Fight Aging! Newsletter, February 26th 2024
In conclusion, mTORC1 signaling contributes to the ISC fate decision, enabling regional control of intestinal cell differentiation in response to nutrition.
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Reviewing the Development of Senotherapeutics to Treat Aging
https://www.fightaging.org/archives/2024/02/reviewing-the-development-of-senotherapeutics-to-treat-aging/
Senescent cells accumulate with age and contribute meaningfully to chronic inflammation and degenerative aging. Destroying these cells produces rapid and sizable reversal of age-related diseases in mice, demonstrating that the presence of senescence cells ...
Source: Fight Aging! - February 25, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Update on Kimer Med, Improving on the DRACO Antiviral Technology and Moving Towards the Clinic
The state of anti-viral therapies isn't that great, all things considered. Technology has not yet advanced to the point at which a viral infection can be simply shut down, as is the case for near all bacterial infections. The present anti-viral drugs are either vaccines (useful!) or merely shift the odds somewhat by interfering in some part of the viral life cycle, but nowhere near as effectively as desired. Many persistent viral infections are thought to contribute meaningfully to forms of age-related dysfunction, and there is too little that can be done about that at the present time.
This landscape is one of the ...
Source: Fight Aging! - February 23, 2024 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Some Like It Hot! A Century-Old Disease on Our Southern Shores
By MIKE MAGEE
Naomi Orestes PhD, Professor of the History of Science at Harvard, didn’t mince words as she placed our predicament in context when she said, “If you know your Greek tragedies you know power, hubris, and tragedy go hand in hand. If we don’t address the harmful aspects of human activities, most obviously disruptive climate change, we are headed for tragedy.”
At the time, as a member of the Anthropocene Workgroup, she and a group of international climate scientists were focused on defining and measuring nine “planetary boundaries,” environmental indicators of planetary health. At...
Source: The Health Care Blog - October 30, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Avian Flu Climate Change Pandemic Sea level change Yellow Fever Source Type: blogs
Slideshow: Circles of Life
Every year on March 14, many people eat pie in honor of Pi Day. Mathematically speaking, pi (π) is the ratio of a circle’s circumference (the distance around the outside) to its diameter (the length from one side of the circle to the other, straight through the center). That means if you divide the circumference of any circle by its diameter, the solution will always be pi, which is roughly 3.14—hence March 14, or 3/14. But pi is an irrational number, which means that the numbers after the decimal point never end. With the help of computers, mathematicians have determined trillions of digits of pi.
To celebrate Pi ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 14, 2023 Category: Research Authors: Chrissa Chverchko Tags: Cells Molecular Structures Cellular Imaging Cool Images Microbes Research Organisms Source Type: blogs
Automated Feeding Platform to Study Mosquito Disease Transmission
A team at Rice University has developed an automated feeding platform for mosquitoes that allows researchers to test different types of repellent and investigate mosquito-borne disease transmission. Traditionally, such mosquito research would require human volunteers or animal subjects for the mosquitos to feed on, but this is obviously inconvenient and a little distasteful. This new system dispenses with the need for human volunteers and associated laborious data collection and analysis. The technology consists of 3D printed synthetic skin with real blood that flows through small vessels. Mosquitos can feed through the sk...
Source: Medgadget - February 14, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Public Health riceuniversity Source Type: blogs
Return to McAllen: A Father-Son Interview
By IAN ROBERTSON KIBBE
You are going to hear a little more about McAllen, TX on THCB Shortly. And before we dive into what’s happened there lately, I thought those of you who weren’t here back in the day might want to read an article on THCB from July 2009. Where then THCB editor Ian Kibbe interviewed his dad David Kibbe about what he was doing as a primary care doc in McAllen–Matthew Holt
By now, Dr. Atul Gawande’s article on McAllen’s high cost of health care has been widely read. The article spawned a number of responses and catalyzed a national discussion on cost controls and t...
Source: The Health Care Blog - January 27, 2023 Category: Consumer Health News Authors: matthew holt Tags: Uncategorized David Kibbe Ian Robertson Kibbe McAllen Physicians TX Source Type: blogs
TWiV 944: Hacking through Borneo with Kathryn Hanley
Kathryn Hanley joins TWiV to discuss her career and the research in her laboratory on the molecular biology, evolution and ecology of emerging RNA viruses and their insect vectors. (Source: virology blog)
Source: virology blog - October 9, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology arbovirus blackfly deforestation dengue virus emergence spillover vesicular stomatitis virus viral viruses vsv West Nile virus Source Type: blogs
TWiV 939: From lizards to Lassa with Tom Monath
Tom Monath joins TWiV to discuss his wide-ranging career that includes medicine, field work and vaccine development while working for the US government, the US military, and multiple biotechnology companies. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit Guest: Tom Monath Click arrow to playDownload TWiV 939 (73 MB .mp3, 121 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email […] (Source: virology blog)
Source: virology blog - September 25, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology Acambis COVID-19 dengue vaccine ebola virus Lassa virus NewLink Genetics vaccine platform viral viruses yellow fever virus Source Type: blogs
The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
September 08, 2022 Edition-----In the US we are seeing the outcomes of Climate Change really of and running with droughts and fires etc. Biden amped up the partisan divide with a fiery anti-Republican speech!In Russia the last leader of Soviet Russia died.In the UK we have a new PM while in Europe the energy crisis is just getting worse.In OZ we have survived the Jobs and Skills Summit with 36 prearranged outcomes. Stage management +++ in action. The GP crisis is not being addressed fully and worries regarding the Global Economy - esp. China - worsen.-----Major Issues.-----https://www.afr.com/work-and-careers/educati...
Source: Australian Health Information Technology - September 8, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Fighting Viruses with Viruses
by Gertrud U. Rey Errors during viral replication can give rise to shortened and/or rearranged genomic sequences known as “defective viral genomes” (DVGs). Because DVGs often lack critical elements needed for replication and formation of new viral particles, virions containing DVGs can only complete a replication cycle if they co-infect a cell together with respective […] (Source: virology blog)
Source: virology blog - May 5, 2022 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey antiviral Chikungunya virus defective viral genomes dengue virus DVGs mosquitoes zika virus Source Type: blogs
Multiplex Immunoassay for Dengue Diagnosis
Researchers at the University of Reading in the UK created a rapid multiplex immunoassay for the detection of Dengue fever. The technology, which the researchers call the Cygnus system, aims to provide improved sensitivity compared with lateral flow tests and improved convenience and speed compared with conventional lab tests. As a point-of-care device, the system is operable in the field and the results can be recorded and shared using a smartphone. The device can also perform ten tests at once and can identify which of the four Dengue virus types are present in the sample, reducing the need for lab testing.
Dengue fev...
Source: Medgadget - April 20, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Medicine Public Health Source Type: blogs
D-Cube syndrome : DES-Dengue-DAPT
Background
A 52-year-old diabetic woman who had undergone recent PCI with a DES developed a febrile illness which was diagnosed as Dengue fever. She has been taking DAPT (Dual antiplatelet) meticulously to maintain her stent. Now, her platelet count has dropped from 1.5 and subsequently to 1 lakh. She is asking now, whether to stop DAPT or not? What is the risk of stent occlusion if she stops?
The D³ cube syndrome
Infectious diseases rarely bother a cardiologist (maybe a few IE, myocarditis, etc). Now, a unique situation is emerging.
*Dengue affects 50-100 million people worldwide every year and one billion are ...
Source: Dr.S.Venkatesan MD - September 9, 2021 Category: Cardiology Authors: dr s venkatesan Tags: anti platelet drug antiplatelet drugs in dengue clopidogrel prasugrel ticagrelol in dengue fever dapt in dengue fever therapeutic issues in dengue and cad warfarin heparin in dengue Source Type: blogs
Paul and the Mosquitos
From the authors of Paul Has Measles and Paul Stays Home comes Paul and the Mosquitos, an illustrated book for children about mosquito-borne diseases. (Source: virology blog)
Source: virology blog - July 30, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Chikungunya dengue fever malaria mosquito mosquito borne disease viral virus viruses yellow fever Source Type: blogs
More Than 25 Years of Competition and Collaboration Advance the Prediction of Protein Shapes
Proteins (such as hemoglobin, actin, and amylase) are workhorse molecules that contribute to virtually every activity in the body. Some of proteins’ many jobs include carrying oxygen from your lungs to the rest of your body (hemoglobin), allowing your muscles to move (actin and myosin), and digesting your food (amylase, pepsin, and lactase). All proteins are made up of chains of amino acids that fold into specific 3D structures, and each protein’s structure allows it to perform its distinct job. Proteins that are misfolded or misshapen can cause diseases such as Parkinson’s or cataracts.
While it’s straightforwa...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - July 14, 2021 Category: Research Authors: Chrissa Chverchko Tags: Molecular Structures Cool Tools/Techniques Modeling Proteins Scientific Process Source Type: blogs
Correlative Adventures with COVID
By ANISH KOKA
“The patient in room 1 should be a quick one, its an addon, they just need a prescription for ivermectin”
I’m a bit puzzled by this sentence from my assistant doing his best to help me through a very busy day in the clinic that I’m already behind in. I walk into the room, a script pad stuffed into my hand as I enter the room, to meet a very nice couple. The wife sits patiently with hands crossed on the exam table.
“So, you’re here for Ivermectin?”, I ask.
Why yes, a trip to Texas is planned.. COVID is in the air, the internet, and some important people who have ‘inside ...
Source: The Health Care Blog - March 5, 2021 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Health Policy Anish Koka COVID vaccine COVID-19 vaccine Ivermectin Source Type: blogs
