GSE264625 Functional genomics screens reveal a role for TBC1D24 and SV2B in antibody-dependent enhancement of dengue virus infection.
Contributors : Laura Belmont ; Maya Contreras ; Catiana H Cartwright-Acar ; Caleb D Marceau ; Aditi Agrawal ; Lisa M Levoir ; Jay Lubow ; Leslie GooSeries Type : OtherOrganism : Homo sapiensDengue virus (DENV) can hijack non-neutralizing IgG antibodies to facilitate its uptake into target cells expressing Fc gamma receptors (FcgR) - a process known as antibody-dependent enhancement (ADE) of infection. Beyond a requirement for FcgR, host dependency factors for this non-canonical infection route remain unknown. To identify cellular factors exclusively required for ADE, here, we performed CRISPR knockout screens in an in...
Source: GEO: Gene Expression Omnibus - April 27, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Changing etiological spectrum of acute liver failure
ConclusionsThe most common cause for ALF was hepatitis A virus, followed by hepatitis B virus, while in ALF mimics it was malaria followed by dengue fever, in our study. Patients of ALF mimics can have similar presentation, but a high index of suspicion and awareness is required to identify the common infectious ALF mimics for early diagnosis.Graphical Abstract (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - April 27, 2024 Category: Gastroenterology Source Type: research
NOD2 Responds to Dengue Virus Type 2 Infection in Macrophage-like Cells Interacting with MAVS Adaptor and Affecting IFN- α Production and Virus Titers
Pathogens. 2024 Apr 10;13(4):306. doi: 10.3390/pathogens13040306.ABSTRACTIn pathogen recognition, the nucleotide-binding domain (NBD) and leucine rich repeat receptors (NLRs) have noteworthy functions in the activation of the innate immune response. These receptors respond to several viral infections, among them NOD2, a very dynamic NLR, whose role in dengue virus (DENV) infection remains unclear. This research aimed to determine the role of human NOD2 in THP-1 macrophage-like cells during DENV-2 infection. NOD2 levels in DENV-2 infected THP-1 macrophage-like cells was evaluated by RT-PCR and Western blot, and an increase ...
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Diana Alhel í Domínguez-Martínez Mayra Silvia P érez-Flores Daniel N úñez-Avellaneda Jes ús M Torres-Flores Gloria Le ón-Avila Blanca Estela Garc ía-Pérez Ma Isabel Salazar Source Type: research
Prevalence of arboviruses in sickle cell disease patients from two major cities in northeast region of Brazil
Braz J Infect Dis. 2024 Apr 23:103741. doi: 10.1016/j.bjid.2024.103741. Online ahead of print.ABSTRACTSickle Cell Disease (SCD) is a hereditary disease characterized by extravascular and intravascular hemolysis and clinical variability, from mild pain to potentially life-threatening. Arboviruses include mainly Zika (ZIKV), Chikungunya (CHKV), and Dengue (DENV) virus, and are considered a public and social health problem. The present cross-sectional observational study aimed to investigate the prevalence of arbovirus infection in SCD patients from two Brazilian cities, Salvador and Manaus located in Bahia and Amazonas state...
Source: Braz J Infect Dis - April 26, 2024 Category: Infectious Diseases Authors: Jos é Pereira Moura Neto Cinthia Cristina Matheus Xerez Albuquerque Setondji Cocou Modeste Alexandre Yahouedehou Marcos Vinicius Lima Francisco Nelson Abrahim Fraiji Isadora Cristina de Siqueira Marilda Souza Gon çalves Source Type: research
Prevalence of arboviruses in sickle cell disease patients from two major cities in northeast region of Brazil
Braz J Infect Dis. 2024 Apr 23:103741. doi: 10.1016/j.bjid.2024.103741. Online ahead of print.ABSTRACTSickle Cell Disease (SCD) is a hereditary disease characterized by extravascular and intravascular hemolysis and clinical variability, from mild pain to potentially life-threatening. Arboviruses include mainly Zika (ZIKV), Chikungunya (CHKV), and Dengue (DENV) virus, and are considered a public and social health problem. The present cross-sectional observational study aimed to investigate the prevalence of arbovirus infection in SCD patients from two Brazilian cities, Salvador and Manaus located in Bahia and Amazonas state...
Source: Braz J Infect Dis - April 26, 2024 Category: Infectious Diseases Authors: Jos é Pereira Moura Neto Cinthia Cristina Matheus Xerez Albuquerque Setondji Cocou Modeste Alexandre Yahouedehou Marcos Vinicius Lima Francisco Nelson Abrahim Fraiji Isadora Cristina de Siqueira Marilda Souza Gon çalves Source Type: research
Dengue Cases Surge in Latin America and Caribbean
Millions of people in the Americas have been infected with dengue and more than 1000 have died in the first 3 months of 2024, tripling the number of dengue cases that occurred in 2023 during the same period, according to a statement by the Pan American Health Organization (PAHO). Last year, more than 4.5 million cases of the mosquito-borne illness were reported in the region, which itself was a record. Still, the case fatality rate remained low, a trend that Jarbas Barbosa, MD, PhD, MS, the director of PAHO, called “very encouraging.” (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 26, 2024 Category: General Medicine Source Type: research
Clinical and laboratory profile of Expanded Dengue Syndrome: experience of 2019 outbreak from Dhaka, Bangladesh
CONCLUSION: In the year 2019, an unusual rise in EDS cases with about 15.4% fatalities were observed in this study. Hepatitis was the most common presentation and cause of death. Here, we report the first ARDS case encountered in Bangladesh. Despite the multifaceted presentation of EDS, indiscriminate use of antibiotics and steroid was minimal. Early recognition of multifarious features of EDS is important for choosing the targeted treatment option which can avert many deaths. The results of this study underline the necessity for more in-depth research into the risk factors that are contributing to mortality in EDS cases.P...
Source: Journal of Vector Borne Diseases - April 22, 2024 Category: Infectious Diseases Authors: Zazeba Hossain Forhad U Chowdhury Mohammad A Bari Sudip R Deb Ujjwal Mallik Sakib Aman Mohammad A Haque Syeda S Ahmed Waild Mohammad Afsan Bulbul Md Arman Hossain Murada Alam Muhammad K Islam Umma Salma Md Mujibur Rahman Fazle R Chowdhury Source Type: research
Circulating serotypes and genotypes of dengue virus in North India: An observational study
CONCLUSION: DENV-1, DENV-2 and DENV-3 were found to be in circulation in North India. Predominant serotype/genotype changed at times, but not at regular intervals.PMID:38648413 | DOI:10.4103/0972-9062.392258 (Source: Journal of Vector Borne Diseases)
Source: Journal of Vector Borne Diseases - April 22, 2024 Category: Infectious Diseases Authors: Om Prakash Anil Kumar Verma Asutosh Paliwal Faisal Abbas Ashish Kumar Srivastava Vivek Kumar Mishra Shruti Radera Amita Jain Source Type: research
Assessment of larval and pupal indices of dengue mosquito vectors in a North-Eastern state of Tripura, India
CONCLUSION: The present study identified Ae. albopictus as a potential vector of dengue in Tripura. The study gave important insights on the preferred larval habitats and provides information on the indication of displacement of Ae. albopictus from rural to urban and semi-urban areas. However, longitudinal studies for longer time frame are necessary for any conclusive remarks.PMID:38648411 | DOI:10.4103/0972-9062.392268 (Source: Journal of Vector Borne Diseases)
Source: Journal of Vector Borne Diseases - April 22, 2024 Category: Infectious Diseases Authors: Siraj Ahmed Khan Smita Bordoloi Anisha Shah Subrata Baidya Source Type: research
Seroprevalence study of dengue-malaria coinfection in an East-Cameroonian public hospital: A comparison between malarial and non-malarial groups
CONCLUSION: In the study, coinfected patients were found to be more vulnerable to dengue, emphasizing the importance of epidemiological surveillance.PMID:38648408 | DOI:10.4103/0972-9062.392260 (Source: Journal of Vector Borne Diseases)
Source: Journal of Vector Borne Diseases - April 22, 2024 Category: Infectious Diseases Authors: Elodie Ayangma Ndeme Borris Rosnay Galani Tietcheu Sylvie Agokeng Demanou Dieudonne Pascal Chuisseu Djamen Nicolas Njintang Yanou Source Type: research
Isolation and molecular detection of dengue and chikungunya virus from field-collected adult mosquitoes in Kelantan, Malaysia
CONCLUSION: The presence of DENV and the main vectors of arboviruses in Kelantan are pertinent indicators of the need to improve vector controls to reduce arbovirus infections among people in the localities.PMID:38648407 | DOI:10.4103/0972-9062.392269 (Source: Journal of Vector Borne Diseases)
Source: Journal of Vector Borne Diseases - April 22, 2024 Category: Infectious Diseases Authors: Tuan Nur A Mat Jusoh Izhan S Jaafar Rafidah H Shueb Source Type: research
MBORS: Mosquito vector Biocontrol Ontology and Recommendation System
CONCLUSION: The MVAont predicts harmless biocontrol agents which help to diminish the rate of vector-borne diseases. On the other hand, the MosqVecRS system raises awareness of vectors and vector-borne diseases by recommending suitable biocontrol agents to the vector control community and researchers.PMID:38648406 | DOI:10.4103/0972-9062.383640 (Source: Journal of Vector Borne Diseases)
Source: Journal of Vector Borne Diseases - April 22, 2024 Category: Infectious Diseases Authors: G Jeyakodi P Shanthi Bala O T Sruthi K Swathi Source Type: research
Clinical and laboratory profile of Expanded Dengue Syndrome: experience of 2019 outbreak from Dhaka, Bangladesh
CONCLUSION: In the year 2019, an unusual rise in EDS cases with about 15.4% fatalities were observed in this study. Hepatitis was the most common presentation and cause of death. Here, we report the first ARDS case encountered in Bangladesh. Despite the multifaceted presentation of EDS, indiscriminate use of antibiotics and steroid was minimal. Early recognition of multifarious features of EDS is important for choosing the targeted treatment option which can avert many deaths. The results of this study underline the necessity for more in-depth research into the risk factors that are contributing to mortality in EDS cases.P...
Source: Journal of Vector Borne Diseases - April 22, 2024 Category: Infectious Diseases Authors: Zazeba Hossain Forhad U Chowdhury Mohammad A Bari Sudip R Deb Ujjwal Mallik Sakib Aman Mohammad A Haque Syeda S Ahmed Waild Mohammad Afsan Bulbul Md Arman Hossain Murada Alam Muhammad K Islam Umma Salma Md Mujibur Rahman Fazle R Chowdhury Source Type: research
Circulating serotypes and genotypes of dengue virus in North India: An observational study
CONCLUSION: DENV-1, DENV-2 and DENV-3 were found to be in circulation in North India. Predominant serotype/genotype changed at times, but not at regular intervals.PMID:38648413 | DOI:10.4103/0972-9062.392258 (Source: Journal of Vector Borne Diseases)
Source: Journal of Vector Borne Diseases - April 22, 2024 Category: Infectious Diseases Authors: Om Prakash Anil Kumar Verma Asutosh Paliwal Faisal Abbas Ashish Kumar Srivastava Vivek Kumar Mishra Shruti Radera Amita Jain Source Type: research
