The role of phosphodiesterase 9A inhibitors in heart failure
Expert Opin Investig Drugs. 2024 May 3. doi: 10.1080/13543784.2024.2349813. Online ahead of print.ABSTRACTINTRODUCTION: There are currently limited effective treatments available to improve lusitropy in patients suffering from heart failure with preserved ejection fraction. The role of PDE9A in diastolic dysfunction has been well-studied over recent years, with a special focus on its association with myocardial hypertrophy. Recent insights into PDE9A inhibition have brought to light the potential for reversal of cardiac remodeling, with multiple studies showing promising results in preclinical data.AREAS COVERED: This expe...
Source: Expert Opinion on Investigational Drugs - May 4, 2024 Category: Drugs & Pharmacology Authors: Saam Foroshani Avrohom Karp Wilbert S Aronow Gregg M Lanier Source Type: research
Efficacy and safety of venetoclax-based combination therapy for previously untreated acute myeloid leukemia: a meta-analysis
CONCLUSION: Venetoclax combined with azacitidine, decitabine, or LDAC significantly improved the CR/CRi and OS of patients with previously untreated AML. However, venetoclax plus azacitidine or LDAC was more likely to lead to increased febrile neutropenia and gastrointestinal toxicity.PMID:38703055 | DOI:10.1080/16078454.2024.2343604 (Source: Hematology)
Source: Hematology - May 4, 2024 Category: Hematology Authors: Hongbo He Xiaojia Wen Huyong Zheng Source Type: research
Pipelle Endometrial Sampling With a Full Bladder Compared With Standard Care: A Randomized Controlled Trial
CONCLUSION: Pipelle endometrial sampling with a full bladder reduces the initial insertion failure rate, procedure-related pain, and duration of sampling and increases patient satisfaction compared with the standard process.CLINICAL TRIAL REGISTRATION: ISRCTN, ISRCTN33938192.PMID:38703361 | DOI:10.1097/AOG.0000000000005597 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - May 4, 2024 Category: OBGYN Authors: Erwina Hashim Jesrine Hong Yin Ling Woo Mukhri Hamdan Peng Chiong Tan Source Type: research
Integrated Models of Population Pharmacokinetics and Exposure Response to Optimize Dosage Regimen for Anaprazole Sodium in Duodenal Ulcer
In conclusion, the drug is safe when dosing between 20 and 100 mg once a day.PMID:38703917 | DOI:10.1016/j.ejps.2024.106781 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - May 4, 2024 Category: Drugs & Pharmacology Authors: Lei Zhang Ling Song Cheng Cui Chunyang Wang Yi Zhang Xueting Yao Dongyang Liu Source Type: research
The Efficacy and Tolerability of Irbesartan/Amlodipine Combination Therapy in Patients With Essential Hypertension Whose Blood Pressure Were not Controlled by Irbesartan Monotherapy
This study aimed to evaluate the efficacy and tolerability of irbesartan (IRB) and amlodipine (AML) combination therapy in patients with essential hypertension whose blood pressure (BP) was not controlled by IRB monotherapy.METHODS: Two multicenter, randomized, double-blind, placebo-controlled, phase III studies were conducted in Korea (the I-DUO 301 study and the I-DUO 302 study). After a 4-week run-in period with either 150 mg IRB (I-DUO 301 study) or 300 mg IRB (I-DUO 302 study), patients with uncontrolled BP (ie, mean sitting systolic BP [MSSBP] ≥140 mmHg to <180 mmHg and mean sitting diastolic BP <110 mmHg) we...
Source: Clinical Therapeutics - May 4, 2024 Category: Drugs & Pharmacology Authors: Hae-Young Lee Kyung Wan Min Kyung Ah Han Jeong Su Kim Jeong Cheon Ahn Moo Hyun Kim Jin Bae Lee Sung-Hee Shin Chong-Jin Kim Kye Hun Kim Deok-Kyu Cho Junghyun Choi Moo-Yong Rhee Sung-Ho Her Weon Kim Jin Oh Na Goo-Yeong Cho Seok Yeon Kim Gyung-Min Park Bong- Source Type: research
High serum sodium predicts immunotherapy response in metastatic renal cell and urothelial carcinoma
CONCLUSIONS: Patients exhibiting elevated serum sodium levels derive the greatest benefit from immunotherapy, suggesting that baseline serum concentration could serve as a valuable and cost-effective predictive biomarker for immunotherapy across entities.PMID:38703618 | DOI:10.1016/j.ejca.2024.114089 (Source: Cancer Control)
Source: Cancer Control - May 4, 2024 Category: Cancer & Oncology Authors: Niklas Kl ümper Alexander Cox Markus Eckstein Christoph Kuppe Manuel Ritter Peter Brossart Julian Luetkens Michael H ölzel Johannes Stein Jonas Saal Source Type: research
Everolimus plus endocrine therapy beyond CDK4/6 inhibitors progression for HR+ /HER2- advanced breast cancer: a real-world evidence cohort
CONCLUSION: This retrospective analysis cohort of everolimus plus ET in mBC patients previously treated with a CDK4/6 inhibitor suggests a longer estimated mPFS when compared with the mPFS with ET monotherapy obtained from current randomized clinical data. Everolimus plus ET may be considered as a valid control arm in novel clinical trial designs.PMID:38703285 | DOI:10.1007/s10549-024-07324-8 (Source: Cancer Control)
Source: Cancer Control - May 4, 2024 Category: Cancer & Oncology Authors: Rodrigo S ánchez-Bayona Alfonso Lopez de Sa Yolanda Jerez Gilarranz Ana Sanchez de Torre Manuel Alva Isabel Echavarria Fernando Moreno Pablo Tolosa Blanca Herrero Lopez Alicia de Luna Laura Lema Salvador Gamez Casado Ainhoa Madariaga Sara L ópez-Tarruel Source Type: research
The role of phosphodiesterase 9A inhibitors in heart failure
Expert Opin Investig Drugs. 2024 May 3. doi: 10.1080/13543784.2024.2349813. Online ahead of print.ABSTRACTINTRODUCTION: There are currently limited effective treatments available to improve lusitropy in patients suffering from heart failure with preserved ejection fraction. The role of PDE9A in diastolic dysfunction has been well-studied over recent years, with a special focus on its association with myocardial hypertrophy. Recent insights into PDE9A inhibition have brought to light the potential for reversal of cardiac remodeling, with multiple studies showing promising results in preclinical data.AREAS COVERED: This expe...
Source: Expert Opinion on Investigational Drugs - May 4, 2024 Category: Drugs & Pharmacology Authors: Saam Foroshani Avrohom Karp Wilbert S Aronow Gregg M Lanier Source Type: research
Three-Year Outcomes of a Randomized Clinical Trial of Perioperative Vaginal Estrogen as Adjunct to Native Tissue Vaginal Apical Prolapse Repair
As the muscular and connective tissue components of the vagina are estrogen-responsive, clinicians may recommend vaginal estrogen to optimize tissues preoperatively and as a possible means to reduce prolapse recurrence, but long-term effects of perioperative intravaginal estrogen on surgical prolapse management are uncertain. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - May 4, 2024 Category: OBGYN Authors: David D. Rahn, Holly E. Richter, Vivian W. Sung, Jessica E. Pruszynski Tags: Meeting Papers: Society of Gynecologic Surgeons Source Type: research
Collaborative Model of Care between Orthopaedics and Allied Healthcare Professionals (CONNACT) in knee osteoarthritis: Effectiveness-implementation hybrid randomized controlled trial of a community-based, multidisciplinary, stratified intervention
To compare the clinical and cost effectiveness of the Collaborative Model of Care between Orthopaedics and Allied Healthcare Professionals (CONNACT), a community-based, stratified, multidisciplinary intervention consisting of exercise, education, psychological and nutrition delivered through a chronic care model to usual hospital care in adults with knee osteoarthritis (OA). (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - May 4, 2024 Category: Rheumatology Authors: Bryan Yijia TAN, YANG Su-Yin, Michelle Jessica Pereira, TAN Chun Yue, LIM Chien Joo, NG Julia Poh-Hwee, LEE Keng Thiam, PUA Yong Hao, Andrew M. Briggs, David J. Hunter, Soren T. Skou, Julian Thumboo, Josip Car Tags: Clinical Trial Source Type: research
Cancers, Vol. 16, Pages 1772: Macrophages Orchestrate the Liver Tumor Microenvironment
elli
Liver cancer is one of the leading causes of cancer-related mortality. Hepatocellular carcinoma and cholangiocarcinoma are the most common types, and despite numerous advances, therapeutic options still remain poor for these cancer patients. Tumor development and progression strictly depend on a supportive tumor microenvironment (TME). Tumor-associated macrophages (TAMs) are the most abundant immune cells population within a tumorigenic liver; they sustain cancer cells&rsquo; growth and invasiveness, and their presence is correlated with a poor prognosis. Furthermore, TAM cross-talk with cells and componen...
Source: Cancers - May 4, 2024 Category: Cancer & Oncology Authors: Valeria Quaranta Costanza Ballar ò Gianluigi Giannelli Tags: Review Source Type: research
Evidence Base for Pharmacogenetic Tests Still Lacking, APA Workgroup Finds
There is still not enough evidence to support the use of pharmacogenetic tests in the treatment of depression, according toupdated recommendations from APA ’s Workgroup on Biomarkers and Novel Treatments. The recommendations were published inAJP in Advance.Pharmacogenetic tests analyze an individual ’s genes (obtained via blood, saliva, or cheek swabs) to find genetic variants that may influence how fast antidepressants are metabolized or how well they attach to their receptors. Using special algorithms, the tests then calculate the combined impact of all the variants and offer readouts of an tidepressants that might b...
Source: Psychiatr News - May 3, 2024 Category: Psychiatry Tags: American Journal of Psychiatry antidepressant clinical trials Council on Research depression PGx pharmacogenetics position statement treatment response Source Type: research
Use of medical therapy and risk of clinical events according to frailty in heart failure patients – A real‐life cohort study
ConclusionIn real-world HF patients, frailty was associated with lower HF therapy use and with a higher incidence of clinical outcomes including mortality and non-HF hospitalization. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - May 3, 2024 Category: Cardiology Authors: Deewa Zahir Anjum,
Jarl E. Strange,
Emil Fosb øl,
Caroline Hartwell Garred,
Mariam Elmegaard,
Charlotte Andersson,
Pardeep S. Jhund,
John J.V. McMurray,
Mark C. Petrie,
Lars Kober,
Morten Schou Tags: Research Article Source Type: research
Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients
CONCLUSIONS: Prophylaxis with antiviral medications reduces CMV disease and CMV-associated death, compared with placebo or no treatment, in solid organ transplant recipients. These data support the continued routine use of antiviral prophylaxis in CMV-positive recipients and CMV-negative recipients of CMV-positive organ transplants.PMID:38700045 | PMC:PMC11066972 | DOI:10.1002/14651858.CD003774.pub5 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - May 3, 2024 Category: General Medicine Authors: Robin Wm Vernooij Mini Michael Maleeka Ladhani Angela C Webster Giovanni Fm Strippoli Jonathan C Craig Elisabeth M Hodson Source Type: research
The Missing Trial Variable: A Case Report on Dietary Modification in a Patient with Durable Complete Remission After an Immunotherapy Clinical Trial for Metastatic Bladder Cancer
Altern Ther Health Med. 2024 May 3:AT9333. Online ahead of print.ABSTRACTA patient with metastatic bladder cancer has had an ongoing 9-year complete remission on a clinical trial of immunotherapy with nivolumab and ipimumab, but he also was following an intensive dietary and nutritional supplement regimen. Whether this combination or the immunotherapy alone brought about his good outcome is unknown but could be clarified in future trials by improved data collection about dietary and supplement choices.PMID:38702166 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - May 3, 2024 Category: Complementary Medicine Authors: Linda L Isaacs Nicholas J Gonzalez Source Type: research
