Challenges and pitfalls during CRT implantation in patients with persistent left superior vena cava
ConclusionsThis case series shows that although challenging, conventional endovascular CRT implantation is feasible in PLSVC patients. Specialized tools for visualization and fixation may help. Our experiences highlight the importance of preprocedural evaluation of the anatomy and precise intervention planning.Graphical Abstract (Source: Journal of Interventional Cardiac Electrophysiology)
Source: Journal of Interventional Cardiac Electrophysiology - February 12, 2024 Category: Cardiology Source Type: research
TBX5 variants and cardiac phenotype: A systematic review of the literature and a novel variant
We report a novel missense variant in TBX5 in a family with an atypical Holt-Oram syndrome phenotype.PMID:38336121 | DOI:10.1016/j.ejmg.2024.104920 (Source: European Journal of Medical Genetics)
Source: European Journal of Medical Genetics - February 9, 2024 Category: Genetics & Stem Cells Authors: Anne Kathrine M øller Nielsen Anna Maria Dehn Vibeke Hjortdal Lars Allan Larsen Source Type: research
A novel likely pathogenic homozygous RBCK1 variant in dilated cardiomyopathy with muscle weakness
ConclusionsOur study offers novel findings indicating anRBCK1 variant in individuals of Iranian ancestry presenting with DCM leading to heart transplantation and myopathy without immunodeficiency or auto-inflammation. (Source: ESC Heart Failure)
Source: ESC Heart Failure - February 9, 2024 Category: Cardiology Authors: MohammadHossein MozafaryBazargany,
Shiva Esmaeili,
Mahshid Hesami,
Golnaz Houshmand,
Mohamad Mahdavi,
Majid Maleki,
Samira Kalayinia Tags: Original Article Source Type: research
Clinical Trajectories and Long-Term Outcomes of Alcoholic Versus Other Forms of Dilated Cardiomyopathy
Alcoholic cardiomyopathy (ACM) is a form of dilated cardiomyopathy (DCM) occurring secondary to long-standing heavy alcohol use and is associated with poor outcomes, but the cause-specific risks are insufficiently understood. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - February 8, 2024 Category: Cardiology Authors: Amanda Fernandes, Alan Manivannan, Morten Schou, Emil Fosb øl, Lars Køber, Finn Gustafsson, Gunnar H. Gislason, Christian Torp-Pedersen, Charlotte Andersson Tags: Original Article Source Type: research
Should echocardiogram be undertaken routinely when a child has severe iron deficiency anaemia?
Paediatr Int Child Health. 2024 Feb 6:1-5. doi: 10.1080/20469047.2024.2310351. Online ahead of print.ABSTRACTIron deficiency anaemia (IDA) is common in children. Treatment usually consists of oral iron therapy and, if severe, inpatient hospitalisation with blood transfusion. Providers may also undertake an echocardiogram, depending on availability and the severity of anaemia. A male toddler with nutritional IDA, haemoglobin of 1.7 g/dL (the lowest level in the literature) and hypertension had left ventricular hypertrophy (LVH) on the initial echocardiogram. He was managed acutely with judicious blood transfusion, followed ...
Source: Paediatrics and international child health - February 7, 2024 Category: Pediatrics Authors: Riwaaj Lamsal Jerry Walkup Source Type: research
Non ‐dilated left ventricular cardiomyopathy vs. dilated cardiomyopathy: clinical background and outcomes
ConclusionsThere was no significant difference in the incidence of cardiac events between NDLVC –REF and DCM. Among NDLVC–REF patients, 18% of patients who showed LV dilatation after diagnosis had poor outcomes. Therefore, both NDLVC–REF and DCM patients may require equivalent attention to follow-up and regular assessment of LV function. (Source: ESC Heart Failure)
Source: ESC Heart Failure - February 7, 2024 Category: Cardiology Authors: Yuko Eda,
Takeru Nabeta,
Saeko Iikura,
Yu Takigami,
Teppei Fujita,
Yuichiro Iida,
Yuki Ikeda,
Shunsuke Ishii,
Junya Ako Tags: Original Article Source Type: research
Construction and evaluation of immune-related diagnostic model in patients with heart failure caused by idiopathic dilated cardiomyopathy
The purpose of the study was to construct the potential diagnostic model of immune-related genes during the development of heart failure caused by idiopathic dilated cardiomyopathy. (Source: BMC Cardiovascular Disorders)
Source: BMC Cardiovascular Disorders - February 6, 2024 Category: Cardiology Authors: Sichi Xu, Zhaogui Wu and Haihua Chen Tags: Research Source Type: research
Exploration of neuron heterogeneity in human heart failure with dilated cardiomyopathy through single-cell RNA sequencing analysis
We aimed to explore the heterogeneity of neurons in heart failure with dilated cardiomyopathy (DCM). (Source: BMC Cardiovascular Disorders)
Source: BMC Cardiovascular Disorders - February 3, 2024 Category: Cardiology Authors: Yu-Hui Cui, Chun-Rong Wu, Dan Xu and Jian-Guo Tang Tags: Research Source Type: research
Treatment Strategies for Dilated Cardiomyopathy in Children: Scientific Statement from the American Heart Association —A Real Advance! But Please More Specific!
(Source: Pediatric Cardiology)
Source: Pediatric Cardiology - February 3, 2024 Category: Cardiology Source Type: research
Genes, Vol. 15, Pages 200: Polymorphic Variants of SCN5A Gene (rs41312433 and rs1805124) Associated with Coronary Artery Affliction in Patients with Severe Arrhythmias
Conclusions: Our study presents a highly sensitive and specific association of two polymorphisms in SCN5A with significant coronary artery stenoses in patients with potentially fatal ventricular arrhythmias. At the same time, these polymorphisms were not associated with arrhythmias themselves. Thus, SCN5A gene polymorphic variants may form a part of germ cell gene predisposition to ischemia. (Source: Genes)
Source: Genes - February 2, 2024 Category: Genetics & Stem Cells Authors: Anna Va šků Tom áš Novotný Jind řich Špinar Tags: Article Source Type: research
LncRNA CHKB-DT Downregulation Enhances Dilated Cardiomyopathy Through ALDH2
CONCLUSIONS: CHKB-DT is significantly downregulated in DCM. CHKB-DT acts as an energy metabolism-associated long noncoding RNA and represents a promising therapeutic target against DCM.PMID:38299365 | DOI:10.1161/CIRCRESAHA.123.323428 (Source: Circulation Research)
Source: Circulation Research - February 1, 2024 Category: Cardiology Authors: Xiang Nie Jiahui Fan Beibei Dai Zheng Wen Huaping Li Chen Chen Dao Wen Wang Source Type: research
The impact of type 2 diabetes mellitus on the clinical profile, myocardial fibrosis, and prognosis in non-ischemic dilated cardiomyopathy: a prospective cohort study
The impact of the coexistence of type 2 diabetes mellitus (T2DM) in patients with non-ischemic dilated cardiomyopathy (DCM) on clinical profiles, myocardial fibrosis, and outcomes remain incompletely understood. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 1, 2024 Category: Cardiology Authors: Yangjie Li, Hong Xian, Yuanwei Xu, Weihao Li, Jiajun Guo, Ke Wan, Jie Wang, Ziqian Xu, Qing Zhang, Yuchi Han, Jiayu Sun and Yucheng Chen Tags: Research Source Type: research
Striated preferentially expressed gene deficiency leads to mitochondrial dysfunction in developing cardiomyocytes
AbstractA deficiency of striated preferentially expressed gene (Speg), a member of the myosin light chain kinase family, results in abnormal myofibril structure and function of immature cardiomyocytes (CMs), corresponding with a dilated cardiomyopathy, heart failure and perinatal death. Mitochondrial development plays a role in cardiomyocyte maturation. Therefore, this study investigated whetherSpeg deficiency ( – / – ) in CMs would result in mitochondrial abnormalities.Speg wild-type andSpeg−/− C57BL/6 littermate mice were utilized for assessment of mitochondrial structure by transmission electron and confocal m...
Source: Basic Research in Cardiology - February 1, 2024 Category: Cardiology Source Type: research
