Identification of Novel and Safe Fungicidal Molecules against < em > Fusarium oxysporum < /em > from Plant Essential Oils: In Vitro and Computational Approaches
Biomed Res Int. 2022 Jul 26;2022:5347224. doi: 10.1155/2022/5347224. eCollection 2022.ABSTRACTPhytopathogenic fungi are serious threats in the agriculture sector especially in fruit and vegetable production. The use of plant essential oil as antifungal agents has been in practice from many years. Plant essential oils (PEOs) of Cuminum cyminum, Trachyspermum ammi, Azadirachta indica, Syzygium aromaticum, Moringa oleifera, Mentha spicata, Eucalyptus grandis, Allium sativum, and Citrus sinensis were tested against Fusarium oxysporum. Three phase trials consist of lab testing (MIC and MFC), field testing (seed treatment and fo...
Source: Biomed Res - August 5, 2022 Category: Research Authors: Qudsia Yousafi Shabana Bibi Shahzad Saleem Abrar Hussain Mohammad Mehedi Hasan Maria Tufail Amina Qandeel Muhammad Saad Khan Sania Mazhar Maha Yousaf Mahmoud Moustafa Mohammed Al-Shehri Mohammad Khalid Atul Kabra Source Type: research
Phytotherapy known and applied by head-neck cancer patients and medical students to treat oral discomfort in Germany: an observational study
CONCLUSION: The majority of surveyed cancer patients as well as medical students use phytotherapy for treating oral discomfort. Both groups know and use similar plants. However, indications of written folk medicine differ from the lived and practiced tradition.PMID:35870011 | DOI:10.1007/s00432-022-04200-0 (Source: Clin Med Res)
Source: Clin Med Res - July 23, 2022 Category: Research Authors: Maria-Louisa Ritschel Jutta H übner Rebecca Wurm-Kuczera Judith B üntzel Source Type: research
Phytotherapy known and applied by head-neck cancer patients and medical students to treat oral discomfort in Germany: an observational study
CONCLUSION: The majority of surveyed cancer patients as well as medical students use phytotherapy for treating oral discomfort. Both groups know and use similar plants. However, indications of written folk medicine differ from the lived and practiced tradition.PMID:35870011 | DOI:10.1007/s00432-022-04200-0 (Source: Clin Med Res)
Source: Clin Med Res - July 23, 2022 Category: Research Authors: Maria-Louisa Ritschel Jutta H übner Rebecca Wurm-Kuczera Judith B üntzel Source Type: research
Phytotherapy known and applied by head-neck cancer patients and medical students to treat oral discomfort in Germany: an observational study
CONCLUSION: The majority of surveyed cancer patients as well as medical students use phytotherapy for treating oral discomfort. Both groups know and use similar plants. However, indications of written folk medicine differ from the lived and practiced tradition.PMID:35870011 | DOI:10.1007/s00432-022-04200-0 (Source: Clin Med Res)
Source: Clin Med Res - July 23, 2022 Category: Research Authors: Maria-Louisa Ritschel Jutta H übner Rebecca Wurm-Kuczera Judith B üntzel Source Type: research
The influence of Nigella sativa essential oil on proliferation, activation, and apoptosis of human T lymphocytes in vitro
In this study, we examined the immunomodulatory properties of essential oil (EO) obtained from the NS seeds by hydrodistillation and its two main constituents: thymoquinone (TQ) and p-cymene. We analyzed the proliferation, activation phenotype, and apoptosis rates of human T lymphocytes stimulated with an immobilized monoclonal anti-CD3 antibody in the presence of serial ethanol dilutions of tested oil or serial distilled water dilutions of tested compounds with flow cytometry. Our results showed that NSEO significantly inhibited the proliferation of CD4+ and CD8+ T lymphocytes, induced cell death in a dose-dependent manne...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 2, 2022 Category: Drugs & Pharmacology Authors: Klaudia Ciesielska-Figlon Agnieszka Daca Adam Kokotkiewicz Maria Łuczkiewicz Bo żena Zabiegała Jacek M Witkowski Katarzyna A Lisowska Source Type: research
The influence of Nigella sativa essential oil on proliferation, activation, and apoptosis of human T lymphocytes in vitro
In this study, we examined the immunomodulatory properties of essential oil (EO) obtained from the NS seeds by hydrodistillation and its two main constituents: thymoquinone (TQ) and p-cymene. We analyzed the proliferation, activation phenotype, and apoptosis rates of human T lymphocytes stimulated with an immobilized monoclonal anti-CD3 antibody in the presence of serial ethanol dilutions of tested oil or serial distilled water dilutions of tested compounds with flow cytometry. Our results showed that NSEO significantly inhibited the proliferation of CD4+ and CD8+ T lymphocytes, induced cell death in a dose-dependent manne...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 2, 2022 Category: Drugs & Pharmacology Authors: Klaudia Ciesielska-Figlon Agnieszka Daca Adam Kokotkiewicz Maria Łuczkiewicz Bo żena Zabiegała Jacek M Witkowski Katarzyna A Lisowska Source Type: research
Molecules, Vol. 27, Pages 4101: Umbelliferose Isolated from Cuminum cyminum L. Seeds Inhibits Antigen-Induced Degranulation in Rat Basophilic Leukemia RBL-2H3 Cells
Takuya Sugahara
Cuminum cyminum L. (cumin) is an annual plant of the Umbelliferae family native to Egypt. We previously showed that the aqueous extract of cumin seeds suppresses degranulation by downregulating the activation of antigen-induced intracellular signaling molecules in rat basophilic leukemia RBL-2H3 cells. However, the active substances in the extract have not yet been identified. Accordingly, herein, we aimed to ascertain the water-soluble substances present in cumin seeds that inhibit degranulation, which led to the identification of umbelliferose, a characteristic trisaccharide present in plants of the U...
Source: Molecules - June 25, 2022 Category: Chemistry Authors: Momoko Ishida Rika Ohara Fuka Miyagawa Hiroe Kikuzaki Kosuke Nishi Hiroyuki Onda Nanami Yoshino Takuya Sugahara Tags: Article Source Type: research
Effect of C. cyminum and L. sativum on Pharmacokinetics and Pharmacodynamics of Antidiabetic Drug Gliclazide
CONCLUSION: PK/PD based herb-drug interaction was observed. Concurrently administered garden cress + GLZ showed improved antidiabetic effect and has enhanced GLZ bioavailability.PMID:35747964 | DOI:10.2174/1389200223666220623155939 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - June 24, 2022 Category: Drugs & Pharmacology Authors: Abdulelah I Al-Suwaydani Mohd Aftab Alam Mohammed Raish Yousef A Bin Jardan Abdul Ahad Fahad I Al-Jenoobi Source Type: research
Effect of C. cyminum and L. sativum on Pharmacokinetics and Pharmacodynamics of Antidiabetic Drug Gliclazide
CONCLUSION: PK/PD based herb-drug interaction was observed. Concurrently administered garden cress + GLZ showed improved antidiabetic effect and has enhanced GLZ bioavailability.PMID:35747964 | DOI:10.2174/1389200223666220623155939 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - June 24, 2022 Category: Drugs & Pharmacology Authors: Abdulelah I Al-Suwaydani Mohd Aftab Alam Mohammed Raish Yousef A Bin Jardan Abdul Ahad Fahad I Al-Jenoobi Source Type: research
Effect of C. cyminum and L. sativum on Pharmacokinetics and Pharmacodynamics of Antidiabetic Drug Gliclazide
CONCLUSION: PK/PD based herb-drug interaction was observed. Concurrently administered garden cress + GLZ showed improved antidiabetic effect and has enhanced GLZ bioavailability.PMID:35747964 | DOI:10.2174/1389200223666220623155939 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - June 24, 2022 Category: Drugs & Pharmacology Authors: Abdulelah I Al-Suwaydani Mohd Aftab Alam Mohammed Raish Yousef A Bin Jardan Abdul Ahad Fahad I Al-Jenoobi Source Type: research
Effect of C. cyminum and L. sativum on Pharmacokinetics and Pharmacodynamics of Antidiabetic Drug Gliclazide
CONCLUSION: PK/PD based herb-drug interaction was observed. Concurrently administered garden cress + GLZ showed improved antidiabetic effect and has enhanced GLZ bioavailability.PMID:35747964 | DOI:10.2174/1389200223666220623155939 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - June 24, 2022 Category: Drugs & Pharmacology Authors: Abdulelah I Al-Suwaydani Mohd Aftab Alam Mohammed Raish Yousef A Bin Jardan Abdul Ahad Fahad I Al-Jenoobi Source Type: research
Polyphenolics, antioxidant characterization and DNA barcoding of Kala zeera [Bunium persicum (Boiss.) Fedtsch] through multiple barcode analysis to unravel best barcode combination
CONCLUSION: Based on molecular barcoding, best barcode combination was identified that may discriminate the Kala zeera germplasm vis-a-vis can authenticate their purity. Moreover, the identified DNA barcodes will have significant role in studying the evolutionary biology of Bunium species and will be important for designing a strategy to conserve the selected Kala zeera germplasm lines. The identified genotypes with high phenolic content and antioxidant activity can further be utilized in Kala zeera breeding programmes.PMID:35729477 | DOI:10.1007/s11033-022-07682-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - June 21, 2022 Category: Molecular Biology Authors: Salima Fayaz Reetika Mahajan Ammarah Hami Amjad M Husaini Sajad Ahmad Bhat Imtiyaz Murtaza Bhagyashree Dhekale Bilal A Bhat Sajad Majeed Zargar Source Type: research
Polyphenolics, antioxidant characterization and DNA barcoding of Kala zeera [Bunium persicum (Boiss.) Fedtsch] through multiple barcode analysis to unravel best barcode combination
CONCLUSION: Based on molecular barcoding, best barcode combination was identified that may discriminate the Kala zeera germplasm vis-a-vis can authenticate their purity. Moreover, the identified DNA barcodes will have significant role in studying the evolutionary biology of Bunium species and will be important for designing a strategy to conserve the selected Kala zeera germplasm lines. The identified genotypes with high phenolic content and antioxidant activity can further be utilized in Kala zeera breeding programmes.PMID:35729477 | DOI:10.1007/s11033-022-07682-w (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - June 21, 2022 Category: Molecular Biology Authors: Salima Fayaz Reetika Mahajan Ammarah Hami Amjad M Husaini Sajad Ahmad Bhat Imtiyaz Murtaza Bhagyashree Dhekale Bilal A Bhat Sajad Majeed Zargar Source Type: research
Genome analysis uncovers the prolific antagonistic and plant growth-promoting potential of endophyte Bacillus velezensis K1
Gene. 2022 Jun 14:146671. doi: 10.1016/j.gene.2022.146671. Online ahead of print.ABSTRACTInsights into the application of endophytic bacilli in sustainable agricultural practices have opened up new avenues for the inhibition of soil-borne pathogens and the improvement of plant health. Bacillus subtilis K1, an endophytic bacterium originally isolated from aerial roots of Ficus benghalensis is a potential biocontrol agent secreting a mixture of surfactins, iturins and fengycins. The current study extends the characterization of this bacterium through genomic and comparative genomics approaches. The sequencing of the bacteria...
Source: Cell Research - June 17, 2022 Category: Cytology Authors: Sandhya Nanjani Riteshri Soni Dhiraj Paul Hareshkumar Keharia Source Type: research
Genome analysis uncovers the prolific antagonistic and plant growth-promoting potential of endophyte Bacillus velezensis K1
Gene. 2022 Jun 14:146671. doi: 10.1016/j.gene.2022.146671. Online ahead of print.ABSTRACTInsights into the application of endophytic bacilli in sustainable agricultural practices have opened up new avenues for the inhibition of soil-borne pathogens and the improvement of plant health. Bacillus subtilis K1, an endophytic bacterium originally isolated from aerial roots of Ficus benghalensis is a potential biocontrol agent secreting a mixture of surfactins, iturins and fengycins. The current study extends the characterization of this bacterium through genomic and comparative genomics approaches. The sequencing of the bacteria...
Source: Gene - June 17, 2022 Category: Genetics & Stem Cells Authors: Sandhya Nanjani Riteshri Soni Dhiraj Paul Hareshkumar Keharia Source Type: research
