Real-world study on the use of pegylated interferon alpha-2a for treatment of mycosis fungoides/S ézary syndrome using Time to Next Treatment as a measure of clinical benefit: An EORTC CLTG study
CONCLUSIONS: PEG IFN α-2a for MF/SS showed ORR of 53%, TTNT of 9.2 months, superiority of combination regimens in comparison to monotherapy and doses of 180 mcg/weekly related to higher ORR.PMID:38596857 | DOI:10.1093/bjd/ljae152 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 10, 2024 Category: Dermatology Authors: Keila Mitsunaga Martine Bagot Caroline Ram-Wolff Emmanuella Guenova Christina von Gugelberg Emmilia Hodak Iris Amitay-Laish Evangelia Papadavid Constanze Jonak Stefanie Porkert Julia Scarisbrick Rona Applewaite Marie Beylot-Barry Jan Nicolay Pietro Quagli Source Type: research
Paradoxical Psoriasis
Cytokine blocking therapies have revolutionized the management of psoriasis and atopic dermatitis but can lead to the development of paradoxic psoriasis (PP). Patients treated with biologics should be closely monitored for the development of PP and other paradoxical eruptions (including inflammatory joint disease, inflammatory bowel disease, eczematous eruptions, lupus like eruptions, sarcoidal eruptions, and others) and occasionally the development of cutaneous T-cell lymphoma. Further understanding the immunologic mechanism of these processes will ultimately drive our understanding of and ability to predict and manage PP...
Source: Dermatologic Clinics - April 10, 2024 Category: Dermatology Authors: Mariam Abdelghaffar, Sita Kottilil, Michael J. Murphy, Jeffrey M. Cohen, William Damsky Source Type: research
Folliculotropic mycosis fungoides associated with follicular mucinosis: A case report and mini review
Clin Case Rep. 2024 Apr 5;12(4):e8731. doi: 10.1002/ccr3.8731. eCollection 2024 Apr.ABSTRACTKEY CLINICAL MESSAGE: F-MF is a rare non-classic variant of MF. In the case of hair loss, this should be a diagnostic consideration. The essence of the diagnosis of F-MF is a careful medical history, physical examination, and a combination of immunohistological and molecular analyses (Cureus. 2022; 14:e21231, Ann Saudi Med. 2012; 32:283, Oman Med J. 2012; 27:134, Int J Dermatol. 2016; 55:1396, Saudi Med J. 2018; 39:994 and Case Rep Oncol. 2018; 11:436).ABSTRACT: Mycosis fungoides (MF) is a primary cutaneous T-cell lymphoma with mult...
Source: Ann Oncol - April 8, 2024 Category: Cancer & Oncology Authors: Majed Saleh Aldayhum Mohammed Saad Alshahrani Mahmoud Rezk A Hussein Abdulmajeed Saad Alshahrani Toka M R Hussein Source Type: research
Dupilumab therapy for atopic dermatitis is associated with increased risk of cutaneous T cell lymphoma: a retrospective cohort study
Dupilumab, a human monoclonal antibody targeting the IL4 alpha receptor, is used for treatment of moderate to severe atopic dermatitis (AD). Previous studies have reported diagnoses of cutaneous T cell lymphoma (CTCL) after dupilumab use. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 6, 2024 Category: Dermatology Authors: Iraj Hasan, Lauren Parsons, Sabrina Duran, Zachary Zinn Source Type: research
Folliculotropic mycosis fungoides associated with follicular mucinosis: A case report and mini review
Histological features of follicular mycosis fungoides. (A-B) Dense superficial and deep dermal lymphocytic infiltrate with a predominantly perifollicular/folliculocentric distribution extending into the mid-dermis. Atypical lymphocytes are located along the basal cell layer of the hair follicle epithelium. Some neoplastic lymphocytes are surrounded by a halo. Although there is epidermal thinning, there is no atypia or epidermotropism, or Pautrier microabscesses. The interfollicular epidermis is not involved. (Hematoxylin and eosin staining, original magnification, A:x20, B:x40). (C-D) Exocytosis of small and medium-sized h...
Source: Clinical Case Reports - April 5, 2024 Category: General Medicine Authors: Majed Saleh Aldayhum,
Mohammed Saad Alshahrani,
Mahmoud Rezk A. Hussein,
Abdulmajeed Saad Alshahrani,
Toka M. R. Hussein Tags: CASE REPORT Source Type: research
Cutaneous T-cell lymphoma care across Europe: insights from the Horizon Project
Br J Dermatol. 2024 Apr 5:ljae145. doi: 10.1093/bjd/ljae145. Online ahead of print.NO ABSTRACTPMID:38576352 | DOI:10.1093/bjd/ljae145 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 5, 2024 Category: Dermatology Authors: Gabriele Roccuzzo Joana Calv ão Gabor Dobos Erika Morsia Pablo Mozas Elizabeth Peterknecht Anne M R Schrader Francesca Zottarelli Martine Bagot Rudolf Stadler Maarten Vermeer Pietro Quaglino Julia Scarisbrick Source Type: research
Cutaneous T-cell lymphoma care across Europe: insights from the Horizon Project
Br J Dermatol. 2024 Apr 5:ljae145. doi: 10.1093/bjd/ljae145. Online ahead of print.NO ABSTRACTPMID:38576352 | DOI:10.1093/bjd/ljae145 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 5, 2024 Category: Dermatology Authors: Gabriele Roccuzzo Joana Calv ão Gabor Dobos Erika Morsia Pablo Mozas Elizabeth Peterknecht Anne M R Schrader Francesca Zottarelli Martine Bagot Rudolf Stadler Maarten Vermeer Pietro Quaglino Julia Scarisbrick Source Type: research
Matrine Enhances the Antitumor Efficacy of Chidamide in CTCL by Promoting Apoptosis
CONCLUSION: Our data have demonstrated chidamide combined with matrine to exhibit elevated antitumor activity in both CTCL cells and xenograft models of NOD/SCID mice, which may be a potential treatment option for CTCL.PMID:38571359 | DOI:10.2174/0115748928289036240318040756 (Source: Recent Patents on Anti-Cancer Drug Discovery)
Source: Recent Patents on Anti-Cancer Drug Discovery - April 4, 2024 Category: Cancer & Oncology Authors: Xinglan He Guanyu Wang Yimeng Wang Chunlei Zhang Source Type: research
Adrenal Insufficiency after Long-term use of Topical Glucocorticoids in Patients with Advanced Cutaneous T-cell Lymphomas: A Case Series
Acta Derm Venereol. 2024 Apr 2;104:adv19672. doi: 10.2340/actadv.v104.19672.NO ABSTRACTPMID:38566532 | DOI:10.2340/actadv.v104.19672 (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - April 3, 2024 Category: Dermatology Authors: Valerie Glutsch Patrick Schummer Ann-Cathrin Koschker Matthias Goebeler Marion Wobser Source Type: research
Adrenal Insufficiency after Long-term use of Topical Glucocorticoids in Patients with Advanced Cutaneous T-cell Lymphomas: A Case Series
Acta Derm Venereol. 2024 Apr 2;104:adv19672. doi: 10.2340/actadv.v104.19672.NO ABSTRACTPMID:38566532 | DOI:10.2340/actadv.v104.19672 (Source: Acta Derm Venereol A...)
Source: Acta Derm Venereol A... - April 3, 2024 Category: Dermatology Authors: Valerie Glutsch Patrick Schummer Ann-Cathrin Koschker Matthias Goebeler Marion Wobser Source Type: research
Adrenal Insufficiency after Long-term use of Topical Glucocorticoids in Patients with Advanced Cutaneous T-cell Lymphomas: A Case Series
Acta Derm Venereol. 2024 Apr 2;104:adv19672. doi: 10.2340/actadv.v104.19672.NO ABSTRACTPMID:38566532 | DOI:10.2340/actadv.v104.19672 (Source: Acta Derm Venereol A...)
Source: Acta Derm Venereol A... - April 3, 2024 Category: Dermatology Authors: Valerie Glutsch Patrick Schummer Ann-Cathrin Koschker Matthias Goebeler Marion Wobser Source Type: research
Adrenal Insufficiency after Long-term use of Topical Glucocorticoids in Patients with Advanced Cutaneous T-cell Lymphomas: A Case Series
Acta Derm Venereol. 2024 Apr 2;104:adv19672. doi: 10.2340/actadv.v104.19672.NO ABSTRACTPMID:38566532 | DOI:10.2340/actadv.v104.19672 (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - April 3, 2024 Category: Dermatology Authors: Valerie Glutsch Patrick Schummer Ann-Cathrin Koschker Matthias Goebeler Marion Wobser Source Type: research
