Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink
Conclusions
Adverse events were more common when allopurinol was initiated with prophylaxis, particularly diarrhoea with colchicine. Other events were uncommon, providing reassurance for patients and clinicians to enable shared decision-making. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - November 10, 2023 Category: Rheumatology Authors: Roddy, E., Bajpai, R., Forrester, H., Partington, R. J., Mallen, C. D., Clarson, L. E., Padmanabhan, N., Whittle, R., Muller, S. Tags: Open access, ARD, Crystal arthropathies Source Type: research
Is colchicine prophylaxis required with start-low go-slow allopurinol dose escalation in gout? A non-inferiority randomised double-blind placebo-controlled trial
Conclusions
Placebo is not non-inferior to colchicine in prevention of gout flares in the first 6 months of starting allopurinol using the ‘start-low go-slow’ strategy. After stopping colchicine, gout flares rise with no difference in the mean number of gout flares/month between groups over a 12-month period.
Trial registration number
ACTRN 12618001179224. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - November 10, 2023 Category: Rheumatology Authors: Stamp, L., Horne, A., Mihov, B., Drake, J., Haslett, J., Chapman, P. T., Frampton, C., Dalbeth, N. Tags: ARD Lay summaries, ARD, Crystal arthropathies Source Type: research
Asymptomatic Gouty Tophi in Thyroid Cartilage: A Case Report and Literature Review
This article reports a case involving an elderly male with asymptomatic gouty tophi in the thyroid cartilage. The patient had a history of gout for over 10 years and presented with a painless thyroid mass that had been present for at least 3 years. He had not received systemic treatment. Preoperative contrast-enhanced cervical CT results indicated a high likelihood of gouty tophi. Postoperative pathology confirmed the mass to be consistent with gouty nodules. Following the procedure, the patient was treated symptomatically with non-busulfan tablets and colchicine. No recurrence was observed at the 1-year follow-up. This re...
Source: Ear, Nose and Throat Journal - November 9, 2023 Category: ENT & OMF Authors: None Zhen-Li None De-Dai Hui-Kuan Chen Xin-Kai Zhou Source Type: research
Asymptomatic Gouty Tophi in Thyroid Cartilage: A Case Report and Literature Review
This article reports a case involving an elderly male with asymptomatic gouty tophi in the thyroid cartilage. The patient had a history of gout for over 10 years and presented with a painless thyroid mass that had been present for at least 3 years. He had not received systemic treatment. Preoperative contrast-enhanced cervical CT results indicated a high likelihood of gouty tophi. Postoperative pathology confirmed the mass to be consistent with gouty nodules. Following the procedure, the patient was treated symptomatically with non-busulfan tablets and colchicine. No recurrence was observed at the 1-year follow-up. This re...
Source: Ear, Nose and Throat Journal - November 9, 2023 Category: ENT & OMF Authors: None Zhen-Li None De-Dai Hui-Kuan Chen Xin-Kai Zhou Source Type: research
Peripheral Artery Disease: Underappreciated Impact and Residual Cardiovascular Risk Despite Revascularization
Clin Ther. 2023 Nov 6:S0149-2918(23)00384-3. doi: 10.1016/j.clinthera.2023.09.021. Online ahead of print.ABSTRACTThis Commentary highlights the under-recognized prevalence and heavy burden of peripheral artery disease (PAD) and its important role as a harbinger of complications of atherosclerotic cardiovascular disease. Although increasing in prevalence globally, PAD is being further accelerated with diabetes, and patients with advanced PAD are at high risk for chronic limb-threatening ischemia. The need for (repeated) revascularization and amputation places a heavy social burden on patients and family, and a heavy financi...
Source: Atherosclerosis - November 8, 2023 Category: Cardiology Authors: Shirley Jansen Gert J de Borst Robert Hinchliffe Martin Teraa Source Type: research
Peripheral Artery Disease: Underappreciated Impact and Residual Cardiovascular Risk Despite Revascularization
Clin Ther. 2023 Nov 6:S0149-2918(23)00384-3. doi: 10.1016/j.clinthera.2023.09.021. Online ahead of print.ABSTRACTThis Commentary highlights the under-recognized prevalence and heavy burden of peripheral artery disease (PAD) and its important role as a harbinger of complications of atherosclerotic cardiovascular disease. Although increasing in prevalence globally, PAD is being further accelerated with diabetes, and patients with advanced PAD are at high risk for chronic limb-threatening ischemia. The need for (repeated) revascularization and amputation places a heavy social burden on patients and family, and a heavy financi...
Source: Clinical Therapeutics - November 8, 2023 Category: Drugs & Pharmacology Authors: Shirley Jansen Gert J de Borst Robert Hinchliffe Martin Teraa Source Type: research
Peripheral Artery Disease: Underappreciated Impact and Residual Cardiovascular Risk Despite Revascularization
Clin Ther. 2023 Nov 6:S0149-2918(23)00384-3. doi: 10.1016/j.clinthera.2023.09.021. Online ahead of print.ABSTRACTThis Commentary highlights the under-recognized prevalence and heavy burden of peripheral artery disease (PAD) and its important role as a harbinger of complications of atherosclerotic cardiovascular disease. Although increasing in prevalence globally, PAD is being further accelerated with diabetes, and patients with advanced PAD are at high risk for chronic limb-threatening ischemia. The need for (repeated) revascularization and amputation places a heavy social burden on patients and family, and a heavy financi...
Source: Atherosclerosis - November 8, 2023 Category: Cardiology Authors: Shirley Jansen Gert J de Borst Robert Hinchliffe Martin Teraa Source Type: research
Peripheral Artery Disease: Underappreciated Impact and Residual Cardiovascular Risk Despite Revascularization
Clin Ther. 2023 Nov 6:S0149-2918(23)00384-3. doi: 10.1016/j.clinthera.2023.09.021. Online ahead of print.ABSTRACTThis Commentary highlights the under-recognized prevalence and heavy burden of peripheral artery disease (PAD) and its important role as a harbinger of complications of atherosclerotic cardiovascular disease. Although increasing in prevalence globally, PAD is being further accelerated with diabetes, and patients with advanced PAD are at high risk for chronic limb-threatening ischemia. The need for (repeated) revascularization and amputation places a heavy social burden on patients and family, and a heavy financi...
Source: Clinical Therapeutics - November 8, 2023 Category: Drugs & Pharmacology Authors: Shirley Jansen Gert J de Borst Robert Hinchliffe Martin Teraa Source Type: research
Does switching from coated colchicine to compressed colchicine improves treatment response in patients with familial Mediterranean fever?
CONCLUSIONS: Compressed colchicine was shown to be a useful treatment option before initiating biological agents in non-responders to coated colchicine, especially those with side effects.PMID:37927190 (Source: Croatian Medical Journal)
Source: Croatian Medical Journal - November 6, 2023 Category: General Medicine Authors: Nimet Öner Elif Çelikel Zahide Ekici Tekin Vildan G üngörer Tuba Kurt M üge Sezer Nil üfer Tekgöz C üneyt Karagöl Serkan Co şkun Melike Mehve ş Kaplan Merve Cansu Polat Banu Çelikel Acar Source Type: research
Does switching from coated colchicine to compressed colchicine improves treatment response in patients with familial Mediterranean fever?
CONCLUSIONS: Compressed colchicine was shown to be a useful treatment option before initiating biological agents in non-responders to coated colchicine, especially those with side effects.PMID:37927190 (Source: Croatian Medical Journal)
Source: Croatian Medical Journal - November 6, 2023 Category: General Medicine Authors: Nimet Öner Elif Çelikel Zahide Ekici Tekin Vildan G üngörer Tuba Kurt M üge Sezer Nil üfer Tekgöz C üneyt Karagöl Serkan Co şkun Melike Mehve ş Kaplan Merve Cansu Polat Banu Çelikel Acar Source Type: research
Does switching from coated colchicine to compressed colchicine improves treatment response in patients with familial Mediterranean fever?
CONCLUSIONS: Compressed colchicine was shown to be a useful treatment option before initiating biological agents in non-responders to coated colchicine, especially those with side effects.PMID:37927190 (Source: Croatian Medical Journal)
Source: Croatian Medical Journal - November 6, 2023 Category: General Medicine Authors: Nimet Öner Elif Çelikel Zahide Ekici Tekin Vildan G üngörer Tuba Kurt M üge Sezer Nil üfer Tekgöz C üneyt Karagöl Serkan Co şkun Melike Mehve ş Kaplan Merve Cansu Polat Banu Çelikel Acar Source Type: research
Does switching from coated colchicine to compressed colchicine improves treatment response in patients with familial Mediterranean fever?
CONCLUSIONS: Compressed colchicine was shown to be a useful treatment option before initiating biological agents in non-responders to coated colchicine, especially those with side effects.PMID:37927190 (Source: Croatian Medical Journal)
Source: Croatian Medical Journal - November 6, 2023 Category: General Medicine Authors: Nimet Öner Elif Çelikel Zahide Ekici Tekin Vildan G üngörer Tuba Kurt M üge Sezer Nil üfer Tekgöz C üneyt Karagöl Serkan Co şkun Melike Mehve ş Kaplan Merve Cansu Polat Banu Çelikel Acar Source Type: research
Does switching from coated colchicine to compressed colchicine improves treatment response in patients with familial Mediterranean fever?
CONCLUSIONS: Compressed colchicine was shown to be a useful treatment option before initiating biological agents in non-responders to coated colchicine, especially those with side effects.PMID:37927190 (Source: Croatian Medical Journal)
Source: Croatian Medical Journal - November 6, 2023 Category: General Medicine Authors: Nimet Öner Elif Çelikel Zahide Ekici Tekin Vildan G üngörer Tuba Kurt M üge Sezer Nil üfer Tekgöz C üneyt Karagöl Serkan Co şkun Melike Mehve ş Kaplan Merve Cansu Polat Banu Çelikel Acar Source Type: research
Does switching from coated colchicine to compressed colchicine improves treatment response in patients with familial Mediterranean fever?
CONCLUSIONS: Compressed colchicine was shown to be a useful treatment option before initiating biological agents in non-responders to coated colchicine, especially those with side effects.PMID:37927190 (Source: Croatian Medical Journal)
Source: Croatian Medical Journal - November 6, 2023 Category: General Medicine Authors: Nimet Öner Elif Çelikel Zahide Ekici Tekin Vildan G üngörer Tuba Kurt M üge Sezer Nil üfer Tekgöz C üneyt Karagöl Serkan Co şkun Melike Mehve ş Kaplan Merve Cansu Polat Banu Çelikel Acar Source Type: research
Does switching from coated colchicine to compressed colchicine improves treatment response in patients with familial Mediterranean fever?
CONCLUSIONS: Compressed colchicine was shown to be a useful treatment option before initiating biological agents in non-responders to coated colchicine, especially those with side effects.PMID:37927190 (Source: Croatian Medical Journal)
Source: Croatian Medical Journal - November 6, 2023 Category: General Medicine Authors: Nimet Öner Elif Çelikel Zahide Ekici Tekin Vildan G üngörer Tuba Kurt M üge Sezer Nil üfer Tekgöz C üneyt Karagöl Serkan Co şkun Melike Mehve ş Kaplan Merve Cansu Polat Banu Çelikel Acar Source Type: research
