Two cases of mycosis fungoides with large cell transformation with KMT2A rearrangements
AbstractCutaneous T-cell lymphomas (CTCL) are a clinically and molecularly heterogeneous class of lymphomas of the skin-homing T cell, and their genetic profiles are not fully characterized. Previously, rearrangements of the Lysine Methyltransferase 2A (KMT2A) gene have been identified as driver mutations only in acute leukemias.KMT2A plays a role in epigenetic regulation, and cancers with such rearrangements are responsive to epigenetic therapy including hypomethylating agents. Here, we report two cases of CTCL with novel genetic profiles.KMT2A rearrangements were identified in two aggressive cases of mycosis fungoides wi...
Source: Journal of Hematopathology - November 23, 2023 Category: Pathology Source Type: research

What ’s New in Cutaneous T-Cell Lymphoma-Associated Pruritus
AbstractCutaneous T-cell lymphomas are a heterogenous group of lymphomas that cause various skin manifestations. Severe pruritus occurs frequently in cutaneous T-cell lymphoma and negatively impacts patients ’ quality of life. The pathophysiology of cutaneous T-cell lymphoma-associated itch is complex and involves various immune cells, inflammatory cytokines, and neuroimmune interactions. Treating cutaneous T-cell lymphoma pruritus can be challenging, and there have been few randomized controlled stud ies evaluating the use of antipruritic treatments in these patients. Systemic therapies targeting the disease have also b...
Source: American Journal of Clinical Dermatology - November 16, 2023 Category: Dermatology Source Type: research

Old Sins Cast Long Shadows: News on Staphylococcus aureus in Cutaneous T Cell Lymphoma
Patients with cutaneous T-cell lymphoma (CTCL) face an increased susceptibility to bacterial infections, and among these infections, Staphylococcus aureus (S aureus) stands out as a major causative pathogen (Bobrowicz et al., 2020). In fact, over half of the patients afflicted with advanced-stage CTCL succumb to infections rather than the cancer itself, emphasizing the crucial clinical significance of bacterial complications, especially in those with advanced disease (as reviewed in the study by Willerslev-Olsen et  al, 2013). (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - November 16, 2023 Category: Dermatology Authors: Emmanuella Guenova, Niels Ødum Tags: Commentary Source Type: research

Non-invasive Skin Imaging in Cutaneous Lymphomas
AbstractThe diagnosis of cutaneous lymphomas is challenging and requires skin tissue for histology and immunophenotyping using immunohistochemistry and molecular studies. In recent years, the role of non-invasive imaging techniques has been described as part of the clinical assessment of cutaneous lymphoma lesions. Imaging modalities such as dermoscopy, reflectance confocal microscopy (RCM), and high frequency ultrasound (HFUS) have been shown to be very valuable in raising the clinical suspicion for lymphomas of the skin, and in distinguishing cutaneous lymphomas from inflammatory dermatoses such as lupus, psoriasis, or e...
Source: American Journal of Clinical Dermatology - November 14, 2023 Category: Dermatology Source Type: research

Psoriasiform mycosis fungoides: A clinical and prognostic retrospective cohort study
Br J Dermatol. 2023 Nov 4:ljad423. doi: 10.1093/bjd/ljad423. Online ahead of print.NO ABSTRACTPMID:37936328 | DOI:10.1093/bjd/ljad423 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 8, 2023 Category: Dermatology Authors: Joon Min Jung Hye Soo Cho Gyeong Hoon Kim Chong Hyun Won Sung Eun Chang Chan Sik Park Mi Woo Lee Woo Jin Lee Source Type: research

Psoriasiform mycosis fungoides: A clinical and prognostic retrospective cohort study
Br J Dermatol. 2023 Nov 4:ljad423. doi: 10.1093/bjd/ljad423. Online ahead of print.NO ABSTRACTPMID:37936328 | DOI:10.1093/bjd/ljad423 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 8, 2023 Category: Dermatology Authors: Joon Min Jung Hye Soo Cho Gyeong Hoon Kim Chong Hyun Won Sung Eun Chang Chan Sik Park Mi Woo Lee Woo Jin Lee Source Type: research

The combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell lymphoma cells through the enhancement of apoptosis
CONCLUSION: The use of chidamide in conjunction with BV may positively affect and enhance T-cellular apoptotic pathways without offsetting each other.PMID:37921901 | DOI:10.1007/s00280-023-04609-5 (Source: Cancer Control)
Source: Cancer Control - November 3, 2023 Category: Cancer & Oncology Authors: Yukio Tonozuka Hiroshi Tanaka Kazumi Nomura Kazuya Sakaguchi Junpei Soeda Yoshihide Kakimoto Source Type: research

Tache and talon noir in patient with mycosis fungoides on acitretin
Dermatol Online J. 2023 Aug 15;29(4). doi: 10.5070/D329461918.NO ABSTRACTPMID:37921829 | DOI:10.5070/D329461918 (Source: Dermatol Online J)
Source: Dermatol Online J - November 3, 2023 Category: Dermatology Authors: Chinemelum Obijiofor Emily Yin Marianna Shvartsbeyn Jo-Ann Latkowski Ian Ahearn Daniel Gutierrez Source Type: research

Tache and talon noir in patient with mycosis fungoides on acitretin
Dermatol Online J. 2023 Aug 15;29(4). doi: 10.5070/D329461918.NO ABSTRACTPMID:37921829 | DOI:10.5070/D329461918 (Source: Dermatol Online J)
Source: Dermatol Online J - November 3, 2023 Category: Dermatology Authors: Chinemelum Obijiofor Emily Yin Marianna Shvartsbeyn Jo-Ann Latkowski Ian Ahearn Daniel Gutierrez Source Type: research

Tache and talon noir in patient with mycosis fungoides on acitretin
Dermatol Online J. 2023 Aug 15;29(4). doi: 10.5070/D329461918.NO ABSTRACTPMID:37921829 | DOI:10.5070/D329461918 (Source: Dermatol Online J)
Source: Dermatol Online J - November 3, 2023 Category: Dermatology Authors: Chinemelum Obijiofor Emily Yin Marianna Shvartsbeyn Jo-Ann Latkowski Ian Ahearn Daniel Gutierrez Source Type: research

Tache and talon noir in patient with mycosis fungoides on acitretin
Dermatol Online J. 2023 Aug 15;29(4). doi: 10.5070/D329461918.NO ABSTRACTPMID:37921829 | DOI:10.5070/D329461918 (Source: Dermatol Online J)
Source: Dermatol Online J - November 3, 2023 Category: Dermatology Authors: Chinemelum Obijiofor Emily Yin Marianna Shvartsbeyn Jo-Ann Latkowski Ian Ahearn Daniel Gutierrez Source Type: research

Tache and talon noir in patient with mycosis fungoides on acitretin
Dermatol Online J. 2023 Aug 15;29(4). doi: 10.5070/D329461918.NO ABSTRACTPMID:37921829 | DOI:10.5070/D329461918 (Source: Dermatol Online J)
Source: Dermatol Online J - November 3, 2023 Category: Dermatology Authors: Chinemelum Obijiofor Emily Yin Marianna Shvartsbeyn Jo-Ann Latkowski Ian Ahearn Daniel Gutierrez Source Type: research

Tache and talon noir in patient with mycosis fungoides on acitretin
Dermatol Online J. 2023 Aug 15;29(4). doi: 10.5070/D329461918.NO ABSTRACTPMID:37921829 | DOI:10.5070/D329461918 (Source: Dermatol Online J)
Source: Dermatol Online J - November 3, 2023 Category: Dermatology Authors: Chinemelum Obijiofor Emily Yin Marianna Shvartsbeyn Jo-Ann Latkowski Ian Ahearn Daniel Gutierrez Source Type: research

Tache and talon noir in patient with mycosis fungoides on acitretin
Dermatol Online J. 2023 Aug 15;29(4). doi: 10.5070/D329461918.NO ABSTRACTPMID:37921829 | DOI:10.5070/D329461918 (Source: Dermatol Online J)
Source: Dermatol Online J - November 3, 2023 Category: Dermatology Authors: Chinemelum Obijiofor Emily Yin Marianna Shvartsbeyn Jo-Ann Latkowski Ian Ahearn Daniel Gutierrez Source Type: research

Tache and talon noir in patient with mycosis fungoides on acitretin
Dermatol Online J. 2023 Aug 15;29(4). doi: 10.5070/D329461918.NO ABSTRACTPMID:37921829 | DOI:10.5070/D329461918 (Source: Dermatol Online J)
Source: Dermatol Online J - November 3, 2023 Category: Dermatology Authors: Chinemelum Obijiofor Emily Yin Marianna Shvartsbeyn Jo-Ann Latkowski Ian Ahearn Daniel Gutierrez Source Type: research