Genetic predisposition to early mycosis fungoides: investigating genetic polymorphisms in tissue-resident memory T-cell genes
CONCLUSIONS: The presence of genetic variations in one or more TRM functional gene may predispose patients to develop MF. Further studies involving a larger patient population and a comparative analysis of protein expression will be necessary to validate these findings.PMID:38546260 | DOI:10.1177/03000605241239034 (Source: Cell Research)
Source: Cell Research - March 28, 2024 Category: Cytology Authors: Nour Almaani Fatima Farhan Salsabiela Bani Hamad Eman A Abuhawileh Lana Koubaitary Mamoun Ahram Tariq N Aladily Source Type: research
Targeting TGF-beta activation in cutaneous T-cell lymphomas
Cutaneous T-cell lymphomas (CTCL) are T-cell malignancies of the skin. In advanced-stage CTCL, the remissions are generally rare and short, and overall survival (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - March 28, 2024 Category: Dermatology Authors: J érôme GIUSTINIANI, Van Anh TA, Sadjia Belkhelouat, Maxime BATTISTELLA, Dina OUAHBI, Caroline RAM-WOLFF, Baptiste LOUVEAU, Samia MOURAH, Martine BAGOT, Hélène MOINS-TEISSERENC, Nicolas Ortonne, Armand BENSUSSAN, Adèle DE. MASSON Tags: Letters to the Editor Source Type: research
Targeting TGF- β Activation in Cutaneous T-Cell Lymphomas
Cutaneous T-cell lymphomas (CTCLs) are T-cell malignancies of the skin. In advanced-stage CTCLs, the remissions are generally rare and short, and overall survival is (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - March 28, 2024 Category: Dermatology Authors: J érôme Giustiniani, Van Anh Ta, Sadjia Belkhelouat, Maxime Battistella, Dina Ouahbi, Caroline Ram-Wolff, Baptiste Louveau, Samia Mourah, Martine Bagot, Hélène Moins-Teisserenc, Nicolas Ortonne, Armand Bensussan, Adèle De Masson Tags: Letters to the Editor Source Type: research
Allogeneic hematopoietic stem cell transplantation after mogamulizumab in T-cell lymphoma patients: a retrospective analysis
Int J Hematol. 2024 Mar 27. doi: 10.1007/s12185-024-03753-9. Online ahead of print.ABSTRACTAllogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important therapy for patients with T-cell lymphomas, including cutaneous T-cell lymphoma (CTCL), adult T-cell lymphoma (ATL), and peripheral T-cell lymphoma (PTCL). Mogamulizumab is an anti-CCR4 antibody that has been associated with an increased risk of transplant-related complications in retrospective analyses of ATL, particularly when administered within 50 days before transplantation. This post hoc analysis of 3 clinical trials examined safety and outcome data ...
Source: International Journal of Hematology - March 27, 2024 Category: Hematology Authors: Mary Jo Lechowicz Christy Smith Robert Ristuccia Karen Dwyer Source Type: research
Tailoring Radiation Therapy for Patients With Limited Cutaneous T Cell Lymphoma: Preliminary Clinical Experience With Subtotal Skin Electron Therapy
CONCLUSION: This analysis demonstrated that treatment of CTCL patients with low disease burden with STSEBT results in similar overall response and time to progression compared to treatment with TSEBT.PMID:38537978 | DOI:10.21873/anticanres.16945 (Source: Cell Research)
Source: Cell Research - March 27, 2024 Category: Cytology Authors: Brady S Laughlin Isabella Zaniletti Madeline G Foster John Lucido Aaron R Mangold Allison C Rosenthal Charles VAN DER Walt William Breen Scott Lester Bradford Hoppe Jennifer Petersen Michael D Armstrong Aaron Bogan William G Rule Source Type: research
Allogeneic hematopoietic stem cell transplantation after mogamulizumab in T-cell lymphoma patients: a retrospective analysis
Int J Hematol. 2024 Mar 27. doi: 10.1007/s12185-024-03753-9. Online ahead of print.ABSTRACTAllogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important therapy for patients with T-cell lymphomas, including cutaneous T-cell lymphoma (CTCL), adult T-cell lymphoma (ATL), and peripheral T-cell lymphoma (PTCL). Mogamulizumab is an anti-CCR4 antibody that has been associated with an increased risk of transplant-related complications in retrospective analyses of ATL, particularly when administered within 50 days before transplantation. This post hoc analysis of 3 clinical trials examined safety and outcome data ...
Source: International Journal of Hematology - March 27, 2024 Category: Hematology Authors: Mary Jo Lechowicz Christy Smith Robert Ristuccia Karen Dwyer Source Type: research
Genomic profiling of Mycosis Fungoides identifies patients at high risk of disease progression
Blood Adv. 2024 Mar 21:bloodadvances.2023012125. doi: 10.1182/bloodadvances.2023012125. Online ahead of print.ABSTRACTMycosis fungoides (MF) is the most prevalent primary cutaneous T-cell lymphoma, with an indolent or aggressive course and poor survival. The pathogenesis of MF remains unclear, and prognostic factors in the early stages are not well-established. Here, we characterized the most recurrent genomic alterations using whole-exome sequencing of 67 samples from 48 patients from Lille University Hospital (France), including 18 sequential samples drawn across stages of the malignancy. Genomic data were analyzed on th...
Source: Adv Data - March 21, 2024 Category: Epidemiology Authors: L éa Fléchon In ès Arib Ankit K Dutta Lama Hasan Bou Issa Romanos Sklavenitis-Pistofidis Remi Tilmont Chip Stewart Romain Dubois St éphanie Poulain Marie-Christine Copin Sahir Javed Morgane Nudel Doriane Cavalieri Guillaume Escure Nicolas Gower Paul C Source Type: research
Genes, Vol. 15, Pages 358: New Genetic Markers of Skin T-Cell Lymphoma Treatment
Conclusion: Although genotyping results were not known during the treatment decision and could not modify it, the clinical decision on severity and therapy reflected some aspects of the genetic background of this complicated T-cell-associated disease very well. (Source: Genes)
Source: Genes - March 13, 2024 Category: Genetics & Stem Cells Authors: Vladim ír Vašků Petra Fialov á Anna Va šků Tags: Article Source Type: research
Mycosis Fungoides: successful re-treatment with Brentuximab Vedotin
Br J Dermatol. 2024 Mar 12:ljae097. doi: 10.1093/bjd/ljae097. Online ahead of print.NO ABSTRACTPMID:38470968 | DOI:10.1093/bjd/ljae097 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 12, 2024 Category: Dermatology Authors: Mariel James Mano Nakamura Sean Whittaker Stephen Morris Source Type: research
Long term outcomes of nonmyeloablative allogeneic stem cell transplantation with TSEB TLI and ATG for Mycosis Fungoides and Sezary Syndrome
Bone Marrow Transplantation, Published online: 12 March 2024; doi:10.1038/s41409-024-02236-zLong term outcomes of nonmyeloablative allogeneic stem cell transplantation with TSEB TLI and ATG for Mycosis Fungoides and Sezary Syndrome (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - March 12, 2024 Category: Hematology Authors: S. L. Morris B. R. Thomas R. Palanicawandar S. Whittaker F. Child M. Wain V. Sim R. Szydlo S. Mangar E. Olavarria S. Lozano Cerrada A. Muzamil E. Kanfer Source Type: research
Erythema gyratum repens-like presentation of folliculotropic mycosis fungoides
(Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Hida, Yasutoshi Source Type: research
Milia en plaque on the shoulder as an early manifestations of mycosis fungoides
Milia en plaque (MEP) is an uncommon skin condition identified as retroauricular confluent milium by Boulzer and Fouqet in 1903 [1]. It can be mistaken for other dermatoses like Favre-Racouchot nodular elastosis, steatocystoma multiplex, and nevus comedonicus. Milia en plaque can either be primary or secondary and is typically benign, often triggered by dermatological procedures like cryotherapy, as reported in this journal. In some cases, MEP can arise as a secondary manifestation of other diseases, including folliculotropic mycosis fungoides (FMF). Despite this association, there are few documented cases in the literatur...
Source: Dermatology Online Journal - March 12, 2024 Category: Dermatology Authors: Rodrigues, Felipe Tavares Source Type: research
Mycosis fungoides-like eruptions associated with abatacept
Australas J Dermatol. 2024 Mar 7. doi: 10.1111/ajd.14249. Online ahead of print.NO ABSTRACTPMID:38454790 | DOI:10.1111/ajd.14249 (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - March 8, 2024 Category: Dermatology Authors: Daichi Hoshina Yuri Nagata Source Type: research
Mycosis fungoides-like eruptions associated with abatacept
Australas J Dermatol. 2024 Mar 7. doi: 10.1111/ajd.14249. Online ahead of print.NO ABSTRACTPMID:38454790 | DOI:10.1111/ajd.14249 (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - March 8, 2024 Category: Dermatology Authors: Daichi Hoshina Yuri Nagata Source Type: research
Mycosis fungoides-like eruptions associated with abatacept
Australas J Dermatol. 2024 Mar 7. doi: 10.1111/ajd.14249. Online ahead of print.NO ABSTRACTPMID:38454790 | DOI:10.1111/ajd.14249 (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - March 8, 2024 Category: Dermatology Authors: Daichi Hoshina Yuri Nagata Source Type: research
