Surgical evacuation with intraoperative ultrasound (SEE U): A randomised controlled trial
CONCLUSIONS: This multicentre pilot study showed that a large RCT comparing surgical management of miscarriage with and without intraoperative ultrasound is feasible.PMID:38705012 | DOI:10.1016/j.ejogrb.2024.04.004 (Source: Reproductive Biology)
Source: Reproductive Biology - May 5, 2024 Category: Reproduction Medicine Authors: Paul P Smith Versha Cheed Lee Middleton Adam J Devall Feras Izzat T Justin Clark Source Type: research
Environmental Implications and Nanotechnological Advances in Octocrylene-Enriched Sunscreen Formulations: A Comprehensive Review
Chemosphere. 2024 May 3:142235. doi: 10.1016/j.chemosphere.2024.142235. Online ahead of print.ABSTRACTUltraviolet (UV) radiation is a major contributor to skin aging, cancer, and other detrimental health effects. Sunscreens containing FDA-approved UV filters, like avobenzone, offer protection but suffer from photodegradation and potential phototoxicity. Encapsulation, antioxidants, and photostabilizers are strategies employed to combat these drawbacks. Octocrylene, an organic UV filter, utilizes nanotechnology to enhance sun protection factor (SPF). This review examines recent literature on octocrylene-enriched sunscreens,...
Source: Chemosphere - May 5, 2024 Category: Chemistry Authors: Amol D Gholap Sagar R Pardeshi Navnath T Hatvate Nilesh Dhorkule Sadikali F Sayyad Md Faiyazuddin Mohammad Khalid Source Type: research
Environmental Implications and Nanotechnological Advances in Octocrylene-Enriched Sunscreen Formulations: A Comprehensive Review
Chemosphere. 2024 May 3:142235. doi: 10.1016/j.chemosphere.2024.142235. Online ahead of print.ABSTRACTUltraviolet (UV) radiation is a major contributor to skin aging, cancer, and other detrimental health effects. Sunscreens containing FDA-approved UV filters, like avobenzone, offer protection but suffer from photodegradation and potential phototoxicity. Encapsulation, antioxidants, and photostabilizers are strategies employed to combat these drawbacks. Octocrylene, an organic UV filter, utilizes nanotechnology to enhance sun protection factor (SPF). This review examines recent literature on octocrylene-enriched sunscreens,...
Source: Chemosphere - May 5, 2024 Category: Chemistry Authors: Amol D Gholap Sagar R Pardeshi Navnath T Hatvate Nilesh Dhorkule Sadikali F Sayyad Md Faiyazuddin Mohammad Khalid Source Type: research
Long-Term Comparative Efficacy and Safety of Risdiplam and Nusinersen in Children with Type 1 Spinal Muscular Atrophy
CONCLUSION: Long-term data supported risdiplam as a superior alternative to nusinersen in children with type 1 SMA. Video abstract available for this article. Video abstract (MP4 184542 KB).PMID:38705943 | DOI:10.1007/s12325-024-02845-6 (Source: Adv Data)
Source: Adv Data - May 5, 2024 Category: Epidemiology Authors: Christos Kokaliaris Rachel Evans Neil Hawkins Anadi Mahajan David Alexander Scott C Simone Sutherland Julian Nam Gautam Sajeev Source Type: research
Co-Occurrence of Apathy and Impulse Control Disorders in Parkinson Disease: Variation across Multiple Measures
CONCLUSIONS: We observed a co-occurrence of apathy and ICDs in PD patients with each apathy instrument; however, limited concurrent validity exists across measures. This is important for future investigations into shared pathophysiology and the design of future clinical trials aimed at improving the early detection and treatment of these debilitating syndromes.PMID:38704737 | DOI:10.1093/arclin/acae036 (Source: Archives of Clinical Neuropsychology)
Source: Archives of Clinical Neuropsychology - May 5, 2024 Category: Psychiatry & Psychology Authors: Bonnie M Scott Robert S Eisinger Roshan Mara Amtul-Noor Rana Sable Thompson Michael S Okun Aysegul Gunduz Dawn Bowers Source Type: research
Microbiome dynamics in immune checkpoint blockade
Trends Endocrinol Metab. 2024 May 4:S1043-2760(24)00096-1. doi: 10.1016/j.tem.2024.04.013. Online ahead of print.ABSTRACTImmune checkpoint blockade (ICB) is one of the leading immunotherapies, although a variable extent of resistance has been observed among patients and across cancer types. Among the efforts underway to overcome this challenge, the microbiome has emerged as a factor affecting the responsiveness and efficacy of ICB. Active research, facilitated by advances in sequencing techniques, is assessing the predominant influence of the intestinal microbiome, as well as the effects of the presence of an intratumoral ...
Source: Trends in Endocrinology and Metabolism: TEM - May 5, 2024 Category: Endocrinology Authors: Chae Won Kim Hyun-Jin Kim Heung Kyu Lee Source Type: research
Tension band versus locking plate fixation for patella fractures - a protocol of a randomised controlled trial
CONCLUSIONS: Findings from the present study are expected to advance our understanding of outcome following surgical treatment of patella fractures.FUNDING: This study is funded, in part, by the Novo Nordisk Foundation, Denmark.CLINICALTRIALS: gov ID: NCT04891549.PMID:38704836 | DOI:10.61409/A12230753 (Source: Danish Medical Journal)
Source: Danish Medical Journal - May 5, 2024 Category: General Medicine Authors: Rasmus Elsoe Rikke Thorninger Rasmus Severinsen Jens-Christian Beuke Rikke Serritslev Steffen Skov Jensen Morten Kjerri Rasmussen Peter Szephalmi Juozas Petruskevicius Jeppe Barckman Niels Henrik Bruun Peter Larsen Source Type: research
Is it possible to treat melanoma by intercepting the CXCR4/CXCL12 pathway?
We present an overview of the CXCR4/CXCL12 axis in cancer progression and explain its role in the melanoma microenvironment in this paper. Furthermore, we investigate CXCR4's predictive usefulness as a possible biomarker for monitoring melanoma progression. Finally, we discuss the most recent research and clinical trials on CXCR4 inhibitors, emphasizing their efficacy and limits. We hope to improve the quality of life for melanoma patients by better understanding the role of CXCR4 and investigating novel therapeutic options.PMID:38704961 | DOI:10.1016/j.cyto.2024.156629 (Source: Cytokine)
Source: Cytokine - May 5, 2024 Category: Molecular Biology Authors: Miriam Motlak Meghna Mathews Omar S Al-Odat Manoj K Pandey Source Type: research
Circulating miRNA and circulating tumor DNA application as liquid biopsy markers in gastric cancer
Clin Biochem. 2024 May 3:110767. doi: 10.1016/j.clinbiochem.2024.110767. Online ahead of print.ABSTRACTLiquid biopsy has been investigated as a novel method to overcome the numerous challenges in gastric cancer (GC) management. This non-invasive, feasible, and easy-to-repeat method has been shown to be cost-effective and capable of increasing diagnostic sensitivity and prognostic assessment. Additionally, it is potentially accurate to aid decision-making and personalized treatment planning. MicroRNA (miRNA) and circulating tumor DNA (ctDNA) markers can enhance GC management in various aspects, including diagnosis (mainly e...
Source: Clinical Biochemistry - May 5, 2024 Category: Biochemistry Authors: Farhad Shaker Sepideh Razi Nima Rezaei Source Type: research
Surgical evacuation with intraoperative ultrasound (SEE U): A randomised controlled trial
CONCLUSIONS: This multicentre pilot study showed that a large RCT comparing surgical management of miscarriage with and without intraoperative ultrasound is feasible.PMID:38705012 | DOI:10.1016/j.ejogrb.2024.04.004 (Source: Reproductive Biology)
Source: Reproductive Biology - May 5, 2024 Category: Reproduction Medicine Authors: Paul P Smith Versha Cheed Lee Middleton Adam J Devall Feras Izzat T Justin Clark Source Type: research
Environmental Implications and Nanotechnological Advances in Octocrylene-Enriched Sunscreen Formulations: A Comprehensive Review
Chemosphere. 2024 May 3:142235. doi: 10.1016/j.chemosphere.2024.142235. Online ahead of print.ABSTRACTUltraviolet (UV) radiation is a major contributor to skin aging, cancer, and other detrimental health effects. Sunscreens containing FDA-approved UV filters, like avobenzone, offer protection but suffer from photodegradation and potential phototoxicity. Encapsulation, antioxidants, and photostabilizers are strategies employed to combat these drawbacks. Octocrylene, an organic UV filter, utilizes nanotechnology to enhance sun protection factor (SPF). This review examines recent literature on octocrylene-enriched sunscreens,...
Source: Chemosphere - May 5, 2024 Category: Chemistry Authors: Amol D Gholap Sagar R Pardeshi Navnath T Hatvate Nilesh Dhorkule Sadikali F Sayyad Md Faiyazuddin Mohammad Khalid Source Type: research
Co-Occurrence of Apathy and Impulse Control Disorders in Parkinson Disease: Variation across Multiple Measures
CONCLUSIONS: We observed a co-occurrence of apathy and ICDs in PD patients with each apathy instrument; however, limited concurrent validity exists across measures. This is important for future investigations into shared pathophysiology and the design of future clinical trials aimed at improving the early detection and treatment of these debilitating syndromes.PMID:38704737 | DOI:10.1093/arclin/acae036 (Source: Archives of Clinical Neuropsychology)
Source: Archives of Clinical Neuropsychology - May 5, 2024 Category: Psychiatry & Psychology Authors: Bonnie M Scott Robert S Eisinger Roshan Mara Amtul-Noor Rana Sable Thompson Michael S Okun Aysegul Gunduz Dawn Bowers Source Type: research
Cancers, Vol. 16, Pages 1779: Opaganib Downregulates N-Myc Expression and Suppresses In Vitro and In Vivo Growth of Neuroblastoma Cells
D. Smith
Neuroblastoma (NB), the most common cancer in infants and the most common solid tumor outside the brain in children, grows aggressively and responds poorly to current therapies. We have identified a new drug (opaganib, also known as ABC294640) that modulates sphingolipid metabolism by inhibiting the synthesis of sphingosine 1-phosphate (S1P) by sphingosine kinase-2 and elevating dihydroceramides by inhibition of dihydroceramide desaturase. The present studies sought to determine the potential therapeutic activity of opaganib in cell culture and xenograft models of NB. Cytotoxicity assays demonstrated that NB ...
Source: Cancers - May 5, 2024 Category: Cancer & Oncology Authors: Lynn W. Maines Staci N. Keller Ryan A. Smith Randy S. Schrecengost Charles D. Smith Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1780: How Immunotherapy Has Redefined the Treatment Paradigm of Metastatic or Locally Advanced Muscle-Invasive Urothelial Bladder Carcinoma
oss-Goupil
In the past decade, the therapeutic arsenal for metastatic bladder cancer has expanded considerably, with the development of immune checkpoint inhibitors (ICIs), antibody–drug conjugates such as enfortumab vedotin, and anti-fibroblast growth factor receptor agents. Clinical trials evaluating ICIs as neoadjuvants, adjuvants, or first- or second-line treatments have produced conflicting results. However, first-line therapeutic strategies have been redefined by the recent publication of results from two clinical trials: CheckMate-901, which demonstrated the superiority of combined treatment with n...
Source: Cancers - May 5, 2024 Category: Cancer & Oncology Authors: Mathieu Larroquette F élix Lefort Charlotte Domblides Luc H éraudet Gr égoire Robert Alain Ravaud Marine Gross-Goupil Tags: Review Source Type: research
Unearthing naturally-occurring cyclic antibacterial peptides and their structural optimization strategies
We present here a detail review on the novel naturally-occurring CABPs discovered in the past decade and some of them are under clinical trials, exhibiting anticipated application potential. According to their chemical structures, they were broadly classified into five groups, including (i) lactam/lactone-based CABPs, (ii) cyclic lipopeptides, (iii) glycopeptides, (iv) cyclic sulfur-rich peptides and (v) multiple-modified CABPs. Their chemical structures, antibacterial spectrums and proposed mechanisms are discussed. Moreover, engineered analogs of these novel CABPs are also summarized to preliminarily analyze their struct...
Source: Biotechnology Advances - May 4, 2024 Category: Biotechnology Authors: Ping Zeng Honglan Wang Pengfei Zhang Sharon Shui Yee Leung Source Type: research
