Colchicine Attenuates Microvascular Obstruction after Myocardial Ischemia-Reperfusion Injury by Inhibiting the Proliferation of Neutrophil in Bone Marrow
ConclusionsColchicine attenuated MVO after myocardial I/R injury by inhibiting the proliferation of neutrophils in BM through the neutrophil-derived S100A8/A9 inflammatory signaling pathway. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - December 8, 2023 Category: Cardiology Source Type: research
Correction: Topical betamethasone and systemic colchicine for treatment of recurrent aphthous stomatitis: a randomised clinical trial
(Source: BMC Oral Health)
Source: BMC Oral Health - December 8, 2023 Category: Dentistry Authors: Surab Alsahaf, Khlood A. Alkurdi, Stephen J. Challacombe and Anwar Tappuni Tags: Correction Source Type: research
Correction to: Empagliflozin and colchicine in patients with reduced left ventricular ejection fraction following ST-elevation myocardial infarction: a randomized, double-blinded, three-arm parallel-group, controlled trial
(Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - December 2, 2023 Category: Drugs & Pharmacology Source Type: research
Colchicine delivered by a novel nanoparticle platform alleviates atherosclerosis by targeted inhibition of NF- κB/NLRP3 pathways in inflammatory endothelial cells
J Nanobiotechnology. 2023 Nov 30;21(1):460. doi: 10.1186/s12951-023-02228-z.ABSTRACTAtherosclerosis, a chronic inflammatory disease characterized by arterial plaque formation, is one of the most prominent causes of cardiovascular diseases. However, the current treatments often do not adequately compromise the chronic inflammation-mediated plaque accumulation and the disease progression. Therefore, a new and effective strategy that blocks atherosclerosis-associated inflammation is urgently needed to further reduce the risk. Colchicine, a potent anti-inflammatory medication, has shown great potential in the treatment of athe...
Source: Atherosclerosis - December 1, 2023 Category: Cardiology Authors: Juan Tang Tao Li Xiaojing Xiong Qiaoyun Yang Zedazhong Su Minming Zheng Qingwei Chen Source Type: research
Colchicine delivered by a novel nanoparticle platform alleviates atherosclerosis by targeted inhibition of NF- κB/NLRP3 pathways in inflammatory endothelial cells
J Nanobiotechnology. 2023 Nov 30;21(1):460. doi: 10.1186/s12951-023-02228-z.ABSTRACTAtherosclerosis, a chronic inflammatory disease characterized by arterial plaque formation, is one of the most prominent causes of cardiovascular diseases. However, the current treatments often do not adequately compromise the chronic inflammation-mediated plaque accumulation and the disease progression. Therefore, a new and effective strategy that blocks atherosclerosis-associated inflammation is urgently needed to further reduce the risk. Colchicine, a potent anti-inflammatory medication, has shown great potential in the treatment of athe...
Source: Atherosclerosis - December 1, 2023 Category: Cardiology Authors: Juan Tang Tao Li Xiaojing Xiong Qiaoyun Yang Zedazhong Su Minming Zheng Qingwei Chen Source Type: research
Colchicine delivered by a novel nanoparticle platform alleviates atherosclerosis by targeted inhibition of NF- κB/NLRP3 pathways in inflammatory endothelial cells
Atherosclerosis, a chronic inflammatory disease characterized by arterial plaque formation, is one of the most prominent causes of cardiovascular diseases. However, the current treatments often do not adequate... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - November 30, 2023 Category: Nanotechnology Authors: Juan Tang, Tao Li, Xiaojing Xiong, Qiaoyun Yang, Zedazhong Su, Minming Zheng and Qingwei Chen Tags: Research Source Type: research
A rare cause of AA amyloidosis: Glomus tumor and treatment with anakinra —Case report and literature review
AbstractSystemic AA amyloidosis is associated with poorly controlled chronic inflammatory disorders. Chronic infections and inflammatory arthritis are the most common causes; however, they can also rarely occur as a complication of neoplastic disorders. The development of AA amyloidosis secondary to paraganglioma, which is a rare type of tumor, has rarely been reported in the literature. In this case, an 85-year-old female patient with a glomus tumor in the neck, who has been followed up over 50 years, applied with complaints of loss of appetite, nausea, and diarrhea for 5–6 months. While evaluating the patient, who...
Source: International Journal of Rheumatic Diseases - November 28, 2023 Category: Rheumatology Authors: Fatih Tastekin,
Duygu Kerim,
Sait Sen,
Yasemin Kabasakal Tags: CASE REPORT Source Type: research
pH-driven preparation of pea protein isolate-curcumin nanoparticles effectively enhances antitumor activity
Int J Biol Macromol. 2023 Nov 22:128383. doi: 10.1016/j.ijbiomac.2023.128383. Online ahead of print.ABSTRACTSoluble pea protein isolate-curcumin nanoparticles were successfully prepared at a novel pH combination, with encapsulation efficiency and drug loading amount of 95.69 ± 1.63 % and 32.73 ± 0.56 μg/mg, respectively, resulting in >4000-fold increase in the water solubility of curcumin. The encapsulation propensity and interaction mechanism of pea protein isolates with curcumin and colchicine were comparatively evaluated by structural characterization, molecular dynamics simulations and molecular docking. The resu...
Source: International Journal of Biological Macromolecules - November 24, 2023 Category: Biochemistry Authors: Jie Ren Hanshuo Wu Zhihao Lu Qingyu Qin Xinru Jiao Ganlu Meng Wenying Liu Guoming Li Source Type: research
pH-driven preparation of pea protein isolate-curcumin nanoparticles effectively enhances antitumor activity
Int J Biol Macromol. 2023 Nov 22:128383. doi: 10.1016/j.ijbiomac.2023.128383. Online ahead of print.ABSTRACTSoluble pea protein isolate-curcumin nanoparticles were successfully prepared at a novel pH combination, with encapsulation efficiency and drug loading amount of 95.69 ± 1.63 % and 32.73 ± 0.56 μg/mg, respectively, resulting in >4000-fold increase in the water solubility of curcumin. The encapsulation propensity and interaction mechanism of pea protein isolates with curcumin and colchicine were comparatively evaluated by structural characterization, molecular dynamics simulations and molecular docking. The resu...
Source: International Journal of Biological Macromolecules - November 24, 2023 Category: Biochemistry Authors: Jie Ren Hanshuo Wu Zhihao Lu Qingyu Qin Xinru Jiao Ganlu Meng Wenying Liu Guoming Li Source Type: research
Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF- κB and MAPKs: implications in vascular diseases
Smoking, alcohol abuse, and hypertension are – among others, potential risk factors for cardiovascular diseases. These risk factors generate oxidative stress and cause oxidative stress-induced DNA damage, resu... (Source: Journal of Inflammation)
Source: Journal of Inflammation - November 24, 2023 Category: Allergy & Immunology Authors: Huakang Zhou, Dilaware Khan, Sajid Muhammad Hussain, Norbert Gerdes, Carsten Hagenbeck, Majeed Rana, Jan Frederick Cornelius and Sajjad Muhammad Tags: Research Source Type: research
Total flavonoids extracted from Penthorum chinense Pursh mitigates CCl4-induced hepatic fibrosis in rats via inactivation of TLR4-MyD88-mediated NF- κB pathways and regulation of liver metabolism
Conclusion: Our findings indicated that TFPCP can ameliorate hepatic fibrosis by improving liver function and morphology via the inactivation of the TLR4/MyD88-mediated NF-κB pathway and the regulation of liver metabolism. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 23, 2023 Category: Drugs & Pharmacology Source Type: research
Is it possible to extend the dose interval of canakinumab treatment in children with familial Mediterranean fever? PeRA group experience
This study aimed to ass... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - November 23, 2023 Category: Rheumatology Authors: G ülşah Kavrul Kayaalp, Şengül Çağlayan, Fatma Gül Demirkan, Vafa Guliyeva, Gülçin Otar Yener, Kübra Öztürk, Ferhat Demir, Semanur Özdel, Mustafa Çakan, Hafize Emine Sönmez, Betül Sözeri and Nuray Aktay Ayaz Tags: Research article Source Type: research
Synthesis and biological evaluation of structurally diverse 6-aryl-3-aroyl-indole analogues as inhibitors of tubulin polymerization
Eur J Med Chem. 2023 Sep 6;263:115794. doi: 10.1016/j.ejmech.2023.115794. Online ahead of print.ABSTRACTThe synthesis and evaluation of small-molecule inhibitors of tubulin polymerization remains a promising approach for the development of new therapeutic agents for cancer treatment. The natural products colchicine and combretastatin A-4 (CA4) inspired significant drug discovery campaigns targeting the colchicine site located on the beta-subunit of the tubulin heterodimer, but so far these efforts have not yielded an approved drug for cancer treatment in human patients. Interest in the colchicine site was enhanced by the d...
Source: European Journal of Medicinal Chemistry - November 20, 2023 Category: Chemistry Authors: Wen Ren Yuling Deng Jacob D Ward Rebecca Vairin Ruoli Bai Hashini I Wanniarachchi Khagendra B Hamal Pouguiniseli E Tankoano Caleb S Tamminga Lorena M A Bueno Ernest Hamel Ralph P Mason Mary Lynn Trawick Kevin G Pinney Source Type: research
Natural product-inspired discovery of trimethoxyphenyl-1,2,4-triazolo-sulfonamides as potent tubulin polymerization inhibitors
This study represents the importance of the design strategy in medicinal chemistry and the molecular structural features relevant to anticancer anti-tubulin properties. The explored molecules have the potential for further development.PMID:37975190 | DOI:10.1002/cmdc.202300562 (Source: ChemMedChem)
Source: ChemMedChem - November 17, 2023 Category: Chemistry Authors: Vajja Krishna Rao Anvesh Ashtam Dulal Panda Sankar Kumar Guchhait Source Type: research
