Systemic inflammation and its relationship with pruritus in early-stage mycosis fungoides
This study provides evidence of enhanced systemic inflammation in early-stage MF patients. Additionally, the correlation between pruritus with mSWAT scores and systemic inflammation parameters suggests a potential link between pruritus and the inflammatory milieu in MF.PMID:38332520 | PMC:PMC10853580 | DOI:10.1111/jcmm.18125 (Source: J Cell Mol Med)
Source: J Cell Mol Med - February 9, 2024 Category: Molecular Biology Authors: Berna Solak Rabia Öztaş Kara Source Type: research
Outcomes of extracorporeal photopheresis in a diverse cohort of patients with cutaneous T-cell lymphoma: a retrospective study at a tertiary care hospital
J Dermatolog Treat. 2024 Dec;35(1):2312250. doi: 10.1080/09546634.2024.2312250. Epub 2024 Feb 8.NO ABSTRACTPMID:38331434 | DOI:10.1080/09546634.2024.2312250 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - February 8, 2024 Category: Dermatology Authors: David M Weiner Priyanka Kumar Ravi Varadhan Ronald Sweren Noori Kim Sima Rozati Source Type: research
GZ17-6.02 interacts with bexarotene to kill mycosis fungoides cells
Oncotarget. 2024 Feb 8;15:124-133. doi: 10.18632/oncotarget.28557.ABSTRACTGZ17-6.02, composed of curcumin, harmine and isovanillin, has undergone phase I evaluation in patients with solid tumors (NCT03775525) with an RP2D of 375 mg PO BID. The biology of GZ17-6.02 in malignant T cells and in particular those derived from mycosis fungoides (MF) patients, has not been studied. GZ17-6.02 alone and in combination with standard-of-care agents was effective in killing MF cells. All three components are necessary for optimal killing of MF cells. GZ17-6.02 activated ATM, the AMPK, NFκB and PERK and inactivated ERK1/2, AKT, ULK1, ...
Source: Oncotarget - February 8, 2024 Category: Cancer & Oncology Authors: Michael R Booth Laurence Booth Jane L Roberts Cameron West Paul Dent Source Type: research
Construction and in Vitro Evaluation of a Novel Anti-CD25 Chimeric Antigen Recepto
The interleukin-2 (IL-2) receptor has been an attractive target to treat hematologic malignancies for decades, in as much as CD25 is expressed on lymphoma or leukemia cells of T- and B-cell origin, including Adult T-cell leukemia/lymphoma, chronic lymphocytic leukemia, cutaneous T-cell lymphoma (CTCL), Hodgkin's disease, as well as B-cell non-Hodgkin's lymphoma. To date, there are no FDA approved chimeric antigen receptor T-cells (CAR-T) that treat T-cell neoplasms, so an effective CAR-T that targets a T-cell neoplasm such as Adult T-cell leukemia/lymphoma, is direly needed. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 1, 2024 Category: Hematology Authors: Ira Braunschweig Tags: 225 Source Type: research
Nerve biopsy in T-cell lymphoma with neurolymphomatosis: where and when
We report a patient with a diagnostically challenging cutaneous T-cell lymphoma and multifocal mononeuropathies in whom a targeted nerve biopsy identified lymphomatous infiltration of nerves and expedited combination treatment with chemotherapy and an autologous stem cell transplant. She showed an excellent response with a complete metabolic response on positron emission tomography imaging and significant clinical improvement, maintained 5 years post-treatment.PMID:38272664 | DOI:10.1136/pn-2023-003992 (Source: Practical Neurology)
Source: Practical Neurology - January 25, 2024 Category: Neurology Authors: Menelaos Pipis Zane Jaunmuktane Teresa Marafioti Sebastian Brandner Elaine C Smith Shirley D'Sa Michael P Lunn Kate Cwynarski Doreen Fialho Sachit Shah Geraint N Fuller Mary M Reilly Source Type: research
Racial Disparities in Mycosis Fungoides/S ézary Syndrome-A Single-Center Observational Study of 292 Patients
CONCLUSIONS: AA/black patients with MF/SS have a significant worse survival outcome compared to white patients. The association between clinical phenotypes and survival differed between these groups. Further studies are required to investigate whether race-specific pathogenesis or genetic factors may explain these differences.PMID:38245472 | DOI:10.1016/j.clml.2023.12.017 (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - January 20, 2024 Category: Cancer & Oncology Authors: Ashley R Gandham Shamir Geller Stephen W Dusza Thomas S Kupper Patricia L Myskowski Source Type: research
Utility of Low-Dose Duvelisib for Advanced Mycosis Fungoides: A Single-Institution Study
Oncologist. 2024 Jan 18:oyad345. doi: 10.1093/oncolo/oyad345. Online ahead of print.ABSTRACTDuvelisib, a small-molecule phosphatidylinositol 3-kinase-δ,γ inhibitor, has shown efficacy for mycosis fungoides (MF) at dosage ranges of 25-100 mg twice daily (BID), but with significant toxicity. We conducted a retrospective cohort study of patients with advanced MF treated with low-dose duvelisib (15 mg every other day to BID), in an effort to minimize toxicity. A total of 7 patients were included. The overall response rate on duvelisib was 71%, with the remaining patients maintaining stable disease. Mean modified Severity Wei...
Source: The Oncologist - January 20, 2024 Category: Cancer & Oncology Authors: Christopher Bazewicz Nicolena Verardi Oleg Akilov Source Type: research
Development of a tetrahydroindazolone-based HDAC6 inhibitor with in-vivo anti-arthritic activity
Bioorg Med Chem. 2024 Feb 1;99:117587. doi: 10.1016/j.bmc.2024.117587. Epub 2024 Jan 7.ABSTRACTHistone deacetylase 6 (HDAC6) induces the expression of pro-inflammatory cytokines in macrophages; therefore, HDAC inhibitors may be beneficial for the treatment of macrophage-associated immune disorders and chronic inflammatory diseases, including atherosclerosis and rheumatoid arthritis. Structure-activity relationship studies were conducted on various phenyl hydroxamate HDAC6 inhibitors with indolone/indazolone-based bi- or tricyclic ring moieties as the cap group aiming to develop novel anti-arthritic drug candidates. Several...
Source: Bioorganic and Medicinal Chemistry - January 18, 2024 Category: Chemistry Authors: Hyun-Mo Yang Changsik Lee Jaeki Min Nina Ha Daekwon Bae Gibeom Nam Hyun-Ju Park Source Type: research
Chemical exposures and demographic associations in cutaneous T-cell lymphoma: a large single institution physician validated cohort study
AbstractCutaneous T-cell lymphomas (CTCL) are a rare group of T-cell neoplasms which infiltrate the skin and can result in substantial morbidity and mortality. Risk factors for CTCL are still poorly understood though recent studies suggest chemical exposures may play a role in its development. To further characterize patient-centered risk factors for CTCL, especially compared with matched controls, we performed one of the largest prospective cohort survey studies to date to examine patient-reported exposures and health-related quality of life (HRQoL) in association with concurrent clinical disease characteristics. Patient ...
Source: Archives of Dermatological Research - January 18, 2024 Category: Dermatology Source Type: research
