A Male Japanese Patient with Temple Syndrome Complicated by Type 2 Diabetes Mellitus
Intern Med. 2024 May 16. doi: 10.2169/internalmedicine.2743-23. Online ahead of print.ABSTRACTWe herein present the case of a 21-year-old male Japanese diabetic patient with Temple syndrome, caused by maternal uniparental disomy of chromosome 14. The patient was overweight and had type 2 diabetes, dyslipidemia, metabolic dysfunction-associated steatotic liver disease, and microalbuminuria. He had an increased fat mass in the truncal region and a decreased lean mass throughout the body. This may lead to insulin resistance due to the absence of delta-like homolog 1 (DLK1) and retrotransposon gag-like 1 (RTL1). The patient ha...
Source: Internal Medicine - May 15, 2024 Category: Internal Medicine Authors: Masanori Iwanishi Tohru Yorifuji Yukako Yamamoto Jun Ito-Kobayashi Akira Shimatsu Shingo Kikugawa Masayo Kagami Source Type: research
Low-Income Participants' Preference Between Financial Incentives for Behavioral Goals vs Weight Loss Targets and Associations With Behavioral Goal Adherence
CONCLUSION: Receiving one's preferred incentive design may not play a strong role in behavioral goal adherence during financially incentivized weight loss interventions.PMID:38748662 | DOI:10.1177/08901171241254366 (Source: American Journal of Health Promotion : AJHP)
Source: American Journal of Health Promotion : AJHP - May 15, 2024 Category: International Medicine & Public Health Authors: Akshitha Adhiyaman Melanie Jay Un Young Rebecca Chung Andres N Gronda Chi-Hong Tseng Judith Wylie-Rosett Sandra Wittleder Soma Wali Joseph A Ladapo Stephanie L Orstad Source Type: research
A New Case of Abetalipoproteinemia Caused by Novel Compound Heterozygote Mutations in the MTTP Gene without Fat or Vitamin Malabsorption
J Atheroscler Thromb. 2024 May 14. doi: 10.5551/jat.64730. Online ahead of print.ABSTRACTAbetalipoproteinemia (ABL) is a rare disease characterized by extremely low apolipoprotein B (apoB)-containing lipoprotein levels, dietary fat, and fat-soluble vitamin malabsorption, leading to gastrointestinal, neuromuscular, and ophthalmological symptoms. We herein report a case of ABL with novel compound heterozygous mutations in the microsomal triglyceride transfer protein gene (c.1686_1687del [p.Ser563TyrfsTer10] and c.1862T>C [p.Ile621Thr]), identified via panel sequencing. Although the patient had extremely reduced low-densit...
Source: Journal of Atherosclerosis and Thrombosis - May 15, 2024 Category: Cardiology Authors: Kei Sasaki Hayato Tada Tomohiro Komatsu Hisato Terada Yasuhiro Endo Katsunori Ikewaki Yoshinari Uehara Source Type: research
Obesity and Depression: Common Link and Possible Targets
CNS Neurol Disord Drug Targets. 2024 May 13. doi: 10.2174/0118715273291985240430074053. Online ahead of print.ABSTRACTDepression is among the main causes of disability, and its protracted manifestations could make it even harder to treat metabolic diseases. Obesity is linked to episodes of depression, which is closely correlated to abdominal adiposity and impaired food quality. The present review is aimed at studying possible links between obesity and depression along with targets to disrupt it. Research output in Pubmed and Scopus were referred for writing this manuscript. Obesity and depression are related, with the grea...
Source: CNS and Neurological Disorders Drug Targets - May 15, 2024 Category: Drugs & Pharmacology Authors: Srikanth Jitte Saritha Keluth Priya Bisht Pranay Wal Sanjiv Singh Krishna Murti Nitesh Kumar Source Type: research
Oral microbiota of patients with phenylketonuria: A nation-based cross-sectional study
CONCLUSIONS: PKU patients' reduced microbial diversity may be due to their diet's metabolic challenges disrupting microbial and immune balance, thus increasing oral inflammation. Higher alpha diversity in PKU patients with oral inflammation is likely related to expanded microbial niches.PMID:38745393 | DOI:10.1111/jcpe.13998 (Source: Journal of Clinical Periodontology)
Source: Journal of Clinical Periodontology - May 15, 2024 Category: Dentistry Authors: Memduh Bing öl Alessio Cardilli Anne Carolin Bing öl Ulrike L öber Corinna Bang Andre Franke Theodosia Bartzela Skadi Beblo Eberhard M önch Simone Stolz Arne S Schaefer Sofia Kirke Forslund Gesa M Richter Source Type: research
Sirtuin 6 Deacetylates Apoptosis-Associated Speck-Like Protein (ASC) to Inhibit Endothelial Cell Pyroptosis in Atherosclerosis
In conclusion, SIRT6 deacetylated ASC to inhibit its interaction with NLRP3 and then suppressed pyroptosis of endothelial cells, thus, decelerating the progression of AS. The findings provide new insights into the function of SIRT6 in AS.PMID:38749754 | DOI:10.1536/ihj.23-334 (Source: Atherosclerosis)
Source: Atherosclerosis - May 15, 2024 Category: Cardiology Authors: Jian Huang Shuilin Dong Yanhui Wu Huiming Yi Wei Zhang Xi Ai Source Type: research
Short-chain fatty acids: Important components of the gut-brain axis against AD
Biomed Pharmacother. 2024 May 14;175:116601. doi: 10.1016/j.biopha.2024.116601. Online ahead of print.ABSTRACTAlzheimer's disease (AD) comprises a group of neurodegenerative disorders with some changes in the brain, which could lead to the deposition of certain proteins and result in the degeneration and death of brain cells. Patients with AD manifest primarily as cognitive decline, psychiatric symptoms, and behavioural disorders. Short-chain fatty acids (SCFAs) are a class of saturated fatty acids (SFAs) produced by gut microorganisms through the fermentation of dietary fibre ingested. SCFAs, as a significant mediator of ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 15, 2024 Category: Drugs & Pharmacology Authors: Yan Huang Yi Feng Wang Jing Miao Rui Fang Zheng Jin Yao Li Source Type: research
Sirtuin 6 Deacetylates Apoptosis-Associated Speck-Like Protein (ASC) to Inhibit Endothelial Cell Pyroptosis in Atherosclerosis
In conclusion, SIRT6 deacetylated ASC to inhibit its interaction with NLRP3 and then suppressed pyroptosis of endothelial cells, thus, decelerating the progression of AS. The findings provide new insights into the function of SIRT6 in AS.PMID:38749754 | DOI:10.1536/ihj.23-334 (Source: International Heart Journal)
Source: International Heart Journal - May 15, 2024 Category: Cardiology Authors: Jian Huang Shuilin Dong Yanhui Wu Huiming Yi Wei Zhang Xi Ai Source Type: research
Gastrointestinal adverse reaction to food (GARF) and endoscopic confocal laser endomicroscopy (eCLE)
CONCLUSION: The results of our study indicate that eCLE with DFC is a technique to clinically evaluate patients with disorders of the gut brain axis and GARF resulting in a high proportion of patients reporting symptom benefit upon food exclusion dietary advice focussed on the results of eCLE.PMID:38749460 | DOI:10.1055/a-2258-8509 (Source: Zeitschrift fur Gastroenterologie)
Source: Zeitschrift fur Gastroenterologie - May 15, 2024 Category: Gastroenterology Authors: Thomas Frieling Besmir Gjini Ilka Melchior Philipp Euler Christian Kreysel Sigrid Kalde Britta Krummen Ralf Kiesslich Bernhard Hemmerlein Source Type: research
Is food and drink advertising across various settings associated with dietary behaviours and intake among Australian adolescents? Findings from a national cross-sectional survey
CONCLUSIONS: Australian adolescents are vulnerable to the persuasive effects of food and drink marketing. SO WHAT?: Greater restrictions on the way the food and drink industry can market their products to adolescents are needed to better support them in developing and maintaining positive dietary behaviours.PMID:38749507 | DOI:10.1002/hpja.872 (Source: Health Promotion Journal of Australia)
Source: Health Promotion Journal of Australia - May 15, 2024 Category: International Medicine & Public Health Authors: Claudia Gascoyne Maree Scully Belinda Morley Source Type: research
How healthy are the healthcare staff in a rural health service? A cross-sectional study
CONCLUSIONS: Several high-risk health areas along with opportunities for supporting improved wellbeing were identified in this group of healthcare workers. Psychological distress of healthcare workers urgently needs to be addressed, and this is reinforced by the need to understand the longitudinal impact of COVID-19 on the health and wellbeing of healthcare workers. Workplace settings, such as a health service, is an ideal setting to invest in healthcare workers with individual, organisational, and broader community benefits.PMID:38746794 | PMC:PMC11080437 | DOI:10.1016/j.ijnsa.2024.100186 (Source: Adv Data)
Source: Adv Data - May 15, 2024 Category: Epidemiology Authors: Kristy A Bolton Penny Fraser Steven Allender Rohan Fitzgerald Susan Brumby Source Type: research
Nutritional and productive performance of purebred Nellore heifers and crossed with Brangus and Braford finished in a feedlot system
This study evaluated the nutritional and productive performance of Nellore purebred heifers and crossbred Brangus x Nellore (BGNE) and Braford x Nellore (BFNE) in a feedlot system. Thirty heifers (10 of each genetic group) with an average age of 18 months and an initial body weight of 261 kg were used. The experiment was structured and conducted according to a completely randomized design, with three treatments. Heifers received two diets (60 days each) during the experimental period. The experiment lasted 120 days with four experimental periods. Nellore heifers had a lower intake than crossbred heifers (P <0.05). There...
Source: An Acad Bras Cienc - May 15, 2024 Category: Science Authors: Felipe C Bento Kamila A K DE Moraes Cl áudio Vieira DE Araujo Vin ícius Augusto Machado Natan L Cecconello Lorrayne O DA Cunha Jarliane DO Nascimento Sousa Karine R Dos Santos Naves Juliana C Ortelam Leandro F Moreno Eduardo Henrique B K DE Moraes Source Type: research
Influence of taurine on the zootechnical performance and health parameters of juvenile Nile tilapia in a recirculating aquaculture system
This study evaluated the supplementation of taurine on growth performance, hematological and immunological parameters, production costs, and survival of Nile tilapia (Oreochromis niloticus) juveniles raised in a recirculating aquaculture system (RAS). A control diet was formulated with 360 g kg-1 of crude protein without fish meal and without taurine supplementation (Control). From the control diet, another diet supplemented with 9.7 g of taurine per kg of feed (Taurine) was produced. Fish fed diet supplemented with taurine had lower daily average weight gain and final average weight compared to the control diet (p < 0....
Source: An Acad Bras Cienc - May 15, 2024 Category: Science Authors: Maiara P Vilvert Eduardo DA Silva Julio Cesar B Rodhermel Larissa Stockhausen Jaqueline In ês A DE Andrade Adolfo Jatob á Source Type: research
Effects of maternal nutrition regimen of ewes on performance, carcass, and meat traits of their feedlot-finished lambs
The objective of this study was to evaluate the effects of diets with two energy levels fed to Ile de France ewes during the last third of gestation on the performance, carcass, and meat traits of their offspring. Treatments were: D0: maternal diet meeting the requirements for the last third of gestation, and D20: maternal diet containing an additional 20% energy requirements. Twenty single-born male lambs, ten from each group of ewes, were weaned at 60 d (18.3 ± 1.4 kg initial BW) and fed a common finishing diet. Animals were slaughtered when they reached 32 kg BW. Dry matter intake, average daily gain, feed conversion, ...
Source: An Acad Bras Cienc - May 15, 2024 Category: Science Authors: Nomaiaci DE Andrade Am érico G DA Silva Sobrinho Thiago Henrique Borghi Roberta DE Lima Valen ça Eli éder P Romanzini Eric H C B VAN Cleef Source Type: research
Abundance of the bat Sturnira lilium (Phyllostomidae) in relation Solanum mauritianum (Solanaceae) diaspores in an Atlantic Forest fragment of southern Brazil
An Acad Bras Cienc. 2024 May 10;96(2):e20220830. doi: 10.1590/0001-3765202420220830. eCollection 2024.ABSTRACTFrugivore bats are important seed dispersers in forests and their abundance are associated with the presence of zoochoric plants. In this context, the aim of our study was to investigate the association of the frugivore bat S. lilium with the diaspores of the zoochoric plant S. mauritianum, a common arboreal species present in forest fragments of southern Brazil. We also investigated the diet of the species based on seed content present in feces of individuals. Bats were mist-netted from November 2017 to April 2018...
Source: An Acad Bras Cienc - May 15, 2024 Category: Science Authors: Denyelle Hennayra Cor á Fernanda W Oliveira Luan Marcos V Lazzarotto David L Biassi Ronei Baldissera Adriano D DE Oliveira Daniel Galiano Source Type: research
