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Colchicine alleviates myocardial ischemia-reperfusion injury in mice by activating AMPK
CONCLUSION: Colchicine alleviates myocardial I/R injury and protects cardiac function in mice by reducing myocardial oxidative stress and apoptosis via activating AMPK.PMID:38501407 | PMC:PMC10954522 | DOI:10.12122/j.issn.1673-4254.2024.02.04 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - March 19, 2024 Category: Universities & Medical Training Authors: G Chen S Luo Source Type: research

The effect of colchicine on cholesterol crystal formation, expansion and morphology: a potential mechanism in atherosclerosis
CONCLUSIONS: Colchicine can reduce CC formation and expansion and alter CC morphology. These previously unappreciated effects of colchicine may contribute to its clinical benefit in patients with CV disease independent of its anti-inflammatory effects.PMID:38495937 | PMC:PMC10941200 | DOI:10.3389/fcvm.2024.1345521 (Source: Atherosclerosis)
Source: Atherosclerosis - March 18, 2024 Category: Cardiology Authors: Zain Ul Abideen Dorothy R Pathak Rand Sabanci Megan Manu George S Abela Source Type: research

A case of acute promyelocytic leukemia with pericardial effusion successfully managed with colchicine during ATO administration
(Source: Annals of Hematology)
Source: Annals of Hematology - March 15, 2024 Category: Hematology Source Type: research

Structure-based approaches for the design of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d][1,2,3]triazoles as tubulin polymerization inhibitors
In conclusion, this report shows a successful case of the structure-based design approach of a potent tubulin polymerization inhibitor for cancer treatment.PMID:38471357 | DOI:10.1016/j.ejmech.2024.116309 (Source: European Journal of Medicinal Chemistry)
Source: European Journal of Medicinal Chemistry - March 12, 2024 Category: Chemistry Authors: Mingxin Huang Hongyao Han Haoyuan Liu Runlai Liu Jiwei Li Mi Li Qi Guan Weige Zhang Dun Wang Source Type: research

Prediction of matrilineal specific patatin-like protein governing in-vivo maternal haploid induction in maize using support vector machine and di-peptide composition
Amino Acids. 2024 Mar 9;56(1):20. doi: 10.1007/s00726-023-03368-0.ABSTRACTThe mutant matrilineal (mtl) gene encoding patatin-like phospholipase activity is involved in in-vivo maternal haploid induction in maize. Doubling of chromosomes in haploids by colchicine treatment leads to complete fixation of inbreds in just one generation compared to 6-7 generations of selfing. Thus, knowledge of patatin-like proteins in other crops assumes great significance for in-vivo haploid induction. So far, no online tool is available that can classify unknown proteins into patatin-like proteins. Here, we aimed to optimize a machine learni...
Source: Amino Acids - March 9, 2024 Category: Biochemistry Authors: Suman Dutta Rajkumar U Zunjare Anirban Sil Dwijesh Chandra Mishra Alka Arora Nisrita Gain Gulab Chand Rashmi Chhabra Vignesh Muthusamy Firoz Hossain Source Type: research

Reversible Influence of Hemipiperazine Photochromism on the Early Development of Zebrafish Embryo
This study explores the potential of controlling organismal development with light by using reversible photomodulation of activity in bioactive compounds. Specifically, our research focuses on plinabulin 1, an inhibitor of tubulin dynamics that contains a photochromic motif called hemipiperazine. The two isomeric forms, Z-1 and E-1, can partially interconvert with light, yet show remarkable thermal stability in darkness. The Z-isomer exhibits higher cytotoxicity due to stronger binding to α-tubulin's colchicine site. The less toxic E-1 form, considered a "pro-drug", can be isolated in vitro and stored. Upon activation by ...
Source: Chembiochem - March 5, 2024 Category: Biochemistry Authors: Angelika Seliwjorstow Masanari Takamiya Sepand Rastegar Zbigniew Pianowski Source Type: research

Synthesis, biological and computational evaluation of novel cyanomethyl vinyl ether derivatives
This work explores the biological evaluation of novel cyanomethyl vinyl ether derivatives as antiproliferative agents. Tubulin, crucial to microtubule structure and function, is a target for cancer therapies. In vitro cytotoxicity assessments revealed significant activity in SKOV3 ovarian carcinoma cells and A549 lung carcinoma cells. Structure-Activity Relationship (SAR) analysis indicated that the E isomer and specific substitutions influenced the biological activity. Computational assays predicted favorable ADME properties, highlighting potential as anticancerous agents. Molecular docking studies demonstrated that compo...
Source: Frontiers in Pharmacology - March 4, 2024 Category: Drugs & Pharmacology Source Type: research

SYNERGY- Everolimus eluting stent with a bioabsorbable polymer in ST elevation myocardial infarction- CLEAR SYNERGY OASIS-9 Registry
Our objective was to evaluate the clinical effectiveness of the SYNERGY stent in patients with ST elevation myocardial infarction (STEMI). The only drug eluting stent approved for treatment of STEMI by the FDA is the Taxus stent which is no longer commercially available, so further data are needed. The CLEAR SYNERGY stent registry was embedded into a larger randomized trial of patients with STEMI (N=7000), comparing colchicine vs. placebo and spironolactone vs. placebo. The primary outcome for the SYNERGY stent registry is major adverse cardiac events (MACE) as defined by cardiovascular death, recurrent MI, or unplanned is...
Source: The American Journal of Cardiology - March 3, 2024 Category: Cardiology Authors: Sanjit S. Jolly, Shun Fu Lee, Rajibul Mian, Sasko Kedev, Shahar Lavi, Raul Moreno, Gilles Montalescot, Ali Hillani, Timothy D. Henry, Valon Asani, Robert F. Storey, Johanne Silvain, James C.S. Spratt, Marc-Andr é d'Entremont, Goran Stankovic, Biljana Zaf Source Type: research