A novel NLRP3 inhibitor as a therapeutic agent against monosodium urate-induced gout
ConclusionSLC3037, a NLRP3 inhibitor blocking NEK7 binding to NLRP3, could be a novel agent against diseases associated with NLRP3 inflammasome activation such as gout, cardiovascular diseases, metabolic syndrome or neurodegenerative diseases. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - February 2, 2024 Category: Allergy & Immunology Source Type: research
The expanding clinical spectrum of autoinflammatory diseases with NOD2 variants: a case series and literature review
ConclusionNOD2 variants were detected in 1 out of 7 SAID patients and seem to have an impact on disease phenotype and treatment response. Further studies should validate combined molecular and clinical data to better understand these distinct nosological entities. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - January 29, 2024 Category: Allergy & Immunology Source Type: research
Design and synthesis of novel 3-amino-5-phenylpyrazole derivatives as tubulin polymerization inhibitors targeting the colchicine-binding site
Eur J Med Chem. 2024 Jan 24;267:116177. doi: 10.1016/j.ejmech.2024.116177. Online ahead of print.ABSTRACTAs the basic unit of microtubules, tubulin is one of the most important targets in the study of anticarcinogens. A novel series of 3-amino-5-phenylpyrazole derivatives were designed and synthesized, and evaluates for their biological activities. Among them, a majority of compounds exerted excellent inhibitory activities against five cancer cell lines in vitro. Especially, compound 5b showed a strong antiproliferative activity against MCF-7 cells, with IC50 value of 38.37 nM. Further research indicated that compound 5b c...
Source: European Journal of Medicinal Chemistry - January 27, 2024 Category: Chemistry Authors: Yang Yang Yan Cao Jingwen Yu Xinyu Yu Yali Guo Fei Wang Qingjia Ren Caolong Li Source Type: research
Anakinra in idiopathic recurrent pericarditis: a comprehensive case series and literature review
CONCLUSION: In conclusion, the study adds to the growing evidence for the efficacy of interleukin-1 inhibitors, such as anakinra, as a promising treatment modality for IRP in cases resistant to conventional treatment.PMID:38277021 | DOI:10.1007/s00393-023-01471-x (Source: Zeitschrift fur Rheumatologie)
Source: Zeitschrift fur Rheumatologie - January 26, 2024 Category: Rheumatology Authors: Zeynep Toker Dincer Sejla Karup Erkin Yilmaz Osman Corbali Feyza Nur Azman Melike Melikoglu Serdal Ugurlu Source Type: research
Anti-rheumatic colchicine phytochemical exhibits potent antiviral activities against avian and seasonal Influenza A viruses (IAVs) via targeting different stages of IAV replication cycle
The continuous evolution of drug-resistant influenza viruses highlights the necessity for repurposing naturally-derived and safe phytochemicals with anti-influenza activity as novel broad-spectrum anti-influen... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - January 22, 2024 Category: Complementary Medicine Authors: Akram Hegazy, Raya Soltane, Ahlam Alasiri, Islam Mostafa, Ahmed M. Metwaly, Ibrahim H. Eissa, Sara H. Mahmoud, Abdou Kamal Allayeh, Noura M. Abo Shama, Ahmed A. Khalil, Ramya S. Barre, Assem Mohamed El-Shazly, Mohamed A. Ali, Luis Martinez-Sobrido and Ahm Tags: Research Source Type: research
The impact of colchicine on patients with acute and chronic coronary artery disease
Eur J Intern Med. 2024 Jan 17:S0953-6205(24)00011-6. doi: 10.1016/j.ejim.2024.01.004. Online ahead of print.ABSTRACTInflammation plays a central role in coronary artery disease (CAD), and recent data have shown that anti-inflammatory drugs have the potential to reduce ischemic events in CAD patients. Colchicine is an ancient anti-inflammatory drug that targets neutrophil and inflammasome activities. It has been prescribed for decades for different rheumatological conditions. Given the important role of inflammation in the development of cardiovascular disease, there has been considerable interest in studying colchicine's p...
Source: European Journal of Internal Medicine - January 18, 2024 Category: Internal Medicine Authors: Mehdi Madanchi Mabelle Young Gregorio Tersalvi Giacomo Maria Cioffi Adrian Attinger-Toller Florim Cuculi Reto Kurmann Matthias Bossard Source Type: research
Pyrin Inflammasome Activation Defines Colchicine-Responsive SURF Patients from FMF and Other Recurrent Fevers
AbstractSyndrome of undifferentiated recurrent fever (SURF) is characterized by recurrent fevers, a lack of confirmed molecular diagnosis, and a complete or partial response to colchicine. Despite the clinical similarities to familial Mediterranean fever (FMF), the underlying inflammatory mechanisms of SURF are not yet understood. We here analyzed the in vitro activation of the pyrin inflammasome in a cohort of SURF patients compared to FMF and PFAPA patients. Peripheral blood mononuclear cells (PBMC) were collected from SURF (both colchicine-treated and untreated), FMF, PFAPA patients, and healthy donors. PBMC were stimul...
Source: Journal of Clinical Immunology - January 17, 2024 Category: Allergy & Immunology Source Type: research
Chest pain in children with familial Mediterranean fever
CONCLUSIONS: Patients with recurrent chest pain seem to have early onset symptoms, often are more likely to have family history, and have a higher disease severity. In addition, the presence of homozygous M694V mutation is more common in patients with chest pain.PMID:38204312 | DOI:10.24953/turkjped.2023.227 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - January 11, 2024 Category: Pediatrics Authors: Emine Nur Sunar-Yayla Pelin Esmeray Şenol Deniz Gezgin Y ıldırım O ğuz Söylemezoğlu Source Type: research
Chest pain in children with familial Mediterranean fever
CONCLUSIONS: Patients with recurrent chest pain seem to have early onset symptoms, often are more likely to have family history, and have a higher disease severity. In addition, the presence of homozygous M694V mutation is more common in patients with chest pain.PMID:38204312 | DOI:10.24953/turkjped.2023.227 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - January 11, 2024 Category: Pediatrics Authors: Emine Nur Sunar-Yayla Pelin Esmeray Şenol Deniz Gezgin Y ıldırım O ğuz Söylemezoğlu Source Type: research
Chest pain in children with familial Mediterranean fever
CONCLUSIONS: Patients with recurrent chest pain seem to have early onset symptoms, often are more likely to have family history, and have a higher disease severity. In addition, the presence of homozygous M694V mutation is more common in patients with chest pain.PMID:38204312 | DOI:10.24953/turkjped.2023.227 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - January 11, 2024 Category: Pediatrics Authors: Emine Nur Sunar-Yayla Pelin Esmeray Şenol Deniz Gezgin Y ıldırım O ğuz Söylemezoğlu Source Type: research
Chest pain in children with familial Mediterranean fever
CONCLUSIONS: Patients with recurrent chest pain seem to have early onset symptoms, often are more likely to have family history, and have a higher disease severity. In addition, the presence of homozygous M694V mutation is more common in patients with chest pain.PMID:38204312 | DOI:10.24953/turkjped.2023.227 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - January 11, 2024 Category: Pediatrics Authors: Emine Nur Sunar-Yayla Pelin Esmeray Şenol Deniz Gezgin Y ıldırım O ğuz Söylemezoğlu Source Type: research
Chest pain in children with familial Mediterranean fever
CONCLUSIONS: Patients with recurrent chest pain seem to have early onset symptoms, often are more likely to have family history, and have a higher disease severity. In addition, the presence of homozygous M694V mutation is more common in patients with chest pain.PMID:38204312 | DOI:10.24953/turkjped.2023.227 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - January 11, 2024 Category: Pediatrics Authors: Emine Nur Sunar-Yayla Pelin Esmeray Şenol Deniz Gezgin Y ıldırım O ğuz Söylemezoğlu Source Type: research
