STING-dependent trained immunity contributes to host defense against Clostridium perfringens infection via mTOR signaling
AbstractClostridium perfringens (C. perfringens) infection is recognized as one of the most challenging issues threatening food safety and perplexing agricultural development. To date, the molecular mechanisms of the interactions betweenC. perfringens and the host remain poorly understood. Here, we show that stimulator of interferon genes (STING)-dependent trained immunity protected againstC. perfringens infection through mTOR signaling. Heat-killedCandida albicans (HKCA) training elicited elevated TNF- α and IL-6 production after LPS restimulation in mouse peritoneal macrophages (PM). Although HKCA-trained PM produced de...
Source: Veterinary Research - April 15, 2024 Category: Veterinary Research Source Type: research
Retraction for Harrison et al., "Molecular Characterization of < em > Clostridium perfringens < /em > Isolates from Humans with Sporadic Diarrhea: Evidence for Transcriptional Regulation of the Beta2-Toxin-Encoding Gene"
Appl Environ Microbiol. 2024 Apr 12:e0025924. doi: 10.1128/aem.00259-24. Online ahead of print.NO ABSTRACTPMID:38606962 | DOI:10.1128/aem.00259-24 (Source: Applied and Environmental Microbiology)
Source: Applied and Environmental Microbiology - April 12, 2024 Category: Microbiology Authors: Ben Harrison Deepa Raju Helen S Garmory Moira M Brett Richard W Titball Mahfuzur R Sarker Source Type: research
Retraction for Sarker et al., "Comparative Experiments To Examine the Effects of Heating on Vegetative Cells and Spores of < em > Clostridium perfringens < /em > Isolates Carrying Plasmid Genes versus Chromosomal Enterotoxin Genes"
Appl Environ Microbiol. 2024 Apr 12:e0024924. doi: 10.1128/aem.00249-24. Online ahead of print.NO ABSTRACTPMID:38606961 | DOI:10.1128/aem.00249-24 (Source: Applied and Environmental Microbiology)
Source: Applied and Environmental Microbiology - April 12, 2024 Category: Microbiology Authors: Mahfuzur R Sarker Robert P Shivers Shauna G Sparks Vijay K Juneja Bruce A McClane Source Type: research
Mechanisms of Intestinal Epithelial Cell Damage by Clostridium perfringens
Anaerobe. 2024 Apr 10:102856. doi: 10.1016/j.anaerobe.2024.102856. Online ahead of print.ABSTRACTClostridium perfringens, a Gram-positive bacterium, causes intestinal diseases in humans and livestock through its toxins, related to alpha toxin (CPA), beta toxin (CPB), C. perfringens enterotoxin (CPE), epsilon toxin (ETX), Iota toxin (ITX), and necrotic enteritis B-like toxin (NetB). These toxins disrupt intestinal barrier, leading to various cell death mechanisms such as necrosis, apoptosis, and necroptosis. Additionally, non-toxin factors like adhesins and degradative enzymes contribute to virulence by enhancing colonizati...
Source: Anaerobe - April 12, 2024 Category: Microbiology Authors: O U Lan-Xin Y E Bijin Sun Mingfei Qi Nanshan Li Juan Lv Minna Lin Xuhui Cai Haiming Hu Junjing Song Yongle Chen Xiangjie Zhu Yibin Yin Lijun Zhang Jianfei Liao Shenquan Zhang Haoji Source Type: research
Retraction for Harrison et al., "Molecular Characterization of < em > Clostridium perfringens < /em > Isolates from Humans with Sporadic Diarrhea: Evidence for Transcriptional Regulation of the Beta2-Toxin-Encoding Gene"
Appl Environ Microbiol. 2024 Apr 12:e0025924. doi: 10.1128/aem.00259-24. Online ahead of print.NO ABSTRACTPMID:38606962 | DOI:10.1128/aem.00259-24 (Source: Applied and Environmental Microbiology)
Source: Applied and Environmental Microbiology - April 12, 2024 Category: Microbiology Authors: Ben Harrison Deepa Raju Helen S Garmory Moira M Brett Richard W Titball Mahfuzur R Sarker Source Type: research
Retraction for Sarker et al., "Comparative Experiments To Examine the Effects of Heating on Vegetative Cells and Spores of < em > Clostridium perfringens < /em > Isolates Carrying Plasmid Genes versus Chromosomal Enterotoxin Genes"
Appl Environ Microbiol. 2024 Apr 12:e0024924. doi: 10.1128/aem.00249-24. Online ahead of print.NO ABSTRACTPMID:38606961 | DOI:10.1128/aem.00249-24 (Source: Applied and Environmental Microbiology)
Source: Applied and Environmental Microbiology - April 12, 2024 Category: Microbiology Authors: Mahfuzur R Sarker Robert P Shivers Shauna G Sparks Vijay K Juneja Bruce A McClane Source Type: research
Retraction for Harrison et al., "Molecular Characterization of < em > Clostridium perfringens < /em > Isolates from Humans with Sporadic Diarrhea: Evidence for Transcriptional Regulation of the Beta2-Toxin-Encoding Gene"
Appl Environ Microbiol. 2024 Apr 12:e0025924. doi: 10.1128/aem.00259-24. Online ahead of print.NO ABSTRACTPMID:38606962 | DOI:10.1128/aem.00259-24 (Source: Applied and Environmental Microbiology)
Source: Applied and Environmental Microbiology - April 12, 2024 Category: Microbiology Authors: Ben Harrison Deepa Raju Helen S Garmory Moira M Brett Richard W Titball Mahfuzur R Sarker Source Type: research
Retraction for Sarker et al., "Comparative Experiments To Examine the Effects of Heating on Vegetative Cells and Spores of < em > Clostridium perfringens < /em > Isolates Carrying Plasmid Genes versus Chromosomal Enterotoxin Genes"
Appl Environ Microbiol. 2024 Apr 12:e0024924. doi: 10.1128/aem.00249-24. Online ahead of print.NO ABSTRACTPMID:38606961 | DOI:10.1128/aem.00249-24 (Source: Applied and Environmental Microbiology)
Source: Applied and Environmental Microbiology - April 12, 2024 Category: Microbiology Authors: Mahfuzur R Sarker Robert P Shivers Shauna G Sparks Vijay K Juneja Bruce A McClane Source Type: research
Retraction for Waters et al., “Regulated Expression of the Beta2-Toxin Gene (cpb2) in Clostridium perfringens Type A Isolates from Horses with Gastrointestinal Diseases”
Journal of Clinical Microbiology, Ahead of Print. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - April 12, 2024 Category: Microbiology Authors: Michael WatersDeepa RajuHelen S. GarmoryMichel R. PopoffMahfuzur R. Sarker Source Type: research
Retraction for Waters et al., “Genotyping and Phenotyping of Beta2-Toxigenic Clostridium perfringens Fecal Isolates Associated with Gastrointestinal Diseases in Piglets
Journal of Clinical Microbiology, Ahead of Print. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - April 12, 2024 Category: Microbiology Authors: Michael WatersAmanda SavoieHelen S. GarmoryDawn BueschelMichel R. PopoffJ. Glenn SongerRichard W. TitballBruce A. McClaneMahfuzur R. Sarker Source Type: research
Cu-doped Fe < sub > 3 < /sub > O < sub > 4 < /sub > nanoparticles for efficient detoxification of epsilon toxin: Toward substituting magnetically recyclable detoxifying agent for formaldehyde
This study provides valuable insights into the development of an efficient and safe detoxifying agent, enabling the production of toxoids with a native-like structure. The magnetically recoverable and reusable nature of Cu-Fe3O4 nanoparticles offers practical advantages for easy recovery and reuse in detoxification reactions.PMID:38579983 | DOI:10.1016/j.toxicon.2024.107707 (Source: Toxicon)
Source: Toxicon - April 5, 2024 Category: Toxicology Authors: Parvaneh Esmaeilnejad-Ahranjani Marzieh Lotfi Azadeh Zahmatkesh Abbass Ali Esskandary Source Type: research
Cu-doped Fe < sub > 3 < /sub > O < sub > 4 < /sub > nanoparticles for efficient detoxification of epsilon toxin: Toward substituting magnetically recyclable detoxifying agent for formaldehyde
This study provides valuable insights into the development of an efficient and safe detoxifying agent, enabling the production of toxoids with a native-like structure. The magnetically recoverable and reusable nature of Cu-Fe3O4 nanoparticles offers practical advantages for easy recovery and reuse in detoxification reactions.PMID:38579983 | DOI:10.1016/j.toxicon.2024.107707 (Source: Toxicon)
Source: Toxicon - April 5, 2024 Category: Toxicology Authors: Parvaneh Esmaeilnejad-Ahranjani Marzieh Lotfi Azadeh Zahmatkesh Abbass Ali Esskandary Source Type: research
Cu-doped Fe < sub > 3 < /sub > O < sub > 4 < /sub > nanoparticles for efficient detoxification of epsilon toxin: Toward substituting magnetically recyclable detoxifying agent for formaldehyde
This study provides valuable insights into the development of an efficient and safe detoxifying agent, enabling the production of toxoids with a native-like structure. The magnetically recoverable and reusable nature of Cu-Fe3O4 nanoparticles offers practical advantages for easy recovery and reuse in detoxification reactions.PMID:38579983 | DOI:10.1016/j.toxicon.2024.107707 (Source: Toxicon)
Source: Toxicon - April 5, 2024 Category: Toxicology Authors: Parvaneh Esmaeilnejad-Ahranjani Marzieh Lotfi Azadeh Zahmatkesh Abbass Ali Esskandary Source Type: research
Intestinal Colonization by < em > Campylobacter jejuni < /em > , < em > Clostridium difficile < /em > , and < em > Clostridium perfringens < /em > among Commensal < em > Rattus norvegicus < /em > in the Urban Areas of Tehran, Iran
CONCLUSION: According to the findings, rats are the main reservoirs for diseases. Therefore, rodent control coupled with the implementation of surveillance systems should be prioritized for urban health.PMID:38572169 | PMC:PMC10990632 | DOI:10.1155/2024/2929315 (Source: Biomed Res)
Source: Biomed Res - April 4, 2024 Category: Research Authors: Taher Azimi Sina Nasrollahian Sahar Sabour Mehrdad Mosadegh Nahal Hadi Leila Azimi Fatemeh Fallah Mohammad Reza Pourmand Source Type: research
Intestinal Colonization by < em > Campylobacter jejuni < /em > , < em > Clostridium difficile < /em > , and < em > Clostridium perfringens < /em > among Commensal < em > Rattus norvegicus < /em > in the Urban Areas of Tehran, Iran
CONCLUSION: According to the findings, rats are the main reservoirs for diseases. Therefore, rodent control coupled with the implementation of surveillance systems should be prioritized for urban health.PMID:38572169 | PMC:PMC10990632 | DOI:10.1155/2024/2929315 (Source: Biomed Res)
Source: Biomed Res - April 4, 2024 Category: Research Authors: Taher Azimi Sina Nasrollahian Sahar Sabour Mehrdad Mosadegh Nahal Hadi Leila Azimi Fatemeh Fallah Mohammad Reza Pourmand Source Type: research
