Natural product-inspired discovery of trimethoxyphenyl-1,2,4-triazolo-sulfonamides as potent tubulin polymerization inhibitors
This study represents the importance of the design strategy in medicinal chemistry and the molecular structural features relevant to anticancer anti-tubulin properties. The explored molecules have the potential for further development.PMID:37975190 | DOI:10.1002/cmdc.202300562 (Source: ChemMedChem)
Source: ChemMedChem - November 17, 2023 Category: Chemistry Authors: Vajja Krishna Rao Anvesh Ashtam Dulal Panda Sankar Kumar Guchhait Source Type: research
Natural product-inspired discovery of trimethoxyphenyl-1,2,4-triazolo-sulfonamides as potent tubulin polymerization inhibitors
This study represents the importance of the design strategy in medicinal chemistry and the molecular structural features relevant to anticancer anti-tubulin properties. The explored molecules have the potential for further development.PMID:37975190 | DOI:10.1002/cmdc.202300562 (Source: ChemMedChem)
Source: ChemMedChem - November 17, 2023 Category: Chemistry Authors: Vajja Krishna Rao Anvesh Ashtam Dulal Panda Sankar Kumar Guchhait Source Type: research
Induction of tetraploids in Paper Mulberry (Broussonetia papyrifera (L.) L ’Hér. ex Vent.) by colchicine
Broussonetia papyrifera (L.) L ’Hér. ex Vent. has the characteristics of strong stress resistance, high crude protein content, and pruning tolerance. It is an ecological, economic, and medicinal plant. Polyploid p... (Source: BMC Plant Biology)
Source: BMC Plant Biology - November 17, 2023 Category: Biology Authors: Jiana Lin, Bingnan Zhang, Jintuo Zou, Zhen Luo, Hao Yang, Peng Zhou, Xiaoyang Chen and Wei Zhou Tags: Research article Source Type: research
Is compressed colchicine tablet superior to other colchicine preparations in patients with familial Mediterranean fever?
CONCLUSION: Compressed colchicine tablets were shown to be superior to other colchicine preparations and compressed colchicine tablets to be a useful treatment option before initiating biological agents in patients who were unresponsive to coated colchicine.PMID:37969097 | DOI:10.5414/CP204494 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - November 16, 2023 Category: Drugs & Pharmacology Authors: İbrahim Vasi R ıza Can Kardaş Derya Y ıldırım Burcug ül Kaya Rahime Duran Hazan Karadeniz Asl ıhan Avanoğlu Güler Abdulsamet Erden Hamit K üçük Berna G öker Abdurrahman Tufan Mehmet Akif Öztürk Source Type: research
Is compressed colchicine tablet superior to other colchicine preparations in patients with familial Mediterranean fever?
CONCLUSION: Compressed colchicine tablets were shown to be superior to other colchicine preparations and compressed colchicine tablets to be a useful treatment option before initiating biological agents in patients who were unresponsive to coated colchicine.PMID:37969097 | DOI:10.5414/CP204494 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 16, 2023 Category: Drugs & Pharmacology Authors: İbrahim Vasi R ıza Can Kardaş Derya Y ıldırım Burcug ül Kaya Rahime Duran Hazan Karadeniz Asl ıhan Avanoğlu Güler Abdulsamet Erden Hamit K üçük Berna G öker Abdurrahman Tufan Mehmet Akif Öztürk Source Type: research
Is compressed colchicine tablet superior to other colchicine preparations in patients with familial Mediterranean fever?
CONCLUSION: Compressed colchicine tablets were shown to be superior to other colchicine preparations and compressed colchicine tablets to be a useful treatment option before initiating biological agents in patients who were unresponsive to coated colchicine.PMID:37969097 | DOI:10.5414/CP204494 (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - November 16, 2023 Category: Drugs & Pharmacology Authors: İbrahim Vasi R ıza Can Kardaş Derya Y ıldırım Burcug ül Kaya Rahime Duran Hazan Karadeniz Asl ıhan Avanoğlu Güler Abdulsamet Erden Hamit K üçük Berna G öker Abdurrahman Tufan Mehmet Akif Öztürk Source Type: research
Is compressed colchicine tablet superior to other colchicine preparations in patients with familial Mediterranean fever?
CONCLUSION: Compressed colchicine tablets were shown to be superior to other colchicine preparations and compressed colchicine tablets to be a useful treatment option before initiating biological agents in patients who were unresponsive to coated colchicine.PMID:37969097 | DOI:10.5414/CP204494 (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 16, 2023 Category: Drugs & Pharmacology Authors: İbrahim Vasi R ıza Can Kardaş Derya Y ıldırım Burcug ül Kaya Rahime Duran Hazan Karadeniz Asl ıhan Avanoğlu Güler Abdulsamet Erden Hamit K üçük Berna G öker Abdurrahman Tufan Mehmet Akif Öztürk Source Type: research
Ternary Deep Eutectic Solvents System of Colchicine, 4-Hydroxyacetophenone, and Protocatechuic Acid and Characterization of Transdermal Enhancement Mechanism
This study aimed to prepare colchicine (CO), 4-hydroxyacetophenone (HA), and protocatechuic acid (CA) contained in transdermal rubber plasters into a more releasable and acrylate pressure-sensitive adhesive (PSA) to optimize traditional Touguling rubber plasters (TOU) with enhanced transdermal permeability by using deep eutectic solvents (DES) technology. We compared the difference in the release behavior of CO between rubber plaster and PSA, determined the composition of the patch through pharmacodynamic experiments, explored the transdermal behavior of the three components, optimized the patch formula factors, and improv...
Source: AAPS PharmSciTech - November 14, 2023 Category: Drugs & Pharmacology Authors: Huiqing Piao Wanchen Xie Shiqi Li Jiaqi Wang Chao Liu Peng Quan Liang Fang Source Type: research
Ternary Deep Eutectic Solvents System of Colchicine, 4-Hydroxyacetophenone, and Protocatechuic Acid and Characterization of Transdermal Enhancement Mechanism
This study aimed to prepare colchicine (CO), 4-hydroxyacetophenone (HA), and protocatechuic acid (CA) contained in transdermal rubber plasters into a more releasable and acrylate pressure-sensitive adhesive (PSA) to optimize traditional Touguling rubber plasters (TOU) with enhanced transdermal permeability by using deep eutectic solvents (DES) technology. We compared the difference in the release behavior of CO between rubber plaster and PSA, determined the composition of the patch through pharmacodynamic experiments, explored the transdermal behavior of the three components, optimized the patch formula factors, and improv...
Source: AAPS PharmSciTech - November 14, 2023 Category: Drugs & Pharmacology Authors: Huiqing Piao Wanchen Xie Shiqi Li Jiaqi Wang Chao Liu Peng Quan Liang Fang Source Type: research
The Canadian Study of Arterial Inflammation in Patients with Diabetes and Recent Vascular Events, Evaluation of Colchicine Effectiveness (CADENCE): protocol for a randomised, double-blind, placebo-controlled trial
Discussion
Colchicine is an exciting potential new therapy for CV risk reduction. However, its use is associated with side effects and greater understanding of its underlying mechanism of action is needed. Importantly, the current study will determine whether its anti-inflammatory action is an indirect systemic effect, or a more local plaque action that decreases inflammation. The results will also help identify patients who will benefit most from such therapy.
Trial registration number
NCT04181996. (Source: BMJ Open)
Source: BMJ Open - November 10, 2023 Category: General Medicine Authors: Boczar, K. E., Shin, S., deKemp, R. A., Dowlatshahi, D., Tavoosi, A., Wiefels, C., Liu, P., Lochnan, H., MacPherson, P. A., Chong, A. Y., Torres, C., Leung, E., Tawakol, A., Ahmadi, A., Garrard, L., Lefebvre, C., Kelly, C., MacPhee, P., Tilokee, E., Raggi Tags: Open access, Cardiovascular medicine Source Type: research
