A Male Japanese Patient with Temple Syndrome Complicated by Type 2 Diabetes Mellitus

Intern Med. 2024 May 16. doi: 10.2169/internalmedicine.2743-23. Online ahead of print.ABSTRACTWe herein present the case of a 21-year-old male Japanese diabetic patient with Temple syndrome, caused by maternal uniparental disomy of chromosome 14. The patient was overweight and had type 2 diabetes, dyslipidemia, metabolic dysfunction-associated steatotic liver disease, and microalbuminuria. He had an increased fat mass in the truncal region and a decreased lean mass throughout the body. This may lead to insulin resistance due to the absence of delta-like homolog 1 (DLK1) and retrotransposon gag-like 1 (RTL1). The patient had experienced social withdrawal at home (hikikomori in Japanese), had poorly controlled type 2 diabetes, and was overweight despite receiving diet therapy and oral hypoglycemic agents.PMID:38749734 | DOI:10.2169/internalmedicine.2743-23
Source: Internal Medicine - Category: Internal Medicine Authors: Source Type: research