Molecular and cellular characterization of immunity conferred by lactobacilli against necrotic enteritis in chickens
In conclusion, the results presented here suggest that treatment with the lactobacilli cocktail containing L. johnsonii and L. reuteri reduced necrotic enteritis lesions in the small intestine of chickens, possibly through the modulation of immune responses. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - November 7, 2023 Category: Allergy & Immunology Source Type: research
Comparative analysis of the intestinal microbiome in Rattus norvegicus from different geographies
In conclusion, we explored diverse microbial communities in R. norvegicus intestines captured from different regions. Further, we identified several opportunistic and potential bacterial pathogens, which still need to be tested for their underlying pathogenesis. The findings of our current study should be considered a warning to the health authorities to implement rat control and surveillance strategies globally. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - November 3, 2023 Category: Microbiology Source Type: research
Clostridium perfringens phospholipase C, an archetypal bacterial virulence factor, induces the formation of extracellular traps by human neutrophils
Neutrophil extracellular traps (NETs) are networks of DNA and various microbicidal proteins released to kill invading microorganisms and prevent their dissemination. However, a NETs excess is detrimental to the host and involved in the pathogenesis of various inflammatory and immunothrombotic diseases. Clostridium perfringens is a widely distributed pathogen associated with several animal and human diseases, that produces many exotoxins, including the phospholipase C (CpPLC), the main virulence factor in gas gangrene. During this disease, CpPLC generates the formation of neutrophil/platelet aggregates within the vasculatur...
Source: Frontiers in cellular and infection microbiology - October 27, 2023 Category: Microbiology Source Type: research
Percutaneous decompression of primary hepatic gas gangrene caused by Clostridium perfringens
(Source: Journal of Vascular and Interventional Radiology : JVIR)
Source: Journal of Vascular and Interventional Radiology : JVIR - October 27, 2023 Category: Radiology Authors: Rachel Brader, Hyeon Yu Tags: Letter to the Editor Source Type: research
Cancers, Vol. 15, Pages 5091: Computed Tomography-Based Quantitative Texture Analysis and Gut Microbial Community Signatures Predict Survival in Non-Small Cell Lung Cancer
This study aims to combine computed tomography (CT)-based texture analysis (QTA) and a microbiome-based biomarker signature to predict the overall survival (OS) of immune checkpoint inhibitor (ICI)-treated non-small cell lung cancer (NSCLC) patients by analyzing their CT scans (n = 129) and fecal microbiome (n = 58). One hundred and five continuous CT parameters were obtained, where principal component analysis (PCA) identified seven major components that explained 80% of the data variation. Shotgun metagenomics (MG) and ITS analysis were performed to reveal the abundance of bacterial and fungal species. The relative abund...
Source: Cancers - October 21, 2023 Category: Cancer & Oncology Authors: David Dora Glen J. Weiss Zsolt Megyesfalvi Gabriella G állfy Edit Dulka Anna Kerpel-Fronius Judit Berta Judit Moldvay Balazs Dome Zoltan Lohinai Tags: Article Source Type: research
Evaluation of an in vitro experimental platform of human polarized intestinal epithelial monolayers for the hazard assessment of insecticidal proteins
Food Chem Toxicol. 2023 Oct 16:114106. doi: 10.1016/j.fct.2023.114106. Online ahead of print.ABSTRACTPrevious work demonstrated the utility of using human-derived intestinal epithelial cell (IEC) lines cultured as polarized monolayers on Transwell® filters to differentiate between hazardous and non-hazardous proteins. The current study seeks to further resolve appropriate concentrations for evaluating proteins of unknown hazard potential using the IEC experimental platform and leverages these parameters for evaluating the potential toxicity of insecticidal proteins characteristic of those expressed in genetically modified...
Source: Food and Chemical Toxicology - October 18, 2023 Category: Food Science Authors: Cindi S Zimmermann Ryan F Snow Brittany Wilson-Mifsud Kristine LeRoy Chad Boeckman Emily Huang Carey A Mathesius Jason M Roper Bryan P Hurley Source Type: research
Evaluation of an in vitro experimental platform of human polarized intestinal epithelial monolayers for the hazard assessment of insecticidal proteins
Food Chem Toxicol. 2023 Oct 16:114106. doi: 10.1016/j.fct.2023.114106. Online ahead of print.ABSTRACTPrevious work demonstrated the utility of using human-derived intestinal epithelial cell (IEC) lines cultured as polarized monolayers on Transwell® filters to differentiate between hazardous and non-hazardous proteins. The current study seeks to further resolve appropriate concentrations for evaluating proteins of unknown hazard potential using the IEC experimental platform and leverages these parameters for evaluating the potential toxicity of insecticidal proteins characteristic of those expressed in genetically modified...
Source: Food and Chemical Toxicology - October 18, 2023 Category: Food Science Authors: Cindi S Zimmermann Ryan F Snow Brittany Wilson-Mifsud Kristine LeRoy Chad Boeckman Emily Huang Carey A Mathesius Jason M Roper Bryan P Hurley Source Type: research
A specific gut microbiota signature is associated with an enhanced GLP-1 and GLP-2 secretion and improved metabolic control in patients with type 2 diabetes after metabolic Roux-en-Y gastric bypass
ConclusionsPatients with obesity and T2D submitted to mRYGB show an enhanced incretin response, a reduced gut permeability and a metabolic improvement, associated with a specific microbiota signature. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - October 17, 2023 Category: Endocrinology Source Type: research
In vitro antibacterial effects of Broussonetia papyrifera leaf extract and its anti-colitis in DSS-treated mice
Recently, the hybrid Broussonetia papyrifera (BP) has been extensively cultivated and predominantly utilized in ruminants because of its high protein and bioactive compound content. In the present study, the effects of an ethanolic extract of BP leaves (BPE, 200 mg/kg) on mitigating 2% dextran sodium sulfate (DSS)-induced intestinal inflammation in mice were evaluated. BPE is rich in flavonoids, polyphenols, and polysaccharides, and displays potent antioxidant and antibacterial activities against pathogenic strains such as Clostridium perfringens, Salmonella Typhimurium, and Salmonella enterica subsp. enterica in vitro. In...
Source: Frontiers in cellular and infection microbiology - October 16, 2023 Category: Microbiology Source Type: research
Acquisition site-based remodelling of Clostridium perfringens- and Clostridioides difficile-related gut microbiota
CONCLUSION: The alterations reported herein may have been influenced by C. difficile and diarrhoea acquisition site, despite C. perfringens' ability to cause alterations in microbiota due to its virulence factors. Our findings highlight the need for a holistic view of gut microbiota.PMID:37832162 | DOI:10.1016/j.cimid.2023.102074 (Source: Comparative immunology, microbiology and infectious diseases.)
Source: Comparative immunology, microbiology and infectious diseases. - October 13, 2023 Category: Allergy & Immunology Authors: Giovanny Herrera Laura Vega Anny Camargo Manuel Alfonso Patarroyo Juan David Ram írez Marina Mu ñoz Source Type: research
Acquisition site-based remodelling of Clostridium perfringens- and Clostridioides difficile-related gut microbiota
CONCLUSION: The alterations reported herein may have been influenced by C. difficile and diarrhoea acquisition site, despite C. perfringens' ability to cause alterations in microbiota due to its virulence factors. Our findings highlight the need for a holistic view of gut microbiota.PMID:37832162 | DOI:10.1016/j.cimid.2023.102074 (Source: Comparative immunology, microbiology and infectious diseases.)
Source: Comparative immunology, microbiology and infectious diseases. - October 13, 2023 Category: Allergy & Immunology Authors: Giovanny Herrera Laura Vega Anny Camargo Manuel Alfonso Patarroyo Juan David Ram írez Marina Mu ñoz Source Type: research
Acquisition site-based remodelling of Clostridium perfringens- and Clostridioides difficile-related gut microbiota
CONCLUSION: The alterations reported herein may have been influenced by C. difficile and diarrhoea acquisition site, despite C. perfringens' ability to cause alterations in microbiota due to its virulence factors. Our findings highlight the need for a holistic view of gut microbiota.PMID:37832162 | DOI:10.1016/j.cimid.2023.102074 (Source: Comparative immunology, microbiology and infectious diseases.)
Source: Comparative immunology, microbiology and infectious diseases. - October 13, 2023 Category: Allergy & Immunology Authors: Giovanny Herrera Laura Vega Anny Camargo Manuel Alfonso Patarroyo Juan David Ram írez Marina Mu ñoz Source Type: research
IJERPH, Vol. 20, Pages 6898: Could Necroleachate Be the Cemetery & rsquo;s Sewage? A Panorama from Brazilian Legislation
IJERPH, Vol. 20, Pages 6898: Could Necroleachate Be the Cemetery’s Sewage? A Panorama from Brazilian Legislation
International Journal of Environmental Research and Public Health doi: 10.3390/ijerph20196898
Authors:
Ana Paula Chein Bueno de Azevedo
Telma Abdalla de Oliveira Cardoso
Simone Cynamon Cohen
Cemeteries can be compared to landfills, as the leachate produced in these areas, also known as necroleachate, can be environmentally transported, polluting groundwater, surface water, and soil. In Brazil, to ensure no negative environmental impacts and public health risks, cemetery management is the re...
Source: International Journal of Environmental Research and Public Health - October 8, 2023 Category: Environmental Health Authors: Ana Paula Chein Bueno de Azevedo Telma Abdalla de Oliveira Cardoso Simone Cynamon Cohen Tags: Article Source Type: research
