Cluster of Differentiation-44-Targeting Prussian Blue Nanoparticles Onloaded with Colchicine for Atherosclerotic Plaque Regression in a Mice Model
In this study, the cluster of differentiation-44 receptor was verified to be overexpressed in inflammatory macrophages within plaques both in vitro and in vivo. Subsequently, a Prussian blue-based nanomedical loading system with hyaluronic acid (HA) coating was constructed, and its effects were observed on the atherosclerosis regression. Colchicine and Cy5.5 were encapsulated within Prussian blue nanoparticles through self-assembly, followed by conjugation with hyaluronic acid to create col@PBNP@HA. The formulated col@PBNP@HA displayed a cubic shape and scattered distribution. Importantly, col@PBNP@HA demonstrated specific...
Source: Atherosclerosis - February 19, 2024 Category: Cardiology Authors: Yan Zhu Yan Fang Yujia Wang Dong Han Jing Liu Lei Tian Mengqi Xu Yabin Wang Feng Cao Source Type: research
Mesenteric artery smooth muscle cells from hypertensive rats have increased microtubule acetylation
Conclusions:</p> Acetylation of tubulin at Lys40 is elevated in mesenteric arteries from the SHR. Furthermore, this study shows that tubacin has an endothelial-dependent bimodal effect on isoprenaline-mediated vasorelaxation.PMID:38373073 | DOI:10.1042/BCJ20230420 (Source: The Biochemical Journal)
Source: The Biochemical Journal - February 19, 2024 Category: Biochemistry Authors: Anthony M Mozzicato Joakim A Bastrup Jose L Sanchez Alonso Jennifer van der Horst Julia Gorelik Per M årten Hägglund Thomas Jepps Source Type: research
Cluster of Differentiation-44-Targeting Prussian Blue Nanoparticles Onloaded with Colchicine for Atherosclerotic Plaque Regression in a Mice Model
In this study, the cluster of differentiation-44 receptor was verified to be overexpressed in inflammatory macrophages within plaques both in vitro and in vivo. Subsequently, a Prussian blue-based nanomedical loading system with hyaluronic acid (HA) coating was constructed, and its effects were observed on the atherosclerosis regression. Colchicine and Cy5.5 were encapsulated within Prussian blue nanoparticles through self-assembly, followed by conjugation with hyaluronic acid to create col@PBNP@HA. The formulated col@PBNP@HA displayed a cubic shape and scattered distribution. Importantly, col@PBNP@HA demonstrated specific...
Source: Atherosclerosis - February 19, 2024 Category: Cardiology Authors: Yan Zhu Yan Fang Yujia Wang Dong Han Jing Liu Lei Tian Mengqi Xu Yabin Wang Feng Cao Source Type: research
Mesenteric artery smooth muscle cells from hypertensive rats have increased microtubule acetylation
Conclusions:</p> Acetylation of tubulin at Lys40 is elevated in mesenteric arteries from the SHR. Furthermore, this study shows that tubacin has an endothelial-dependent bimodal effect on isoprenaline-mediated vasorelaxation.PMID:38373073 | DOI:10.1042/BCJ20230420 (Source: The Biochemical Journal)
Source: The Biochemical Journal - February 19, 2024 Category: Biochemistry Authors: Anthony M Mozzicato Joakim A Bastrup Jose L Sanchez Alonso Jennifer van der Horst Julia Gorelik Per M årten Hägglund Thomas Jepps Source Type: research
Molecules, Vol. 29, Pages 914: Novel Antineoplastic Inducers of Mitochondrial Apoptosis in Human Cancer Cells
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I propose a new strategy to suppress human cancer completely with two entirely new drug compounds exploiting cancer&rsquo;s Warburg effect characterized by a defective mitochondrial aerobic respiration, substituted by cytosolic aerobic fermentation/glycolysis of D-(+)-glucose into L-(+)-lactic acid. The two essentially new drugs, compound 1 [P(op)T(est)162] and compound 3 (PT167), represent new highly symmetric, four-bladed propeller-shaped polyammonium cations. The in vitro antineoplastic highly efficacious drug compound 3 represents a covalent combination of compound 1 and compound 2 (PT166). The intermedia...
Source: Molecules - February 19, 2024 Category: Chemistry Authors: Andreas J. Kesel Tags: Article Source Type: research
Interventions to prevent postoperative atrial fibrillation in Dutch cardiothoracic centres: a survey study
CONCLUSION: Despite the use of various preventive strategies, the reported incidence of POAF was similar in Dutch cardiothoracic centres. This study highlights limited use of prophylactic amiodarone and colchicine, despite recommendations by numerous guidelines, and restricted implementation of surgical strategies to prevent POAF.PMID:38358408 | DOI:10.1007/s12471-023-01849-1 (Source: Netherlands Heart Journal)
Source: Netherlands Heart Journal - February 15, 2024 Category: Cardiology Authors: Angelique Emiola Jolanda Kluin Sulayman El Mathari Joris R de Groot Wim-Jan van Boven Cardiothoracic Surgery Data Registration Committee of the Netherlands Heart Registry Source Type: research
Interventions to prevent postoperative atrial fibrillation in Dutch cardiothoracic centres: a survey study
CONCLUSION: Despite the use of various preventive strategies, the reported incidence of POAF was similar in Dutch cardiothoracic centres. This study highlights limited use of prophylactic amiodarone and colchicine, despite recommendations by numerous guidelines, and restricted implementation of surgical strategies to prevent POAF.PMID:38358408 | DOI:10.1007/s12471-023-01849-1 (Source: Netherlands Heart Journal)
Source: Netherlands Heart Journal - February 15, 2024 Category: Cardiology Authors: Angelique Emiola Jolanda Kluin Sulayman El Mathari Joris R de Groot Wim-Jan van Boven Cardiothoracic Surgery Data Registration Committee of the Netherlands Heart Registry Source Type: research
Novel 4-Aryl-4H-chromene derivative displayed excellent in vivo anti-glioblastoma efficacy as the microtubule-targeting agent
In this study, a series of novel 4-Aryl-4H-chromene derivatives (D1-D31) were designed and synthesized by integrating quinoline heterocycle to crolibulin template molecule based on the strategy of molecular hybridization. One of these compounds D19 displayed positive antiproliferative activity against U87 cancer cell line (IC50 = 0.90 ± 0.03 μM). Compound D19 was verified as the microtubule-targeting agent through downregulating tubulin related genes of U87 cells, destroying the cytoskeleton of tubulins and interacting with the colchicine-binding site to inhibit the polymerization of tubulins by transcriptome analysis, i...
Source: European Journal of Medicinal Chemistry - February 13, 2024 Category: Chemistry Authors: Haoyi Yang Dongyu Zhang Ziyang Yuan Haishi Qiao Zhuolu Xia Feng Cao Yuanyuan Lu Feng Jiang Source Type: research
Anticancer mechanism of coumarin-based derivatives
Eur J Med Chem. 2024 Jan 30;267:116179. doi: 10.1016/j.ejmech.2024.116179. Online ahead of print.ABSTRACTThe structural motif of coumarins is related with various biological activities and pharmacological properties. Both natural coumarin extracted from various plants or a new coumarin derivative synthesized by modification of the basic structure of coumarin, in vitro experiments showed that coumarins are a promising class of anti-tumor agents with high selectivity. Cancer is a complex and multifaceted group of diseases characterized by the uncontrolled and abnormal growth of cells in the body. This review focuses on the a...
Source: European Journal of Medicinal Chemistry - February 10, 2024 Category: Chemistry Authors: Anand Kumar Yadav Ramina Maharjan Shrestha Paras Nath Yadav Source Type: research
Update on the Role of Colchicine in Cardiovascular Disease
AbstractPurpose of ReviewThis review focuses on the use of colchicine to target inflammation to prevent cardiovascular events among those at-risk for or with established coronary artery disease.Recent FindingsColchicine is an anti-inflammatory drug that reduces cardiovascular events through its effect on the IL-1 β/IL-6/CRP pathway, which promotes the progression and rupture of atherosclerotic plaques. Clinical trials have demonstrated that colchicine reduces cardiovascular events by 31% among those with chronic coronary disease, and by 23% among those with recent myocardial infarction. Its ability to dampe n inflammation...
Source: Current Cardiology Reports - February 10, 2024 Category: Cardiology Source Type: research
Investigating the Promising Anticancer Activity of Cetuximab and Fenbendazole Combination as Dual CBS and VEGFR-2 Inhibitors and Endowed with Apoptotic Potential
Chem Biodivers. 2024 Feb 6:e202302081. doi: 10.1002/cbdv.202302081. Online ahead of print.ABSTRACTIn this work, the cytotoxicity of monoclonal antibody (Cetuximab, Ce) and Fenbendazole (Fen), as well as their combination therapy were tested with the MTT assay. On the other side, Ce, Fen, and a combination between them were subjected to a colchicine-tubulin binding test, which was conducted and compared to Colchicine as a reference standard. Besides, Ce, Fen, and the combination of them were tested against the VEGFR-2 target receptor, compared to Sorafenib as the standard medication. Moreover, the qRT-PCR technique was used...
Source: Chemistry and Biodiversity - February 6, 2024 Category: Biochemistry Authors: Norhan M Eid Ahmed A Al-Karmalawy Taha M A Eldebss Heba K A Elhakim Source Type: research
Colchicine disrupts bile acid metabolic homeostasis by affecting the enterohepatic circulation in mice
In conclusion, our study revealed that COL treatment affected bile acid biosynthesis and enterohepatic circulation, thereby disrupting bile acid metabolic homeostasis in mice. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - February 5, 2024 Category: Toxicology Authors: Yongpeng Shi,
Li Wei,
Fang Jin,
Ji Wang,
Hanwen Cao,
Ying Yang,
Lan Gao Tags: RESEARCH ARTICLE Source Type: research
Gout: one year in review 2023
Clin Exp Rheumatol. 2024 Jan;42(1):1-9. doi: 10.55563/clinexprheumatol/uhyzcr. Epub 2024 Jan 24.ABSTRACTGout is a chronic joint disease caused by the deposition of monosodium urate crystals into and around the articular tissues. In the last two years, new insights regarding diagnosis, genetic involvement, pathogenesis, comorbidities, and clinical data, have allowed the identification of new strategies to improve the control of the disease and its flares. In keeping, the discover of new mechanisms concerning crystal-induced inflammation have suggested new ways for the management not only of gout, but also other systemic dis...
Source: Clinical and Experimental Rheumatology - February 2, 2024 Category: Rheumatology Authors: Leonardo Punzi Paola Galozzi Roberto Luisetto Anna Scanu Roberta Ramonda Francesca Oliviero Source Type: research
