Dengue dynamics: Prognostic and disease monitoring through molecular and serological profiling of clinical isolates
CONCLUSION: Our laboratory effectively standardized an RT-PCR-based approach for molecular identification of dengue virus in clinical specimens. This adaptive technique which used numerous primer sets displayed good specificity and sensitivity in serotype detection. The technology provides for quick and reliable identification of dengue virus infections, allowing for targeted treatment and preventative actions for successful disease management in highly populated regions.PMID:38634367 | DOI:10.4103/JVBD.JVBD_202_23 (Source: Journal of Vector Borne Diseases)
Source: Journal of Vector Borne Diseases - April 18, 2024 Category: Infectious Diseases Authors: Vikas Tiwari Mohd Afzal Abhishek Sharma Jaishree Tiwari Source Type: research
Shifting spatial, temporal and demographic patterns of dengue incidence and associated meteorological factors in Jazan Region of Saudi Arabia from 2015-2020
CONCLUSION: Enhanced surveillance, outbreak forecasting, targeted control activities, and integrated prevention policies grounded in continuous evidence assessment can effectively address endemic dengue transmission in Jazan. This study provides key insights to optimize data-driven decision-making for dengue control in Saudi Arabia.PMID:38634364 | DOI:10.4103/JVBD.JVBD_15_24 (Source: Journal of Vector Borne Diseases)
Source: Journal of Vector Borne Diseases - April 18, 2024 Category: Infectious Diseases Authors: Ahmad Y Alqassim Mohammed Badedi Mohammed A Muaddi Abdullah A Alharbi Mohammad A Jareebi Anwar M Makeen Maged El-Setouhy Osama B Albasheer Abdullah Sabai Ahmed Sahly Source Type: research
Viruses, Vol. 16, Pages 630: Identification of Bacteria and Viruses Associated with Patients with Acute Febrile Illness in Khon Kaen Province, Thailand
Piyada Linsuwanon
The majority of cases of undifferentiated acute febrile illness (AFI) in the tropics have an undefined etiology. In Thailand, AFI accounts for two-thirds of illnesses reported to the Ministry of Public Health. To characterize the bacterial and viral causes of these AFIs, we conducted molecular pathogen screening and serological analyses in patients who sought treatment in Chum Phae Hospital, Khon Kaen province, during the period from 2015 to 2016. Through integrated approaches, we successfully identified the etiology in 25.5% of cases, with dengue virus infection being the most common cause, noted i...
Source: Viruses - April 18, 2024 Category: Virology Authors: Rungrat Jitvaropas Vorthon Sawaswong Yong Poovorawan Nutthanun Auysawasdi Viboonsak Vuthitanachot Sirima Wongwairot Wuttikon Rodkvamtook Erica Lindroth Sunchai Payungporn Piyada Linsuwanon Tags: Article Source Type: research
Design, development, and validation of multi-epitope proteins for serological diagnosis of Zika virus infections and discrimination from dengue virus seropositivity
by Samille Henriques Pereira, Mateus S á Magalhães Serafim, Thaís de Fátima Silva Moraes, Nathalia Zini, Jônatas Santos Abrahão, Maurício Lacerda Nogueira, Jordana Grazziela Alves Coelho dos Reis, Flávia Fonseca Bagno, Flávio Guimarães da Fonseca
Zika virus (ZIKV), an arbovirus from theFlaviviridae family, is the causative agent of Zika fever, a mild and frequent oligosymptomatic disease in humans. Nonetheless, on rare occasions, ZIKV infection can be associated with Guillain-Barr é Syndrome (GBS), and severe congenital complications, such as microcephaly. The oligosymptomatic disease, however, presents symptom...
Source: PLoS Neglected Tropical Diseases - April 18, 2024 Category: Tropical Medicine Authors: Samille Henriques Pereira Source Type: research
Impact of climate change on dengue incidence in Singapore: time-series seasonal analysis
. (Source: International Journal of Environmental Health Research)
Source: International Journal of Environmental Health Research - April 17, 2024 Category: Environmental Health Authors: Md. Tauhedul IslamA S M Maksud KamalMd. Momin IslamSorif Hossaina Department of Disaster Science and Climate Resilience, University of Dhaka, Dhaka, Bangladeshb Department of Meteorology, University of Dhaka, Dhaka, Bangladeshc Department of Statistics, N Source Type: research
Dengue vector control in high-income, city settings: A scoping review of approaches and methods
ConclusionsAs most studies reported reductions in vector densities, rather than any effects on human DENV incidence or prevalence, we can draw no clear conclusions on which interventions might be most effective in reducing dengue in high-income, city areas. More research is needed linking evidence on the effects of different DENV vector control methods with dengue incidence/prevalence or mosquito vector densities in high-income, city settings as this is likely to differ from low-income settings. This is a significant evidence gap as climate changes increase the global reach of DENV. The importance of community involvement ...
Source: PLoS Neglected Tropical Diseases - April 17, 2024 Category: Tropical Medicine Authors: Anna Durrance-Bagale Source Type: research
Perceived needs of disease vector control programs: A review and synthesis of (sub)national assessments from South Asia and the Middle East
by Henk van den Berg, Kabirul Bashar, Rajib Chowdhury, Rajendra M. Bhatt, Hardev Prasad Gupta, Ashwani Kumar, Shanmugavelu Sabesan, Ananganallur N. Shriram, Hari Kishan Raju Konuganti, Akhouri T. S. Sinha, Mohammad Mehdi Sedaghat, Ahmadali Enayati, Hameeda Mohammed Hassan, Aishath Shaheen Najmee, Sana Saleem, Surendra Uranw, Pahalagedera H. D. Kusumawathie, Devika Perera, Mohammed A. Esmail, Lauren B. Carrington, Samira M. Al-Eryani, Roop Kumari, Bhupender N. Nagpal, Sabera Sultana, Raman Velayudhan, Rajpal S. Yadav
Systems for disease vector control should be effective, efficient, and flexible to be able to tackle contem...
Source: PLoS Neglected Tropical Diseases - April 17, 2024 Category: Tropical Medicine Authors: Henk van den Berg Source Type: research
Super epitope dengue vaccine instigated serotype independent immune protection in-silico
Vaccine. 2024 Apr 13:S0264-410X(24)00423-7. doi: 10.1016/j.vaccine.2024.04.009. Online ahead of print.ABSTRACTDengue becomes the most common life-threatening infectious arbovirus disease globally, with prevalence in the tropical and subtropical areas. The major clinical features include dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS), a condition of hypovolemic shock. Four different serotypes of the dengue virus, known as dengue virus serotype (DENV)- 1, 2, 3 and 4 can infect humans. Only one vaccine is available in the market, named Dengvaxia by Sanofi Pasteur, but there is no desired outcome of this treat...
Source: Vaccine - April 15, 2024 Category: Allergy & Immunology Authors: Shovan Naskar Hitesh Harsukhbhai Chandpa Shalini Agarwal Jairam Meena Source Type: research
Super epitope dengue vaccine instigated serotype independent immune protection in-silico
Vaccine. 2024 Apr 13:S0264-410X(24)00423-7. doi: 10.1016/j.vaccine.2024.04.009. Online ahead of print.ABSTRACTDengue becomes the most common life-threatening infectious arbovirus disease globally, with prevalence in the tropical and subtropical areas. The major clinical features include dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS), a condition of hypovolemic shock. Four different serotypes of the dengue virus, known as dengue virus serotype (DENV)- 1, 2, 3 and 4 can infect humans. Only one vaccine is available in the market, named Dengvaxia by Sanofi Pasteur, but there is no desired outcome of this treat...
Source: Vaccine - April 15, 2024 Category: Allergy & Immunology Authors: Shovan Naskar Hitesh Harsukhbhai Chandpa Shalini Agarwal Jairam Meena Source Type: research
Dengue hospitalizations and in-hospital mortality changes in trend in Ecuador: a nationwide study from 2015 to 2022
. (Source: Infectious Diseases)
Source: Infectious Diseases - April 15, 2024 Category: Infectious Diseases Authors: German Josuet Lapo-TalledoSchool of Medicine, Faculty of Health Sciences, Universidad T écnica de Manabí, Portoviejo, Ecuador Source Type: research
Role of auto-antibodies in the mechanisms of dengue pathogenesis and its progression: a comprehensive review
Arch Microbiol. 2024 Apr 15;206(5):214. doi: 10.1007/s00203-024-03954-0.ABSTRACTA complex interaction among virulence factors, host-genes and host immune system is considered to be responsible for dengue virus (DENV) infection and disease progression. Generation of auto-antibodies during DENV infection is a major phenomenon that plays a role in the pathophysiology of dengue hemorrhagic fever and dengue shock syndrome. Hemostasis, thrombocytopenia, hepatic endothelial dysfunction, and autoimmune blistering skin disease (pemphigus) are different clinical manifestations of dengue pathogenesis; produced due to the molecular mi...
Source: Archives of Microbiology - April 14, 2024 Category: Microbiology Authors: Tanusree Ghorai Avipsha Sarkar Anirban Roy Bijita Bhowmick Debadatta Nayak Satadal Das Source Type: research
APRI as a predictor of severe dengue fever
CONCLUSION: APRI is a straightforward index that can be easily derived from AST and platelet values. APRI values of >3.2 can predict severe dengue with a sensitivity of 69.2 and a specificity of 84.2. APRI values of >3.2 are also associated with the length of hospital stay and requirement of platelet transfusion.PMID:38605798 | PMC:PMC11006074 | DOI:10.4103/jfmpc.jfmpc_1127_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Ajith K Jayachandran Vincy Nelson K Anisha Source Type: research
APRI as a predictor of severe dengue fever
CONCLUSION: APRI is a straightforward index that can be easily derived from AST and platelet values. APRI values of >3.2 can predict severe dengue with a sensitivity of 69.2 and a specificity of 84.2. APRI values of >3.2 are also associated with the length of hospital stay and requirement of platelet transfusion.PMID:38605798 | PMC:PMC11006074 | DOI:10.4103/jfmpc.jfmpc_1127_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Ajith K Jayachandran Vincy Nelson K Anisha Source Type: research
APRI as a predictor of severe dengue fever
CONCLUSION: APRI is a straightforward index that can be easily derived from AST and platelet values. APRI values of >3.2 can predict severe dengue with a sensitivity of 69.2 and a specificity of 84.2. APRI values of >3.2 are also associated with the length of hospital stay and requirement of platelet transfusion.PMID:38605798 | PMC:PMC11006074 | DOI:10.4103/jfmpc.jfmpc_1127_23 (Source: Primary Care)
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Ajith K Jayachandran Vincy Nelson K Anisha Source Type: research
