Romidepsin and afatinib abrogate JAK-STAT signaling and elicit synergistic antitumor effects in cutaneous T-cell lymphoma
Cutaneous T-cell lymphomas (CTCL) are mature lymphoid neoplasias resulting from the malignant transformation of skin-resident T cells. A distinctive clinical feature of CTCL is their sensitivity to treatment with histone deacetylase (HDAC) inhibitors. However, responses to HDAC inhibitor therapy are universally transient and non-curative, highlighting the need for effective and durable drug combinations. Here we demonstrate that the combination of romidepsin, a selective class I HDAC inhibitor, with afatinib, an epidermal growth factor receptor (EGFR) family inhibitor, induces strongly synergistic antitumor effects in CTCL...
Source: Journal of Investigative Dermatology - January 12, 2024 Category: Dermatology Authors: Bobby B. Shih, Cindy Ma, Jose R. Cortes, Clara Reglero, Hannah Miller, S. Aidan Quinn, Robert Albero, Anouchka P. Laurent, Adam Mackey, Adolfo A. Ferrando, Larisa Geskin, Teresa Palomero Tags: Original Article Source Type: research

Romidepsin and Afatinib Abrogate Jak –Signal Transducer and Activator of Transcription Signaling and Elicit Synergistic Antitumor Effects in Cutaneous T-Cell Lymphoma
In this study, we demonstrate that the combination of romidepsin, a selective class I histone deacetylase inhibitor, with afatinib, an EGFR family inhibitor, induces strongly synergistic antitumor effects in cutaneous T-cell lymphoma models in  vitro and in vivo through abrogation of Jak–signal transducer and activator of transcription signaling. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - January 12, 2024 Category: Dermatology Authors: Bobby B. Shih, Cindy Ma, Jose R. Cortes, Clara Reglero, Hannah Miller, S. Aidan Quinn, Robert Albero, Anouchka P. Laurent, Adam Mackey, Adolfo A. Ferrando, Larisa Geskin, Teresa Palomero Tags: Original Article Source Type: research

Effectiveness and tolerability of chlormethine gel for the management of mycosis fungoides: a multicenter real-life evaluation
ConclusionsOur observations support the use of CL gel in patients with early- and advanced-stage MF, making it a valuable treatment option. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 4, 2024 Category: Cancer & Oncology Source Type: research

Racial disparities in Mycosis Fungoides/S ézary Syndrome – A Single-center observational study of 292 patients.
In this study, we aim to characterize differences between AA/black and white patients with MF/SS. (Source: Clinical Lymphoma, Myeloma and Leukemia)
Source: Clinical Lymphoma, Myeloma and Leukemia - January 3, 2024 Category: Hematology Authors: Ashley R. Gandham, Shamir Geller, Stephen W. Dusza, Thomas S. Kupper, Patricia. L. Myskowski Tags: Original Study Source Type: research

Racial Disparities in Mycosis Fungoides/S ézary Syndrome–A Single-Center Observational Study of 292 Patients
We report worse survival in black patients compared to white patients with different survival risk for hypopigmentation, erythroderma and ulceration between the races. The underlying mechanisms require further investigation and may have impact on treatment strategies in these groups. (Source: Clinical Lymphoma, Myeloma and Leukemia)
Source: Clinical Lymphoma, Myeloma and Leukemia - January 3, 2024 Category: Hematology Authors: Ashley R. Gandham, Shamir Geller, Stephen W. Dusza, Thomas S. Kupper, Patricia. L. Myskowski Tags: Original Study Source Type: research

GATA-3 Dependent Gene Transcription is Impaired upon HDAC Inhibition
CONCLUSIONS: Beyond shedding new light on the mechanism of action associated with HDACi in CTCL, these findings have significant implications for their use, both as single agents and in combination with other novel agents, in GATA-3 driven lymphoproliferative neoplasms.PMID:38165708 | DOI:10.1158/1078-0432.CCR-23-1699 (Source: Cell Research)
Source: Cell Research - January 2, 2024 Category: Cytology Authors: Xiangrong Geng Chenguang Wang Suhaib Abdelrahman Thilini Perera Badeia Saed Ying S Hu Ashley Wolfe John Reneau Carlos Murga-Zamalloa Ryan A Wilcox Source Type: research

GATA-3 Dependent Gene Transcription is Impaired upon HDAC Inhibition
CONCLUSIONS: Beyond shedding new light on the mechanism of action associated with HDACi in CTCL, these findings have significant implications for their use, both as single agents and in combination with other novel agents, in GATA-3 driven lymphoproliferative neoplasms.PMID:38165708 | DOI:10.1158/1078-0432.CCR-23-1699 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - January 2, 2024 Category: Cancer & Oncology Authors: Xiangrong Geng Chenguang Wang Suhaib Abdelrahman Thilini Perera Badeia Saed Ying S Hu Ashley Wolfe John Reneau Carlos Murga-Zamalloa Ryan A Wilcox Source Type: research

GATA-3 Dependent Gene Transcription is Impaired upon HDAC Inhibition
CONCLUSIONS: Beyond shedding new light on the mechanism of action associated with HDACi in CTCL, these findings have significant implications for their use, both as single agents and in combination with other novel agents, in GATA-3 driven lymphoproliferative neoplasms.PMID:38165708 | DOI:10.1158/1078-0432.CCR-23-1699 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - January 2, 2024 Category: Cancer & Oncology Authors: Xiangrong Geng Chenguang Wang Suhaib Abdelrahman Thilini Perera Badeia Saed Ying S Hu Ashley Wolfe John Reneau Carlos Murga-Zamalloa Ryan A Wilcox Source Type: research

Cancers, Vol. 16, Pages 217: Identification of Skin Lesions by Snapshot Hyperspectral Imaging
This study pioneers the application of artificial intelligence (AI) and hyperspectral imaging (HSI) in the diagnosis of skin cancer lesions, particularly focusing on Mycosis fungoides (MF) and its differentiation from psoriasis (PsO) and atopic dermatitis (AD). By utilizing a comprehensive dataset of 1659 skin images, including cases of MF, PsO, AD, and normal skin, a novel multi-frame AI algorithm was used for computer-aided diagnosis. The automatic segmentation and classification of skin lesions were further explored using advanced techniques, such as U-Net Attention models and XGBoost algorithms, transforming images fro...
Source: Cancers - January 2, 2024 Category: Cancer & Oncology Authors: Hung-Yi Huang Hong-Thai Nguyen Teng-Li Lin Penchun Saenprasarn Ping-Hung Liu Hsiang-Chen Wang Tags: Article Source Type: research

Survival analysis and prognostic factors in a case series of 148 cutaneous T-cell lymphomas
CONCLUSIONS: Stage IVA and the presence of LCT at diagnosis stood out as independent factors of unfavorable prognosis. LCT was the variable that most significantly impacted the patients' survival and was closely associated with tumor skin involvement and stage IIB.PMID:38159841 | DOI:10.1016/j.ad.2023.12.002 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - December 30, 2023 Category: Dermatology Authors: C Moreno-V ílchez O Servitje Ó Íñiguez-Arroyo C Muniesa Source Type: research