β1-adrenergic Receptor (β1AR) Autoantibodies Endogenously Bias β1AR Signaling

Autoimmune response to self-antigens results in autoantibodies (AAbs), wherein AAbs against extra cellular loop 2 (ECL2) of β1AR is known to underlie dilated cardiomyopathy (DCM). Contrarily, recent studies show that patients with β1AR AAbs belonging to the IgG3 subclass have beneficial outcomes. However, the signaling mechanisms that underlie the beneficial outcomes are not well understood.

https://onlinejcf.com/article/S1071-9164(23)00453-0/fulltext?rss=yes

Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Maradumane Mohan, Chia-Feng Liu, Khuraijam Dhanachandra Singh, Sadashiva S. Karnik, Wai Hong Tang, Sathyamangla V. Naga Prasad Tags: 066 Source Type: research