Folliculotropic mycosis fungoides associated with follicular mucinosis: A case report and mini review

Histological features of follicular mycosis fungoides. (A-B) Dense superficial and deep dermal lymphocytic infiltrate with a predominantly perifollicular/folliculocentric distribution extending into the mid-dermis. Atypical lymphocytes are located along the basal cell layer of the hair follicle epithelium. Some neoplastic lymphocytes are surrounded by a halo. Although there is epidermal thinning, there is no atypia or epidermotropism, or Pautrier microabscesses. The interfollicular epidermis is not involved. (Hematoxylin and eosin staining, original magnification, A:x20, B:x40). (C-D) Exocytosis of small and medium-sized hyperchromatic lymphocytes into the follicular epithelium of the bulbar and isthmic portions of the hair follicle with disproportionate spongiosis and destruction of the hair follicles. The follicular epithelium is focally spongiotic. The sebaceous epithelium is also infiltrated by the atypical lymphocytes (hematoxylin-eosin stain, original magnification, C: x200, D: x400, E-G:x400, and H-I:x600). Key Clinical MessageF-MF is a rare non-classic variant of MF. In the case of hair loss, this should be a diagnostic consideration. The essence of the diagnosis of F-MF is a careful medical history, physical examination, and a combination of immunohistological and molecular analyses (Cureus. 2022; 14:e21231,Ann Saudi Med. 2012; 32:283,Oman Med J. 2012; 27:134,Int J Dermatol. 2016; 55:1396,Saudi Med J. 2018; 39:994 andCase Rep Oncol. 2018; 11:436).AbstractMycosis fung...
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research