How a gooey slime helps bacteria survive
(University of Tsukuba) Researchers from the University of Tsukuba found that the bacterium C. perfringens modulates the structure of its biofilm at different temperatures by regulating the expression of the novel extracellular protein BsaA. They showed the number of BsaA-producing cells decreases when the temperature increases from 25 ° C to 37 ° C, and BsaA-producing cells cover non-BsaA-producing cells to provide tolerance to external stresses. These findings help us understand how bacteria adapt to their environment to survive. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - August 3, 2020 Category: Biology Source Type: news

Chipotle Mexican Grill Agrees to Pay $25 Million Fine to Resolve Charges Stemming from More Than 1,100 Cases of Foodborne Illness
FDA OCI, Chipotle, $25 million, food safety, foodborne illness, compliance, adulterated food, Newport Beach CA, DPA, deferred prosecution agreement, norovirus, food safety protocols, failure to follow, Boston MA, Powell OH, c. perfringens, audits, training, criminal information (Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - April 22, 2020 Category: Medical Law Authors: DOJ Source Type: news

Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell
(Impact Journals LLC) Oncotarget Volume 11, Issue 4: Treatment of human oral squamous cell carcinoma cell lines HSC3 and HSC4 with Clostridium perfringens enterotoxin, induced CLDN4 nuclear translocation to enhance epithelial-mesenchymal transition, stemness, cell proliferation, and invasive ability. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 4, 2020 Category: Cancer & Oncology Source Type: news

Breast Milk Combats Growth of Bad Bacteria
The study found that human breast milk inhibits the growth of the harmful bacteria Staphylococcus aureus, Bacillus subtilis and Clostridium perfringens, but neither cow's milk or infant formula had any effect on those bacteria. (Source: WebMD Health)
Source: WebMD Health - October 16, 2019 Category: Consumer Health News Source Type: news

How bacteria play pass the parcel -- and help each other evade antibiotics
(Monash University) Bacteria are very sneaky in their efforts to develop resistance to antibiotics. Some strains of bacteria package up the genetic instructions for how they defend themselves and cause disease, and pass this information on to neighbouring, na ï ve, bacteria -- essentially gifting their colleagues with the defences they need to survive against our medical armoury of antibiotics. Scientists have now answered a key question about how a dangerous bacterium, Clostridium perfringens, shares its genetic information. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 13, 2018 Category: International Medicine & Public Health Source Type: news

NYC Mice Are Carrying Antibiotic-Resistant Germs
People who live in cities are used to the company of furry vermin. But a new study reveals that mice and men may be sharing much more than just living quarters. In a study published in the journal mBio, researchers led by Dr. Ian Lipkin, professor of epidemiology at the Mailman School of Public Health at Columbia University, studied the gut microbes of 416 mice collected from mostly residential buildings all over New York City. Lipkin and his team did a thorough genetic analysis of the microbes they extracted from the feces of the mice, and found that they contained a number of disease-causing bacteria. Nearly 40% of the ...
Source: TIME: Health - April 17, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Bacteria healthytime Source Type: news

Notes from the Field: Clostridium perfringens Outbreak at a Catered Lunch — Connecticut, September 2016
(Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - September 7, 2017 Category: American Health Source Type: news

Notes from the Field: Clostridium perfringens Gastroenteritis Outbreak Associated with a Catered Lunch — North Carolina, November 2015
(Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - November 23, 2016 Category: American Health Source Type: news

Trusting Your Gut: Diagnosis and Management of Clostridium septicum Infections
Clostridium septicum is a Gram-positive anaerobic bacillus that causes serious, life-threatening infections, including aggressive septicemia and myonecrosis. Clostridial myonecrosis can be broadly classified into two defined clinical presentations: traumatic and spontaneous. Clostridium perfringens is the most common cause of traumatic myonecrosis, while C. septicum is the most common etiological agent of spontaneous myonecrosis. Although rarely clinically encountered, C. septicum infections are often fatal. (Source: Clinical Microbiology Newsletter)
Source: Clinical Microbiology Newsletter - November 19, 2016 Category: Microbiology Authors: Michael J.G. Mallozzi, Andrew E. Clark Source Type: news

Stopping foodborne illness — faster testing, vigilance at home
The steady stream of reports about foodborne illness is making me think twice about what’s on my dinner plate. This year alone, we’ve seen dozens of food recalls, including one involving frozen tuna that was linked to 62 cases of Salmonella infection, and another that implicated ice cream in 10 cases of Listeria infection — and three deaths. Foodborne illness sickens 48 million people annually, sending 128,000 to the hospital and killing 3,000. You can get a foodborne illness from red meat, poultry, fish, eggs, dairy foods, and even fruits and vegetables. Bacteria in the Salmonella family are culprit No. 1; o...
Source: New Harvard Health Information - July 30, 2015 Category: Consumer Health News Authors: Heidi Godman Tags: Safety food safety foodborne illness Source Type: news

Oncoleaking: Use of the Pore-Forming Clostridium perfringens Enterotoxin (CPE) for Suicide Gene Therapy
Suicide gene therapy has been shown to be very efficient in tumor eradication. Numerous suicide genes were tested in vitro and in vivo demonstrating their therapeutic potential in clinical trials. Apart from this, still growing efforts are made to generate more targeted and more effective suicide gene systems for cancer gene therapy. In this regard bacterial toxins are an alternative, which add to the broad spectrum of different suicide strategies. In this context, the claudin-targeted bacterial Clostridium perfringens enterotoxin (CPE) is an attractive new type of suicide oncoleaking gene, which as pore-forming protein ex...
Source: Springer protocols feed by Cancer Research - June 26, 2015 Category: Cancer & Oncology Source Type: news

Gate for bacterial toxins found
(University of Freiburg) Prof. Dr. Dr. Klaus Aktories and Dr. Panagiotis Papatheodorou from the University of Freiburg have discovered the receptor responsible for smuggling the toxin of the bacterium Clostridium perfringens into the cell. The TpeL toxin is formed by C. perfringens, a pathogen that causes gas gangrene and food poisoning. It is very similar to the toxins of many other hospital germs of the genus Clostridium. Aktories is member of the BIOSS Centre for Biological Signalling Studies. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 16, 2014 Category: Biology Source Type: news

MS could be linked to food poisoning bacteria
Research in mice and small studies in humans suggest that a toxin produced by the bacterium C. perfringens could be a trigger for MS. (Source: Multiple Sclerosis Trust)
Source: Multiple Sclerosis Trust - January 29, 2014 Category: Neurology Source Type: news

Bacterial Toxin May Trigger Multiple Sclerosis Bacterial Toxin May Trigger Multiple Sclerosis
Researchers have identified a toxin produced by Clostridium perfringens type B as a possible trigger for MS, raising the potential for some novel therapeutic strategies. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 25, 2013 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Soil-based bacteria discovered in humans 'may trigger MS'
Scientists have discovered a soil-based bacteria in humans for the first time, and they believe it may be a trigger of multiple sclerosis. This is according to a study published in the journal PLOS ONE. Researchers from Weill Cornell Medical College and Rockefeller University discovered the bacterium Clostridium C. perfringens type B in a 21-year-old patient suffering from multiple sclerosis (MS). The researchers say although their study is small, their findings are so "intriguing" that it has caused them to start work on new treatments for the debilitating disorder... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 21, 2013 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news