A patient with widespread skin lesions presenting with massive pleural effusion
Tuberk Toraks. 2023 Dec;71(4):420-427. doi: 10.5578/tt.20239610.ABSTRACTMycosis fungoides is the most commonly seen type of cutaneous T-cell lymphoproliferative disease. While mycosis fungoides is linked to an increased risk of developing secondary malignancies, the occurrence of B-cell-originated disease in association with it is exceedingly rare. A 66-year-old male with persistent papillomatous skin eruption was admitted due to dyspnea. Chest X-ray, positron emission tomography, and chest computed tomography revealed axillary and mediastinal lymph node enlargement and right lower pulmonary lobe infiltration along with ri...
Source: Tuberkuloz ve Toraks - December 28, 2023 Category: Respiratory Medicine Authors: Asl ıhan Gürün Kaya Pervin Top çuoğlu Ayten Kay ı Cangır Nihal Kundak çı I şınsu Kuzu Aylin Ok çu Heper Demet Karnak Source Type: research

A patient with widespread skin lesions presenting with massive pleural effusion
Tuberk Toraks. 2023 Dec;71(4):420-427. doi: 10.5578/tt.20239610.ABSTRACTMycosis fungoides is the most commonly seen type of cutaneous T-cell lymphoproliferative disease. While mycosis fungoides is linked to an increased risk of developing secondary malignancies, the occurrence of B-cell-originated disease in association with it is exceedingly rare. A 66-year-old male with persistent papillomatous skin eruption was admitted due to dyspnea. Chest X-ray, positron emission tomography, and chest computed tomography revealed axillary and mediastinal lymph node enlargement and right lower pulmonary lobe infiltration along with ri...
Source: Tuberkuloz ve Toraks - December 28, 2023 Category: Respiratory Medicine Authors: Asl ıhan Gürün Kaya Pervin Top çuoğlu Ayten Kay ı Cangır Nihal Kundak çı I şınsu Kuzu Aylin Ok çu Heper Demet Karnak Source Type: research

A patient with widespread skin lesions presenting with massive pleural effusion
Tuberk Toraks. 2023 Dec;71(4):420-427. doi: 10.5578/tt.20239610.ABSTRACTMycosis fungoides is the most commonly seen type of cutaneous T-cell lymphoproliferative disease. While mycosis fungoides is linked to an increased risk of developing secondary malignancies, the occurrence of B-cell-originated disease in association with it is exceedingly rare. A 66-year-old male with persistent papillomatous skin eruption was admitted due to dyspnea. Chest X-ray, positron emission tomography, and chest computed tomography revealed axillary and mediastinal lymph node enlargement and right lower pulmonary lobe infiltration along with ri...
Source: Tuberkuloz ve Toraks - December 28, 2023 Category: Respiratory Medicine Authors: Asl ıhan Gürün Kaya Pervin Top çuoğlu Ayten Kay ı Cangır Nihal Kundak çı I şınsu Kuzu Aylin Ok çu Heper Demet Karnak Source Type: research

A patient with widespread skin lesions presenting with massive pleural effusion
Tuberk Toraks. 2023 Dec;71(4):420-427. doi: 10.5578/tt.20239610.ABSTRACTMycosis fungoides is the most commonly seen type of cutaneous T-cell lymphoproliferative disease. While mycosis fungoides is linked to an increased risk of developing secondary malignancies, the occurrence of B-cell-originated disease in association with it is exceedingly rare. A 66-year-old male with persistent papillomatous skin eruption was admitted due to dyspnea. Chest X-ray, positron emission tomography, and chest computed tomography revealed axillary and mediastinal lymph node enlargement and right lower pulmonary lobe infiltration along with ri...
Source: Tuberkuloz ve Toraks - December 28, 2023 Category: Respiratory Medicine Authors: Asl ıhan Gürün Kaya Pervin Top çuoğlu Ayten Kay ı Cangır Nihal Kundak çı I şınsu Kuzu Aylin Ok çu Heper Demet Karnak Source Type: research

A patient with widespread skin lesions presenting with massive pleural effusion
Tuberk Toraks. 2023 Dec;71(4):420-427. doi: 10.5578/tt.20239610.ABSTRACTMycosis fungoides is the most commonly seen type of cutaneous T-cell lymphoproliferative disease. While mycosis fungoides is linked to an increased risk of developing secondary malignancies, the occurrence of B-cell-originated disease in association with it is exceedingly rare. A 66-year-old male with persistent papillomatous skin eruption was admitted due to dyspnea. Chest X-ray, positron emission tomography, and chest computed tomography revealed axillary and mediastinal lymph node enlargement and right lower pulmonary lobe infiltration along with ri...
Source: Tuberkuloz ve Toraks - December 28, 2023 Category: Respiratory Medicine Authors: Asl ıhan Gürün Kaya Pervin Top çuoğlu Ayten Kay ı Cangır Nihal Kundak çı I şınsu Kuzu Aylin Ok çu Heper Demet Karnak Source Type: research

A patient with widespread skin lesions presenting with massive pleural effusion
Tuberk Toraks. 2023 Dec;71(4):420-427. doi: 10.5578/tt.20239610.ABSTRACTMycosis fungoides is the most commonly seen type of cutaneous T-cell lymphoproliferative disease. While mycosis fungoides is linked to an increased risk of developing secondary malignancies, the occurrence of B-cell-originated disease in association with it is exceedingly rare. A 66-year-old male with persistent papillomatous skin eruption was admitted due to dyspnea. Chest X-ray, positron emission tomography, and chest computed tomography revealed axillary and mediastinal lymph node enlargement and right lower pulmonary lobe infiltration along with ri...
Source: Tuberkuloz ve Toraks - December 28, 2023 Category: Respiratory Medicine Authors: Asl ıhan Gürün Kaya Pervin Top çuoğlu Ayten Kay ı Cangır Nihal Kundak çı I şınsu Kuzu Aylin Ok çu Heper Demet Karnak Source Type: research

A patient with widespread skin lesions presenting with massive pleural effusion
Tuberk Toraks. 2023 Dec;71(4):420-427. doi: 10.5578/tt.20239610.ABSTRACTMycosis fungoides is the most commonly seen type of cutaneous T-cell lymphoproliferative disease. While mycosis fungoides is linked to an increased risk of developing secondary malignancies, the occurrence of B-cell-originated disease in association with it is exceedingly rare. A 66-year-old male with persistent papillomatous skin eruption was admitted due to dyspnea. Chest X-ray, positron emission tomography, and chest computed tomography revealed axillary and mediastinal lymph node enlargement and right lower pulmonary lobe infiltration along with ri...
Source: Tuberkuloz ve Toraks - December 28, 2023 Category: Respiratory Medicine Authors: Asl ıhan Gürün Kaya Pervin Top çuoğlu Ayten Kay ı Cangır Nihal Kundak çı I şınsu Kuzu Aylin Ok çu Heper Demet Karnak Source Type: research

GSE224449 Single cell RNA sequencing of blood and skin T cells from patient with mycosis fungoides
Contributors : Yun-Tsan Chang ; Desislava Ignatova ; Emmanuella GuenovaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCapture and processing of single skin and blood T cells was performed using the Fluidigm C1 Autoprep system. Cells were loaded at a concentration of 2,000 cells/ µL onto C1 integrated fluidic circuit chips for 5–10-µm cells. All C1 capture sites were microscopically inspected to identify the sites that contained only a single cell. Empty sites and those with multiple cells were excluded from further analysis. External RNA Controls Consortium spike-in RNA s serv...
Source: GEO: Gene Expression Omnibus - December 28, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Cancers, Vol. 16, Pages 141: Mogamulizumab Combined with Extracorporeal Photopheresis as a Novel Therapy in Erythrodermic Cutaneous T-cell Lymphoma
Conclusions: Our study presents the combination of mogamulizumab and ECP as an effective therapy in the blood and skin in CTCL with good tolerability, similar to mogamulizumab monotherapy. (Source: Cancers)
Source: Cancers - December 27, 2023 Category: Cancer & Oncology Authors: Nadia Ninosu Susanne Melchers Max Kappenstein Nina Booken Inga Hansen Ma ël Blanchard Emmanuella Guenova Chalid Assaf Sergij Goerdt Jan P. Nicolay Tags: Article Source Type: research

Role of Antigenic Stimulation in Cutaneous T-Cell Lymphomas
Cutaneous T-cell lymphoma (CTCL) involves a clonal expansion of malignant cells accumulating in the skin, a primary barrier site. CTCL has long been hypothesized to be caused or perpetuated by chronic antigen stimulation due to unknown exposures. These antigenic triggers, defined as any element that may cause activation of malignant T cells through TCR signaling, have been hypothesized to range from chemicals to microbes. This review covers current evidence supporting chemical and microbial stimuli that may act as antigenic triggers of CTCL and summarizes novel areas of investigation, in which the potential antigenicity of...
Source: Journal of Investigative Dermatology - December 26, 2023 Category: Dermatology Authors: Megan E. Gumina, Madeline J. Hooper, Xiaolong A. Zhou, Sergei B. Koralov Tags: Review Source Type: research

ATF5 promotes malignant T cell survival through the PI3K/AKT/mTOR pathway in cutaneous T cell lymphoma
ConclusionsThese findings revealed the tumor-specific overexpression of the transcription factor ATF5 with its underlying mechanisms in promoting tumor survival in CTCL, providing new insight into the understanding of CTCL’s pathology. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - December 22, 2023 Category: Allergy & Immunology Source Type: research

Immunosequencing applications in cutaneous T-cell lymphoma
We describe the significance of T-cell clonality and the methods used to detect it, including a detailed comparison between PCR paired with capillary electrophoresis and HTS-TCR. The utilization of immunosequencing in the blood and skin of CTCL patients is discussed in depth, specifically outlining how HTS-TCR can assist in diagnosing CTCL, predicting outcomes, and tracking disease progression. Finally, we address the potential applications of immunosequencing in clinical management and research as well as the novel challenges it presents. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - December 21, 2023 Category: Allergy & Immunology Source Type: research

Lichenoid mycosis fungoides: Report of a case with lichen planus ‐like histopathologic features
We report a 61-year-old patient with 5-year history of generalized violaceous patches and plaques. His biopsy revealed a marked lichenoid band-like infiltrate of inflammatory cells along the basal layer with basal layer vacuolar changes; the diagnosis of lichen planus was first made histopathologically. Several biopsy specimens, clinicopathologic correlation, and immunohistochemistry findings confirmed the diagnosis of lichenoid MF. Awareness of peculiar histopathologic findings of MF is essential to avoid a potential misdiagnosis. When in doubt, multiple biopsies with other diagnostic methods should be employed. (Source: ...
Source: Clinical Case Reports - December 20, 2023 Category: General Medicine Authors: Nika Kianfar, Alireza Ghanadan, Zeinab Aryanian, Ifa Etesami Tags: CASE REPORT Source Type: research

Photochemical Deoxygenative Hydroalkylation of Unactivated Alkenes Promoted by a Nucleophilic Organocatalyst
Angew Chem Int Ed Engl. 2023 Dec 18:e202317190. doi: 10.1002/anie.202317190. Online ahead of print.ABSTRACTThe direct utilization of simple and abundant feedstocks in carbon-carbon bond-forming reactions to embellish sp3-enriched chemical space is highly desirable. Herein, we report a novel photochemical deoxygenative hydroalkylation of unactivated alkenes with readily available carboxylic acid derivatives. The reaction displays broad functional group tolerance, accommodating carboxylic acid-, alcohol-, ester-, ketone-, amide-, silane-, and boronic ester groups, as well as nitrile-containing substrates. The reaction is ope...
Source: Angewandte Chemie - December 18, 2023 Category: Chemistry Authors: Jadab Majhi Bianca Matsuo Hyunjung Oh Saegun Kim Mohammed Sharique Gary Molander Source Type: research

Photochemical Deoxygenative Hydroalkylation of Unactivated Alkenes Promoted by a Nucleophilic Organocatalyst
Angew Chem Int Ed Engl. 2023 Dec 18:e202317190. doi: 10.1002/anie.202317190. Online ahead of print.ABSTRACTThe direct utilization of simple and abundant feedstocks in carbon-carbon bond-forming reactions to embellish sp3-enriched chemical space is highly desirable. Herein, we report a novel photochemical deoxygenative hydroalkylation of unactivated alkenes with readily available carboxylic acid derivatives. The reaction displays broad functional group tolerance, accommodating carboxylic acid-, alcohol-, ester-, ketone-, amide-, silane-, and boronic ester groups, as well as nitrile-containing substrates. The reaction is ope...
Source: Angewandte Chemie - December 18, 2023 Category: Chemistry Authors: Jadab Majhi Bianca Matsuo Hyunjung Oh Saegun Kim Mohammed Sharique Gary Molander Source Type: research