Adipocyte-Specific Disruption of the BBSome Causes Metabolic and Autonomic Dysfunction
Am J Physiol Regul Integr Comp Physiol. 2024 May 13. doi: 10.1152/ajpregu.00039.2024. Online ahead of print.ABSTRACTObesity is a major public health issue due to its association with type 2 diabetes, hypertension, and other cardiovascular risks. The BBSome, a complex of 8 conserved Bardet-Biedl Syndrome (BBS) proteins, has emerged as a key regulator of energy and glucose homeostasis as well as cardiovascular function. However, the importance of adipocyte BBSome in controlling these physiological processes is not clear. Here, we show that adipocyte-specific constitutive disruption of the BBSome through selective deletion of...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - May 13, 2024 Category: Physiology Authors: Yuying Zhao Deng-Fu Guo Donald A Morgan Young-Eun Cho Kamal Rahmouni Source Type: research
Punicalagin attenuates isoproterenol-induced myocardial infarction through nuclear factor erythroid 2-related factor 2/silent information regulator transcript-1-mediated inhibition of inflammation and cardiac stress markers in experimental animal models
This study aimed to assess the preventive impact of PCN, with its potential anti-inflammatory and antioxidant properties, on myocardial injury caused by isoproterenol (ISO) in rats and elucidate the possible underlying mechanisms. Experimental rats were randomly categorized into four groups: control group (fed a regular diet for 15 days), PCN group (orally administered PCN at 50 mg/kg body weight (b.w.) for 15 days), ISO group (subcutaneously administered ISO (85 mg/kg b.w.) on days 14 and 15 to induce MI), and PCN+ISO group (orally preadministered PCN (50 mg/kg b.w.) for 15 days and administered ISO (85 mg/kg b.w.) on day...
Source: J Physiol Pharmacol - May 13, 2024 Category: Drugs & Pharmacology Authors: X Y Liao P Liu T F Luo Y Li Y Gao F Y Pan K C Wang Source Type: research
Punicalagin attenuates isoproterenol-induced myocardial infarction through nuclear factor erythroid 2-related factor 2/silent information regulator transcript-1-mediated inhibition of inflammation and cardiac stress markers in experimental animal models
This study aimed to assess the preventive impact of PCN, with its potential anti-inflammatory and antioxidant properties, on myocardial injury caused by isoproterenol (ISO) in rats and elucidate the possible underlying mechanisms. Experimental rats were randomly categorized into four groups: control group (fed a regular diet for 15 days), PCN group (orally administered PCN at 50 mg/kg body weight (b.w.) for 15 days), ISO group (subcutaneously administered ISO (85 mg/kg b.w.) on days 14 and 15 to induce MI), and PCN+ISO group (orally preadministered PCN (50 mg/kg b.w.) for 15 days and administered ISO (85 mg/kg b.w.) on day...
Source: Journal of Physiology and Pharmacology - May 13, 2024 Category: Drugs & Pharmacology Authors: X Y Liao P Liu T F Luo Y Li Y Gao F Y Pan K C Wang Source Type: research
Reduced Incretin Receptor Trafficking upon Activation Enhances Glycemic Control and Reverses Obesity in Diet-Induced Obese Mice
Am J Physiol Cell Physiol. 2024 May 13. doi: 10.1152/ajpcell.00474.2023. Online ahead of print.ABSTRACTActivation of incretin receptors by their cognate agonists augments sustained cAMP generation both from the plasma membrane as well as from the endosome. To address the functional outcome of this spatiotemporal signaling, we developed a non-acylated glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor dual agonist I-M-150847 that reduced receptor internalization following activation of the incretin receptors. The incretin receptor dual agonist I-M-150847 was developed by replacin...
Source: American Journal of Physiology. Cell Physiology - May 13, 2024 Category: Cytology Authors: Rathin Bauri Shilpak Bele Jhansi Edelli Neelesh C Reddy Sreenivasulu Kurukuti Tom Devasia Ahamed Ibrahim Vishal Rai Prasenjit Mitra Source Type: research
Reduced Incretin Receptor Trafficking upon Activation Enhances Glycemic Control and Reverses Obesity in Diet-Induced Obese Mice
Am J Physiol Cell Physiol. 2024 May 13. doi: 10.1152/ajpcell.00474.2023. Online ahead of print.ABSTRACTActivation of incretin receptors by their cognate agonists augments sustained cAMP generation both from the plasma membrane as well as from the endosome. To address the functional outcome of this spatiotemporal signaling, we developed a non-acylated glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor dual agonist I-M-150847 that reduced receptor internalization following activation of the incretin receptors. The incretin receptor dual agonist I-M-150847 was developed by replacin...
Source: Am J Physiol Cell Ph... - May 13, 2024 Category: Cytology Authors: Rathin Bauri Shilpak Bele Jhansi Edelli Neelesh C Reddy Sreenivasulu Kurukuti Tom Devasia Ahamed Ibrahim Vishal Rai Prasenjit Mitra Source Type: research
FicD regulates adaptation to the unfolded protein response in the murine liver
Biochimie. 2024 May 11:S0300-9084(24)00106-8. doi: 10.1016/j.biochi.2024.05.012. Online ahead of print.ABSTRACTThe unfolded protein response (UPR) is a cellular stress response that is activated when misfolded proteins accumulate in the endoplasmic reticulum (ER). Regulation of the UPR response must be adapted to the needs of the cell as prolonged UPR responses can result in disrupted cellular function and tissue damage. Previously, we discovered that the enzyme FicD (also known as Fic or HYPE) through its AMPylation and deAMPylation activity can modulate the UPR response via post-translational modification of BiP. FicD AM...
Source: Biochimie - May 13, 2024 Category: Biochemistry Authors: Amanda K Casey Nathan M Stewart Naqi Zaidi Hillery F Gray Amelia Cox Hazel A Fields Kim Orth Source Type: research
Adipocyte-Specific Disruption of the BBSome Causes Metabolic and Autonomic Dysfunction
Am J Physiol Regul Integr Comp Physiol. 2024 May 13. doi: 10.1152/ajpregu.00039.2024. Online ahead of print.ABSTRACTObesity is a major public health issue due to its association with type 2 diabetes, hypertension, and other cardiovascular risks. The BBSome, a complex of 8 conserved Bardet-Biedl Syndrome (BBS) proteins, has emerged as a key regulator of energy and glucose homeostasis as well as cardiovascular function. However, the importance of adipocyte BBSome in controlling these physiological processes is not clear. Here, we show that adipocyte-specific constitutive disruption of the BBSome through selective deletion of...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - May 13, 2024 Category: Physiology Authors: Yuying Zhao Deng-Fu Guo Donald A Morgan Young-Eun Cho Kamal Rahmouni Source Type: research
Dietary additive ferulic acid alleviated oxidative stress, inflammation, and apoptosis induced by chronic exposure to avermectin in the liver of common carp (Cyprinus carpio)
Toxicon. 2024 May 11:107755. doi: 10.1016/j.toxicon.2024.107755. Online ahead of print.ABSTRACTAvermectin (AVM) has been utilized extensively in agricultural production since it is a low-toxicity pesticide. However, the pollution caused by its residues to fisheries aquaculture has been neglected. As an abundant polyphenolic substance in plants, ferulic acid (FA) possesses anti-inflammatory and antioxidant effects. The goal of the study is to assess the FA's ability to reduce liver damage in carp brought on by AVM exposure. Four groups of carp were created at random: the control group; the AVM group; the FA group; and the F...
Source: Toxicon - May 13, 2024 Category: Toxicology Authors: Zunhan Hu Ying Sun Shujuan Liu Yannan Xiang Mengxin Li Ying Li Yuanyuan Li Xiguang Liu Mian Fu Source Type: research
Mode of action analysis for fluxapyroxad-induced rat liver tumour formation: evidence for activation of the constitutive androstane receptor and assessment of human relevance
In conclusion, a series of in vivo and in vitro investigative studies have demonstrated that fluxapyroxad is a CAR activator in rat liver, with similar properties to the prototypical CAR activator phenobarbital. A robust MOA for fluxapyroxad-induced rat liver tumour formation has been established. Based on the lack of effect of fluxapyroxad on RDS in human hepatocytes, it is considered that the MOA for fluxapyroxad-induced liver tumour formation is qualitatively not plausible for humans.PMID:38740169 | DOI:10.1016/j.tox.2024.153828 (Source: Toxicology)
Source: Toxicology - May 13, 2024 Category: Toxicology Authors: Manuela Goettel Christoph Werner Naveed Honarvar Sibylle Gr öters Ivana Fegert Corinne Haines Lynsey R Chatham Audrey Vardy Brian G Lake Source Type: research
Punicalagin attenuates isoproterenol-induced myocardial infarction through nuclear factor erythroid 2-related factor 2/silent information regulator transcript-1-mediated inhibition of inflammation and cardiac stress markers in experimental animal models
This study aimed to assess the preventive impact of PCN, with its potential anti-inflammatory and antioxidant properties, on myocardial injury caused by isoproterenol (ISO) in rats and elucidate the possible underlying mechanisms. Experimental rats were randomly categorized into four groups: control group (fed a regular diet for 15 days), PCN group (orally administered PCN at 50 mg/kg body weight (b.w.) for 15 days), ISO group (subcutaneously administered ISO (85 mg/kg b.w.) on days 14 and 15 to induce MI), and PCN+ISO group (orally preadministered PCN (50 mg/kg b.w.) for 15 days and administered ISO (85 mg/kg b.w.) on day...
Source: Journal of Physiology and Pharmacology - May 13, 2024 Category: Drugs & Pharmacology Authors: X Y Liao P Liu T F Luo Y Li Y Gao F Y Pan K C Wang Source Type: research
Punicalagin attenuates isoproterenol-induced myocardial infarction through nuclear factor erythroid 2-related factor 2/silent information regulator transcript-1-mediated inhibition of inflammation and cardiac stress markers in experimental animal models
This study aimed to assess the preventive impact of PCN, with its potential anti-inflammatory and antioxidant properties, on myocardial injury caused by isoproterenol (ISO) in rats and elucidate the possible underlying mechanisms. Experimental rats were randomly categorized into four groups: control group (fed a regular diet for 15 days), PCN group (orally administered PCN at 50 mg/kg body weight (b.w.) for 15 days), ISO group (subcutaneously administered ISO (85 mg/kg b.w.) on days 14 and 15 to induce MI), and PCN+ISO group (orally preadministered PCN (50 mg/kg b.w.) for 15 days and administered ISO (85 mg/kg b.w.) on day...
Source: J Physiol Pharmacol - May 13, 2024 Category: Drugs & Pharmacology Authors: X Y Liao P Liu T F Luo Y Li Y Gao F Y Pan K C Wang Source Type: research
FicD regulates adaptation to the unfolded protein response in the murine liver
Biochimie. 2024 May 11:S0300-9084(24)00106-8. doi: 10.1016/j.biochi.2024.05.012. Online ahead of print.ABSTRACTThe unfolded protein response (UPR) is a cellular stress response that is activated when misfolded proteins accumulate in the endoplasmic reticulum (ER). Regulation of the UPR response must be adapted to the needs of the cell as prolonged UPR responses can result in disrupted cellular function and tissue damage. Previously, we discovered that the enzyme FicD (also known as Fic or HYPE) through its AMPylation and deAMPylation activity can modulate the UPR response via post-translational modification of BiP. FicD AM...
Source: Biochimie - May 13, 2024 Category: Biochemistry Authors: Amanda K Casey Nathan M Stewart Naqi Zaidi Hillery F Gray Amelia Cox Hazel A Fields Kim Orth Source Type: research
Microplastic contamination in some beverages marketed in t ürkiye: Characteristics, dietary exposure and risk assessment
In this study, microplastic contamination in water, natural mineral water and mineral water, sparkling soft drinks, cold tea and some traditional beverages marketed in Türkiye were assessed. Microplastics physically and chemically characterized by microscope and ATR/FT-IR, respectively. Microplastics were detected in 9 out of 47 beverage samples. A total of 250 microplastics with 5 different polymers, 2 different shapes, and 7 different colours were detected in 47 beverage samples. The average microplastic concentration was 2.24 ± 9.86 particles/L for all beverages analysed. The highest average microplastic concentration...
Source: Food and Chemical Toxicology - May 13, 2024 Category: Food Science Authors: Burhan Basaran Ülgen Aytan Yasemen Şentürk Zehra Özçifçi Hakk ı Türker Akçay Source Type: research
Solid-state fermentation using wheat bran to produce glucose syrup and functional cereal bars
Bioprocess Biosyst Eng. 2024 May 13. doi: 10.1007/s00449-024-03032-1. Online ahead of print.ABSTRACTWheat bran is one of the most abundant by-products from grain milling, which can be used as substrate for solid-state fermentation (SSF) to obtain enzymes able to convert this agro-industrial waste into glucose syrup, which in turn can be applied for the production of different food products. The present study aimed to determine centesimal composition of wheat bran, obtain enzymatic extract that converts wheat bran into wheat glucose syrup (WGS), produce rice flakes cereal bars (RFCB), and evaluate their nutritional composit...
Source: Bioprocess and Biosystems Engineering - May 13, 2024 Category: Biomedical Engineering Authors: C élia Cristina Malaguti Figueiredo Filipe Oliveira Granero Luciana Pereira Silva Ilca Fabiane Am âncio Nogueira Joyce Faria de Souza Bruna Escaramboni Pedro de Oliva Neto Regildo M árcio Gonçalves da Silva Source Type: research
Reduced Incretin Receptor Trafficking upon Activation Enhances Glycemic Control and Reverses Obesity in Diet-Induced Obese Mice
Am J Physiol Cell Physiol. 2024 May 13. doi: 10.1152/ajpcell.00474.2023. Online ahead of print.ABSTRACTActivation of incretin receptors by their cognate agonists augments sustained cAMP generation both from the plasma membrane as well as from the endosome. To address the functional outcome of this spatiotemporal signaling, we developed a non-acylated glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor dual agonist I-M-150847 that reduced receptor internalization following activation of the incretin receptors. The incretin receptor dual agonist I-M-150847 was developed by replacin...
Source: Am J Physiol Cell Ph... - May 13, 2024 Category: Cytology Authors: Rathin Bauri Shilpak Bele Jhansi Edelli Neelesh C Reddy Sreenivasulu Kurukuti Tom Devasia Ahamed Ibrahim Vishal Rai Prasenjit Mitra Source Type: research
