Folliculotropic mycosis fungoides associated with follicular mucinosis: A case report and mini review
Clin Case Rep. 2024 Apr 5;12(4):e8731. doi: 10.1002/ccr3.8731. eCollection 2024 Apr.ABSTRACTKEY CLINICAL MESSAGE: F-MF is a rare non-classic variant of MF. In the case of hair loss, this should be a diagnostic consideration. The essence of the diagnosis of F-MF is a careful medical history, physical examination, and a combination of immunohistological and molecular analyses (Cureus. 2022; 14:e21231, Ann Saudi Med. 2012; 32:283, Oman Med J. 2012; 27:134, Int J Dermatol. 2016; 55:1396, Saudi Med J. 2018; 39:994 and Case Rep Oncol. 2018; 11:436).ABSTRACT: Mycosis fungoides (MF) is a primary cutaneous T-cell lymphoma with multiple subtypes. Follicular MF (F-MF) is a non-classic variant of MF. Histological features entail folliculotropism and damage of the epithelium lining of the hair follicles with or without mucin deposition. A 52-year-old male patient complained of recurrent skin lesions on the scalp over 8 months. The lesions appeared suddenly, enlarged over time, and became itchy. A skin punch biopsy was performed. Histological features included mucin deposits in the epithelium of the hair follicles and dense, predominantly perifollicular atypical lymphocytes infiltrating the follicular epithelium. The lymphoid cells were composed of CD3-positive T cells (CD4/CD8-positive T cells) with a shift in favor of the former. The case was diagnosed as F-MF on an immunohistological basis. The diagnosis of F-MF is often difficult for dermatologists and dermatopathologists alike. Not on...
Source: Ann Oncol - Category: Cancer & Oncology Authors: Majed Saleh Aldayhum Mohammed Saad Alshahrani Mahmoud Rezk A Hussein Abdulmajeed Saad Alshahrani Toka M R Hussein Source Type: research
More News: Alopecia | Cancer & Oncology | Cutaneous T cell lymphoma | Dermatology | Itchiness | Lymphoma | Middle East Health | Mycosis Fungoides | Oman Health | Saudi Arabia Health | Skin | Skin Biopsy | T-cell Lymphoma