GATA-3 Dependent Gene Transcription is Impaired upon HDAC Inhibition
CONCLUSIONS: Beyond shedding new light on the mechanism of action associated with HDACi in CTCL, these findings have significant implications for their use, both as single agents and in combination with other novel agents, in GATA-3 driven lymphoproliferative neoplasms.PMID:38165708 | DOI:10.1158/1078-0432.CCR-23-1699 (Source: Cell Research)
Source: Cell Research - January 2, 2024 Category: Cytology Authors: Xiangrong Geng Chenguang Wang Suhaib Abdelrahman Thilini Perera Badeia Saed Ying S Hu Ashley Wolfe John Reneau Carlos Murga-Zamalloa Ryan A Wilcox Source Type: research
GATA-3 Dependent Gene Transcription is Impaired upon HDAC Inhibition
CONCLUSIONS: Beyond shedding new light on the mechanism of action associated with HDACi in CTCL, these findings have significant implications for their use, both as single agents and in combination with other novel agents, in GATA-3 driven lymphoproliferative neoplasms.PMID:38165708 | DOI:10.1158/1078-0432.CCR-23-1699 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - January 2, 2024 Category: Cancer & Oncology Authors: Xiangrong Geng Chenguang Wang Suhaib Abdelrahman Thilini Perera Badeia Saed Ying S Hu Ashley Wolfe John Reneau Carlos Murga-Zamalloa Ryan A Wilcox Source Type: research
GATA-3 Dependent Gene Transcription is Impaired upon HDAC Inhibition
CONCLUSIONS: Beyond shedding new light on the mechanism of action associated with HDACi in CTCL, these findings have significant implications for their use, both as single agents and in combination with other novel agents, in GATA-3 driven lymphoproliferative neoplasms.PMID:38165708 | DOI:10.1158/1078-0432.CCR-23-1699 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - January 2, 2024 Category: Cancer & Oncology Authors: Xiangrong Geng Chenguang Wang Suhaib Abdelrahman Thilini Perera Badeia Saed Ying S Hu Ashley Wolfe John Reneau Carlos Murga-Zamalloa Ryan A Wilcox Source Type: research
Cancers, Vol. 16, Pages 217: Identification of Skin Lesions by Snapshot Hyperspectral Imaging
This study pioneers the application of artificial intelligence (AI) and hyperspectral imaging (HSI) in the diagnosis of skin cancer lesions, particularly focusing on Mycosis fungoides (MF) and its differentiation from psoriasis (PsO) and atopic dermatitis (AD). By utilizing a comprehensive dataset of 1659 skin images, including cases of MF, PsO, AD, and normal skin, a novel multi-frame AI algorithm was used for computer-aided diagnosis. The automatic segmentation and classification of skin lesions were further explored using advanced techniques, such as U-Net Attention models and XGBoost algorithms, transforming images fro...
Source: Cancers - January 2, 2024 Category: Cancer & Oncology Authors: Hung-Yi Huang Hong-Thai Nguyen Teng-Li Lin Penchun Saenprasarn Ping-Hung Liu Hsiang-Chen Wang Tags: Article Source Type: research
Survival analysis and prognostic factors in a case series of 148 cutaneous T-cell lymphomas
CONCLUSIONS: Stage IVA and the presence of LCT at diagnosis stood out as independent factors of unfavorable prognosis. LCT was the variable that most significantly impacted the patients' survival and was closely associated with tumor skin involvement and stage IIB.PMID:38159841 | DOI:10.1016/j.ad.2023.12.002 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - December 30, 2023 Category: Dermatology Authors: C Moreno-V ílchez O Servitje Ó Íñiguez-Arroyo C Muniesa Source Type: research
Survival analysis and prognostic factors in a case series of 148 cutaneous T-cell lymphomas
CONCLUSIONS: Stage IVA and the presence of LCT at diagnosis stood out as independent factors of unfavorable prognosis. LCT was the variable that most significantly impacted the patients' survival and was closely associated with tumor skin involvement and stage IIB.PMID:38159841 | DOI:10.1016/j.ad.2023.12.002 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - December 30, 2023 Category: Dermatology Authors: C Moreno-V ílchez O Servitje Ó Íñiguez-Arroyo C Muniesa Source Type: research
Survival analysis and prognostic factors in a case series of 148 cutaneous T-cell lymphomas
CONCLUSIONS: Stage IVA and the presence of LCT at diagnosis stood out as independent factors of unfavorable prognosis. LCT was the variable that most significantly impacted the patients' survival and was closely associated with tumor skin involvement and stage IIB.PMID:38159841 | DOI:10.1016/j.ad.2023.12.002 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - December 30, 2023 Category: Dermatology Authors: C Moreno-V ílchez O Servitje Ó Íñiguez-Arroyo C Muniesa Source Type: research
Survival analysis and prognostic factors in a case series of 148 cutaneous T-cell lymphomas
CONCLUSIONS: Stage IVA and the presence of LCT at diagnosis stood out as independent factors of unfavorable prognosis. LCT was the variable that most significantly impacted the patients' survival and was closely associated with tumor skin involvement and stage IIB.PMID:38159841 | DOI:10.1016/j.ad.2023.12.002 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - December 30, 2023 Category: Dermatology Authors: C Moreno-V ílchez O Servitje Ó Íñiguez-Arroyo C Muniesa Source Type: research
A patient with widespread skin lesions presenting with massive pleural effusion
Tuberk Toraks. 2023 Dec;71(4):420-427. doi: 10.5578/tt.20239610.ABSTRACTMycosis fungoides is the most commonly seen type of cutaneous T-cell lymphoproliferative disease. While mycosis fungoides is linked to an increased risk of developing secondary malignancies, the occurrence of B-cell-originated disease in association with it is exceedingly rare. A 66-year-old male with persistent papillomatous skin eruption was admitted due to dyspnea. Chest X-ray, positron emission tomography, and chest computed tomography revealed axillary and mediastinal lymph node enlargement and right lower pulmonary lobe infiltration along with ri...
Source: Tuberkuloz ve Toraks - December 28, 2023 Category: Respiratory Medicine Authors: Asl ıhan Gürün Kaya Pervin Top çuoğlu Ayten Kay ı Cangır Nihal Kundak çı I şınsu Kuzu Aylin Ok çu Heper Demet Karnak Source Type: research
A patient with widespread skin lesions presenting with massive pleural effusion
Tuberk Toraks. 2023 Dec;71(4):420-427. doi: 10.5578/tt.20239610.ABSTRACTMycosis fungoides is the most commonly seen type of cutaneous T-cell lymphoproliferative disease. While mycosis fungoides is linked to an increased risk of developing secondary malignancies, the occurrence of B-cell-originated disease in association with it is exceedingly rare. A 66-year-old male with persistent papillomatous skin eruption was admitted due to dyspnea. Chest X-ray, positron emission tomography, and chest computed tomography revealed axillary and mediastinal lymph node enlargement and right lower pulmonary lobe infiltration along with ri...
Source: Tuberkuloz ve Toraks - December 28, 2023 Category: Respiratory Medicine Authors: Asl ıhan Gürün Kaya Pervin Top çuoğlu Ayten Kay ı Cangır Nihal Kundak çı I şınsu Kuzu Aylin Ok çu Heper Demet Karnak Source Type: research
A patient with widespread skin lesions presenting with massive pleural effusion
Tuberk Toraks. 2023 Dec;71(4):420-427. doi: 10.5578/tt.20239610.ABSTRACTMycosis fungoides is the most commonly seen type of cutaneous T-cell lymphoproliferative disease. While mycosis fungoides is linked to an increased risk of developing secondary malignancies, the occurrence of B-cell-originated disease in association with it is exceedingly rare. A 66-year-old male with persistent papillomatous skin eruption was admitted due to dyspnea. Chest X-ray, positron emission tomography, and chest computed tomography revealed axillary and mediastinal lymph node enlargement and right lower pulmonary lobe infiltration along with ri...
Source: Tuberkuloz ve Toraks - December 28, 2023 Category: Respiratory Medicine Authors: Asl ıhan Gürün Kaya Pervin Top çuoğlu Ayten Kay ı Cangır Nihal Kundak çı I şınsu Kuzu Aylin Ok çu Heper Demet Karnak Source Type: research
A patient with widespread skin lesions presenting with massive pleural effusion
Tuberk Toraks. 2023 Dec;71(4):420-427. doi: 10.5578/tt.20239610.ABSTRACTMycosis fungoides is the most commonly seen type of cutaneous T-cell lymphoproliferative disease. While mycosis fungoides is linked to an increased risk of developing secondary malignancies, the occurrence of B-cell-originated disease in association with it is exceedingly rare. A 66-year-old male with persistent papillomatous skin eruption was admitted due to dyspnea. Chest X-ray, positron emission tomography, and chest computed tomography revealed axillary and mediastinal lymph node enlargement and right lower pulmonary lobe infiltration along with ri...
Source: Tuberkuloz ve Toraks - December 28, 2023 Category: Respiratory Medicine Authors: Asl ıhan Gürün Kaya Pervin Top çuoğlu Ayten Kay ı Cangır Nihal Kundak çı I şınsu Kuzu Aylin Ok çu Heper Demet Karnak Source Type: research
A patient with widespread skin lesions presenting with massive pleural effusion
Tuberk Toraks. 2023 Dec;71(4):420-427. doi: 10.5578/tt.20239610.ABSTRACTMycosis fungoides is the most commonly seen type of cutaneous T-cell lymphoproliferative disease. While mycosis fungoides is linked to an increased risk of developing secondary malignancies, the occurrence of B-cell-originated disease in association with it is exceedingly rare. A 66-year-old male with persistent papillomatous skin eruption was admitted due to dyspnea. Chest X-ray, positron emission tomography, and chest computed tomography revealed axillary and mediastinal lymph node enlargement and right lower pulmonary lobe infiltration along with ri...
Source: Tuberkuloz ve Toraks - December 28, 2023 Category: Respiratory Medicine Authors: Asl ıhan Gürün Kaya Pervin Top çuoğlu Ayten Kay ı Cangır Nihal Kundak çı I şınsu Kuzu Aylin Ok çu Heper Demet Karnak Source Type: research
A patient with widespread skin lesions presenting with massive pleural effusion
Tuberk Toraks. 2023 Dec;71(4):420-427. doi: 10.5578/tt.20239610.ABSTRACTMycosis fungoides is the most commonly seen type of cutaneous T-cell lymphoproliferative disease. While mycosis fungoides is linked to an increased risk of developing secondary malignancies, the occurrence of B-cell-originated disease in association with it is exceedingly rare. A 66-year-old male with persistent papillomatous skin eruption was admitted due to dyspnea. Chest X-ray, positron emission tomography, and chest computed tomography revealed axillary and mediastinal lymph node enlargement and right lower pulmonary lobe infiltration along with ri...
Source: Tuberkuloz ve Toraks - December 28, 2023 Category: Respiratory Medicine Authors: Asl ıhan Gürün Kaya Pervin Top çuoğlu Ayten Kay ı Cangır Nihal Kundak çı I şınsu Kuzu Aylin Ok çu Heper Demet Karnak Source Type: research
A patient with widespread skin lesions presenting with massive pleural effusion
Tuberk Toraks. 2023 Dec;71(4):420-427. doi: 10.5578/tt.20239610.ABSTRACTMycosis fungoides is the most commonly seen type of cutaneous T-cell lymphoproliferative disease. While mycosis fungoides is linked to an increased risk of developing secondary malignancies, the occurrence of B-cell-originated disease in association with it is exceedingly rare. A 66-year-old male with persistent papillomatous skin eruption was admitted due to dyspnea. Chest X-ray, positron emission tomography, and chest computed tomography revealed axillary and mediastinal lymph node enlargement and right lower pulmonary lobe infiltration along with ri...
Source: Tuberkuloz ve Toraks - December 28, 2023 Category: Respiratory Medicine Authors: Asl ıhan Gürün Kaya Pervin Top çuoğlu Ayten Kay ı Cangır Nihal Kundak çı I şınsu Kuzu Aylin Ok çu Heper Demet Karnak Source Type: research
