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Nanoemulsion and Nanogel Containing Cuminum cyminum L Essential Oil: Antioxidant, Anticancer, Antibacterial, and Antilarval Properties
J Trop Med. 2023 Feb 6;2023:5075581. doi: 10.1155/2023/5075581. eCollection 2023.ABSTRACTCuminum cyminum L. is a widespread medicinal plant with a broad spectrum of biological activity. In the present study, the chemical structure of its essential oil was examined utilizing GC-MS analysis (gas chromatography-mass spectrometry). Then, a nanoemulsion dosage form was prepared with a droplet size and droplet size distribution (SPAN) of 121 ± 3 nm and 0.96. After that, the dosage form of the nanogel was prepared; the nanoemulsion was gelified by the addition of 3.0% carboxymethyl cellulose. In addition, the successful loading ...
Source: Journal of Tropical Medicine - February 16, 2023 Category: Tropical Medicine Authors: Razie Ranjbar Elham Zarenezhad Abbas Abdollahi Marjan Nasrizadeh Samira Firooziyan Najmeh Namdar Mahmoud Osanloo Source Type: research

ANKRD26 is a new regulator of type I cytokine receptor signaling in normal and pathological hematopoiesis
Haematologica. 2023 Feb 16. doi: 10.3324/haematol.2022.282049. Online ahead of print.ABSTRACTSustained ANKRD26 expression associated with germline ANKRD26 mutations causes Thrombocytopenia 2 (THC2), an inherited platelet disorder associated with leukemia predisposition. Some patients also present with erythrocytosis and/or leukocytosis. Using multiple human-relevant in vitro models (cell lines, primary patient cells and patient-derived iPSCs) we demonstrate for the first time that ANKRD26 is expressed during the early steps of erythroid, megakaryocyte and granulocyte differentiation, and is necessary for progenitor prolife...
Source: Haematologica - February 16, 2023 Category: Hematology Authors: Francesca Basso-Valentina Alessandro Donada Vladimir T Manchev Manuel Lisetto Nathalie Balayn Jean Edouard Martin Delphine Muller Cecilia Paola Marin Oyarzun H élène Duparc Brahim Arkoun Alessandro Cumin Lionel Faivre Nathalie Droin Ida Biunno Alessandr Source Type: research

 68 Ga radiolabeled chitosan/cur cumin/biotin nanocomposite as a drug carrier and early-stage cancer detection
Int J Biol Macromol. 2023 Feb 9:123619. doi: 10.1016/j.ijbiomac.2023.123619. Online ahead of print.ABSTRACTNano chitosan was extracted from shrimp wastes. Biotin, as a tumor-targeting agent, and curcumin, as potential carriers of 68Ga, were immobilized on the nano chitosan, and a novel bio-nanocomposite was designed. It was characterized by FT-IR, SEM, TEM, XRD, TGA, and elemental analysis. It seems that the chitosan has a fibril shape with an average size of 70 nm, and the biotin and curcumin are evenly distributed as obtained SEM images. While, the size of Chit/Cur@Biot bio-nanocomposite was between 10 and 20 nm accordin...
Source: International Journal of Biological Macromolecules - February 11, 2023 Category: Biochemistry Authors: Atena Naeimi Fereshteh Ezzati Ghadi Zahra Pakdin Parizi Mohamad Saleh Rezakhani Source Type: research

 68 Ga radiolabeled chitosan/cur cumin/biotin nanocomposite as a drug carrier and early-stage cancer detection
Int J Biol Macromol. 2023 Feb 9:123619. doi: 10.1016/j.ijbiomac.2023.123619. Online ahead of print.ABSTRACTNano chitosan was extracted from shrimp wastes. Biotin, as a tumor-targeting agent, and curcumin, as potential carriers of 68Ga, were immobilized on the nano chitosan, and a novel bio-nanocomposite was designed. It was characterized by FT-IR, SEM, TEM, XRD, TGA, and elemental analysis. It seems that the chitosan has a fibril shape with an average size of 70 nm, and the biotin and curcumin are evenly distributed as obtained SEM images. While, the size of Chit/Cur@Biot bio-nanocomposite was between 10 and 20 nm accordin...
Source: Cancer Control - February 11, 2023 Category: Cancer & Oncology Authors: Atena Naeimi Fereshteh Ezzati Ghadi Zahra Pakdin Parizi Mohamad Saleh Rezakhani Source Type: research

Correction to: Effects of cumin (Cuminum cyminum L.) essential oil and chronic heat stress on growth performance, carcass characteristics, serum biochemistry, antioxidant enzyme activity, and intestinal microbiology in broiler chickens
(Source: Veterinary Research Communications)
Source: Veterinary Research Communications - January 20, 2023 Category: Veterinary Research Source Type: research

Molecules, Vol. 28, Pages 901: Plant Essential Oils as Healthy Functional Ingredients of Nutraceuticals and Diet Supplements: A Review
migli Essential oils (EOs) are mixtures of volatile molecules endowed with health-promoting biological activities that go beyond their role as aromas and natural preservatives and can be exploited to develop functional foods and diet supplements. Their composition is briefly addressed along with regulatory aspects. The potential health benefit of human diet supplementation with EOs is outlined through a review of the recent literature on available clinical trials and preclinical research concerning EOs activity towards: (1) irritable bowel syndrome; (2) inflammatory bowel disease; (3) regulation of microbiota; (4) gast...
Source: Molecules - January 16, 2023 Category: Chemistry Authors: Riccardo Matera Elena Lucchi Luca Valgimigli Tags: Review Source Type: research

The synergetic effects of some phytobiotics mix on growth, hematology and microbial loads of broiler chickens
This study investigated the growth and health-promoting effectiveness of three medicinal plants (black cumin, fenugreek, and turmeric) on broilers. A total of 270 (Cobb 500) day-old broiler chicks were randomly assigned to 6 dietary treatments: basal diet (T0), basal diet + oxytetracycline (T1), basal diet + black cumin and fenugreek (T2), basal diet + black cumin and turmeric (T3), basal diet + fenugreek and turmeric (T4), basal diet + black cumin, fenugreek and turmeric (T5). BWG and ADG had no differences (p ≥ 0.05) between T5 and antibiotics-fed birds. Phytobiotic supplemented birds (T2, T3, T4, and T5) had lower fee...
Source: Animal Biotechnology - January 12, 2023 Category: Biotechnology Authors: Yonatan Kassu Yesuf Berhan Tamir Etalem Tesfaye Netsanet Beyero Source Type: research