Cuminum cyminum Ameliorates Urotoxic Effects of Cyclophosphamide by Modulating Antioxidant, Inflammatory Cytokines, and Urinary Bladder Overactivity: In vivo and In Silioc investigations
This study aimed to investigate the effect of aqueous ethanol extract of Cuminum cyminum (AEECC) on oxidative stress, inflammation and overactivity of the urinary bladder induced by cyclophosphamide (CYP). The enhanced nociception behavior, bladder weight, vascular permeability, edema, hemorrhage, nitric oxide, IL-6 and TNF-α levels by CYP administration were significantly reduced by AEECC (250 and 500 mg/kg). A significant increase in serum antioxidant systems such as CAT and GPx was also observed in AEECC-treated rats. The AEECC (3 mg/ml) significantly reduced urinary bladder tone in the strips pre-contracted with carba...
Source: Chemistry and Biodiversity - October 16, 2023 Category: Biochemistry Authors: Mohammed Bourhia Irfan Anjum Daanyaal Ali Mueen Ahmad Chaudhry Farhan Siddique Mehvish Bibi Abdel-Rhman Z Gaafar Touriya Zair Farid Khallouki Source Type: research
Cuminum cyminum Ameliorates Urotoxic Effects of Cyclophosphamide by Modulating Antioxidant, Inflammatory Cytokines, and Urinary Bladder Overactivity: In vivo and In Silioc investigations
This study aimed to investigate the effect of aqueous ethanol extract of Cuminum cyminum (AEECC) on oxidative stress, inflammation and overactivity of the urinary bladder induced by cyclophosphamide (CYP). The enhanced nociception behavior, bladder weight, vascular permeability, edema, hemorrhage, nitric oxide, IL-6 and TNF-α levels by CYP administration were significantly reduced by AEECC (250 and 500 mg/kg). A significant increase in serum antioxidant systems such as CAT and GPx was also observed in AEECC-treated rats. The AEECC (3 mg/ml) significantly reduced urinary bladder tone in the strips pre-contracted with carba...
Source: Chemistry and Biodiversity - October 16, 2023 Category: Biochemistry Authors: Mohammed Bourhia Irfan Anjum Daanyaal Ali Mueen Ahmad Chaudhry Farhan Siddique Mehvish Bibi Abdel-Rhman Z Gaafar Touriya Zair Farid Khallouki Source Type: research
A descriptive survey study in endocrinology clinic: evaluation of the use of natural products
CONCLUSION: Herbal product monitoring in patients should be performed in collaboration with pharmacists, herbal product use should be investigated, and counseling services should be made available in order to maintain and promote public health.PMID:37830875 | DOI:10.1080/03007995.2023.2270898 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - October 13, 2023 Category: Research Authors: İçim Gökkaya G ülin Renda H ülya Coşkun Mustafa Ko çak Ufuk Özgen Source Type: research
Dynamic headspace GC-MS/MS analysis of ethylene oxide and 2-chloroethanol in dry food commodities: a novel approach
This study, for the first time, aimed at establishing a dynamic headspace-GC-MS/MS method for the simultaneous determination of these two analytes in acetonitrile extracts of cumin, ashwagandha, chilli powder, turmeric powder, guar gum, locust bean gum, and ginger powder. The samples (4 g) were extracted using acetonitrile (10 mL). A dispersive-solid phase extraction cleanup step with primary secondary amine sorbent (50 mg/mL) reduced the interfering signal of (matrix-derived) acetaldehyde by >40% in chilli powder, ginger, turmeric, and guar gum. This cleanup was not required for sesame seeds. With high selectivity and ...
Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes - October 9, 2023 Category: Environmental Health Authors: Apurva Nerpagar Nagnath Langade Reshma Patil Sanket Chiplunkar Jitendra Kelkar Kaushik Banerjee Source Type: research
Dynamic headspace GC-MS/MS analysis of ethylene oxide and 2-chloroethanol in dry food commodities: a novel approach
This study, for the first time, aimed at establishing a dynamic headspace-GC-MS/MS method for the simultaneous determination of these two analytes in acetonitrile extracts of cumin, ashwagandha, chilli powder, turmeric powder, guar gum, locust bean gum, and ginger powder. The samples (4 g) were extracted using acetonitrile (10 mL). A dispersive-solid phase extraction cleanup step with primary secondary amine sorbent (50 mg/mL) reduced the interfering signal of (matrix-derived) acetaldehyde by >40% in chilli powder, ginger, turmeric, and guar gum. This cleanup was not required for sesame seeds. With high selectivity and ...
Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes - October 9, 2023 Category: Environmental Health Authors: Apurva Nerpagar Nagnath Langade Reshma Patil Sanket Chiplunkar Jitendra Kelkar Kaushik Banerjee Source Type: research
Genes, Vol. 14, Pages 1730: Thymoquinone Potentially Modulates the Expression of Key Onco- and Tumor Suppressor miRNAs in Prostate and Colon Cancer Cell Lines: Insights from PC3 and HCT-15 Cells
This study aimed to investigate the effects of TQ on the expression profile of key tumor suppressor and onco-suppressor miRNAs in PC3 prostate cancer cells and HCT-15 colon cancer cells. Cell viability assays revealed that TQ inhibited the growth of both cell lines in a dose-dependent manner, with IC50 values of approximately 82.59 μM for HCT-15 and 55.83 μM for PC3 cells. Following TQ treatment at the IC50 concentrations, miRNA expression analysis demonstrated that TQ significantly downregulated miR-21-5p expression in HCT-15 cells and upregulated miR-34a-5p, miR-221-5p, miR-17-5p, and miR-21-5p expr...
Source: Genes - August 30, 2023 Category: Genetics & Stem Cells Authors: Sof ía Madeline Osorio-Pérez Carolina Estrada-Meza Luis M. Ruiz-Manriquez Mar ía Goretti Arvizu-Espinosa Aashish Srivastava Ashutosh Sharma Sujay Paul Tags: Brief Report Source Type: research
The interaction impact of compost and biostimulants on growth, yield and oil content of black cumin (Nigella sativa L.) plants
This study was conducted during the seasons 2020/2021 and 2021/2022 to investigate the effect of the interaction between compost and biostimulants on growth measurements, seed yield, and oil production of black cumin (Nigella sativa L.). Four levels of fertilizer (0.6, 12, 18 tons/ha) were used. While the biostimulants were ascorbic acid (AS) at 100 ppm, yeast extract (YE) at 8 g/L, and AS at 100 ppm + 8 g/L YE. The plants were treated with these stimuli as follows: control (without addition), 100 ppm, YE at 8 g/L, and the results showed that fertilization at all levels, as well as foliar spraying with the used stimuli, le...
Source: Braz J Biol - August 23, 2023 Category: Biology Authors: A H Al-Fraihat A A Zatimeh H H Alhrout S Y Al-Dalain M Mostipan Source Type: research
The interaction impact of compost and biostimulants on growth, yield and oil content of black cumin (Nigella sativa L.) plants
This study was conducted during the seasons 2020/2021 and 2021/2022 to investigate the effect of the interaction between compost and biostimulants on growth measurements, seed yield, and oil production of black cumin (Nigella sativa L.). Four levels of fertilizer (0.6, 12, 18 tons/ha) were used. While the biostimulants were ascorbic acid (AS) at 100 ppm, yeast extract (YE) at 8 g/L, and AS at 100 ppm + 8 g/L YE. The plants were treated with these stimuli as follows: control (without addition), 100 ppm, YE at 8 g/L, and the results showed that fertilization at all levels, as well as foliar spraying with the used stimuli, le...
Source: Braz J Biol - August 23, 2023 Category: Biology Authors: A H Al-Fraihat A A Zatimeh H H Alhrout S Y Al-Dalain M Mostipan Source Type: research
The interaction impact of compost and biostimulants on growth, yield and oil content of black cumin (Nigella sativa L.) plants
This study was conducted during the seasons 2020/2021 and 2021/2022 to investigate the effect of the interaction between compost and biostimulants on growth measurements, seed yield, and oil production of black cumin (Nigella sativa L.). Four levels of fertilizer (0.6, 12, 18 tons/ha) were used. While the biostimulants were ascorbic acid (AS) at 100 ppm, yeast extract (YE) at 8 g/L, and AS at 100 ppm + 8 g/L YE. The plants were treated with these stimuli as follows: control (without addition), 100 ppm, YE at 8 g/L, and the results showed that fertilization at all levels, as well as foliar spraying with the used stimuli, le...
Source: Braz J Biol - August 23, 2023 Category: Biology Authors: A H Al-Fraihat A A Zatimeh H H Alhrout S Y Al-Dalain M Mostipan Source Type: research
The interaction impact of compost and biostimulants on growth, yield and oil content of black cumin (Nigella sativa L.) plants
This study was conducted during the seasons 2020/2021 and 2021/2022 to investigate the effect of the interaction between compost and biostimulants on growth measurements, seed yield, and oil production of black cumin (Nigella sativa L.). Four levels of fertilizer (0.6, 12, 18 tons/ha) were used. While the biostimulants were ascorbic acid (AS) at 100 ppm, yeast extract (YE) at 8 g/L, and AS at 100 ppm + 8 g/L YE. The plants were treated with these stimuli as follows: control (without addition), 100 ppm, YE at 8 g/L, and the results showed that fertilization at all levels, as well as foliar spraying with the used stimuli, le...
Source: Braz J Biol - August 23, 2023 Category: Biology Authors: A H Al-Fraihat A A Zatimeh H H Alhrout S Y Al-Dalain M Mostipan Source Type: research
The interaction impact of compost and biostimulants on growth, yield and oil content of black cumin (Nigella sativa L.) plants
This study was conducted during the seasons 2020/2021 and 2021/2022 to investigate the effect of the interaction between compost and biostimulants on growth measurements, seed yield, and oil production of black cumin (Nigella sativa L.). Four levels of fertilizer (0.6, 12, 18 tons/ha) were used. While the biostimulants were ascorbic acid (AS) at 100 ppm, yeast extract (YE) at 8 g/L, and AS at 100 ppm + 8 g/L YE. The plants were treated with these stimuli as follows: control (without addition), 100 ppm, YE at 8 g/L, and the results showed that fertilization at all levels, as well as foliar spraying with the used stimuli, le...
Source: Braz J Biol - August 23, 2023 Category: Biology Authors: A H Al-Fraihat A A Zatimeh H H Alhrout S Y Al-Dalain M Mostipan Source Type: research
The interaction impact of compost and biostimulants on growth, yield and oil content of black cumin (Nigella sativa L.) plants
This study was conducted during the seasons 2020/2021 and 2021/2022 to investigate the effect of the interaction between compost and biostimulants on growth measurements, seed yield, and oil production of black cumin (Nigella sativa L.). Four levels of fertilizer (0.6, 12, 18 tons/ha) were used. While the biostimulants were ascorbic acid (AS) at 100 ppm, yeast extract (YE) at 8 g/L, and AS at 100 ppm + 8 g/L YE. The plants were treated with these stimuli as follows: control (without addition), 100 ppm, YE at 8 g/L, and the results showed that fertilization at all levels, as well as foliar spraying with the used stimuli, le...
Source: Braz J Biol - August 23, 2023 Category: Biology Authors: A H Al-Fraihat A A Zatimeh H H Alhrout S Y Al-Dalain M Mostipan Source Type: research
