dilated cardiomyopathy, hypertrophic cardiomyopathy, and restrictive cardiomyopathy. Ferroptosis involves intricate interactions within cellular iron metabolism, lipid peroxidation, and the balance between polyunsatura...
Source: Atherosclerosis - March 28, 2024 Category: Cardiology Authors: John Dawi Scarlet Affa Edgar Gonzalez Yura Misakyan David Nikoghosyan Karim Hajjar Samuel Kades Sabrina Fardeheb Hayk Mirzoyan Vishwanath Venketaraman Source Type: research
Ferroptosis in Cardiovascular Disease and Cardiomyopathies: Therapeutic Implications of Glutathione and Iron Chelating Agents
Biomedicines. 2024 Mar 1;12(3):558. doi: 10.3390/biomedicines12030558.ABSTRACTThis review explores ferroptosis, a form of regulated cell death reliant on iron-induced phospholipid peroxidation, in diverse physiological and pathological contexts, including neurodegenerative disorders, and ischemia-reperfusion. In the realm of cardiovascular diseases, it significantly contributes to cardiomyopathies, including dilated cardiomyopathy, hypertrophic cardiomyopathy, and restrictive cardiomyopathy. Ferroptosis involves intricate interactions within cellular iron metabolism, lipid peroxidation, and the balance between polyunsatura...
Source: Atherosclerosis - March 28, 2024 Category: Cardiology Authors: John Dawi Scarlet Affa Edgar Gonzalez Yura Misakyan David Nikoghosyan Karim Hajjar Samuel Kades Sabrina Fardeheb Hayk Mirzoyan Vishwanath Venketaraman Source Type: research
LncRNA H19: A Novel Biomarker in Cardiovascular Disease
Acta Cardiol Sin. 2024 Mar;40(2):172-181. doi: 10.6515/ACS.202403_40(2).20230925A.ABSTRACTCardiovascular disease is a major cause of death and disability worldwide. Recently, increasing evidence has demonstrated that long non-coding RNAs (lncRNAs) play critical roles in the pathogenesis of cardiovascular diseases, including atherosclerosis, coronary artery disease, dilated cardiomyopathy, diabetic cardiomyopathy, aortic dissection, and more. LncRNA H19 was the first to be described as a non-protein-coding mRNA-like molecule. A large number of studies have found that lncRNA H19 is related to the pathophysiological processes...
Source: Atherosclerosis - March 27, 2024 Category: Cardiology Authors: Xiaojun Li Yugui Zhang Zhaoran Ding Yijun Chen Wei Wang Source Type: research
Temporal progression of replacement and interstitial fibrosis in optimally managed dilated cardiomyopathy patients: A prospective study
Background: To prospectively examine the dynamic evolution of fibrotic processes within a one-year in patients with dilated cardiomyopathy (DCM). Methods: Between May 2019 and September 2020, 102 DCM patients (mean age 45.2 ± 11.8 years, EF 29.9 ± 11.6%) underwent cardiac magnetic resonance (CMR-1). After 13.9 ± 2.9 months, 92 of these patients underwent a follow-up CMR (CMR-2). Replacement fibrosis was assessed via late gadolinium enhancement (LGE), quantified in terms of LGE mass and extent. Inter stitial fibrosis was evaluated via T1-mapping and expressed as extracellular volume fraction (ECV). (Sour...
Source: International Journal of Cardiology - March 26, 2024 Category: Cardiology Authors: Pawel Rubi ś, Paweł Banyś, Maciej Krupiński, Małgorzata Mielnik, Sylwia Wiśniowska-Śmiałek, Ewa Dziewięcka, Małgorzata Urbańczyk-Zawadzka Source Type: research
Left ventricular assist device temporary explantation as a strategy for infection control in a pediatric patient
We report a case of temporary Berlin Heart EXCOR ® explantation in a pediatric patient with idiopathic dilated cardiomyopathy who suffered an uncontrollable inflow cannulation site infection while on bridge-to-transplantation. Despite failure to thrive and catheter-related infections, once free of the device, the patient was cured of infection us ing systemic antibiotics and surgical debridement. The patient underwent EXCOR® reimplantation after four months, and is awaiting heart transplantation in stable condition. A life-threatening ventricular assist device-related infection may require device explantation under condi...
Source: Journal of Artificial Organs - March 23, 2024 Category: Transplant Surgery Source Type: research
HTRA1-driven detachment of type I collagen from endoplasmic reticulum contributes to myocardial fibrosis in dilated cardiomyopathy
The aberrant secretion and excessive deposition of type I collagen (Col1) are important factors in the pathogenesis of myocardial fibrosis in dilated cardiomyopathy (DCM). However, the precise molecular mechan... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 22, 2024 Category: Research Authors: Hongjie Shi, Ming Yuan, Jie Cai, Lan Lan, Yumou Wang, Wei Wang, Jianliang Zhou, Bin Wang, Wenjun Yu, Zhe Dong, Dawei Deng, Qiaofeng Qian, Yang Li, Xianwu Zhou and Jinping Liu Tags: Research Source Type: research
GSE262123 Mechanisms Underlying Dilated Cardiomyopathy Associated with FKBP12 Deficiency
Contributors : Md Abul Hassan Samee ; Kevin S Ho ; Susan L HamiltonSeries Type : Expression profiling by high throughput sequencingOrganism :To define the role of the immunophilin FKBP12 in cardiac function, two conditional models of FKBP12 deficiency were created using Fkbp1a floxed (FL) mice expressing Cre+ recombinase under the control of different promoters ( α-myosin heavy chain, αMHC, and muscle creatine kinase, MCK) that differ in both developmental stage of expression (E9 versus E 13) and Cre+ expression levels. In adult mice FKBP12 was reduced by 96% and 86% in αMHC-Cre+- and MCK-Cre+-FKBP12 deficient mice, r...
Source: GEO: Gene Expression Omnibus - March 21, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research
Neuromuscular and cardiovascular phenotypes in paediatric titinopathies: a multisite retrospective study
Conclusion
Our cohort demonstrates the genotype–phenotype spectrum of paediatric-onset titinopathies identified in clinical practice and highlights the risk of life-threatening cardiovascular complications. We show the difficulties of obtaining a molecular diagnosis, particularly in neuromuscular patients, and bring awareness to the complexities of genetic counselling in this population. (Source: Journal of Medical Genetics)
Source: Journal of Medical Genetics - March 21, 2024 Category: Genetics & Stem Cells Authors: Meyer, A. P., Barnett, C. L., Myers, K., Siskind, C. E., Moscarello, T., Logan, R., Roggenbuck, J., Rich, K. A. Tags: Genotype-phenotype correlations Source Type: research
Biallelic PKP2 loss of function variants are associated with a lethal perinatal-onset biventricular dilated cardiomyopathy with excessive trabeculations and ventricular septal defects
We report three more cases from two families with homozygous pathogenic PKP2 variants and perinatal-onset, lethal DCM-ET. Identification of the genetic abnormalities played a key role in decision-making and family counselling in these cases. This case series supports the published evidence that biallelic loss of function PKP2 variants cause a lethal, perinatal-onset cardiomyopathy. (Source: Journal of Medical Genetics)
Source: Journal of Medical Genetics - March 21, 2024 Category: Genetics & Stem Cells Authors: Gibb, J., Wall, E., Fields, E., Seale, A., Armstrong, C., Bamber, A., Daubeney, P., Jacobs-Pearson, M., Marton, T., Stals, K., Low, K., Kaski, J. P., Spentzou, G. Tags: Phenotypes Source Type: research
Novel SCN5A gene mutation in a patient affected by multifocal ectopic premature Purkinje ‐related contractions syndrome
We report the case of a 36-year-old woman who presented to the emergency department complaining of palpitations and asthenia. Investigations showed frequent ventricular ectopy and severe left ventricular ejection fraction impairment. She was diagnosed with a peculiar condition defined multifocal ectopic premature Purkinje-related contractions syndrome, which in some cases can be associated with a dilated cardiomyopathy phenotype. Genetic testing showed a novel mutation in the SCN5A gene (c.673C > G). In the context of acute left ventricular dysfunction in a young patient, we discuss the clinical presentation of this...
Source: ESC Heart Failure - March 20, 2024 Category: Cardiology Authors: Nicoletta Ventrella,
Lorenzo Bianchini,
Stefania Riva,
Francesca Pizzamiglio,
Maria Antonietta Dessanai,
Fabrizio Tundo,
Tommaso Sattin,
Francesca De Lio,
Selene Cellucci,
Claudio Tondo Tags: Case Report Source Type: research
Clinical characteristics, treatment, trajectories and outcome of patients with dilated cardiomyopathy in a national heart failure registry
Available data on the clinical characteristics and prognosis of patients with heart failure (HF) due to dilated cardiomyopathy (DCM) derive mainly from tertiary care centres for cardiomyopathies or from drug trial sub-studies, which may entail a referral bias. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - March 19, 2024 Category: Cardiology Authors: Samuela Carigi, Piero Gentile, Mauro Gori, Denitza Tinti, Luisa De Gennaro, Giuseppe Leonardi, Francesco Orso, Anna Rita Felici, Maria Rosaria Catalano, Marina Floresta, Vittoria Rizzello, Donata Lucci, Lucio Gonzini, Renata De Maria, Marco Marini, on beh Source Type: research
BAG3 localizes to mitochondria in cardiac fibroblasts and regulates mitophagy
Am J Physiol Heart Circ Physiol. 2024 Mar 15. doi: 10.1152/ajpheart.00736.2023. Online ahead of print.ABSTRACTThe co-chaperone BAG3 is a central node in protein quality control in the heart. In humans and animal models, decreased BAG3 expression is associated with cardiac dysfunction and dilated cardiomyopathy. While previous studies focused on BAG3 in cardiomyocytes, cardiac fibroblasts are also critical drivers of pathologic remodeling. Yet, BAG3's role in cardiac fibroblasts is almost completely unexplored. Here, we show BAG3 is expressed in primary rat neonatal cardiac fibroblasts and preferentially localizes to mitoch...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 15, 2024 Category: Physiology Authors: Thomas G Martin Laura A Sherer Jonathan A Kirk Source Type: research
BAG3 localizes to mitochondria in cardiac fibroblasts and regulates mitophagy
Am J Physiol Heart Circ Physiol. 2024 Mar 15. doi: 10.1152/ajpheart.00736.2023. Online ahead of print.ABSTRACTThe co-chaperone BAG3 is a central node in protein quality control in the heart. In humans and animal models, decreased BAG3 expression is associated with cardiac dysfunction and dilated cardiomyopathy. While previous studies focused on BAG3 in cardiomyocytes, cardiac fibroblasts are also critical drivers of pathologic remodeling. Yet, BAG3's role in cardiac fibroblasts is almost completely unexplored. Here, we show BAG3 is expressed in primary rat neonatal cardiac fibroblasts and preferentially localizes to mitoch...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 15, 2024 Category: Physiology Authors: Thomas G Martin Laura A Sherer Jonathan A Kirk Source Type: research
