Extensive variation and strain-specificity in dengue virus susceptibility among African < i > Aedes aegypti < /i > populations
by St éphanie Dabo, Annabelle Henrion-Lacritick, Alicia Lecuyer, Davy Jiolle, Christophe Paupy, Diego Ayala, Silvânia da Veiga Leal, Athanase Badolo, Anubis Vega-Rúa, Massamba Sylla, Jewelna Akorli, Sampson Otoo, Joel Lutomiah, Rosemary Sang, John-Paul Mutebi, Maria-Carla Saleh, Noah H. Rose, Carolyn S . McBride, Louis Lambrechts
African populations of the mosquitoAedes aegypti are usually considered less susceptible to infection by human-pathogenic flaviviruses than globally invasive populations found outside Africa. Although this contrast has been well documented for Zika virus (ZIKV), it is unclear to what extent it...
Source: PLoS Neglected Tropical Diseases - March 25, 2024 Category: Tropical Medicine Authors: St éphanie Dabo Source Type: research
Urinary dengue NS1 detection on Au-decorated ZnO nanowire platform
Biosens Bioelectron. 2024 Mar 13;254:116218. doi: 10.1016/j.bios.2024.116218. Online ahead of print.ABSTRACTBiodetection for non-invasive diagnostics of fluids, especially urine, remains a challenge to scientists due to low target concentrations. And biological complexes of the detection target may contain contaminants that also interfere with any assay. Dengue non-structural 1 protein (Dengue NS1) is an important biomarker for dengue hemorrhagic fever and dengue shock syndrome. Here, we developed an Au-decorated nanowire platform and applied it with a sandwich fluorophore-linked immunosorbent well plate assay (FLISA) to d...
Source: Biosensors and Bioelectronics - March 22, 2024 Category: Biotechnology Authors: Kannika Sitthisuwannakul Ratchanon Sukthai Zetao Zhu Kazuki Nagashima Kunanon Chattrairat Supranee Phanthanawiboon Annop Klamchuen Sakon Rahong Yoshinobu Baba Takao Yasui Source Type: research
Multiple receptor tyrosine kinases regulate dengue infection of hepatocytes
DiscussionCollectively, our findings underscore the significance of multiple RTKs in DENV infection and advocate further exploration of RTK-oriented interventions against dengue. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - March 22, 2024 Category: Microbiology Source Type: research
E-Protein Protonation Titration-Induced Single-Particle Chemical Force Spectroscopy for Microscopic Understanding and pI Estimation of Infectious DENV
J Phys Chem B. 2024 Mar 21. doi: 10.1021/acs.jpcb.4c00057. Online ahead of print.ABSTRACTThe ionization state of amino acids on the outer surface of a virus regulates its physicochemical properties toward the sorbent surface. Serologically different strains of the dengue virus (DENV) show different extents of infectivity depending upon their interactions with a receptor on the host cell. To understand the structural dependence of E-protein protonation over its sequence dependence, we have followed E-protein titration kinetics both experimentally and theoretically for two differentially infected dengue serotypes, namely, DE...
Source: Health Physics - March 21, 2024 Category: Physics Authors: Manorama Ghosal Tatini Rakshit Shreya Bhattacharya Sankar Bhattacharyya Priyadarshi Satpati Dulal Senapati Source Type: research
Scoring systems for prediction of malaria and dengue fever in non-endemic areas among travellers arriving from tropical and subtropical areas
Conclusion
The presented scoring systems provide novel tools for structured assessment of patients with tropical fever in a non-endemic area and highlight clinical signs associated with a potential severe aetiology to direct the need for microbial investigation. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - March 21, 2024 Category: Emergency Medicine Authors: Satarvandi, D., van der Werff, S. D., Naucler, P., Hildenwall, H., Sonden, K. Tags: Open access Original research Source Type: research
