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miR ‐2940‐1 is involved in the circadian regulation of oviposition in Aedes albopictus
Aedes albopictus females exhibit oviposition rhythms that are controlled by an endogenous clock, regulated by the zeitgeber of light. Antagomir-mediated knockdown of the rhythmically expressedmiR-2940-1 affected the oviposition rhythm. AbstractThe vast majority of all global species have circadian rhythm cycles that allow them to adapt to natural environments. These regular rhythms are regulated by core clock genes and recent studies have also implicated roles for microRNAs in this regulation. Oviposition is an important circadian behavior in the reproductive cycle of insect vectors of diseases, and little is known about t...
Source: Insect Science - April 1, 2024 Category: Biology Authors: Xiaolin Xiao, Ling Kong, Zhensheng Xie, Hongkai Liu, Lijun Cai, Siyu Zhao, Jiayong Zhou, Shuang Liu, Jing Wu, Yiming Wu, Peilin Wu, Anthony A. James, Xiao ‐Guang Chen Tags: ORIGINAL ARTICLE Source Type: research

Biased virus transmission following sequential coinfection of < i > Aedes aegypti < /i > with dengue and Zika viruses
Conclusions/significanceOur findings suggest that, in contrast to simultaneous arbovirus coinfection in mosquitoes that can promote the transmission and co-circulation of these viruses, sequential coinfection appears to have limited influence on arbovirus transmission dynamics. However, it is important to note that more experimental investigations are needed to refine and expand upon this conclusion. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 1, 2024 Category: Tropical Medicine Authors: Jiameng Peng Source Type: research

Molecular and serological evidence of chikungunya virus infection with high case fatality among pediatric population with acute encephalitis syndrome: first report from Eastern Uttar Pradesh, India
This study advocates constant serological and molecular surveillance of CHIKV in AES endemic regions of India. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 1, 2024 Category: Microbiology Source Type: research

Molecular epidemiology identifies the expansion of the DENV2 epidemic lineage from the French Caribbean Islands to French Guiana and mainland France, 2023 to 2024
Euro Surveill. 2024 Mar;29(13). doi: 10.2807/1560-7917.ES.2024.29.13.2400123.ABSTRACTIn 2023, dengue virus serotype 2 (DENV2) affected most French overseas territories. In the French Caribbean Islands, viral circulation continues with > 30,000 suspected infections by March 2024. Genome sequence analysis reveals that the epidemic lineage in the French Caribbean islands has also become established in French Guiana but not Réunion. It has moreover seeded autochthonous circulation events in mainland France. To guide prevention of further inter-territorial spread and DENV introduction in non-endemic settings, continued mole...
Source: Euro Surveill - March 29, 2024 Category: Infectious Diseases Authors: Rapha ëlle Klitting G éraldine Piorkowski Dominique Rousset Andr é Cabié Etienne Frumence Alis é Lagrave Anne Lavergne Antoine Enfissi George Dos Santos Laurence Fagour Raymond C ésaire Marie-Christine Jaffar-Bandjee Nicolas Traversier Patrick G ér Source Type: research

Molecular epidemiology identifies the expansion of the DENV2 epidemic lineage from the French Caribbean Islands to French Guiana and mainland France, 2023 to 2024
Euro Surveill. 2024 Mar;29(13):2400123. doi: 10.2807/1560-7917.ES.2024.29.13.2400123.ABSTRACTIn 2023, dengue virus serotype 2 (DENV2) affected most French overseas territories. In the French Caribbean Islands, viral circulation continues with > 30,000 suspected infections by March 2024. Genome sequence analysis reveals that the epidemic lineage in the French Caribbean islands has also become established in French Guiana but not Réunion. It has moreover seeded autochthonous circulation events in mainland France. To guide prevention of further inter-territorial spread and DENV introduction in non-endemic settings, contin...
Source: Euro Surveill - March 29, 2024 Category: Infectious Diseases Authors: Rapha ëlle Klitting G éraldine Piorkowski Dominique Rousset Andr é Cabié Etienne Frumence Alis é Lagrave Anne Lavergne Antoine Enfissi George Dos Santos Laurence Fagour Raymond C ésaire Marie-Christine Jaffar-Bandjee Nicolas Traversier Patrick G ér Source Type: research

Proceedings of the 6th Asia Dengue Summit, June 2023
by Nattachai Srisawat, Duane J. Gubler, Tikki Pangestu, Umaporn Limothai, Usa Thisyakorn, Zulkifli Ismail, Daniel Goh, Maria Rosario Capeding, Lulu Bravo, Sutee Yoksan, Terapong Tantawichien, Sri Rezeki Hadinegoro, Kamran Rafiq, Valentina Sanchez Picot, Eng Eong Ooi The 6th Asia Dengue Summit (ADS) themed “Road Map to Zero Dengue Death” was held in Thailand from 15th–16th June 2023. The summit was hosted by Tropical Medicine Cluster, Chulalongkorn University, Bangkok, Thailand in conjunction with Queen Saovabha Memorial Institute, The Thai Red Cross Society; Faculty of Tropical Medicine, Mahido l University; and the...
Source: PLoS Neglected Tropical Diseases - March 29, 2024 Category: Tropical Medicine Authors: Nattachai Srisawat Source Type: research

Transgenic line for characterizing GABA-receptor expression to study the neural basis of olfaction in the yellow-fever mosquito
The mosquito Aedes aegypti is an important vector of diseases including dengue, Zika, chikungunya, and yellow fever. Olfaction is a critical modality for mosquitoes enabling them to locate hosts, sources of nectar, and sites for oviposition. GABA is an essential neurotransmitter in olfactory processing in the insect brain, including the primary olfactory center, the antennal lobe. Previous work with Ae. aegypti has suggested that antennal lobe inhibition via GABA may be involved in the processing of odors. However, little is known about GABA receptor expression in the mosquito brain, or how they may be involved in odor att...
Source: Frontiers in Physiology - March 28, 2024 Category: Physiology Source Type: research

Viruses, Vol. 16, Pages 525: Mosquito E-20-Monooxygenase Gene Knockout Increases Dengue Virus Replication in Aedes aegypti Cells
Zhou Chunxiao Li E-20-monooxygenase (E20MO) is an enzymatic product of the shade (shd) locus (cytochrome p450, E20MO). Initially discovered in Drosophila, E20MO facilitates the conversion of ecdysone (E) into 20-hydroxyecdysone (20E) and is crucial for oogenesis. Prior research has implicated 20E in growth, development, and insecticide resistance. However, little attention has been given to the association between the E20MO gene and DENV2 infection. The transcriptome of Ae. aegypti cells (Aag2 cells) infected with DENV2 revealed the presence of the E20MO gene. The subsequent quantification of E20MO gene expression l...
Source: Viruses - March 28, 2024 Category: Virology Authors: Bo Li Di Wang Xiaoxue Xie Xiaoli Chen Guorui Liang Dan Xing Teng Zhao Jiahong Wu Xinyu Zhou Chunxiao Li Tags: Article Source Type: research

Viruses, Vol. 16, Pages 524: Dissemination of the Flavivirus Subgenomic Replicon Genome and Viral Proteins by Extracellular Vesicles
In this study, the cells that harbor subgenomic replicon derived from the Japanese encephalitis virus and dengue virus without producing any replication-competent viruses were employed as the EV donor. It was demonstrated that the EVs in the culture supernatants of those cells were able to transfer the replicon genome to other cells of various types. It was also shown that the EVs were incorporated by the recipient cells primarily through macropinocytosis after interaction with CD33 and Tim-1/Tim-4 on HeLa and K562 cells, respectively. Since the methods used in this study are free from contamination with infectious viral p...
Source: Viruses - March 28, 2024 Category: Virology Authors: Tomohiro Ishikawa Kentaro Narita Kinichi Matsuyama Michiaki Masuda Tags: Article Source Type: research

Molecular epidemiology identifies the expansion of the DENV2 epidemic lineage from the French Caribbean Islands to French Guiana and mainland France, 2023 to 2024
In 2023, dengue virus serotype 2 (DENV2) affected most French overseas territories. In the French Caribbean Islands, viral circulation continues with > 30,000 suspected infections by March 2024. Genome sequence analysis reveals that the epidemic lineage in the French Caribbean islands has also become established in French Guiana but not Réunion. It has moreover seeded autochthonous circulation events in mainland France. To guide prevention of further inter-territorial spread and DENV introduction in non-endemic settings, continued molecular surveillance and mosquito control are essential. (Source: Eurosurveillance)
Source: Eurosurveillance - March 28, 2024 Category: Infectious Diseases Authors: Rapha ëlle Klitting, Géraldine Piorkowski, Dominique Rousset, André Cabié, Etienne Frumence, Alisé Lagrave, Anne Lavergne, Antoine Enfissi, George Dos Santos, Laurence Fagour, Raymond Césaire, Marie-Christine Jaffar-Bandjee, Nicolas Traversier, Patr Source Type: research

Relationship between air temperature and dengue incidence: time series study in Minas Gerais, Brazil (2010-2019)
Cad Saude Publica. 2024 Mar 25;40(3):e00076723. doi: 10.1590/0102-311XPT076723. eCollection 2024.ABSTRACTAir temperature is a climatic factor that affects the incidence of dengue, with effects varying according to time and space. We investigated the relationship between minimum air temperature and dengue incidence in Minas Gerais, Brazil, and evaluated the influence of socioeconomic and geographic variables on this relationship. This is a time series study with analysis conducted in three distinct stages: modeling using a distributed lag non-linear model, meta-analysis of models obtained, and meta-regression with geographi...
Source: Cadernos de Saude Publica - March 27, 2024 Category: International Medicine & Public Health Authors: Jo ão Pedro Medeiros Gomes Igor Magaton Ribas Pedro Augusto Rosa Valadares Lucas Santos Jardim M ário Círio Nogueira C ássia de Castro Martins Ferreira Aripuan ã Sakurada Aranha Watanabe Let ícia de Castro Martins Ferreira Source Type: research