Abrogation of USP9X is a potential strategy to decrease PEG10 levels and impede tumor progression in cutaneous T-cell lymphoma
Advanced-stage cutaneous T-cell lymphomas (CTCL) are notorious for its highly aggressive behavior, resistance to conventional treatments and poor prognosis, particularly when large-cell transformation (LCT) occurs. Paternally expressed gene 10 (PEG10) has been recently proposed as a potent driver for LCT in CTCL. However, the targeting of PEG10 continues to present a formidable clinical challenge that has yet to be addressed. Here we report an important post-translational regulatory mechanism of PEG10 in CTCL. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 25, 2024 Category: Dermatology Authors: Shan Xiong, Fengjie Liu, Jingru Sun, Shuaixin Gao, Catherine C.L. Wong, Ping Tu, Yang Wang Tags: Original Article Source Type: research
Cytokine signaling pathways as molecular markers of the efficacy of phototherapy in early stages of mycosis fungoides
(Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - April 25, 2024 Category: Dermatology Source Type: research
Experience With Bexarotene to Treat Cutaneous T-Cell Lymphomas: A Study of the Spanish Working Group of Cutaneous Lymphomas
CONCLUSIONS: Our study confirms bexarotene is a safe and effective therapy for the long-term treatment of CTCL.PMID:38653368 | DOI:10.1016/j.ad.2024.04.017 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - April 23, 2024 Category: Dermatology Authors: R Izu-Belloso I Gainza-Apraiz P Ortiz-Romero O Servitje-Bedate R Fern ández de Misa-Cabrera Y Pe ñate-Santana B Hernandez-Machin T Estrach-Panella M Llamas-Velasco J I Yanguas-Bayona M Morillo-Andujar E Acebo-Mari ñas S Perez-Gala J C Armario-Hita P Sa Source Type: research
GSE262491 XPO1 blockade with KPT-330 promotes apoptosis in Cutaneous T- cell Lymphoma by activating the p53-p21 and p27 pathways
Contributors : Nitin Chakravarti ; Amy Boles ; Rachel Burzinski ; Paola Sindaco ; Colleen Isabelle ; Kathleen McConnell ; Anjali Mishra ; Pierluigi PorcuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo assess the effects of XPO1 inhibition with small molecule inhibitor KPT-330 on Cutaneous T-cell Lymphoma after 48 hours of treatment (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Editors ’ Picks
Cutaneous T-cell lymphomas (CTCLs) comprise an incurable form of non-Hodgkin lymphoma, and advanced-stage forms of this disease, mycosis fungoides and Sezary syndrome, have poor prognosis. Previous case series documented long-lasting remission due to a graft-versus-lymphoma effect in patients treated with allogeneic hematopoietic stem cell transplantation (HSCT). In these studies, lymphoma relapse was common, and treatment-related morbidity and mortality were noted, leading to weaker recommendations for HSCT in this patient population. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 19, 2024 Category: Dermatology Tags: Editors' Picks Source Type: research
Paediatric onset lymphomatoid papulosis: results of a multicentre retrospective cohort study, on behalf of the EORTC Cutaneous Lymphoma Tumours Group (CLTG)
CONCLUSIONS: We report epidemiological data from a large international cohort of children and adolescents with LyP. Overall the prognosis of the disease is good, with excellent survival rates for all patients. Due to increased risk of associated HM, a long-term follow-up should be recommended for LyP patients.PMID:38595050 | DOI:10.1093/bjd/ljae150 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 10, 2024 Category: Dermatology Authors: Ma ël Blanchard Marie-Anne Morren Anne-Marie Busschots Esther Hauben Silvia Alberti-Violetti Emilio Berti Gianluca Avallone Gianluca Tavoletti Michele Panzone Pietro Quaglino Cristiana Colonna Rutger C Melchers Maarten H Vermeer Robert Gniadecki Christin Source Type: research
Real-world study on the use of pegylated interferon alpha-2a for treatment of mycosis fungoides/S ézary syndrome using Time to Next Treatment as a measure of clinical benefit: An EORTC CLTG study
CONCLUSIONS: PEG IFN α-2a for MF/SS showed ORR of 53%, TTNT of 9.2 months, superiority of combination regimens in comparison to monotherapy and doses of 180 mcg/weekly related to higher ORR.PMID:38596857 | DOI:10.1093/bjd/ljae152 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 10, 2024 Category: Dermatology Authors: Keila Mitsunaga Martine Bagot Caroline Ram-Wolff Emmanuella Guenova Christina von Gugelberg Emmilia Hodak Iris Amitay-Laish Evangelia Papadavid Constanze Jonak Stefanie Porkert Julia Scarisbrick Rona Applewaite Marie Beylot-Barry Jan Nicolay Pietro Quagli Source Type: research
Paediatric onset lymphomatoid papulosis: results of a multicentre retrospective cohort study, on behalf of the EORTC Cutaneous Lymphoma Tumours Group (CLTG)
CONCLUSIONS: We report epidemiological data from a large international cohort of children and adolescents with LyP. Overall the prognosis of the disease is good, with excellent survival rates for all patients. Due to increased risk of associated HM, a long-term follow-up should be recommended for LyP patients.PMID:38595050 | DOI:10.1093/bjd/ljae150 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 10, 2024 Category: Dermatology Authors: Ma ël Blanchard Marie-Anne Morren Anne-Marie Busschots Esther Hauben Silvia Alberti-Violetti Emilio Berti Gianluca Avallone Gianluca Tavoletti Michele Panzone Pietro Quaglino Cristiana Colonna Rutger C Melchers Maarten H Vermeer Robert Gniadecki Christin Source Type: research
Real-world study on the use of pegylated interferon alpha-2a for treatment of mycosis fungoides/S ézary syndrome using Time to Next Treatment as a measure of clinical benefit: An EORTC CLTG study
CONCLUSIONS: PEG IFN α-2a for MF/SS showed ORR of 53%, TTNT of 9.2 months, superiority of combination regimens in comparison to monotherapy and doses of 180 mcg/weekly related to higher ORR.PMID:38596857 | DOI:10.1093/bjd/ljae152 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 10, 2024 Category: Dermatology Authors: Keila Mitsunaga Martine Bagot Caroline Ram-Wolff Emmanuella Guenova Christina von Gugelberg Emmilia Hodak Iris Amitay-Laish Evangelia Papadavid Constanze Jonak Stefanie Porkert Julia Scarisbrick Rona Applewaite Marie Beylot-Barry Jan Nicolay Pietro Quagli Source Type: research
Paradoxical Psoriasis
Cytokine blocking therapies have revolutionized the management of psoriasis and atopic dermatitis but can lead to the development of paradoxic psoriasis (PP). Patients treated with biologics should be closely monitored for the development of PP and other paradoxical eruptions (including inflammatory joint disease, inflammatory bowel disease, eczematous eruptions, lupus like eruptions, sarcoidal eruptions, and others) and occasionally the development of cutaneous T-cell lymphoma. Further understanding the immunologic mechanism of these processes will ultimately drive our understanding of and ability to predict and manage PP...
Source: Dermatologic Clinics - April 10, 2024 Category: Dermatology Authors: Mariam Abdelghaffar, Sita Kottilil, Michael J. Murphy, Jeffrey M. Cohen, William Damsky Source Type: research
Folliculotropic mycosis fungoides associated with follicular mucinosis: A case report and mini review
Clin Case Rep. 2024 Apr 5;12(4):e8731. doi: 10.1002/ccr3.8731. eCollection 2024 Apr.ABSTRACTKEY CLINICAL MESSAGE: F-MF is a rare non-classic variant of MF. In the case of hair loss, this should be a diagnostic consideration. The essence of the diagnosis of F-MF is a careful medical history, physical examination, and a combination of immunohistological and molecular analyses (Cureus. 2022; 14:e21231, Ann Saudi Med. 2012; 32:283, Oman Med J. 2012; 27:134, Int J Dermatol. 2016; 55:1396, Saudi Med J. 2018; 39:994 and Case Rep Oncol. 2018; 11:436).ABSTRACT: Mycosis fungoides (MF) is a primary cutaneous T-cell lymphoma with mult...
Source: Ann Oncol - April 8, 2024 Category: Cancer & Oncology Authors: Majed Saleh Aldayhum Mohammed Saad Alshahrani Mahmoud Rezk A Hussein Abdulmajeed Saad Alshahrani Toka M R Hussein Source Type: research
Dupilumab therapy for atopic dermatitis is associated with increased risk of cutaneous T cell lymphoma: a retrospective cohort study
Dupilumab, a human monoclonal antibody targeting the IL4 alpha receptor, is used for treatment of moderate to severe atopic dermatitis (AD). Previous studies have reported diagnoses of cutaneous T cell lymphoma (CTCL) after dupilumab use. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 6, 2024 Category: Dermatology Authors: Iraj Hasan, Lauren Parsons, Sabrina Duran, Zachary Zinn Source Type: research
Folliculotropic mycosis fungoides associated with follicular mucinosis: A case report and mini review
Histological features of follicular mycosis fungoides. (A-B) Dense superficial and deep dermal lymphocytic infiltrate with a predominantly perifollicular/folliculocentric distribution extending into the mid-dermis. Atypical lymphocytes are located along the basal cell layer of the hair follicle epithelium. Some neoplastic lymphocytes are surrounded by a halo. Although there is epidermal thinning, there is no atypia or epidermotropism, or Pautrier microabscesses. The interfollicular epidermis is not involved. (Hematoxylin and eosin staining, original magnification, A:x20, B:x40). (C-D) Exocytosis of small and medium-sized h...
Source: Clinical Case Reports - April 5, 2024 Category: General Medicine Authors: Majed Saleh Aldayhum,
Mohammed Saad Alshahrani,
Mahmoud Rezk A. Hussein,
Abdulmajeed Saad Alshahrani,
Toka M. R. Hussein Tags: CASE REPORT Source Type: research
Cutaneous T-cell lymphoma care across Europe: insights from the Horizon Project
Br J Dermatol. 2024 Apr 5:ljae145. doi: 10.1093/bjd/ljae145. Online ahead of print.NO ABSTRACTPMID:38576352 | DOI:10.1093/bjd/ljae145 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 5, 2024 Category: Dermatology Authors: Gabriele Roccuzzo Joana Calv ão Gabor Dobos Erika Morsia Pablo Mozas Elizabeth Peterknecht Anne M R Schrader Francesca Zottarelli Martine Bagot Rudolf Stadler Maarten Vermeer Pietro Quaglino Julia Scarisbrick Source Type: research
Cutaneous T-cell lymphoma care across Europe: insights from the Horizon Project
Br J Dermatol. 2024 Apr 5:ljae145. doi: 10.1093/bjd/ljae145. Online ahead of print.NO ABSTRACTPMID:38576352 | DOI:10.1093/bjd/ljae145 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 5, 2024 Category: Dermatology Authors: Gabriele Roccuzzo Joana Calv ão Gabor Dobos Erika Morsia Pablo Mozas Elizabeth Peterknecht Anne M R Schrader Francesca Zottarelli Martine Bagot Rudolf Stadler Maarten Vermeer Pietro Quaglino Julia Scarisbrick Source Type: research
