Extracellular vesicles (EVs): A promising therapeutic tool in the heart tissue regeneration
Extracellular vesicles paracrine effects play a primary role in the regenerative ability. EVs and the bioactive molecules contained in the human dental pulp stem cells influence the differentiation process toward cardiomyogenic lineage. Differentiation of dental pulp stem cells into cardiomyocytes induced by EVs derived modulating the differentiation process toward cardiomyogenic lineage. AbstractMesenchymal stem cells (MSCs) treatment has been widely explored as a therapy for myocardial infarction, peripheral ischemic vascular diseases, dilated cardiomyopathy, and pulmonary hypertension. Latest in vitro studies suggest th...
Source: BioFactors - December 22, 2023 Category: Biochemistry Authors: Francesca Diomede,
Simone Guarnieri,
Paola Lanuti,
Fani Konstantinidou,
Valentina Gatta,
Thangavelu Soundara Rajan,
Sante D. Pierdomenico,
Oriana Trubiani,
Guya Diletta Marconi,
Jacopo Pizzicannella Tags: RESEARCH ARTICLE Source Type: research
Novel pathogenic variant in MED12 causing non-syndromic dilated cardiomyopathy
Dilated cardiomyopathy (DCM) is a major cause of sudden cardiac death and heart failure. Up to 50% of all DCM cases have a genetic background, with variants in over 250 genes reported in association with DCM. ... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - December 21, 2023 Category: Genetics & Stem Cells Authors: Serwa Ghasemi, Mohammad Mahdavi, Majid Maleki, Iman Salahshourifar and Samira Kalayinia Tags: Research Source Type: research
SCN5A-L256del and L1621F exhibit loss-of-function properties related to autosomal recessive congenital cardiac disorders presenting as sick sinus syndrome, dilated cardiomyopathy, and sudden cardiac death
Gene. 2023 Dec 18:148093. doi: 10.1016/j.gene.2023.148093. Online ahead of print.ABSTRACTPathogenic mutations in SCN5A could result in dysfunctions of Nav1.5 and consequently lead to a wide range of inherited cardiac diseases. However, the presence of numerous SCN5A-related variants with unknown significance (VUS) and the comprehensive genotype-phenotype relationship pose challenges to precise diagnosis and genetic counseling for affected families. Here, we functionally identified two novel compound heterozygous variants (L256del and L1621F) in SCN5A in a Chinese family exhibiting complex congenital cardiac phenotypes from...
Source: Gene - December 20, 2023 Category: Genetics & Stem Cells Authors: Jiaying Shi Xueqi Pan Zhaokun Wang Ming Yi Shengyu Xie Xinyue Zhang Dachang Tao Yuan Yang Yunqiang Liu Source Type: research
A new pseudoexon activation due to ultrarare branch point formation in Duchenne muscular dystrophy
Dystrophinopathies, caused by pathogenic DMD variants, include Duchenne muscular dystrophy (DMD), Becker muscular dystrophy, X-linked dilated cardiomyopathy, and female dystrophinopathy [1]. Genetic therapy is a promising treatment given the monogenetic nature of DMD, but it requires the precise identification of pathogenic variants in the DMD gene. As approximately 97 ∼99% of pathogenic DMD variants are in DMD exons and/or their flanking intronic regions, they can be detected by routine exome analysis of genomic DNA [2,3]. (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - December 19, 2023 Category: Neurology Authors: Zhiying Xie, Chengyue Sun, Chang Liu, Yanyu Lu, Bin Chen, Rui Wu, Yanru Liu, Ran Liu, Qing Peng, Jianwen Deng, Lingchao Meng, Zhaoxia Wang, Wei Zhang, Yun Yuan Tags: Case report Source Type: research
Reduced Ejection Fraction in Elite Endurance Athletes: Clinical and Genetic Overlap With Dilated Cardiomyopathy
CONCLUSIONS: Reduced EF occurs in approximately 1 in 6 elite endurance athletes and is related to genetic predisposition in addition to exercise training. Genetic and imaging markers may help identify endurance athletes in whom scrutiny about long-term clinical outcomes may be appropriate.REGISTRATION: URL: https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374976&isReview=true; Unique identifier: ACTRN12618000716268.PMID:38109351 | DOI:10.1161/CIRCULATIONAHA.122.063777 (Source: Circulation)
Source: Circulation - December 18, 2023 Category: Cardiology Authors: Guido Claessen Ruben De Bosscher Kristel Janssens Paul Young Christophe Dausin Mathias Claeys Piet Claus Kaatje Goetschalckx Jan Bogaert Amy M Mitchell Michael D Flannery Adrian D Elliott Chenglong Yu Olivier Ghekiere Tomas Robyns Caroline M Van De Heynin Source Type: research
Reduced Ejection Fraction in Elite Endurance Athletes: Clinical and Genetic Overlap With Dilated Cardiomyopathy
CONCLUSIONS: Reduced EF occurs in approximately 1 in 6 elite endurance athletes and is related to genetic predisposition in addition to exercise training. Genetic and imaging markers may help identify endurance athletes in whom scrutiny about long-term clinical outcomes may be appropriate.REGISTRATION: URL: https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374976&isReview=true; Unique identifier: ACTRN12618000716268.PMID:38109351 | DOI:10.1161/CIRCULATIONAHA.122.063777 (Source: Circulation)
Source: Circulation - December 18, 2023 Category: Cardiology Authors: Guido Claessen Ruben De Bosscher Kristel Janssens Paul Young Christophe Dausin Mathias Claeys Piet Claus Kaatje Goetschalckx Jan Bogaert Amy M Mitchell Michael D Flannery Adrian D Elliott Chenglong Yu Olivier Ghekiere Tomas Robyns Caroline M Van De Heynin Source Type: research
Retracted: Diagnostic Classification of Patients with Dilated Cardiomyopathy Using Ventricular Strain Analysis Algorithm
Comput Math Methods Med. 2023 Dec 6;2023:9814363. doi: 10.1155/2023/9814363. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.1155/2021/4186648.].PMID:38094433 | PMC:PMC10718709 | DOI:10.1155/2023/9814363 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - December 14, 2023 Category: Statistics Authors: Computational And Mathematical Methods In Medicine Source Type: research
The atrial and ventricular myocardial proteome of end-stage lamin heart disease
Acta Myol. 2023 Sep 30;42(2-3):43-52. doi: 10.36185/2532-1900-339. eCollection 2023.ABSTRACTLamins A/C (encoded by LMNA gene) can lead to dilated cardiomyopathy (DCM). This pilot study sought to explore the postgenomic phenotype of end-stage lamin heart disease. Consecutive patients with end-stage lamin heart disease (LMNA-group, n = 7) and ischaemic DCM (ICM-group, n = 7) undergoing heart transplantation were prospectively enrolled. Samples were obtained from left atrium (LA), left ventricle (LV), right atrium (RA), right ventricle (RV) and interventricular septum (IVS), avoiding the infarcted myocardial segments in the I...
Source: Acta Myologica - December 13, 2023 Category: Neurology Authors: Constantin-Cristian Topriceanu Mashael Alfarih Alun D Hughes Hunain Shiwani Fiona Chan Saidi A Mohiddin William Moody Richard P Steeds Benjamin O'Brien Jakob Vowinckel Petros Syrris Caroline Coats Stephen Pettit Eloisa Arbustini James C Moon Gabriella Cap Source Type: research
CD4 < sup > + < /sup > T < sub > EM < /sub > cells drive the progression from acute myocarditis to dilated cardiomyopathy in CVB3-induced BALB/c mice
In this study, we observed an increase in CD4+TEM cells both in the periphery and the heart, and memory CD4+ T cells were the predominant sources of IL-17A and IFN-γ among inflamed heart-infiltrating CD4+ T cells during the progression from acute myocarditis to chronic myocarditis and DCM in CVB3-induced BALB/c mice. Moreover, splenic CD4+TEM cells sorted from DCM mice induced by CVB3 were found to respond to cardiac self-antigens ex vivo. Additionally, adoptive transfer experiments substantiated their pathogenic impact, inducing sustained myocardial inflammation, tissue fibrosis, cardiac injury, and impairment of cardiac...
Source: International Immunopharmacology - December 13, 2023 Category: Allergy & Immunology Authors: Yanlan Huang Xiaojing Huang Zhe Wei Jingwei Dong Jing Lu Quan Tang Feiyu Lu Zhihong Cen Weifeng Wu Source Type: research
The atrial and ventricular myocardial proteome of end-stage lamin heart disease
Acta Myol. 2023 Sep 30;42(2-3):43-52. doi: 10.36185/2532-1900-339. eCollection 2023.ABSTRACTLamins A/C (encoded by LMNA gene) can lead to dilated cardiomyopathy (DCM). This pilot study sought to explore the postgenomic phenotype of end-stage lamin heart disease. Consecutive patients with end-stage lamin heart disease (LMNA-group, n = 7) and ischaemic DCM (ICM-group, n = 7) undergoing heart transplantation were prospectively enrolled. Samples were obtained from left atrium (LA), left ventricle (LV), right atrium (RA), right ventricle (RV) and interventricular septum (IVS), avoiding the infarcted myocardial segments in the I...
Source: Acta Myologica - December 13, 2023 Category: Neurology Authors: Constantin-Cristian Topriceanu Mashael Alfarih Alun D Hughes Hunain Shiwani Fiona Chan Saidi A Mohiddin William Moody Richard P Steeds Benjamin O'Brien Jakob Vowinckel Petros Syrris Caroline Coats Stephen Pettit Eloisa Arbustini James C Moon Gabriella Cap Source Type: research
